Warts and All: HPV in Primary Immunodeficiencies
Identifieur interne : 003635 ( Pmc/Corpus ); précédent : 003634; suivant : 003636Warts and All: HPV in Primary Immunodeficiencies
Auteurs : Jennifer W. Leiding ; Steven M. HollandSource :
- The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2012.
Abstract
Infection with human papilloma virus (HPV) is almost universal and eventually asymptomatic, but pathologic infection with HPV is severe, recurrent, and recalcitrant to therapy. It is also an underappreciated manifestation of primary immunodeficiency. Mutations in
Url:
DOI: 10.1016/j.jaci.2012.07.049
PubMed: 23036745
PubMed Central: 3517887
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PMC:3517887Le document en format XML
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<author><name sortKey="Leiding, Jennifer W" sort="Leiding, Jennifer W" uniqKey="Leiding J" first="Jennifer W." last="Leiding">Jennifer W. Leiding</name>
<affiliation><nlm:aff id="A1">Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M." last="Holland">Steven M. Holland</name>
<affiliation><nlm:aff id="A1">Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md USA</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Warts and All: HPV in Primary Immunodeficiencies</title>
<author><name sortKey="Leiding, Jennifer W" sort="Leiding, Jennifer W" uniqKey="Leiding J" first="Jennifer W." last="Leiding">Jennifer W. Leiding</name>
<affiliation><nlm:aff id="A1">Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md USA</nlm:aff>
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<author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M." last="Holland">Steven M. Holland</name>
<affiliation><nlm:aff id="A1">Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md USA</nlm:aff>
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<series><title level="j">The Journal of allergy and clinical immunology</title>
<idno type="ISSN">0091-6749</idno>
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<front><div type="abstract" xml:lang="en"><p id="P1">Infection with human papilloma virus (HPV) is almost universal and eventually asymptomatic, but pathologic infection with HPV is severe, recurrent, and recalcitrant to therapy. It is also an underappreciated manifestation of primary immunodeficiency. Mutations in <italic>EVER1, EVER2, GATA2, CXCR4</italic>
, and <italic>DOCK8</italic>
are typically associated with extensive HPV infections, whereas several other primary immune defects have severe HPV much less frequently. We review immunodeficiencies with severe HPV infections and the mechanisms underlying them.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">1275002</journal-id>
<journal-id journal-id-type="pubmed-jr-id">4431</journal-id>
<journal-id journal-id-type="nlm-ta">J Allergy Clin Immunol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Allergy Clin. Immunol.</journal-id>
<journal-title-group><journal-title>The Journal of allergy and clinical immunology</journal-title>
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<title-group><article-title>Warts and All: HPV in Primary Immunodeficiencies</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Leiding</surname>
<given-names>Jennifer W.</given-names>
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<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Holland</surname>
<given-names>Steven M.</given-names>
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<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
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<aff id="A1"><label>1</label>
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md USA</aff>
<author-notes><corresp id="FN1">Corresponding Author Jennifer W. Leiding, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, CRC, Rm B3-4233, MSC 1684, Bethesda, Md 20892-1684, Tel: 301-496-5102, Fax: 301-480-4507, <email>leidingjw@niaid.nih.gov</email>
</corresp>
<corresp id="FN2">Alternate Corresponding Author Steven M. Holland, MD, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, CRC, Rm B3-4233, MSC 1684, Bethesda, Md 20892-1684, Tel: 301-402-7684, Fax: 301-480-4507, <email>smh@nih.gov</email>
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<pub-date pub-type="nihms-submitted"><day>2</day>
<month>11</month>
<year>2012</year>
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<pub-date pub-type="epub"><day>01</day>
<month>10</month>
<year>2012</year>
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<pub-date pub-type="ppub"><month>11</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>11</month>
<year>2013</year>
</pub-date>
<volume>130</volume>
<issue>5</issue>
<fpage>1030</fpage>
<lpage>1048</lpage>
<abstract><p id="P1">Infection with human papilloma virus (HPV) is almost universal and eventually asymptomatic, but pathologic infection with HPV is severe, recurrent, and recalcitrant to therapy. It is also an underappreciated manifestation of primary immunodeficiency. Mutations in <italic>EVER1, EVER2, GATA2, CXCR4</italic>
, and <italic>DOCK8</italic>
are typically associated with extensive HPV infections, whereas several other primary immune defects have severe HPV much less frequently. We review immunodeficiencies with severe HPV infections and the mechanisms underlying them.</p>
</abstract>
<kwd-group><kwd>Immunodeficiency</kwd>
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<kwd>warts</kwd>
<kwd>squamous</kwd>
<kwd>carcinoma</kwd>
<kwd>dysplastic</kwd>
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<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
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