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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical Feasibility of Noninvasive Visualization of Lymphatic Flow using Principles of Spin Labeling MRI: Implications for Lymphedema Assessment</title><author><name sortKey="Rane, Swati" sort="Rane, Swati" uniqKey="Rane S" first="Swati" last="Rane">Swati Rane</name><affiliation><nlm:aff id="A1">Department of Radiology and Radiological Sciences, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Donahue, Paula M C" sort="Donahue, Paula M C" uniqKey="Donahue P" first="Paula M. C." last="Donahue">Paula M. C. Donahue</name><affiliation><nlm:aff id="A2">Vanderbilt Dayani Center for Health and Wellness, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Towse, Ted" sort="Towse, Ted" uniqKey="Towse T" first="Ted" last="Towse">Ted Towse</name><affiliation><nlm:aff id="A1">Department of Radiology and Radiological Sciences, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Ridner, Sheila" sort="Ridner, Sheila" uniqKey="Ridner S" first="Sheila" last="Ridner">Sheila Ridner</name><affiliation><nlm:aff id="A3">School of Nursing, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Chappell, Michael" sort="Chappell, Michael" uniqKey="Chappell M" first="Michael" last="Chappell">Michael Chappell</name><affiliation><nlm:aff id="A6">Department of Physics and Astronomy ,Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Jordi, John" sort="Jordi, John" uniqKey="Jordi J" first="John" last="Jordi">John Jordi</name><affiliation><nlm:aff id="A7">Institute of Biomedical Engineering, University of Oxford, Oxford, England, John Radcliffe Hospital, Oxford Center for Functional MRI of the Brain, Oxford, England</nlm:aff></affiliation></author><author><name sortKey="Gore, John" sort="Gore, John" uniqKey="Gore J" first="John" last="Gore">John Gore</name><affiliation><nlm:aff id="A1">Department of Radiology and Radiological Sciences, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Vanderbilt University Institute of Imaging Science, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Donahue, Manus J" sort="Donahue, Manus J" uniqKey="Donahue M" first="Manus J." last="Donahue">Manus J. Donahue</name><affiliation><nlm:aff id="A1">Department of Radiology and Radiological Sciences, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A3">School of Nursing, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23864103</idno><idno type="pmc">4485559</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485559</idno><idno type="RBID">PMC:4485559</idno><idno type="doi">10.1148/radiol.13120145</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">003390</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003390</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical Feasibility of Noninvasive Visualization of Lymphatic Flow using Principles of Spin Labeling MRI: Implications for Lymphedema Assessment</title><author><name sortKey="Rane, Swati" sort="Rane, Swati" uniqKey="Rane S" first="Swati" last="Rane">Swati Rane</name><affiliation><nlm:aff id="A1">Department of Radiology and Radiological Sciences, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Donahue, Paula M C" sort="Donahue, Paula M C" uniqKey="Donahue P" first="Paula M. C." last="Donahue">Paula M. C. Donahue</name><affiliation><nlm:aff id="A2">Vanderbilt Dayani Center for Health and Wellness, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Towse, Ted" sort="Towse, Ted" uniqKey="Towse T" first="Ted" last="Towse">Ted Towse</name><affiliation><nlm:aff id="A1">Department of Radiology and Radiological Sciences, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Ridner, Sheila" sort="Ridner, Sheila" uniqKey="Ridner S" first="Sheila" last="Ridner">Sheila Ridner</name><affiliation><nlm:aff id="A3">School of Nursing, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Chappell, Michael" sort="Chappell, Michael" uniqKey="Chappell M" first="Michael" last="Chappell">Michael Chappell</name><affiliation><nlm:aff id="A6">Department of Physics and Astronomy ,Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Jordi, John" sort="Jordi, John" uniqKey="Jordi J" first="John" last="Jordi">John Jordi</name><affiliation><nlm:aff id="A7">Institute of Biomedical Engineering, University of Oxford, Oxford, England, John Radcliffe Hospital, Oxford Center for Functional MRI of the Brain, Oxford, England</nlm:aff></affiliation></author><author><name sortKey="Gore, John" sort="Gore, John" uniqKey="Gore J" first="John" last="Gore">John Gore</name><affiliation><nlm:aff id="A1">Department of Radiology and Radiological Sciences, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Vanderbilt University Institute of Imaging Science, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Donahue, Manus J" sort="Donahue, Manus J" uniqKey="Donahue M" first="Manus J." last="Donahue">Manus J. Donahue</name><affiliation><nlm:aff id="A1">Department of Radiology and Radiological Sciences, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A3">School of Nursing, Nashville, TN</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN</nlm:aff></affiliation></author></analytic><series><title level="j">Radiology</title><idno type="ISSN">0033-8419</idno><idno type="eISSN">1527-1315</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">To extend a commonly employed, noninvasive arterial spin labeling (ASL) MRI method for measuring blood flow to evaluate lymphatic flow.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P2">All volunteers (n=12) provided informed consent in accordance with IRB and HIPAA regulations. Quantitative relaxation time (<italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub>) measurements were made in extracted human lymphatic fluid at 3.0T. Guided by these parameters, an ASL MRI approach was adapted to measure lymphatic flow (flow-alternating-inversion-recovery lymphatic water labeling; 3×3×5 mm<sup>3</sup>) in healthy subjects (n=6; 30±1 yrs; recruitment duration=2 months). Lymphatic flow velocity was quantified by performing spin labeling measurements as a function of post-labeling delay time and measuring the time-to-peak of signal in axillary lymph nodes. Clinical feasibility was evaluated in Stage II lymphedema patients (n=3; 60yr/F, 43yr/F, 64yr/F) and control subjects with unilateral cuff-induced lymphatic stenosis (n=3; 31yr/M, 31yr/M, 35yr/F).</p></sec><sec id="S3"><title>Results</title><p id="P3"><italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub> of lymphatic fluid at 3.0T were 3100±160 ms (range=2930-3210 ms; median=3200 ms) and 610±12 ms (range=598-618 ms; median=610 ms), respectively. Healthy lymphatic flow (afferent vessel to axillary node) velocity was found to be 0.61±0.13 cm/min (n=6). A reduction (P<0.005) in lymphatic flow velocity in the affected arms of patients and the affected arms of healthy subjects with manipulated cuff-induced flow reduction was observed. The ratio of unaffected to affected axilla lymphatic velocity (1.24±0.18) was significantly (P<0.005) higher than the Left/Right ratio in healthy subjects (0.91±0.18).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">This work provides a foundation for clinical investigations whereby lymphedema etiogenesis and therapies may be interrogated without exogenous agents and with clinically available imaging equipment.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0401260</journal-id><journal-id journal-id-type="pubmed-jr-id">6859</journal-id><journal-id journal-id-type="nlm-ta">Radiology</journal-id><journal-id journal-id-type="iso-abbrev">Radiology</journal-id><journal-title-group><journal-title>Radiology</journal-title></journal-title-group><issn pub-type="ppub">0033-8419</issn><issn pub-type="epub">1527-1315</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23864103</article-id><article-id pub-id-type="pmc">4485559</article-id><article-id pub-id-type="doi">10.1148/radiol.13120145</article-id><article-id pub-id-type="manuscript">NIHMS698283</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Clinical Feasibility of Noninvasive Visualization of Lymphatic Flow using Principles of Spin Labeling MRI: Implications for Lymphedema Assessment</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rane</surname><given-names>Swati</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Donahue</surname><given-names>Paula M. C.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Towse</surname><given-names>Ted</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ridner</surname><given-names>Sheila</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chappell</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Jordi</surname><given-names>John</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Gore</surname><given-names>John</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Donahue</surname><given-names>Manus J.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Radiology and Radiological Sciences, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</aff><aff id="A2"><label>2</label>Vanderbilt Dayani Center for Health and Wellness, Vanderbilt Physical Medicine and Rehabilitation, Nashville, TN</aff><aff id="A3"><label>3</label>School of Nursing, Nashville, TN</aff><aff id="A4"><label>4</label>Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN</aff><aff id="A5"><label>5</label>Vanderbilt University Institute of Imaging Science, Nashville, TN</aff><aff id="A6"><label>6</label>Department of Physics and Astronomy ,Nashville, TN</aff><aff id="A7"><label>7</label>Institute of Biomedical Engineering, University of Oxford, Oxford, England, John Radcliffe Hospital, Oxford Center for Functional MRI of the Brain, Oxford, England</aff><aff id="A8"><label>8</label>Siskin Hospital Lymphedema Clinic, Chattanooga, TN</aff><author-notes><corresp id="CR1"><bold>Correspondence:</bold> Swati Rane Vanderbilt University Institute of Imaging Science, 1161 21st Ave South, Medical Center North, AA-3107, Nashville, TN 37232-2310</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>18</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>28</day><month>6</month><year>2015</year></pub-date><volume>269</volume><issue>3</issue><fpage>893</fpage><lpage>902</lpage><pmc-comment>elocation-id from pubmed: 10.1148/radiol.13120145</pmc-comment>
<abstract><sec id="S1"><title>Purpose</title><p id="P1">To extend a commonly employed, noninvasive arterial spin labeling (ASL) MRI method for measuring blood flow to evaluate lymphatic flow.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P2">All volunteers (n=12) provided informed consent in accordance with IRB and HIPAA regulations. Quantitative relaxation time (<italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub>) measurements were made in extracted human lymphatic fluid at 3.0T. Guided by these parameters, an ASL MRI approach was adapted to measure lymphatic flow (flow-alternating-inversion-recovery lymphatic water labeling; 3×3×5 mm<sup>3</sup>) in healthy subjects (n=6; 30±1 yrs; recruitment duration=2 months). Lymphatic flow velocity was quantified by performing spin labeling measurements as a function of post-labeling delay time and measuring the time-to-peak of signal in axillary lymph nodes. Clinical feasibility was evaluated in Stage II lymphedema patients (n=3; 60yr/F, 43yr/F, 64yr/F) and control subjects with unilateral cuff-induced lymphatic stenosis (n=3; 31yr/M, 31yr/M, 35yr/F).</p></sec><sec id="S3"><title>Results</title><p id="P3"><italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub> of lymphatic fluid at 3.0T were 3100±160 ms (range=2930-3210 ms; median=3200 ms) and 610±12 ms (range=598-618 ms; median=610 ms), respectively. Healthy lymphatic flow (afferent vessel to axillary node) velocity was found to be 0.61±0.13 cm/min (n=6). A reduction (P<0.005) in lymphatic flow velocity in the affected arms of patients and the affected arms of healthy subjects with manipulated cuff-induced flow reduction was observed. The ratio of unaffected to affected axilla lymphatic velocity (1.24±0.18) was significantly (P<0.005) higher than the Left/Right ratio in healthy subjects (0.91±0.18).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">This work provides a foundation for clinical investigations whereby lymphedema etiogenesis and therapies may be interrogated without exogenous agents and with clinically available imaging equipment.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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