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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent Insights into the Pathobiology of Innate Immune Deficiencies</title><author><name sortKey="Rosenzweig, Sergio D" sort="Rosenzweig, Sergio D" uniqKey="Rosenzweig S" first="Sergio D." last="Rosenzweig">Sergio D. Rosenzweig</name></author><author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M." last="Holland">Steven M. Holland</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21814768</idno><idno type="pmc">3407815</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407815</idno><idno type="RBID">PMC:3407815</idno><idno type="doi">10.1007/s11882-011-0212-9</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">003456</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003456</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recent Insights into the Pathobiology of Innate Immune Deficiencies</title><author><name sortKey="Rosenzweig, Sergio D" sort="Rosenzweig, Sergio D" uniqKey="Rosenzweig S" first="Sergio D." last="Rosenzweig">Sergio D. Rosenzweig</name></author><author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M." last="Holland">Steven M. Holland</name></author></analytic><series><title level="j">Current allergy and asthma reports</title><idno type="ISSN">1529-7322</idno><idno type="eISSN">1534-6315</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Primary immunodeficiencies are a heterogeneous group of genetically inherited diseases affecting the innate and adaptive immune systems that confer susceptibility to infection, autoimmunity, and cancer. Innate immunity includes neutrophils, macrophages, dendritic cells, natural killer cells, and natural killer T cells in conjunction with natural barriers (mostly skin and gastrointestinal and respiratory mucosa), as well as antimicrobial agents, opsonins (e.g., complement), and cytokines. Although somewhat primitive, innate immune cells can orchestrate discrete immune responses through the recognition of diverse pathogens by different pattern-recognition receptors. In this review, we discuss the most recent discoveries as well as the already established pathophysiologic mechanisms underlying innate immunity defects associated with primary immunodeficiencies.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101096440</journal-id><journal-id journal-id-type="pubmed-jr-id">27008</journal-id><journal-id journal-id-type="nlm-ta">Curr Allergy Asthma Rep</journal-id><journal-id journal-id-type="iso-abbrev">Curr Allergy Asthma Rep</journal-id><journal-title-group><journal-title>Current allergy and asthma reports</journal-title></journal-title-group><issn pub-type="ppub">1529-7322</issn><issn pub-type="epub">1534-6315</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21814768</article-id><article-id pub-id-type="pmc">3407815</article-id><article-id pub-id-type="doi">10.1007/s11882-011-0212-9</article-id><article-id pub-id-type="manuscript">NIHMS391733</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Recent Insights into the Pathobiology of Innate Immune Deficiencies</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Rosenzweig</surname><given-names>Sergio D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Holland</surname><given-names>Steven M.</given-names></name></contrib><aff id="A1">Infectious Diseases Susceptibility Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Building 10, CRC 6W-3750, Bethesda, MD 20892-1456, USA</aff></contrib-group><author-notes><corresp id="CR1"><email>srosenzweig@niaid.nih.gov</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2012</year></pub-date><volume>11</volume><issue>5</issue><fpage>369</fpage><lpage>377</lpage><permissions><copyright-statement>© Springer Science+Business Media, LLC (outside the USA) 2011</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P1">Primary immunodeficiencies are a heterogeneous group of genetically inherited diseases affecting the innate and adaptive immune systems that confer susceptibility to infection, autoimmunity, and cancer. Innate immunity includes neutrophils, macrophages, dendritic cells, natural killer cells, and natural killer T cells in conjunction with natural barriers (mostly skin and gastrointestinal and respiratory mucosa), as well as antimicrobial agents, opsonins (e.g., complement), and cytokines. Although somewhat primitive, innate immune cells can orchestrate discrete immune responses through the recognition of diverse pathogens by different pattern-recognition receptors. In this review, we discuss the most recent discoveries as well as the already established pathophysiologic mechanisms underlying innate immunity defects associated with primary immunodeficiencies.</p></abstract><kwd-group><kwd>Primary immunodeficiencies</kwd><kwd>Innate immunity</kwd><kwd>Neutrophils</kwd><kwd>Macrophages</kwd><kwd>Dendritic cells</kwd><kwd>Natural killer cells</kwd><kwd>NK cells</kwd><kwd>NKT cells</kwd><kwd>Opsonins</kwd><kwd>Complement</kwd><kwd>Pattern-recognition receptors</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source><award-id>Z99 AI999999 || AI</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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