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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Critical Appraisal of Molecular Xenomonitoring as a Tool for Assessing Progress toward Elimination of Lymphatic Filariasis</title><author><name sortKey="Farid, Hoda A" sort="Farid, Hoda A" uniqKey="Farid H" first="Hoda A." last="Farid">Hoda A. Farid</name></author><author><name sortKey="Morsy, Zakariya S" sort="Morsy, Zakariya S" uniqKey="Morsy Z" first="Zakariya S." last="Morsy">Zakariya S. Morsy</name></author><author><name sortKey="Helmy, Hanan" sort="Helmy, Hanan" uniqKey="Helmy H" first="Hanan" last="Helmy">Hanan Helmy</name></author><author><name sortKey="Ramzy, Reda M R" sort="Ramzy, Reda M R" uniqKey="Ramzy R" first="Reda M. R." last="Ramzy">Reda M. R. Ramzy</name></author><author><name sortKey="Setouhy, Maged El" sort="Setouhy, Maged El" uniqKey="Setouhy M" first="Maged El" last="Setouhy">Maged El Setouhy</name></author><author><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J." last="Weil">Gary J. Weil</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17978055</idno><idno type="pmc">2196407</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196407</idno><idno type="RBID">PMC:2196407</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">003334</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003334</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Critical Appraisal of Molecular Xenomonitoring as a Tool for Assessing Progress toward Elimination of Lymphatic Filariasis</title><author><name sortKey="Farid, Hoda A" sort="Farid, Hoda A" uniqKey="Farid H" first="Hoda A." last="Farid">Hoda A. Farid</name></author><author><name sortKey="Morsy, Zakariya S" sort="Morsy, Zakariya S" uniqKey="Morsy Z" first="Zakariya S." last="Morsy">Zakariya S. Morsy</name></author><author><name sortKey="Helmy, Hanan" sort="Helmy, Hanan" uniqKey="Helmy H" first="Hanan" last="Helmy">Hanan Helmy</name></author><author><name sortKey="Ramzy, Reda M R" sort="Ramzy, Reda M R" uniqKey="Ramzy R" first="Reda M. R." last="Ramzy">Reda M. R. Ramzy</name></author><author><name sortKey="Setouhy, Maged El" sort="Setouhy, Maged El" uniqKey="Setouhy M" first="Maged El" last="Setouhy">Maged El Setouhy</name></author><author><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J." last="Weil">Gary J. Weil</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><idno type="eISSN">1476-1645</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We used molecular xenomonitoring (MX, detection of filarial DNA in mosquitoes) to evaluate the impact of mass drug administration (MDA) in sentinel locations in Egypt with high (11.5%) and low (4.1%) baseline microfilaria prevalence rates. Blood-fed <italic>Culex pipiens</italic> were pooled by household and tested for <italic>Wuchereria bancrofti</italic> DNA by PCR. There was no significant relationship between the infection status of household residents and parasite DNA status of mosquitoes from the same houses. After 5 MDA rounds, parasite DNA rates in mosquitoes in high- and low-prevalence areas were reduced by 93.8% and 100% to 0.19% (95% CI: 0.076–0.382%) and 0% (95% CI: 0–0.045%), respectively. These changes were consistent with decreases in microfilaria prevalence rates in these sites; they provide insight regarding the minimal mosquito DNA rates necessary for sustained transmission of filariasis in Egypt. We conclude that MX is a powerful tool for monitoring the impact of MDA on filariasis endemicity and transmission.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370507</journal-id><journal-id journal-id-type="pubmed-jr-id">473</journal-id><journal-id journal-id-type="nlm-ta">Am J Trop Med Hyg</journal-id><journal-title>The American journal of tropical medicine and hygiene</journal-title><issn pub-type="ppub">0002-9637</issn><issn pub-type="epub">1476-1645</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17978055</article-id><article-id pub-id-type="pmc">2196407</article-id><article-id pub-id-type="manuscript">NIHMS36842</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A Critical Appraisal of Molecular Xenomonitoring as a Tool for Assessing Progress toward Elimination of Lymphatic Filariasis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Farid</surname><given-names>Hoda A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Morsy</surname><given-names>Zakariya S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Helmy</surname><given-names>Hanan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ramzy</surname><given-names>Reda M. R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Setouhy</surname><given-names>Maged El</given-names></name></contrib><contrib contrib-type="author"><name><surname>Weil</surname><given-names>Gary J.</given-names></name><xref rid="FN1" ref-type="author-notes">*</xref></contrib><aff id="A1">Research and Training Center on Vectors of Diseases, Ain Shams University, Cairo, Egypt; Washington University School of Medicine, St. Louis, Missouri</aff></contrib-group><author-notes><corresp id="FN1">* Address correspondence to Gary J. Weil, Box 8051, 660 S. Euclid Avenue, Washington University School of Medicine, St. Louis, MO 63110. E-mail: <email>gweil@im.wustl.edu</email></corresp><fn id="FN2"><p>Authors’ addresses: Hoda A. Farid, Zakaria S. Morsy, Hanan Helmy, Reda M.R. Ramzy, and Maged El Setouhy, Research and Training Center on Vectors of Diseases, Faculty of Science Building, Ain Shams University, Abbassia, Cairo, Egypt, Telephone/Fax: +20-2-6839622. Gary J. Weil, Infectious Diseases Division, Campus Box 8051, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, Telephone: +1 (314) 454-7782; Fax: +1 (314) 454-5293, E-mail: <email>gweil@im.wustl.edu</email>.</p></fn><fn id="FN3"><p>Reprint requests to: Gary J. Weil, Infectious Diseases Division, Campus Box 8051, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, Telephone: +1 (314) 454-7782; Fax: +1 (314) 454-5293, E-mail: <email>gweil@im.wustl.edu</email>.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>1</month><year>2008</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2007</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>10</month><year>2008</year></pub-date><volume>77</volume><issue>4</issue><fpage>593</fpage><lpage>600</lpage><abstract><p id="P1">We used molecular xenomonitoring (MX, detection of filarial DNA in mosquitoes) to evaluate the impact of mass drug administration (MDA) in sentinel locations in Egypt with high (11.5%) and low (4.1%) baseline microfilaria prevalence rates. Blood-fed <italic>Culex pipiens</italic> were pooled by household and tested for <italic>Wuchereria bancrofti</italic> DNA by PCR. There was no significant relationship between the infection status of household residents and parasite DNA status of mosquitoes from the same houses. After 5 MDA rounds, parasite DNA rates in mosquitoes in high- and low-prevalence areas were reduced by 93.8% and 100% to 0.19% (95% CI: 0.076–0.382%) and 0% (95% CI: 0–0.045%), respectively. These changes were consistent with decreases in microfilaria prevalence rates in these sites; they provide insight regarding the minimal mosquito DNA rates necessary for sustained transmission of filariasis in Egypt. We conclude that MX is a powerful tool for monitoring the impact of MDA on filariasis endemicity and transmission.</p></abstract><contract-num rid="AI1">U19 AI065715-02</contract-num><contract-num rid="AI1">U19 AI065715-01</contract-num><contract-num rid="AI1">U01 AI035855-10S1</contract-num><contract-num rid="AI1">U01 AI035855-10</contract-num><contract-num rid="AI1">U01 AI035855-09</contract-num><contract-num rid="AI1">U01 AI035855-08</contract-num><contract-num rid="AI1">U01 AI035855-07</contract-num><contract-num rid="AI1">U01 AI035855-06</contract-num><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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