Lymphatic communication: Connexin junction, what’s your function?
Identifieur interne : 003260 ( Pmc/Corpus ); précédent : 003259; suivant : 003261Lymphatic communication: Connexin junction, what’s your function?
Auteurs : John D. Kanady ; Alexander M. SimonSource :
- Lymphology [ 0024-7766 ] ; 2011.
Abstract
This article reviews recent findings on expression and function of connexin proteins - the structural subunits of gap junction intercellular channels in the lymphatic vasculature - both during development and in the mature lymphatic vessel. Highlighted in particular are recent mouse connexin knockout studies which show that connexins are crucial for normal lymphatic development. We discuss, in general terms, both channel-dependent as well as channel-independent functions of connexins and raise some of the many unanswered questions about the mechanism(s) of action and physiological roles of connexins in the lymphatic vasculature.
Url:
PubMed: 22165579
PubMed Central: 3520433
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PMC:3520433Le document en format XML
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<author><name sortKey="Kanady, John D" sort="Kanady, John D" uniqKey="Kanady J" first="John D." last="Kanady">John D. Kanady</name>
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<author><name sortKey="Simon, Alexander M" sort="Simon, Alexander M" uniqKey="Simon A" first="Alexander M." last="Simon">Alexander M. Simon</name>
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<series><title level="j">Lymphology</title>
<idno type="ISSN">0024-7766</idno>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p id="P1">This article reviews recent findings on expression and function of connexin proteins - the structural subunits of gap junction intercellular channels in the lymphatic vasculature - both during development and in the mature lymphatic vessel. Highlighted in particular are recent mouse connexin knockout studies which show that connexins are crucial for normal lymphatic development. We discuss, in general terms, both channel-dependent as well as channel-independent functions of connexins and raise some of the many unanswered questions about the mechanism(s) of action and physiological roles of connexins in the lymphatic vasculature.</p>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0155112</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5518</journal-id>
<journal-id journal-id-type="nlm-ta">Lymphology</journal-id>
<journal-id journal-id-type="iso-abbrev">Lymphology</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Lymphatic communication: Connexin junction, what’s your function?</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Kanady</surname>
<given-names>John D.</given-names>
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<degrees>B.S.</degrees>
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<contrib contrib-type="author"><name><surname>Simon</surname>
<given-names>Alexander M.</given-names>
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<degrees>Ph.D.</degrees>
<xref rid="FN1" ref-type="author-notes">*</xref>
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<aff id="A1">Department of Physiology, University of Arizona, Tucson, AZ 85724, USA</aff>
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<author-notes><corresp id="FN1"><label>*</label>
Author for correspondence: Alexander M. Simon, Ph.D., Department of Physiology, University of Arizona, PO Box 245051, Tucson, AZ 85724, USA, Phone: 520-621-9778, Fax: 520-626-2383, <email>amsimon@email.arizona.edu</email>
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<pub-date pub-type="nihms-submitted"><day>30</day>
<month>11</month>
<year>2012</year>
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<pub-date pub-type="ppub"><month>9</month>
<year>2011</year>
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<pub-date pub-type="pmc-release"><day>12</day>
<month>12</month>
<year>2012</year>
</pub-date>
<volume>44</volume>
<issue>3</issue>
<fpage>95</fpage>
<lpage>102</lpage>
<abstract><title>Summary</title>
<p id="P1">This article reviews recent findings on expression and function of connexin proteins - the structural subunits of gap junction intercellular channels in the lymphatic vasculature - both during development and in the mature lymphatic vessel. Highlighted in particular are recent mouse connexin knockout studies which show that connexins are crucial for normal lymphatic development. We discuss, in general terms, both channel-dependent as well as channel-independent functions of connexins and raise some of the many unanswered questions about the mechanism(s) of action and physiological roles of connexins in the lymphatic vasculature.</p>
</abstract>
<kwd-group><kwd>Connexin</kwd>
<kwd>Gap junction</kwd>
<kwd>Lymphatic development</kwd>
<kwd>Lymphatic vasculature</kwd>
<kwd>Lymphatic valve</kwd>
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<funding-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source>
<award-id>R01 HL064232 || HL</award-id>
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