Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dermal lymphatic dilation in a mouse model of alopecia areata</title><author><name sortKey="Sundberg, John P" sort="Sundberg, John P" uniqKey="Sundberg J" first="John P." last="Sundberg">John P. Sundberg</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Pratt, C Herbert" sort="Pratt, C Herbert" uniqKey="Pratt C" first="C. Herbert" last="Pratt">C. Herbert Pratt</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation></author><author><name sortKey="Silva, Kathleen A" sort="Silva, Kathleen A" uniqKey="Silva K" first="Kathleen A." last="Silva">Kathleen A. Silva</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation></author><author><name sortKey="Kennedy, Victoria E" sort="Kennedy, Victoria E" uniqKey="Kennedy V" first="Victoria E." last="Kennedy">Victoria E. Kennedy</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation></author><author><name sortKey="Stearns, Timothy" sort="Stearns, Timothy" uniqKey="Stearns T" first="Timothy" last="Stearns">Timothy Stearns</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation></author><author><name sortKey="Sundberg, Beth A" sort="Sundberg, Beth A" uniqKey="Sundberg B" first="Beth A." last="Sundberg">Beth A. Sundberg</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation></author><author><name sortKey="King, Lloyd E" sort="King, Lloyd E" uniqKey="King L" first="Lloyd E." last="King">Lloyd E. King</name><affiliation><nlm:aff id="A2">Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Hogenesch, Harm" sort="Hogenesch, Harm" uniqKey="Hogenesch H" first="Harm" last="Hogenesch">Harm Hogenesch</name><affiliation><nlm:aff id="A3">Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26960166</idno><idno type="pmc">4823156</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823156</idno><idno type="RBID">PMC:4823156</idno><idno type="doi">10.1016/j.yexmp.2016.03.001</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">003342</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003342</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dermal lymphatic dilation in a mouse model of alopecia areata</title><author><name sortKey="Sundberg, John P" sort="Sundberg, John P" uniqKey="Sundberg J" first="John P." last="Sundberg">John P. Sundberg</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Pratt, C Herbert" sort="Pratt, C Herbert" uniqKey="Pratt C" first="C. Herbert" last="Pratt">C. Herbert Pratt</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation></author><author><name sortKey="Silva, Kathleen A" sort="Silva, Kathleen A" uniqKey="Silva K" first="Kathleen A." last="Silva">Kathleen A. Silva</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation></author><author><name sortKey="Kennedy, Victoria E" sort="Kennedy, Victoria E" uniqKey="Kennedy V" first="Victoria E." last="Kennedy">Victoria E. Kennedy</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation></author><author><name sortKey="Stearns, Timothy" sort="Stearns, Timothy" uniqKey="Stearns T" first="Timothy" last="Stearns">Timothy Stearns</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation></author><author><name sortKey="Sundberg, Beth A" sort="Sundberg, Beth A" uniqKey="Sundberg B" first="Beth A." last="Sundberg">Beth A. Sundberg</name><affiliation><nlm:aff id="A1">The Jackson Laboratory, Bar Harbor, ME</nlm:aff></affiliation></author><author><name sortKey="King, Lloyd E" sort="King, Lloyd E" uniqKey="King L" first="Lloyd E." last="King">Lloyd E. King</name><affiliation><nlm:aff id="A2">Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Hogenesch, Harm" sort="Hogenesch, Harm" uniqKey="Hogenesch H" first="Harm" last="Hogenesch">Harm Hogenesch</name><affiliation><nlm:aff id="A3">Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN</nlm:aff></affiliation></author></analytic><series><title level="j">Experimental and molecular pathology</title><idno type="ISSN">0014-4800</idno><idno type="eISSN">1096-0945</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Mouse models of various types of inflammatory skin disease are often accompanied by increased dermal angiogenesis. The C3H/HeJ inbred strain spontaneously develops alopecia areata (AA), a cell mediated autoimmune disorder that can be controllably expanded using full thickness skin grafts to young unaffected mice. This provides a reproducible and progressive model for AA in which the vascularization of the skin can be examined. Mice receiving skin grafts from AA or normal mice were evaluated at 5, 10, 15, and 20 weeks after engraftment. Lymphatics are often overlooked as they are small slit-like structures above the hair follicle that resemble artifact-like separation of collagen bundles with some fixatives. Lymphatics are easily detected using lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1) by immunohistochemistry to label their endothelial cells. Using LYVE1, there were no changes in distribution or numbers of lymphatics although they were more prominent (dilated) in the mice with AA. <italic>Lyve1</italic> transcripts were not significantly upregulated except at 10 weeks after skin grafting when clinical signs of AA first become apparent. Other genes involved with vascular growth and dilation or movement of immune cells were dysregulated, mostly upregulated. These findings emphasize aspects of AA not commonly considered and provide potential targets for therapeutic intervention.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370711</journal-id><journal-id journal-id-type="pubmed-jr-id">3658</journal-id><journal-id journal-id-type="nlm-ta">Exp Mol Pathol</journal-id><journal-id journal-id-type="iso-abbrev">Exp. Mol. Pathol.</journal-id><journal-title-group><journal-title>Experimental and molecular pathology</journal-title></journal-title-group><issn pub-type="ppub">0014-4800</issn><issn pub-type="epub">1096-0945</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26960166</article-id><article-id pub-id-type="pmc">4823156</article-id><article-id pub-id-type="doi">10.1016/j.yexmp.2016.03.001</article-id><article-id pub-id-type="manuscript">NIHMS768293</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Dermal lymphatic dilation in a mouse model of alopecia areata</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sundberg</surname><given-names>John P.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Pratt</surname><given-names>C. Herbert</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Silva</surname><given-names>Kathleen A.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Kennedy</surname><given-names>Victoria E.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Stearns</surname><given-names>Timothy</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="author-notes" rid="FN2">#</xref></contrib><contrib contrib-type="author"><name><surname>Sundberg</surname><given-names>Beth A.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>King</surname><given-names>Lloyd E.</given-names><suffix>Jr.</suffix></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>HogenEsch</surname><given-names>Harm</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib></contrib-group><aff id="A1"><label>a</label>The Jackson Laboratory, Bar Harbor, ME</aff><aff id="A2"><label>b</label>Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, TN</aff><aff id="A3"><label>c</label>Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN</aff><author-notes><corresp id="CR1"><label>*</label><bold>Corresponding author:</bold> John P. Sundberg, D.V.M., Ph.D., The Jackson Laboratory, 600 Main Street, Bar Harbor, ME USA, <email>john.sundberg@jax.org</email>, Phone: 207-288-6410; FAX: 207-288-6077</corresp><fn fn-type="present-address" id="FN2"><label>#</label><p id="P1">Current address: MDI Biological Laboratory, Salisbury Cove, ME</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>17</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>6</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>4</month><year>2017</year></pub-date><volume>100</volume><issue>2</issue><fpage>332</fpage><lpage>336</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.yexmp.2016.03.001</pmc-comment>
<abstract><p id="P2">Mouse models of various types of inflammatory skin disease are often accompanied by increased dermal angiogenesis. The C3H/HeJ inbred strain spontaneously develops alopecia areata (AA), a cell mediated autoimmune disorder that can be controllably expanded using full thickness skin grafts to young unaffected mice. This provides a reproducible and progressive model for AA in which the vascularization of the skin can be examined. Mice receiving skin grafts from AA or normal mice were evaluated at 5, 10, 15, and 20 weeks after engraftment. Lymphatics are often overlooked as they are small slit-like structures above the hair follicle that resemble artifact-like separation of collagen bundles with some fixatives. Lymphatics are easily detected using lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1) by immunohistochemistry to label their endothelial cells. Using LYVE1, there were no changes in distribution or numbers of lymphatics although they were more prominent (dilated) in the mice with AA. <italic>Lyve1</italic> transcripts were not significantly upregulated except at 10 weeks after skin grafting when clinical signs of AA first become apparent. Other genes involved with vascular growth and dilation or movement of immune cells were dysregulated, mostly upregulated. These findings emphasize aspects of AA not commonly considered and provide potential targets for therapeutic intervention.</p></abstract><kwd-group><kwd>LYVE1</kwd><kwd>PECAM1</kwd><kwd>SMA</kwd><kwd>lymphatics</kwd><kwd>inflammation</kwd><kwd>autoimmune disease</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0033428 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0033428 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.31. |  |