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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The sensitivity and specificity of sentinel lymph node biopsy for breast cancer at Baylor University Medical Center at Dallas: a retrospective review of 488 cases</title><author><name sortKey="Shiller, S Michelle" sort="Shiller, S Michelle" uniqKey="Shiller S" first="S. Michelle" last="Shiller">S. Michelle Shiller</name></author><author><name sortKey="Weir, Robert" sort="Weir, Robert" uniqKey="Weir R" first="Robert" last="Weir">Robert Weir</name></author><author><name sortKey="Pippen, John" sort="Pippen, John" uniqKey="Pippen J" first="John" last="Pippen">John Pippen</name></author><author><name sortKey="Punar, Metin" sort="Punar, Metin" uniqKey="Punar M" first="Metin" last="Punar">Metin Punar</name></author><author><name sortKey="Savino, Daniel" sort="Savino, Daniel" uniqKey="Savino D" first="Daniel" last="Savino">Daniel Savino</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21566748</idno><idno type="pmc">3069509</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069509</idno><idno type="RBID">PMC:3069509</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">003153</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003153</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The sensitivity and specificity of sentinel lymph node biopsy for breast cancer at Baylor University Medical Center at Dallas: a retrospective review of 488 cases</title><author><name sortKey="Shiller, S Michelle" sort="Shiller, S Michelle" uniqKey="Shiller S" first="S. Michelle" last="Shiller">S. Michelle Shiller</name></author><author><name sortKey="Weir, Robert" sort="Weir, Robert" uniqKey="Weir R" first="Robert" last="Weir">Robert Weir</name></author><author><name sortKey="Pippen, John" sort="Pippen, John" uniqKey="Pippen J" first="John" last="Pippen">John Pippen</name></author><author><name sortKey="Punar, Metin" sort="Punar, Metin" uniqKey="Punar M" first="Metin" last="Punar">Metin Punar</name></author><author><name sortKey="Savino, Daniel" sort="Savino, Daniel" uniqKey="Savino D" first="Daniel" last="Savino">Daniel Savino</name></author></analytic><series><title level="j">Proceedings (Baylor University. Medical Center)</title><idno type="ISSN">0899-8280</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Sentinel lymph node (SLN) biopsy has become the standard of care for breast carcinoma management, as it precludes the negative morbid effects—including decreased shoulder range of motion, lymphedema, and paresthesias—of unnecessary axillary lymph node dissection. However, the method of pathologic evaluation of the lymph node has been scrutinized to obtain the greatest sensitivity, specificity, and negative predictive value, ultimately for the benefit of the patient. This retrospective study analyzed 488 biopsies completed by two surgeons and read by multiple pathologists affiliated with Pathologists Biomedical Laboratories. When metastatic disease was not grossly obvious, analysis of the SLN began with touch imprint cytology and, if necessary, a frozen section analysis. On the subsequent day, three levels of the SLN were analyzed with hematoxylin and eosin stain and immunohistochemistry with cytokeratin AE1-3 and the appropriate control. Touch imprint cytology and/or frozen section analysis (where applicable) correctly identified 78 of 89 macrometastases, with a sensitivity of 88%, specificity of 100%, and negative predictive value of 97%. Sensitivity was 72% for micrometastases and 60% for isolated tumor cells, each with 100% specificity. In conclusion, the sensitivity and specificity of SLN biopsy at our institution compares with the higher end of percentages reported in the literature.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc (Bayl Univ Med Cent)</journal-id><journal-id journal-id-type="publisher-id">bumc</journal-id><journal-title-group><journal-title>Proceedings (Baylor University. Medical Center)</journal-title></journal-title-group><issn pub-type="ppub">0899-8280</issn><publisher><publisher-name>Baylor Health Care System</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21566748</article-id><article-id pub-id-type="pmc">3069509</article-id><article-id pub-id-type="publisher-id">bumc0024-0081</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>The sensitivity and specificity of sentinel lymph node biopsy for breast cancer at Baylor University Medical Center at Dallas: a retrospective review of 488 cases</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Shiller</surname><given-names>S. Michelle</given-names></name><degrees>DO</degrees></contrib><contrib contrib-type="author"><name><surname>Weir</surname><given-names>Robert</given-names></name><degrees>PA</degrees></contrib><contrib contrib-type="author"><name><surname>Pippen</surname><given-names>John</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Punar</surname><given-names>Metin</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Savino</surname><given-names>Daniel</given-names></name><degrees>MD</degrees></contrib></contrib-group><aff>From the Department of Pathology (Shiller, Weir, Punar, Savino) and Oncology (Pippen), Baylor University Medical Center at Dallas and Baylor Charles A. Sammons Cancer Center at Dallas. Dr. Shiller is now at the Mayo Clinic, Rochester, Minnesota.</aff><author-notes><corresp><bold>Corresponding author:</bold> S. Michelle Shiller, DO, Department of Laboratory Medicine and Pathology, Mayo Clinic, Molecular Genetics Laboratory-Hilton 920, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55906 (e-mail: <email>michelleshiller@yahoo.com</email>).</corresp></author-notes><pub-date pub-type="ppub"><month>4</month><year>2011</year></pub-date><volume>24</volume><issue>2</issue><fpage>81</fpage><lpage>85</lpage><permissions><copyright-statement>Copyright © 2011, Baylor University Medical Center</copyright-statement></permissions><abstract><p>Sentinel lymph node (SLN) biopsy has become the standard of care for breast carcinoma management, as it precludes the negative morbid effects—including decreased shoulder range of motion, lymphedema, and paresthesias—of unnecessary axillary lymph node dissection. However, the method of pathologic evaluation of the lymph node has been scrutinized to obtain the greatest sensitivity, specificity, and negative predictive value, ultimately for the benefit of the patient. This retrospective study analyzed 488 biopsies completed by two surgeons and read by multiple pathologists affiliated with Pathologists Biomedical Laboratories. When metastatic disease was not grossly obvious, analysis of the SLN began with touch imprint cytology and, if necessary, a frozen section analysis. On the subsequent day, three levels of the SLN were analyzed with hematoxylin and eosin stain and immunohistochemistry with cytokeratin AE1-3 and the appropriate control. Touch imprint cytology and/or frozen section analysis (where applicable) correctly identified 78 of 89 macrometastases, with a sensitivity of 88%, specificity of 100%, and negative predictive value of 97%. Sensitivity was 72% for micrometastases and 60% for isolated tumor cells, each with 100% specificity. In conclusion, the sensitivity and specificity of SLN biopsy at our institution compares with the higher end of percentages reported in the literature.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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