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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Label-free 3D imaging of microstructure, blood and lymphatic vessels within tissue beds <italic>in vivo</italic>
</title>
<author><name sortKey="Zhi, Zhongwei" sort="Zhi, Zhongwei" uniqKey="Zhi Z" first="Zhongwei" last="Zhi">Zhongwei Zhi</name>
</author>
<author><name sortKey="Jung, Yeongri" sort="Jung, Yeongri" uniqKey="Jung Y" first="Yeongri" last="Jung">Yeongri Jung</name>
</author>
<author><name sortKey="Wang, Ruikang K" sort="Wang, Ruikang K" uniqKey="Wang R" first="Ruikang K." last="Wang">Ruikang K. Wang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22378402</idno>
<idno type="pmc">3980723</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980723</idno>
<idno type="RBID">PMC:3980723</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">003703</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003703</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Label-free 3D imaging of microstructure, blood and lymphatic vessels within tissue beds <italic>in vivo</italic>
</title>
<author><name sortKey="Zhi, Zhongwei" sort="Zhi, Zhongwei" uniqKey="Zhi Z" first="Zhongwei" last="Zhi">Zhongwei Zhi</name>
</author>
<author><name sortKey="Jung, Yeongri" sort="Jung, Yeongri" uniqKey="Jung Y" first="Yeongri" last="Jung">Yeongri Jung</name>
</author>
<author><name sortKey="Wang, Ruikang K" sort="Wang, Ruikang K" uniqKey="Wang R" first="Ruikang K." last="Wang">Ruikang K. Wang</name>
</author>
</analytic>
<series><title level="j">Optics letters</title>
<idno type="ISSN">0146-9592</idno>
<idno type="eISSN">1539-4794</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">This letter reports the use of an ultrahigh resolution optical microangiography (OMAG) system for simultaneous 3D imaging of microstructure, lymphatic and blood vessels without the use of exogenous contrast agent. An automatic algorithm is developed to segment the lymphatic vessels from the microstructural images, based on the fact that the lymph fluid is optically transparent. The OMAG system is developed that utilizes a broadband supercontinuum light source, providing an axial resolution of 2.3 μm and lateral resolution of 5.8 μm, capable of resolving the capillary vasculature and lymphatic vessels innervating microcirculatory tissue beds. Experimental demonstration is performed by showing detailed 3D lymphatic and blood vessel maps, coupled with morphology, within mouse ears <italic>in vivo</italic>
.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7708433</journal-id>
<journal-id journal-id-type="pubmed-jr-id">22734</journal-id>
<journal-id journal-id-type="nlm-ta">Opt Lett</journal-id>
<journal-id journal-id-type="iso-abbrev">Opt Lett</journal-id>
<journal-title-group><journal-title>Optics letters</journal-title>
</journal-title-group>
<issn pub-type="ppub">0146-9592</issn>
<issn pub-type="epub">1539-4794</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22378402</article-id>
<article-id pub-id-type="pmc">3980723</article-id>
<article-id pub-id-type="manuscript">NIHMS492776</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Label-free 3D imaging of microstructure, blood and lymphatic vessels within tissue beds <italic>in vivo</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Zhi</surname>
<given-names>Zhongwei</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Jung</surname>
<given-names>Yeongri</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Ruikang K.</given-names>
</name>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<aff id="A1">Department of Bioengineering, University of Washington, Seattle, WA 98195, USA</aff>
</contrib-group>
<author-notes><corresp id="CR1"><label>*</label>
<italic>Corresponding author: <email>wangrk@uw.edu</email>
</italic>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>2</day>
<month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><day>1</day>
<month>3</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>09</day>
<month>4</month>
<year>2014</year>
</pub-date>
<volume>37</volume>
<issue>5</issue>
<fpage>812</fpage>
<lpage>814</lpage>
<permissions><copyright-statement>© 2011 Optical Society of America</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p id="P1">This letter reports the use of an ultrahigh resolution optical microangiography (OMAG) system for simultaneous 3D imaging of microstructure, lymphatic and blood vessels without the use of exogenous contrast agent. An automatic algorithm is developed to segment the lymphatic vessels from the microstructural images, based on the fact that the lymph fluid is optically transparent. The OMAG system is developed that utilizes a broadband supercontinuum light source, providing an axial resolution of 2.3 μm and lateral resolution of 5.8 μm, capable of resolving the capillary vasculature and lymphatic vessels innervating microcirculatory tissue beds. Experimental demonstration is performed by showing detailed 3D lymphatic and blood vessel maps, coupled with morphology, within mouse ears <italic>in vivo</italic>
.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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