Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Utility of Sentinel Lymph Node Biopsy for Solitary Dermal Melanomas</title><author><name sortKey="Hu, Yinin" sort="Hu, Yinin" uniqKey="Hu Y" first="Yinin" last="Hu">Yinin Hu</name><affiliation><nlm:aff id="A1">Department of Surgery/Division of Surgical Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA</nlm:aff></affiliation></author><author><name sortKey="Shah, Puja" sort="Shah, Puja" uniqKey="Shah P" first="Puja" last="Shah">Puja Shah</name><affiliation><nlm:aff id="A1">Department of Surgery/Division of Surgical Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA</nlm:aff></affiliation></author><author><name sortKey="Stukenborg, George J" sort="Stukenborg, George J" uniqKey="Stukenborg G" first="George J." last="Stukenborg">George J. Stukenborg</name><affiliation><nlm:aff id="A2">Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA 22908, USA</nlm:aff></affiliation></author><author><name sortKey="Slingluff, Craig L" sort="Slingluff, Craig L" uniqKey="Slingluff C" first="Craig L." last="Slingluff">Craig L. Slingluff</name><affiliation><nlm:aff id="A1">Department of Surgery/Division of Surgical Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25712273</idno><idno type="pmc">4436976</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436976</idno><idno type="RBID">PMC:4436976</idno><idno type="doi">10.1002/jso.23890</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">003280</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003280</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Utility of Sentinel Lymph Node Biopsy for Solitary Dermal Melanomas</title><author><name sortKey="Hu, Yinin" sort="Hu, Yinin" uniqKey="Hu Y" first="Yinin" last="Hu">Yinin Hu</name><affiliation><nlm:aff id="A1">Department of Surgery/Division of Surgical Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA</nlm:aff></affiliation></author><author><name sortKey="Shah, Puja" sort="Shah, Puja" uniqKey="Shah P" first="Puja" last="Shah">Puja Shah</name><affiliation><nlm:aff id="A1">Department of Surgery/Division of Surgical Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA</nlm:aff></affiliation></author><author><name sortKey="Stukenborg, George J" sort="Stukenborg, George J" uniqKey="Stukenborg G" first="George J." last="Stukenborg">George J. Stukenborg</name><affiliation><nlm:aff id="A2">Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA 22908, USA</nlm:aff></affiliation></author><author><name sortKey="Slingluff, Craig L" sort="Slingluff, Craig L" uniqKey="Slingluff C" first="Craig L." last="Slingluff">Craig L. Slingluff</name><affiliation><nlm:aff id="A1">Department of Surgery/Division of Surgical Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of surgical oncology</title><idno type="ISSN">0022-4790</idno><idno type="eISSN">1096-9098</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background and Objectives</title><p id="P1">Solitary dermal melanoma (SDM) is melanoma confined to subcutaneous and/or dermal layers in the absence of a known primary cutaneous lesion. We hypothesized that sentinel node biopsy is an effective staging strategy for this rare disease.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A Markov decision model was constructed to represent two management strategies for SDM: wide local excision followed by observation, and wide local excision followed by sentinel node biopsy. Utilities, likelihood of positive sentinel node biopsy, and cancer progression rates during a five year time horizon were assigned based on institutional data and a review of existing literature. Estimated costs were derived using Medicare reimbursements.</p></sec><sec id="S3"><title>Results</title><p id="P3">Excision followed by sentinel node biopsy provides greater utility, yielding 3.85 discounted quality-adjusted life years (dQALY) compared to 3.66 for excision alone. The incremental cost-effectiveness ratio for sentinel node biopsy is $19,102 per dQALY. Sensitivity analyses demonstrated that observation is more cost-effective if greater than 23% of sentinel node biopsies are positive (16% reported), or if 5-year survival for observed patients is greater than 76% (69% reported).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Based on existing clinical evidence, sentinel node biopsy yields greater utility than excision alone and is cost-effective for patients presenting with solitary dermal melanoma.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0222643</journal-id><journal-id journal-id-type="pubmed-jr-id">5286</journal-id><journal-id journal-id-type="nlm-ta">J Surg Oncol</journal-id><journal-id journal-id-type="iso-abbrev">J Surg Oncol</journal-id><journal-title-group><journal-title>Journal of surgical oncology</journal-title></journal-title-group><issn pub-type="ppub">0022-4790</issn><issn pub-type="epub">1096-9098</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25712273</article-id><article-id pub-id-type="pmc">4436976</article-id><article-id pub-id-type="doi">10.1002/jso.23890</article-id><article-id pub-id-type="manuscript">NIHMS690058</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Utility of Sentinel Lymph Node Biopsy for Solitary Dermal Melanomas</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Yinin</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Puja</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Stukenborg</surname><given-names>George J.</given-names></name><degrees>Ph.D., M.A.</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Slingluff</surname><given-names>Craig L.</given-names><suffix>Jr.</suffix></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Surgery/Division of Surgical Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA</aff><aff id="A2"><label>2</label>Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA 22908, USA</aff><author-notes><corresp id="cor1"><bold>Corresponding Author:</bold> Yinin Hu, M.D. UVA Department of Surgery, PO Box 800679, Charlottesville, VA 22908-0679, F: (434) 982-5959, <email>yh9b@virginia.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>15</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>24</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>6</month><year>2016</year></pub-date><volume>111</volume><issue>7</issue><fpage>800</fpage><lpage>807</lpage><pmc-comment>elocation-id from pubmed: 10.1002/jso.23890</pmc-comment>
<abstract><sec id="S1"><title>Background and Objectives</title><p id="P1">Solitary dermal melanoma (SDM) is melanoma confined to subcutaneous and/or dermal layers in the absence of a known primary cutaneous lesion. We hypothesized that sentinel node biopsy is an effective staging strategy for this rare disease.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A Markov decision model was constructed to represent two management strategies for SDM: wide local excision followed by observation, and wide local excision followed by sentinel node biopsy. Utilities, likelihood of positive sentinel node biopsy, and cancer progression rates during a five year time horizon were assigned based on institutional data and a review of existing literature. Estimated costs were derived using Medicare reimbursements.</p></sec><sec id="S3"><title>Results</title><p id="P3">Excision followed by sentinel node biopsy provides greater utility, yielding 3.85 discounted quality-adjusted life years (dQALY) compared to 3.66 for excision alone. The incremental cost-effectiveness ratio for sentinel node biopsy is $19,102 per dQALY. Sensitivity analyses demonstrated that observation is more cost-effective if greater than 23% of sentinel node biopsies are positive (16% reported), or if 5-year survival for observed patients is greater than 76% (69% reported).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Based on existing clinical evidence, sentinel node biopsy yields greater utility than excision alone and is cost-effective for patients presenting with solitary dermal melanoma.</p></sec></abstract><kwd-group><kwd>Solitary dermal melanoma</kwd><kwd>Decision analysis</kwd><kwd>Cost-effectiveness</kwd><kwd>Sentinel node biopsy</kwd><kwd>Melanoma</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003280 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 003280 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.31. |  |