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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sub-100 nm Gold Nanomatryoshkas Improve Photo-thermal Therapy Efficacy in Large and Highly Aggressive Triple Negative Breast Tumors</title><author><name sortKey="Ayala Orozco, Ciceron" sort="Ayala Orozco, Ciceron" uniqKey="Ayala Orozco C" first="Ciceron" last="Ayala-Orozco">Ciceron Ayala-Orozco</name><affiliation><nlm:aff id="A1"> Department of Chemistry, Rice University, 6100 Main St, Houston, TX 77005, United States</nlm:aff></affiliation></author><author><name sortKey="Urban, Cordula" sort="Urban, Cordula" uniqKey="Urban C" first="Cordula" last="Urban">Cordula Urban</name><affiliation><nlm:aff id="A2"> Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Mail: BCM 360, One Baylor Plaza, Houston, TX 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Bishnoi, Sandra" sort="Bishnoi, Sandra" uniqKey="Bishnoi S" first="Sandra" last="Bishnoi">Sandra Bishnoi</name><affiliation><nlm:aff id="A3"> Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, United States</nlm:aff></affiliation></author><author><name sortKey="Urban, Alexander" sort="Urban, Alexander" uniqKey="Urban A" first="Alexander" last="Urban">Alexander Urban</name><affiliation><nlm:aff id="A3"> Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, United States</nlm:aff></affiliation></author><author><name sortKey="Charron, Heather" sort="Charron, Heather" uniqKey="Charron H" first="Heather" last="Charron">Heather Charron</name><affiliation><nlm:aff id="A2"> Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Mail: BCM 360, One Baylor Plaza, Houston, TX 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Tamika" sort="Mitchell, Tamika" uniqKey="Mitchell T" first="Tamika" last="Mitchell">Tamika Mitchell</name><affiliation><nlm:aff id="A4"> Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Shea, Martin" sort="Shea, Martin" uniqKey="Shea M" first="Martin" last="Shea">Martin Shea</name><affiliation><nlm:aff id="A4"> Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Nanda, Sarmistha" sort="Nanda, Sarmistha" uniqKey="Nanda S" first="Sarmistha" last="Nanda">Sarmistha Nanda</name><affiliation><nlm:aff id="A4"> Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Schiff, Rachel" sort="Schiff, Rachel" uniqKey="Schiff R" first="Rachel" last="Schiff">Rachel Schiff</name><affiliation><nlm:aff id="A4"> Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Halas, Naomi" sort="Halas, Naomi" uniqKey="Halas N" first="Naomi" last="Halas">Naomi Halas</name><affiliation><nlm:aff id="A1"> Department of Chemistry, Rice University, 6100 Main St, Houston, TX 77005, United States</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, United States</nlm:aff></affiliation></author><author><name sortKey="Joshi, Amit" sort="Joshi, Amit" uniqKey="Joshi A" first="Amit" last="Joshi">Amit Joshi</name><affiliation><nlm:aff id="A2"> Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Mail: BCM 360, One Baylor Plaza, Houston, TX 77030, United States</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25051221</idno><idno type="pmc">4156921</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156921</idno><idno type="RBID">PMC:4156921</idno><idno type="doi">10.1016/j.jconrel.2014.07.038</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003822</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003822</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sub-100 nm Gold Nanomatryoshkas Improve Photo-thermal Therapy Efficacy in Large and Highly Aggressive Triple Negative Breast Tumors</title><author><name sortKey="Ayala Orozco, Ciceron" sort="Ayala Orozco, Ciceron" uniqKey="Ayala Orozco C" first="Ciceron" last="Ayala-Orozco">Ciceron Ayala-Orozco</name><affiliation><nlm:aff id="A1"> Department of Chemistry, Rice University, 6100 Main St, Houston, TX 77005, United States</nlm:aff></affiliation></author><author><name sortKey="Urban, Cordula" sort="Urban, Cordula" uniqKey="Urban C" first="Cordula" last="Urban">Cordula Urban</name><affiliation><nlm:aff id="A2"> Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Mail: BCM 360, One Baylor Plaza, Houston, TX 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Bishnoi, Sandra" sort="Bishnoi, Sandra" uniqKey="Bishnoi S" first="Sandra" last="Bishnoi">Sandra Bishnoi</name><affiliation><nlm:aff id="A3"> Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, United States</nlm:aff></affiliation></author><author><name sortKey="Urban, Alexander" sort="Urban, Alexander" uniqKey="Urban A" first="Alexander" last="Urban">Alexander Urban</name><affiliation><nlm:aff id="A3"> Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, United States</nlm:aff></affiliation></author><author><name sortKey="Charron, Heather" sort="Charron, Heather" uniqKey="Charron H" first="Heather" last="Charron">Heather Charron</name><affiliation><nlm:aff id="A2"> Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Mail: BCM 360, One Baylor Plaza, Houston, TX 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Tamika" sort="Mitchell, Tamika" uniqKey="Mitchell T" first="Tamika" last="Mitchell">Tamika Mitchell</name><affiliation><nlm:aff id="A4"> Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Shea, Martin" sort="Shea, Martin" uniqKey="Shea M" first="Martin" last="Shea">Martin Shea</name><affiliation><nlm:aff id="A4"> Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Nanda, Sarmistha" sort="Nanda, Sarmistha" uniqKey="Nanda S" first="Sarmistha" last="Nanda">Sarmistha Nanda</name><affiliation><nlm:aff id="A4"> Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Schiff, Rachel" sort="Schiff, Rachel" uniqKey="Schiff R" first="Rachel" last="Schiff">Rachel Schiff</name><affiliation><nlm:aff id="A4"> Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, United States</nlm:aff></affiliation></author><author><name sortKey="Halas, Naomi" sort="Halas, Naomi" uniqKey="Halas N" first="Naomi" last="Halas">Naomi Halas</name><affiliation><nlm:aff id="A1"> Department of Chemistry, Rice University, 6100 Main St, Houston, TX 77005, United States</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, United States</nlm:aff></affiliation></author><author><name sortKey="Joshi, Amit" sort="Joshi, Amit" uniqKey="Joshi A" first="Amit" last="Joshi">Amit Joshi</name><affiliation><nlm:aff id="A2"> Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Mail: BCM 360, One Baylor Plaza, Houston, TX 77030, United States</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of controlled release : official journal of the Controlled Release Society</title><idno type="ISSN">0168-3659</idno><idno type="eISSN">1873-4995</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">There is an unmet need for efficient near-infrared photothermal transducers for the treatment of highly aggressive cancers and large tumors where the penetration of light can be substantially reduced, and the intra-tumoral nanoparticle transport is restricted due to the presence of hypoxic or nectrotic regions. We report the performance advantages obtained by sub 100 nm gold nanomatryushkas, comprising of concentric gold-silica-gold layers compared to conventional ~150 nm silica core gold nanoshells for photothermal therapy of triple negative breast cancer. We demonstrate that a 33% reduction in silica-core-gold-shell nanoparticle size, while retaining near-infrared plasmon resonance, and keeping the nanoparticle surface charge constant, results in a four to five fold tumor accumulation of nanoparticles following equal dose of injected gold for both sizes. The survival time of mice bearing large (>1000 mm<sup>3</sup>) and highly aggressive triple negative breast tumors is doubled for the nanomatryushka treatment group under identical photo-thermal therapy conditions. The higher absorption cross-section of a nanomatryoshka results in a higher efficiency of photonic to thermal energy conversion and coupled with 4-5X accumulation within large tumors results in superior therapy efficacy.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8607908</journal-id><journal-id journal-id-type="pubmed-jr-id">21032</journal-id><journal-id journal-id-type="nlm-ta">J Control Release</journal-id><journal-id journal-id-type="iso-abbrev">J Control Release</journal-id><journal-title-group><journal-title>Journal of controlled release : official journal of the Controlled Release Society</journal-title></journal-title-group><issn pub-type="ppub">0168-3659</issn><issn pub-type="epub">1873-4995</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25051221</article-id><article-id pub-id-type="pmc">4156921</article-id><article-id pub-id-type="doi">10.1016/j.jconrel.2014.07.038</article-id><article-id pub-id-type="manuscript">NIHMS615162</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Sub-100 nm Gold Nanomatryoshkas Improve Photo-thermal Therapy Efficacy in Large and Highly Aggressive Triple Negative Breast Tumors</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Ayala-Orozco</surname><given-names>Ciceron</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Urban</surname><given-names>Cordula</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bishnoi</surname><given-names>Sandra</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Urban</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Charron</surname><given-names>Heather</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Tamika</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Shea</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Nanda</surname><given-names>Sarmistha</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Schiff</surname><given-names>Rachel</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Halas</surname><given-names>Naomi</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Joshi</surname><given-names>Amit</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label> Department of Chemistry, Rice University, 6100 Main St, Houston, TX 77005, United States</aff><aff id="A2"><label>2</label> Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Mail: BCM 360, One Baylor Plaza, Houston, TX 77030, United States</aff><aff id="A3"><label>3</label> Department of Electrical and Computer Engineering, Rice University, 6100 Main St, Houston, TX 77005, United States</aff><aff id="A4"><label>4</label> Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, United States</aff><author-notes><corresp id="CR1"><label>*</label> Address Correspondence to <email>amitj@bcm.edu</email>, Phone: +1-281-224-9584, MS BCM 360, One Baylor Plaza, Houston, TX 77030.</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>18</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>19</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>10</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>10</day><month>10</month><year>2015</year></pub-date><volume>191</volume><fpage>90</fpage><lpage>97</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.jconrel.2014.07.038</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P1">There is an unmet need for efficient near-infrared photothermal transducers for the treatment of highly aggressive cancers and large tumors where the penetration of light can be substantially reduced, and the intra-tumoral nanoparticle transport is restricted due to the presence of hypoxic or nectrotic regions. We report the performance advantages obtained by sub 100 nm gold nanomatryushkas, comprising of concentric gold-silica-gold layers compared to conventional ~150 nm silica core gold nanoshells for photothermal therapy of triple negative breast cancer. We demonstrate that a 33% reduction in silica-core-gold-shell nanoparticle size, while retaining near-infrared plasmon resonance, and keeping the nanoparticle surface charge constant, results in a four to five fold tumor accumulation of nanoparticles following equal dose of injected gold for both sizes. The survival time of mice bearing large (>1000 mm<sup>3</sup>) and highly aggressive triple negative breast tumors is doubled for the nanomatryushka treatment group under identical photo-thermal therapy conditions. The higher absorption cross-section of a nanomatryoshka results in a higher efficiency of photonic to thermal energy conversion and coupled with 4-5X accumulation within large tumors results in superior therapy efficacy.</p></abstract><kwd-group><kwd>Nanomatryoshka</kwd><kwd>Multilayer nanoshells Au/SiO<sub>2</sub>/Au</kwd><kwd>photothermal therapy</kwd><kwd>near infrared</kwd><kwd>gold nanoparticle</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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