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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Involvement of Lysosomal Degradation in VEGF-C–Induced Down-Regulation of VEGFR-3</title><author><name sortKey="Han, Kyu Yeon" sort="Han, Kyu Yeon" uniqKey="Han K" first="Kyu-Yeon" last="Han">Kyu-Yeon Han</name><affiliation><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Chang, Jin Hong" sort="Chang, Jin Hong" uniqKey="Chang J" first="Jin-Hong" last="Chang">Jin-Hong Chang</name><affiliation><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Dugas Ford, Jennifer" sort="Dugas Ford, Jennifer" uniqKey="Dugas Ford J" first="Jennifer" last="Dugas-Ford">Jennifer Dugas-Ford</name><affiliation><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Alexander, Jonathan S" sort="Alexander, Jonathan S" uniqKey="Alexander J" first="Jonathan S." last="Alexander">Jonathan S. Alexander</name><affiliation><nlm:aff id="A2">Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana</nlm:aff></affiliation></author><author><name sortKey="Azar, Dimitri T" sort="Azar, Dimitri T" uniqKey="Azar D" first="Dimitri T." last="Azar">Dimitri T. Azar</name><affiliation><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25281926</idno><idno type="pmc">4254303</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254303</idno><idno type="RBID">PMC:4254303</idno><idno type="doi">10.1016/j.febslet.2014.09.034</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003264</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003264</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Involvement of Lysosomal Degradation in VEGF-C–Induced Down-Regulation of VEGFR-3</title><author><name sortKey="Han, Kyu Yeon" sort="Han, Kyu Yeon" uniqKey="Han K" first="Kyu-Yeon" last="Han">Kyu-Yeon Han</name><affiliation><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Chang, Jin Hong" sort="Chang, Jin Hong" uniqKey="Chang J" first="Jin-Hong" last="Chang">Jin-Hong Chang</name><affiliation><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Dugas Ford, Jennifer" sort="Dugas Ford, Jennifer" uniqKey="Dugas Ford J" first="Jennifer" last="Dugas-Ford">Jennifer Dugas-Ford</name><affiliation><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Alexander, Jonathan S" sort="Alexander, Jonathan S" uniqKey="Alexander J" first="Jonathan S." last="Alexander">Jonathan S. Alexander</name><affiliation><nlm:aff id="A2">Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana</nlm:aff></affiliation></author><author><name sortKey="Azar, Dimitri T" sort="Azar, Dimitri T" uniqKey="Azar D" first="Dimitri T." last="Azar">Dimitri T. Azar</name><affiliation><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois</nlm:aff></affiliation></author></analytic><series><title level="j">FEBS letters</title><idno type="ISSN">0014-5793</idno><idno type="eISSN">1873-3468</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The vascular endothelial growth factor (VEGF)-C–induced down-regulation of VEGF receptor (VEGFR)-3 is important in lymphangiogenesis. Here, we demonstrate that VEGF-C, -D, and -C156S, but not VEGF-A, down-regulate VEGFR-3. VEGF-C stimulates VEGFR-3 tyrosyl phosphorylation and transient phosphorylation of ERK, p38, and c-Jun N-terminal kinases in lymphatic endothelial cells. VEGF-C–induced down-regulation of VEGFR-3 was blocked by a VEGF-C trap, tyrosine kinase inhibitor, and LPE (leupeptin, pepstatin, and E64), but was unaffected by Notch 1 activator and γ-secretase inhibitors. Our findings indicate that VEGF-C down-regulates VEGFR-3 in lymphatic endothelial cells through VEGFR-3 kinase activation and, in part, via lysosomal degradation.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0155157</journal-id><journal-id journal-id-type="pubmed-jr-id">3696</journal-id><journal-id journal-id-type="nlm-ta">FEBS Lett</journal-id><journal-id journal-id-type="iso-abbrev">FEBS Lett.</journal-id><journal-title-group><journal-title>FEBS letters</journal-title></journal-title-group><issn pub-type="ppub">0014-5793</issn><issn pub-type="epub">1873-3468</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25281926</article-id><article-id pub-id-type="pmc">4254303</article-id><article-id pub-id-type="doi">10.1016/j.febslet.2014.09.034</article-id><article-id pub-id-type="manuscript">NIHMS635953</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Involvement of Lysosomal Degradation in VEGF-C–Induced Down-Regulation of VEGFR-3</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Han</surname><given-names>Kyu-Yeon</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>Jin-Hong</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Dugas-Ford</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Alexander</surname><given-names>Jonathan S.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Azar</surname><given-names>Dimitri T.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois</aff><aff id="A2"><label>2</label>Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana</aff><author-notes><corresp id="FN1"><label>*</label>Address correspondence to: Jin-Hong Chang, Ph.D. (<email>changr@uic.edu</email>), Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor Street, Chicago, IL 60612</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>1</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>2</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>28</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>28</day><month>11</month><year>2015</year></pub-date><volume>588</volume><issue>23</issue><fpage>4357</fpage><lpage>4363</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.febslet.2014.09.034</pmc-comment>
<abstract><p id="P2">The vascular endothelial growth factor (VEGF)-C–induced down-regulation of VEGF receptor (VEGFR)-3 is important in lymphangiogenesis. Here, we demonstrate that VEGF-C, -D, and -C156S, but not VEGF-A, down-regulate VEGFR-3. VEGF-C stimulates VEGFR-3 tyrosyl phosphorylation and transient phosphorylation of ERK, p38, and c-Jun N-terminal kinases in lymphatic endothelial cells. VEGF-C–induced down-regulation of VEGFR-3 was blocked by a VEGF-C trap, tyrosine kinase inhibitor, and LPE (leupeptin, pepstatin, and E64), but was unaffected by Notch 1 activator and γ-secretase inhibitors. Our findings indicate that VEGF-C down-regulates VEGFR-3 in lymphatic endothelial cells through VEGFR-3 kinase activation and, in part, via lysosomal degradation.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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