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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relationships Between Lymphangiogenesis and Angiogenesis During Inflammation in Rat Mesentery Microvascular Networks</title><author><name sortKey="Sweat, Richard S" sort="Sweat, Richard S" uniqKey="Sweat R" first="Richard S." last="Sweat">Richard S. Sweat</name></author><author><name sortKey="Stapor, Peter C" sort="Stapor, Peter C" uniqKey="Stapor P" first="Peter C." last="Stapor">Peter C. Stapor</name></author><author><name sortKey="Murfee, Walter L" sort="Murfee, Walter L" uniqKey="Murfee W" first="Walter L." last="Murfee">Walter L. Murfee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23240958</idno><idno type="pmc">3525890</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525890</idno><idno type="RBID">PMC:3525890</idno><idno type="doi">10.1089/lrb.2012.0014</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">003023</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003023</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Relationships Between Lymphangiogenesis and Angiogenesis During Inflammation in Rat Mesentery Microvascular Networks</title><author><name sortKey="Sweat, Richard S" sort="Sweat, Richard S" uniqKey="Sweat R" first="Richard S." last="Sweat">Richard S. Sweat</name></author><author><name sortKey="Stapor, Peter C" sort="Stapor, Peter C" uniqKey="Stapor P" first="Peter C." last="Stapor">Peter C. Stapor</name></author><author><name sortKey="Murfee, Walter L" sort="Murfee, Walter L" uniqKey="Murfee W" first="Walter L." last="Murfee">Walter L. Murfee</name></author></analytic><series><title level="j">Lymphatic Research and Biology</title><idno type="ISSN">1539-6851</idno><idno type="eISSN">1557-8585</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec><title>Background</title><p>Lymphatic and blood microvascular systems play a coordinated role in the regulation of interstitial fluid balance and immune cell trafficking during inflammation. The objective of this study was to characterize the temporal and spatial relationships between lymphatic and blood vessel growth in the adult rat mesentery following an inflammatory stimulus.</p></sec><sec><title>Methods and Results</title><p>Mesenteric tissues were harvested from unstimulated adult male Wistar rats and at 3, 10, and 30 days post compound 48/80 stimulation. Tissues were immunolabeled for PECAM, LYVE-1, Prox1, podoplanin, CD11b, and class III β-tubulin. Vascular area, capillary blind end density, and vascular length density were quantified for each vessel system per time point. Blood vascular area increased compared to unstimulated tissues by day 10 and remained increased at day 30. Following the peak in blood capillary sprouting at day 3, blood vascular area and density increased at day 10. The number of blind-ended lymphatic vessels and lymphatic density did not significantly increase until day 10, and lymphatic vascular area was not increased compared to the unstimulated level until day 30. Lymphangiogenesis correlated with the upregulation of class III β-tubulin expression by endothelial cells along lymphatic blind-ended vessels and increased lymphatic/blood endothelial cell connections. In local tissue regions containing both blood and lymphatic vessels, the presence of lymphatics attenuated blood capillary sprouting.</p></sec><sec><title>Conclusions</title><p>Our work suggests that lymphangiogenesis lags angiogenesis during inflammation and motivates the need for future investigations aimed at understanding lymphatic/blood endothelial cell interactions. The results also indicate that lymphatic endothelial cells undergo phenotypic changes during lymphangiogenesis.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Lymphat Res Biol</journal-id><journal-id journal-id-type="iso-abbrev">Lymphat Res Biol</journal-id><journal-id journal-id-type="publisher-id">lrb</journal-id><journal-title-group><journal-title>Lymphatic Research and Biology</journal-title></journal-title-group><issn pub-type="ppub">1539-6851</issn><issn pub-type="epub">1557-8585</issn><publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name><publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23240958</article-id><article-id pub-id-type="pmc">3525890</article-id><article-id pub-id-type="publisher-id">10.1089/lrb.2012.0014</article-id><article-id pub-id-type="doi">10.1089/lrb.2012.0014</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Relationships Between Lymphangiogenesis and Angiogenesis During Inflammation in Rat Mesentery Microvascular Networks</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sweat</surname><given-names>Richard S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Stapor</surname><given-names>Peter C.</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Murfee</surname><given-names>Walter L.</given-names></name><degrees>Ph.D.</degrees></contrib><aff id="aff1">Department of Biomedical Engineering,<institution>Tulane University</institution>, New Orleans, Louisiana.</aff></contrib-group><author-notes><corresp>Address correspondence to: <italic>Walter L. Murfee, Ph.D., Lindy Boggs Center, Suite 500, Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118. E-mail:</italic><email xlink:href="mailto:wmurfee@tulane.edu">wmurfee@tulane.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2012</year><pmc-comment>string-date: December 2012</pmc-comment>
</pub-date><volume>10</volume><issue>4</issue><fpage>198</fpage><lpage>207</lpage><permissions><copyright-statement>Copyright 2012, Mary Ann Liebert, Inc.</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:type="simple" xlink:href="lrb.2012.0014.pdf"></self-uri><abstract><title>Abstract</title><sec><title>Background</title><p>Lymphatic and blood microvascular systems play a coordinated role in the regulation of interstitial fluid balance and immune cell trafficking during inflammation. The objective of this study was to characterize the temporal and spatial relationships between lymphatic and blood vessel growth in the adult rat mesentery following an inflammatory stimulus.</p></sec><sec><title>Methods and Results</title><p>Mesenteric tissues were harvested from unstimulated adult male Wistar rats and at 3, 10, and 30 days post compound 48/80 stimulation. Tissues were immunolabeled for PECAM, LYVE-1, Prox1, podoplanin, CD11b, and class III β-tubulin. Vascular area, capillary blind end density, and vascular length density were quantified for each vessel system per time point. Blood vascular area increased compared to unstimulated tissues by day 10 and remained increased at day 30. Following the peak in blood capillary sprouting at day 3, blood vascular area and density increased at day 10. The number of blind-ended lymphatic vessels and lymphatic density did not significantly increase until day 10, and lymphatic vascular area was not increased compared to the unstimulated level until day 30. Lymphangiogenesis correlated with the upregulation of class III β-tubulin expression by endothelial cells along lymphatic blind-ended vessels and increased lymphatic/blood endothelial cell connections. In local tissue regions containing both blood and lymphatic vessels, the presence of lymphatics attenuated blood capillary sprouting.</p></sec><sec><title>Conclusions</title><p>Our work suggests that lymphangiogenesis lags angiogenesis during inflammation and motivates the need for future investigations aimed at understanding lymphatic/blood endothelial cell interactions. The results also indicate that lymphatic endothelial cells undergo phenotypic changes during lymphangiogenesis.</p></sec></abstract><counts><fig-count count="8"></fig-count><ref-count count="25"></ref-count><page-count count="10"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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