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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions</title><author><name sortKey="Bradbury, Michelle S" sort="Bradbury, Michelle S" uniqKey="Bradbury M" first="Michelle S." last="Bradbury">Michelle S. Bradbury</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Phillips, Evan" sort="Phillips, Evan" uniqKey="Phillips E" first="Evan" last="Phillips">Evan Phillips</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Montero, Pablo H" sort="Montero, Pablo H" uniqKey="Montero P" first="Pablo H." last="Montero">Pablo H. Montero</name><affiliation><nlm:aff id="A2">Department of Surgery, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Cheal, Sarah M" sort="Cheal, Sarah M" uniqKey="Cheal S" first="Sarah M." last="Cheal">Sarah M. Cheal</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Stambuk, Hilda" sort="Stambuk, Hilda" uniqKey="Stambuk H" first="Hilda" last="Stambuk">Hilda Stambuk</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Durack, Jeremy C" sort="Durack, Jeremy C" uniqKey="Durack J" first="Jeremy C." last="Durack">Jeremy C. Durack</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Sofocleous, Constantinos T" sort="Sofocleous, Constantinos T" uniqKey="Sofocleous C" first="Constantinos T." last="Sofocleous">Constantinos T. Sofocleous</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Meester, Richard J C" sort="Meester, Richard J C" uniqKey="Meester R" first="Richard J. C." last="Meester">Richard J. C. Meester</name><affiliation><nlm:aff id="A3">Quest Medical Imaging B.V., Middenmeer, The Netherlands NL-1775PW</nlm:aff></affiliation></author><author><name sortKey="Wiesner, Ulrich" sort="Wiesner, Ulrich" uniqKey="Wiesner U" first="Ulrich" last="Wiesner">Ulrich Wiesner</name><affiliation><nlm:aff id="A4">Department of Materials Science & Engineering, 330 Bard Hall, Cornell University, Ithaca, NY 14853, USA</nlm:aff></affiliation></author><author><name sortKey="Patel, Snehal" sort="Patel, Snehal" uniqKey="Patel S" first="Snehal" last="Patel">Snehal Patel</name><affiliation><nlm:aff id="A2">Department of Surgery, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23138852</idno><idno type="pmc">4428677</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428677</idno><idno type="RBID">PMC:4428677</idno><idno type="doi">10.1039/c2ib20174g</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">003562</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003562</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions</title><author><name sortKey="Bradbury, Michelle S" sort="Bradbury, Michelle S" uniqKey="Bradbury M" first="Michelle S." last="Bradbury">Michelle S. Bradbury</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Phillips, Evan" sort="Phillips, Evan" uniqKey="Phillips E" first="Evan" last="Phillips">Evan Phillips</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Montero, Pablo H" sort="Montero, Pablo H" uniqKey="Montero P" first="Pablo H." last="Montero">Pablo H. Montero</name><affiliation><nlm:aff id="A2">Department of Surgery, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Cheal, Sarah M" sort="Cheal, Sarah M" uniqKey="Cheal S" first="Sarah M." last="Cheal">Sarah M. Cheal</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Stambuk, Hilda" sort="Stambuk, Hilda" uniqKey="Stambuk H" first="Hilda" last="Stambuk">Hilda Stambuk</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Durack, Jeremy C" sort="Durack, Jeremy C" uniqKey="Durack J" first="Jeremy C." last="Durack">Jeremy C. Durack</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Sofocleous, Constantinos T" sort="Sofocleous, Constantinos T" uniqKey="Sofocleous C" first="Constantinos T." last="Sofocleous">Constantinos T. Sofocleous</name><affiliation><nlm:aff id="A1">Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</nlm:aff></affiliation></author><author><name sortKey="Meester, Richard J C" sort="Meester, Richard J C" uniqKey="Meester R" first="Richard J. C." last="Meester">Richard J. C. Meester</name><affiliation><nlm:aff id="A3">Quest Medical Imaging B.V., Middenmeer, The Netherlands NL-1775PW</nlm:aff></affiliation></author><author><name sortKey="Wiesner, Ulrich" sort="Wiesner, Ulrich" uniqKey="Wiesner U" first="Ulrich" last="Wiesner">Ulrich Wiesner</name><affiliation><nlm:aff id="A4">Department of Materials Science & Engineering, 330 Bard Hall, Cornell University, Ithaca, NY 14853, USA</nlm:aff></affiliation></author><author><name sortKey="Patel, Snehal" sort="Patel, Snehal" uniqKey="Patel S" first="Snehal" last="Patel">Snehal Patel</name><affiliation><nlm:aff id="A2">Department of Surgery, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Integrative biology : quantitative biosciences from nano to macro</title><idno type="ISSN">1757-9694</idno><idno type="eISSN">1757-9708</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Early diagnosis and treatment of melanoma are essential to minimizing morbidity and mortality. The presence of lymph node metastases is a vital prognostic predictor, and accurate identification by imaging has important implications for disease staging, prognosis, and clinical outcome. Sentinel lymph node (SLN) mapping procedures are limited by a lack of intraoperative visualization tools that can aid accurate determination of disease spread and delineate nodes from adjacent critical neural and vascular structures. Newer methods for circumventing these issues can exploit a variety of imaging tools, including biocompatible particle-based platforms coupled with portable device technologies for use with image-guided surgical and interventional procedures. We describe herein a clinically-translated, integrin-targeting platform for use with both PET and optical imaging that meets a number of key design criteria for improving SLN tissue localization and retention, target-to-background ratios, and clearance from the site of injection and the body. The use of such agents for selectively probing critical cancer targets may elucidate important insights into cellular and molecular processes that govern metastatic disease spread. Coupled with portable, real-time optical camera systems, we show that pre-operative PET imaging findings for mapping metastatic disease in clinically-relevant larger-animal models can be readily translated into the intraoperative setting for direct visualization of the draining tumor lymphatics and fluorescent SLN/s with histologic correlation. The specificity of this platform, relative to the standard-of-care radiotracer, <sup>18</sup>F-FDG, for potentially discriminating metastatic disease from inflammatory processes is also discussed in the setting of surgically-based or interventionally-driven therapies.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101478378</journal-id><journal-id journal-id-type="pubmed-jr-id">36347</journal-id><journal-id journal-id-type="nlm-ta">Integr Biol (Camb)</journal-id><journal-id journal-id-type="iso-abbrev">Integr Biol (Camb)</journal-id><journal-title-group><journal-title>Integrative biology : quantitative biosciences from nano to macro</journal-title></journal-title-group><issn pub-type="ppub">1757-9694</issn><issn pub-type="epub">1757-9708</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23138852</article-id><article-id pub-id-type="pmc">4428677</article-id><article-id pub-id-type="doi">10.1039/c2ib20174g</article-id><article-id pub-id-type="manuscript">NIHMS687811</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Bradbury</surname><given-names>Michelle S.</given-names></name><xref ref-type="aff" rid="A1">a</xref><email>bradburm@mskcc.org</email></contrib><contrib contrib-type="author"><name><surname>Phillips</surname><given-names>Evan</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Montero</surname><given-names>Pablo H.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Cheal</surname><given-names>Sarah M.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Stambuk</surname><given-names>Hilda</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Durack</surname><given-names>Jeremy C.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Sofocleous</surname><given-names>Constantinos T.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Meester</surname><given-names>Richard J. C.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Wiesner</surname><given-names>Ulrich</given-names></name><xref ref-type="aff" rid="A4">d</xref><xref rid="FN1" ref-type="author-notes">†</xref></contrib><contrib contrib-type="author"><name><surname>Patel</surname><given-names>Snehal</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref rid="FN1" ref-type="author-notes">†</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Radiology, Sloan Kettering Institute for Cancer Research, 1275 York Ave., Z-2001, New York, NY 10065, USA. Fax: +1 (646)-888-3059; Tel: +1 (646)-888-3373</aff><aff id="A2"><label>b</label>Department of Surgery, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA</aff><aff id="A3"><label>c</label>Quest Medical Imaging B.V., Middenmeer, The Netherlands NL-1775PW</aff><aff id="A4"><label>d</label>Department of Materials Science & Engineering, 330 Bard Hall, Cornell University, Ithaca, NY 14853, USA</aff><author-notes><fn id="FN1" fn-type="equal"><label>†</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>5</month><year>2015</year></pub-date><volume>5</volume><issue>1</issue><fpage>74</fpage><lpage>86</lpage><pmc-comment>elocation-id from pubmed: 10.1039/c2ib20174g</pmc-comment>
<permissions><copyright-statement>© The Royal Society of Chemistry 2013</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P1">Early diagnosis and treatment of melanoma are essential to minimizing morbidity and mortality. The presence of lymph node metastases is a vital prognostic predictor, and accurate identification by imaging has important implications for disease staging, prognosis, and clinical outcome. Sentinel lymph node (SLN) mapping procedures are limited by a lack of intraoperative visualization tools that can aid accurate determination of disease spread and delineate nodes from adjacent critical neural and vascular structures. Newer methods for circumventing these issues can exploit a variety of imaging tools, including biocompatible particle-based platforms coupled with portable device technologies for use with image-guided surgical and interventional procedures. We describe herein a clinically-translated, integrin-targeting platform for use with both PET and optical imaging that meets a number of key design criteria for improving SLN tissue localization and retention, target-to-background ratios, and clearance from the site of injection and the body. The use of such agents for selectively probing critical cancer targets may elucidate important insights into cellular and molecular processes that govern metastatic disease spread. Coupled with portable, real-time optical camera systems, we show that pre-operative PET imaging findings for mapping metastatic disease in clinically-relevant larger-animal models can be readily translated into the intraoperative setting for direct visualization of the draining tumor lymphatics and fluorescent SLN/s with histologic correlation. The specificity of this platform, relative to the standard-of-care radiotracer, <sup>18</sup>F-FDG, for potentially discriminating metastatic disease from inflammatory processes is also discussed in the setting of surgically-based or interventionally-driven therapies.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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