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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The solution structure of the forkhead box-O DNA binding domain of <italic>Brugia malayi</italic>
DAF-16a</title>
<author><name sortKey="Casper, Sarah K" sort="Casper, Sarah K" uniqKey="Casper S" first="Sarah K." last="Casper">Sarah K. Casper</name>
<affiliation><nlm:aff id="A1">Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Health Sciences, Blackhawk Technical College, 1740 U.S. 41, Janesville, WI 53545</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schoeller, Scott J" sort="Schoeller, Scott J" uniqKey="Schoeller S" first="Scott J." last="Schoeller">Scott J. Schoeller</name>
<affiliation><nlm:aff id="A3">Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zgoba, Danielle M" sort="Zgoba, Danielle M" uniqKey="Zgoba D" first="Danielle M." last="Zgoba">Danielle M. Zgoba</name>
<affiliation><nlm:aff id="A1">Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Phillips, Andrew J" sort="Phillips, Andrew J" uniqKey="Phillips A" first="Andrew J." last="Phillips">Andrew J. Phillips</name>
<affiliation><nlm:aff id="A3">Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morien, Thomas J" sort="Morien, Thomas J" uniqKey="Morien T" first="Thomas J." last="Morien">Thomas J. Morien</name>
<affiliation><nlm:aff id="A3">Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chaffee, Gary R" sort="Chaffee, Gary R" uniqKey="Chaffee G" first="Gary R." last="Chaffee">Gary R. Chaffee</name>
<affiliation><nlm:aff id="A3">Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sackett, Peter C" sort="Sackett, Peter C" uniqKey="Sackett P" first="Peter C." last="Sackett">Peter C. Sackett</name>
<affiliation><nlm:aff id="A1">Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peterson, Francis C" sort="Peterson, Francis C" uniqKey="Peterson F" first="Francis C." last="Peterson">Francis C. Peterson</name>
<affiliation><nlm:aff id="A4">Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Crossgrove, Kirsten" sort="Crossgrove, Kirsten" uniqKey="Crossgrove K" first="Kirsten" last="Crossgrove">Kirsten Crossgrove</name>
<affiliation><nlm:aff id="A1">Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Veldkamp, Christopher T" sort="Veldkamp, Christopher T" uniqKey="Veldkamp C" first="Christopher T." last="Veldkamp">Christopher T. Veldkamp</name>
<affiliation><nlm:aff id="A3">Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25297652</idno>
<idno type="pmc">4809524</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809524</idno>
<idno type="RBID">PMC:4809524</idno>
<idno type="doi">10.1002/prot.24701</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">003830</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003830</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The solution structure of the forkhead box-O DNA binding domain of <italic>Brugia malayi</italic>
DAF-16a</title>
<author><name sortKey="Casper, Sarah K" sort="Casper, Sarah K" uniqKey="Casper S" first="Sarah K." last="Casper">Sarah K. Casper</name>
<affiliation><nlm:aff id="A1">Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Health Sciences, Blackhawk Technical College, 1740 U.S. 41, Janesville, WI 53545</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schoeller, Scott J" sort="Schoeller, Scott J" uniqKey="Schoeller S" first="Scott J." last="Schoeller">Scott J. Schoeller</name>
<affiliation><nlm:aff id="A3">Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zgoba, Danielle M" sort="Zgoba, Danielle M" uniqKey="Zgoba D" first="Danielle M." last="Zgoba">Danielle M. Zgoba</name>
<affiliation><nlm:aff id="A1">Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Phillips, Andrew J" sort="Phillips, Andrew J" uniqKey="Phillips A" first="Andrew J." last="Phillips">Andrew J. Phillips</name>
<affiliation><nlm:aff id="A3">Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morien, Thomas J" sort="Morien, Thomas J" uniqKey="Morien T" first="Thomas J." last="Morien">Thomas J. Morien</name>
<affiliation><nlm:aff id="A3">Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chaffee, Gary R" sort="Chaffee, Gary R" uniqKey="Chaffee G" first="Gary R." last="Chaffee">Gary R. Chaffee</name>
<affiliation><nlm:aff id="A3">Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sackett, Peter C" sort="Sackett, Peter C" uniqKey="Sackett P" first="Peter C." last="Sackett">Peter C. Sackett</name>
<affiliation><nlm:aff id="A1">Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peterson, Francis C" sort="Peterson, Francis C" uniqKey="Peterson F" first="Francis C." last="Peterson">Francis C. Peterson</name>
<affiliation><nlm:aff id="A4">Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Crossgrove, Kirsten" sort="Crossgrove, Kirsten" uniqKey="Crossgrove K" first="Kirsten" last="Crossgrove">Kirsten Crossgrove</name>
<affiliation><nlm:aff id="A1">Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Veldkamp, Christopher T" sort="Veldkamp, Christopher T" uniqKey="Veldkamp C" first="Christopher T." last="Veldkamp">Christopher T. Veldkamp</name>
<affiliation><nlm:aff id="A3">Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Proteins</title>
<idno type="ISSN">0887-3585</idno>
<idno type="eISSN">1097-0134</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1"><italic>Brugia malayi</italic>
is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of <italic>Brugia malayi</italic>
DAF-16a, a putative ortholog of <italic>Caenorhabditis elegans</italic>
DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. <italic>C. elegans</italic>
DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggest that <italic>B. malayi</italic>
DAF-16a is a member of the FOXO family of forkhead proteins.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8700181</journal-id>
<journal-id journal-id-type="pubmed-jr-id">6646</journal-id>
<journal-id journal-id-type="nlm-ta">Proteins</journal-id>
<journal-id journal-id-type="iso-abbrev">Proteins</journal-id>
<journal-title-group><journal-title>Proteins</journal-title>
</journal-title-group>
<issn pub-type="ppub">0887-3585</issn>
<issn pub-type="epub">1097-0134</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25297652</article-id>
<article-id pub-id-type="pmc">4809524</article-id>
<article-id pub-id-type="doi">10.1002/prot.24701</article-id>
<article-id pub-id-type="manuscript">NIHMS770925</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The solution structure of the forkhead box-O DNA binding domain of <italic>Brugia malayi</italic>
DAF-16a</article-title>
<subtitle>The FOXO domain of <italic>B. malayi</italic>
DAF-16a</subtitle>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Casper</surname>
<given-names>Sarah K.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref rid="FN3" ref-type="author-notes">^</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schoeller</surname>
<given-names>Scott J.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
<xref rid="FN3" ref-type="author-notes">^</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zgoba</surname>
<given-names>Danielle M.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Phillips</surname>
<given-names>Andrew J.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Morien</surname>
<given-names>Thomas J.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chaffee</surname>
<given-names>Gary R.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sackett</surname>
<given-names>Peter C.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN2" ref-type="author-notes">#</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peterson</surname>
<given-names>Francis C.</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Crossgrove</surname>
<given-names>Kirsten</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Veldkamp</surname>
<given-names>Christopher T.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</aff>
<aff id="A2"><label>2</label>
Department of Health Sciences, Blackhawk Technical College, 1740 U.S. 41, Janesville, WI 53545</aff>
<aff id="A3"><label>3</label>
Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</aff>
<aff id="A4"><label>4</label>
Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding authors: Christopher T. Veldkamp, Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190, <email>veldkamc@uww.edu</email>
, Kirsten Crossgrove, Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190, <email>crossgrk@uww.edu</email>
</corresp>
<fn id="FN2" fn-type="present-address"><label>#</label>
<p>Current Address: Evonik Industries, 900 S Palm St, Janesville, WI 53548.</p>
</fn>
<fn id="FN3" fn-type="equal"><label>^</label>
<p>These authors contributed equally.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>22</day>
<month>3</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>21</day>
<month>10</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>28</day>
<month>3</month>
<year>2016</year>
</pub-date>
<volume>82</volume>
<issue>12</issue>
<fpage>3490</fpage>
<lpage>3496</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/prot.24701</pmc-comment>
<abstract><p id="P1"><italic>Brugia malayi</italic>
is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of <italic>Brugia malayi</italic>
DAF-16a, a putative ortholog of <italic>Caenorhabditis elegans</italic>
DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. <italic>C. elegans</italic>
DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggest that <italic>B. malayi</italic>
DAF-16a is a member of the FOXO family of forkhead proteins.</p>
</abstract>
<kwd-group><kwd><italic>Brugia malayi</italic>
</kwd>
<kwd>forkhead box</kwd>
<kwd>winged helix</kwd>
<kwd>FOXO</kwd>
<kwd>FOXO1</kwd>
<kwd>FOXO3a</kwd>
<kwd>FOXO4</kwd>
<kwd>DAF-16</kwd>
<kwd><italic>Caenorhabdtis elegans</italic>
</kwd>
<kwd>insulin-signaling pathway</kwd>
<kwd>filariasis</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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