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A Preliminary Study of the Safety of Red Light Phototherapy of Tissues Harboring Cancer

Identifieur interne : 003136 ( Pmc/Corpus ); précédent : 003135; suivant : 003137

A Preliminary Study of the Safety of Red Light Phototherapy of Tissues Harboring Cancer

Auteurs : Max Myakishev-Rempel ; Istvan Stadler ; Philip Brondon ; David R. Axe ; Mark Friedman ; Frances Barg Nardia ; Raymond Lanzafame

Source :

Photomedicine and Laser Surgery [ 1549-5418 ] ; 2012.

RBID : PMC:3423866

Abstract

Objective: Red light phototherapy is known to stimulate cell proliferation in wound healing. This study investigated whether low-level light therapy (LLLT) would promote tumor growth when pre-existing malignancy is present. Background data: LLLT has been increasingly used for numerous conditions, but its use in cancer patients, including the treatment of lymphedema or various unrelated comorbidities, has been withheld by practitioners because of the fear that LLLT might result in initiation or promotion of metastatic lesions or new primary tumors. There has been little scientific study of oncologic outcomes after use of LLLT in cancer patients. Methods: A standard SKH mouse nonmelanoma UV-induced skin cancer model was used after visible squamous cell carcinomas were present, to study the effects of LLLT on tumor growth. The red light group (n=8) received automated full body 670 nm LLLT delivered twice a day at 5 J/cm² using an LED source. The control group (n=8) was handled similarly, but did not receive LLLT. Measurements on 330 tumors were conducted for 37 consecutive days, while the animals received daily LLLT. Results: Daily tumor measurements demonstrated no measurable effect of LLLT on tumor growth. Conclusions: This experiment suggests that LLLT at these parameters may be safe even when malignant lesions are present. Further studies on the effects of photoirradiation on neoplasms are warranted.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423866

DOI: 10.1089/pho.2011.3186
PubMed: 22853435
PubMed Central: 3423866

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PMC:3423866

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Preliminary Study of the Safety of Red Light Phototherapy of Tissues Harboring Cancer</title>
<author><name sortKey="Myakishev Rempel, Max" sort="Myakishev Rempel, Max" uniqKey="Myakishev Rempel M" first="Max" last="Myakishev-Rempel">Max Myakishev-Rempel</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
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<author><name sortKey="Stadler, Istvan" sort="Stadler, Istvan" uniqKey="Stadler I" first="Istvan" last="Stadler">Istvan Stadler</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
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<author><name sortKey="Brondon, Philip" sort="Brondon, Philip" uniqKey="Brondon P" first="Philip" last="Brondon">Philip Brondon</name>
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<author><name sortKey="Axe, David R" sort="Axe, David R" uniqKey="Axe D" first="David R." last="Axe">David R. Axe</name>
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<author><name sortKey="Friedman, Mark" sort="Friedman, Mark" uniqKey="Friedman M" first="Mark" last="Friedman">Mark Friedman</name>
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<author><name sortKey="Nardia, Frances Barg" sort="Nardia, Frances Barg" uniqKey="Nardia F" first="Frances Barg" last="Nardia">Frances Barg Nardia</name>
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<author><name sortKey="Lanzafame, Raymond" sort="Lanzafame, Raymond" uniqKey="Lanzafame R" first="Raymond" last="Lanzafame">Raymond Lanzafame</name>
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<idno type="doi">10.1089/pho.2011.3186</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Preliminary Study of the Safety of Red Light Phototherapy of Tissues Harboring Cancer</title>
<author><name sortKey="Myakishev Rempel, Max" sort="Myakishev Rempel, Max" uniqKey="Myakishev Rempel M" first="Max" last="Myakishev-Rempel">Max Myakishev-Rempel</name>
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<author><name sortKey="Stadler, Istvan" sort="Stadler, Istvan" uniqKey="Stadler I" first="Istvan" last="Stadler">Istvan Stadler</name>
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<author><name sortKey="Brondon, Philip" sort="Brondon, Philip" uniqKey="Brondon P" first="Philip" last="Brondon">Philip Brondon</name>
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<author><name sortKey="Axe, David R" sort="Axe, David R" uniqKey="Axe D" first="David R." last="Axe">David R. Axe</name>
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<author><name sortKey="Friedman, Mark" sort="Friedman, Mark" uniqKey="Friedman M" first="Mark" last="Friedman">Mark Friedman</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
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</author>
<author><name sortKey="Nardia, Frances Barg" sort="Nardia, Frances Barg" uniqKey="Nardia F" first="Frances Barg" last="Nardia">Frances Barg Nardia</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lanzafame, Raymond" sort="Lanzafame, Raymond" uniqKey="Lanzafame R" first="Raymond" last="Lanzafame">Raymond Lanzafame</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
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<series><title level="j">Photomedicine and Laser Surgery</title>
<idno type="ISSN">1549-5418</idno>
<idno type="eISSN">1557-8550</idno>
<imprint><date when="2012">2012</date>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Objective:</italic>
</bold>
 Red light phototherapy is known to stimulate cell proliferation in wound healing. This study investigated whether low-level light therapy (LLLT) would promote tumor growth when pre-existing malignancy is present. <bold><italic>Background data:</italic>
</bold>
 LLLT has been increasingly used for numerous conditions, but its use in cancer patients, including the treatment of lymphedema or various unrelated comorbidities, has been withheld by practitioners because of the fear that LLLT might result in initiation or promotion of metastatic lesions or new primary tumors. There has been little scientific study of oncologic outcomes after use of LLLT in cancer patients. <bold><italic>Methods:</italic>
</bold>
 A standard SKH mouse nonmelanoma UV-induced skin cancer model was used after visible squamous cell carcinomas were present, to study the effects of LLLT on tumor growth. The red light group <italic>(n</italic>
=8) received automated full body 670 nm LLLT delivered twice a day at 5 J/cm<sup>2</sup>
 using an LED source. The control group <italic>(n</italic>
=8) was handled similarly, but did not receive LLLT. Measurements on 330 tumors were conducted for 37 consecutive days, while the animals received daily LLLT. <bold><italic>Results:</italic>
</bold>
 Daily tumor measurements demonstrated no measurable effect of LLLT on tumor growth. <bold><italic>Conclusions:</italic>
</bold>
 This experiment suggests that LLLT at these parameters may be safe even when malignant lesions are present. Further studies on the effects of photoirradiation on neoplasms are warranted.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Photomed Laser Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">Photomed Laser Surg</journal-id>
<journal-id journal-id-type="publisher-id">pho</journal-id>
<journal-title-group><journal-title>Photomedicine and Laser Surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">1549-5418</issn>
<issn pub-type="epub">1557-8550</issn>
<publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name>
<publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22853435</article-id>
<article-id pub-id-type="pmc">3423866</article-id>
<article-id pub-id-type="publisher-id">10.1089/pho.2011.3186</article-id>
<article-id pub-id-type="doi">10.1089/pho.2011.3186</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>A Preliminary Study of the Safety of Red Light Phototherapy of Tissues Harboring Cancer</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Myakishev-Rempel</surname>
<given-names>Max</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stadler</surname>
<given-names>Istvan</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brondon</surname>
<given-names>Philip</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Axe</surname>
<given-names>David R.</given-names>
</name>
<degrees>M.Sc.</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friedman</surname>
<given-names>Mark</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nardia</surname>
<given-names>Frances Barg</given-names>
</name>
<degrees>M.Sc.</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lanzafame</surname>
<given-names>Raymond</given-names>
</name>
<degrees>M.D., M.B.A.</degrees>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<aff id="aff1"><label><sup>1</sup>
</label>
Department of Dermatology,<institution>University of Rochester</institution>
, Rochester, New York.</aff>
<aff id="aff2"><label><sup>2</sup>
</label>
<institution>Rochester General Hospital Laser Surgical Research Laboratory</institution>
, Rochester, New York.</aff>
<aff id="aff3"><label><sup>3</sup>
</label>
Mathematical Sciences Department,<institution>University of Alabama in Huntsville</institution>
, Huntsville, Alabama.</aff>
</contrib-group>
<author-notes><corresp>Address correspondence to: <italic>Max Myakishev-Rempel, 129 Cobb Terrace, Rochester NY 14620. E-mail:</italic>
<email xlink:href="mailto:max.rempel@gmail.com">max.rempel@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>9</month>
<year>2012</year>
<pmc-comment>string-date: September 2012</pmc-comment>
      </pub-date>
<volume>30</volume>
<issue>9</issue>
<fpage>551</fpage>
<lpage>558</lpage>
<permissions><copyright-statement>Copyright 2012, Mary Ann Liebert, Inc.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<self-uri xlink:type="simple" xlink:href="pho.2011.3186.pdf"></self-uri>
<abstract><title>Abstract</title>
<p><bold><italic>Objective:</italic>
</bold>
 Red light phototherapy is known to stimulate cell proliferation in wound healing. This study investigated whether low-level light therapy (LLLT) would promote tumor growth when pre-existing malignancy is present. <bold><italic>Background data:</italic>
</bold>
 LLLT has been increasingly used for numerous conditions, but its use in cancer patients, including the treatment of lymphedema or various unrelated comorbidities, has been withheld by practitioners because of the fear that LLLT might result in initiation or promotion of metastatic lesions or new primary tumors. There has been little scientific study of oncologic outcomes after use of LLLT in cancer patients. <bold><italic>Methods:</italic>
</bold>
 A standard SKH mouse nonmelanoma UV-induced skin cancer model was used after visible squamous cell carcinomas were present, to study the effects of LLLT on tumor growth. The red light group <italic>(n</italic>
=8) received automated full body 670 nm LLLT delivered twice a day at 5 J/cm<sup>2</sup>
 using an LED source. The control group <italic>(n</italic>
=8) was handled similarly, but did not receive LLLT. Measurements on 330 tumors were conducted for 37 consecutive days, while the animals received daily LLLT. <bold><italic>Results:</italic>
</bold>
 Daily tumor measurements demonstrated no measurable effect of LLLT on tumor growth. <bold><italic>Conclusions:</italic>
</bold>
 This experiment suggests that LLLT at these parameters may be safe even when malignant lesions are present. Further studies on the effects of photoirradiation on neoplasms are warranted.</p>
</abstract>
<counts><fig-count count="8"></fig-count>
<ref-count count="41"></ref-count>
<page-count count="8"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>

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A Preliminary Study of the Safety of Red Light Phototherapy of Tissues Harboring Cancer

A Preliminary Study of the Safety of Red Light Phototherapy of Tissues Harboring Cancer

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Abstract

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