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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Silica-Coated Gold Nanoplates as Stable Photoacoustic Contrast Agents for Sentinel Lymph Node Imaging</title><author><name sortKey="Luke, Geoffrey P" sort="Luke, Geoffrey P" uniqKey="Luke G" first="Geoffrey P." last="Luke">Geoffrey P. Luke</name><affiliation><nlm:aff id="A1">Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Bashyam, Ashvin" sort="Bashyam, Ashvin" uniqKey="Bashyam A" first="Ashvin" last="Bashyam">Ashvin Bashyam</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Homan, Kimberly A" sort="Homan, Kimberly A" uniqKey="Homan K" first="Kimberly A." last="Homan">Kimberly A. Homan</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Makhija, Suraj" sort="Makhija, Suraj" uniqKey="Makhija S" first="Suraj" last="Makhija">Suraj Makhija</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Chen, Yun Sheng" sort="Chen, Yun Sheng" uniqKey="Chen Y" first="Yun-Sheng" last="Chen">Yun-Sheng Chen</name><affiliation><nlm:aff id="A1">Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Emelianov, Stanislav Y" sort="Emelianov, Stanislav Y" uniqKey="Emelianov S" first="Stanislav Y." last="Emelianov">Stanislav Y. Emelianov</name><affiliation><nlm:aff id="A1">Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24121616</idno><idno type="pmc">4000721</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000721</idno><idno type="RBID">PMC:4000721</idno><idno type="doi">10.1088/0957-4484/24/45/455101</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">003502</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003502</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Silica-Coated Gold Nanoplates as Stable Photoacoustic Contrast Agents for Sentinel Lymph Node Imaging</title><author><name sortKey="Luke, Geoffrey P" sort="Luke, Geoffrey P" uniqKey="Luke G" first="Geoffrey P." last="Luke">Geoffrey P. Luke</name><affiliation><nlm:aff id="A1">Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Bashyam, Ashvin" sort="Bashyam, Ashvin" uniqKey="Bashyam A" first="Ashvin" last="Bashyam">Ashvin Bashyam</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Homan, Kimberly A" sort="Homan, Kimberly A" uniqKey="Homan K" first="Kimberly A." last="Homan">Kimberly A. Homan</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Makhija, Suraj" sort="Makhija, Suraj" uniqKey="Makhija S" first="Suraj" last="Makhija">Suraj Makhija</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Chen, Yun Sheng" sort="Chen, Yun Sheng" uniqKey="Chen Y" first="Yun-Sheng" last="Chen">Yun-Sheng Chen</name><affiliation><nlm:aff id="A1">Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Emelianov, Stanislav Y" sort="Emelianov, Stanislav Y" uniqKey="Emelianov S" first="Stanislav Y." last="Emelianov">Stanislav Y. Emelianov</name><affiliation><nlm:aff id="A1">Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation></author></analytic><series><title level="j">Nanotechnology</title><idno type="ISSN">0957-4484</idno><idno type="eISSN">1361-6528</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">A biopsy of the first lymph node to which a tumor drains – the sentinel lymph node (SLN) – is commonly performed to identify micrometastases. Image guidance of the SLN biopsy procedure has the potential to improve its accuracy and decrease its morbidity. We have developed a new stable contrast agent for photoacoustic image-guided SLN biopsy: silica-coated gold nanoplates (Si-AuNPs). The Si-AuNPs exhibit high photothermal stability when exposed to pulsed and continuous wave laser irradiation. This makes them well-suited for <italic>in vivo</italic> photoacoustic imaging. Furthermore, Si-AuNPs are shown to have low cytotoxicity. We tested the Si-AuNPs for SLN mapping in a mouse model where they exhibited a strong, sustained photoacoustic signal. Real-time ultrasound and photoacoustic imaging revealed that the Si-AuNPs quickly drain to the SLN gradually spreading throughout a large portion of the node.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101241272</journal-id><journal-id journal-id-type="pubmed-jr-id">32564</journal-id><journal-id journal-id-type="nlm-ta">Nanotechnology</journal-id><journal-id journal-id-type="iso-abbrev">Nanotechnology</journal-id><journal-title-group><journal-title>Nanotechnology</journal-title></journal-title-group><issn pub-type="ppub">0957-4484</issn><issn pub-type="epub">1361-6528</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24121616</article-id><article-id pub-id-type="pmc">4000721</article-id><article-id pub-id-type="doi">10.1088/0957-4484/24/45/455101</article-id><article-id pub-id-type="manuscript">NIHMS531780</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Silica-Coated Gold Nanoplates as Stable Photoacoustic Contrast Agents for Sentinel Lymph Node Imaging</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Luke</surname><given-names>Geoffrey P.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bashyam</surname><given-names>Ashvin</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Homan</surname><given-names>Kimberly A.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Makhija</surname><given-names>Suraj</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Yun-Sheng</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Emelianov</surname><given-names>Stanislav Y.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712</aff><aff id="A2"><label>2</label>Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712</aff><author-notes><corresp id="cor1"><label>*</label>Corresponding Author, <email>emelian@mail.utexas.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>11</day><month>10</month><year>2013</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>11</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>11</month><year>2014</year></pub-date><volume>24</volume><issue>45</issue><fpage>455101</fpage><lpage>455101</lpage><pmc-comment>elocation-id from pubmed: 10.1088/0957-4484/24/45/455101</pmc-comment>
<abstract><p id="P1">A biopsy of the first lymph node to which a tumor drains – the sentinel lymph node (SLN) – is commonly performed to identify micrometastases. Image guidance of the SLN biopsy procedure has the potential to improve its accuracy and decrease its morbidity. We have developed a new stable contrast agent for photoacoustic image-guided SLN biopsy: silica-coated gold nanoplates (Si-AuNPs). The Si-AuNPs exhibit high photothermal stability when exposed to pulsed and continuous wave laser irradiation. This makes them well-suited for <italic>in vivo</italic> photoacoustic imaging. Furthermore, Si-AuNPs are shown to have low cytotoxicity. We tested the Si-AuNPs for SLN mapping in a mouse model where they exhibited a strong, sustained photoacoustic signal. Real-time ultrasound and photoacoustic imaging revealed that the Si-AuNPs quickly drain to the SLN gradually spreading throughout a large portion of the node.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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