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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">NOVEL CHARACTERIZATION OF bEnd.3 CELLS THAT EXPRESS LYMPHATIC VESSEL ENDOTHELIAL HYALURONAN RECEPTOR-1</title><author><name sortKey="Yuen, D" sort="Yuen, D" uniqKey="Yuen D" first="D." last="Yuen">D. Yuen</name></author><author><name sortKey="Leu, R" sort="Leu, R" uniqKey="Leu R" first="R." last="Leu">R. Leu</name></author><author><name sortKey="Tse, J" sort="Tse, J" uniqKey="Tse J" first="J." last="Tse">J. Tse</name></author><author><name sortKey="Wang, S" sort="Wang, S" uniqKey="Wang S" first="S." last="Wang">S. Wang</name></author><author><name sortKey="Chen, L L" sort="Chen, L L" uniqKey="Chen L" first="L. L." last="Chen">L. L. Chen</name><affiliation><nlm:aff id="A2">Department of Pathology (SW, LLC), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, L" sort="Chen, L" uniqKey="Chen L" first="L." last="Chen">L. Chen</name><affiliation><nlm:aff id="A1">Center for Eye Disease and Development (DY, RL, JT, LC), Program in Vision Science and School of Optometry, University of California, Berkeley, California</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25282873</idno><idno type="pmc">4636729</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636729</idno><idno type="RBID">PMC:4636729</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003262</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003262</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">NOVEL CHARACTERIZATION OF bEnd.3 CELLS THAT EXPRESS LYMPHATIC VESSEL ENDOTHELIAL HYALURONAN RECEPTOR-1</title><author><name sortKey="Yuen, D" sort="Yuen, D" uniqKey="Yuen D" first="D." last="Yuen">D. Yuen</name></author><author><name sortKey="Leu, R" sort="Leu, R" uniqKey="Leu R" first="R." last="Leu">R. Leu</name></author><author><name sortKey="Tse, J" sort="Tse, J" uniqKey="Tse J" first="J." last="Tse">J. Tse</name></author><author><name sortKey="Wang, S" sort="Wang, S" uniqKey="Wang S" first="S." last="Wang">S. Wang</name></author><author><name sortKey="Chen, L L" sort="Chen, L L" uniqKey="Chen L" first="L. L." last="Chen">L. L. Chen</name><affiliation><nlm:aff id="A2">Department of Pathology (SW, LLC), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, L" sort="Chen, L" uniqKey="Chen L" first="L." last="Chen">L. Chen</name><affiliation><nlm:aff id="A1">Center for Eye Disease and Development (DY, RL, JT, LC), Program in Vision Science and School of Optometry, University of California, Berkeley, California</nlm:aff></affiliation></author></analytic><series><title level="j">Lymphology</title><idno type="ISSN">0024-7766</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Murine bEnd.3 endothelioma cell line has been widely used in vascular research and here we report the novel finding that bEnd.3 cells express lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and vascular endothelial growth factor receptor-3 (VEGFR-3). Moreover, these cells express progenitor cell markers of Sca-1 and CD133. Upon stimulation with tumor necrosis factor-alpha (TNF-α), the bEnd.3 cells demonstrate enhanced formation of capillary-type tubes, which express LYVE-1. As the bEnd.3 cell line is derived from murine endothelioma, we further examined human tissues of endothelioma and identified lymphatic vessels in the tumor samples which express both LYVE-1 and podoplanin. Moreover, a significantly higher number of lymphatic vessels were detected in the endothelioma samples compared with normal control. Taken together, this study not only redefines bEnd.3 cells for vascular research, but also indicates a broader category of human diseases that are associated with lymphatics, such as endothelioma.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0155112</journal-id><journal-id journal-id-type="pubmed-jr-id">5518</journal-id><journal-id journal-id-type="nlm-ta">Lymphology</journal-id><journal-id journal-id-type="iso-abbrev">Lymphology</journal-id><journal-title-group><journal-title>Lymphology</journal-title></journal-title-group><issn pub-type="ppub">0024-7766</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25282873</article-id><article-id pub-id-type="pmc">4636729</article-id><article-id pub-id-type="manuscript">NIHMS704610</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>NOVEL CHARACTERIZATION OF bEnd.3 CELLS THAT EXPRESS LYMPHATIC VESSEL ENDOTHELIAL HYALURONAN RECEPTOR-1</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yuen</surname><given-names>D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Leu</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tse</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>L.L.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Center for Eye Disease and Development (DY, RL, JT, LC), Program in Vision Science and School of Optometry, University of California, Berkeley, California</aff><aff id="A2"><label>2</label>Department of Pathology (SW, LLC), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</aff><author-notes><corresp id="cor1">Lu Chen, MD, PhD, 689 Minor Hall, University of California, Berkeley, CA 94720, USA, Phone: 510-642-5076, Fax: 510-643-6528, <email>chenlu@berkeley.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>7</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>07</day><month>11</month><year>2015</year></pub-date><volume>47</volume><issue>2</issue><fpage>73</fpage><lpage>81</lpage><abstract><p id="P1">Murine bEnd.3 endothelioma cell line has been widely used in vascular research and here we report the novel finding that bEnd.3 cells express lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and vascular endothelial growth factor receptor-3 (VEGFR-3). Moreover, these cells express progenitor cell markers of Sca-1 and CD133. Upon stimulation with tumor necrosis factor-alpha (TNF-α), the bEnd.3 cells demonstrate enhanced formation of capillary-type tubes, which express LYVE-1. As the bEnd.3 cell line is derived from murine endothelioma, we further examined human tissues of endothelioma and identified lymphatic vessels in the tumor samples which express both LYVE-1 and podoplanin. Moreover, a significantly higher number of lymphatic vessels were detected in the endothelioma samples compared with normal control. Taken together, this study not only redefines bEnd.3 cells for vascular research, but also indicates a broader category of human diseases that are associated with lymphatics, such as endothelioma.</p></abstract><kwd-group><kwd>bEnd.3 cell</kwd><kwd>LYVE-1</kwd><kwd>lymphatics endothelioma</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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