Challenging and Complex Decisions in the Management of the BRCA Mutation Carrier
Identifieur interne : 003004 ( Pmc/Corpus ); précédent : 003003; suivant : 003005Challenging and Complex Decisions in the Management of the BRCA Mutation Carrier
Auteurs : Daniela L. Stan ; Lynne T. Shuster ; Myra J. Wick ; Casey L. Swanson ; Sandhya Pruthi ; Jamie N. Bakkum-GamezSource :
- Journal of Women's Health [ 1540-9996 ] ; 2013.
Abstract
Women afflicted by the hereditary breast and ovarian cancer syndrome face complex decisions regarding medical interventions aimed at reducing their risk of ovarian and breast cancer, interventions which in turn may interfere with their fertility and cause early menopause. This review addresses selected topics of importance and controversy in the management of the BRCA mutation carrier, such as psychological well-being and quality of life, breast and ovarian cancer screening, risk-reducing interventions for breast cancer and ovarian cancer, the issue of hysterectomy at the time of the risk-reducing salpingo-oophorectomy, health consequences of early surgical menopause, and safety of hormonal therapy after oophorectomy. The information presented is based on an extensive review of the literature on the selected topics and on the expertise of our multidisciplinary team.
Url:
DOI: 10.1089/jwh.2013.4407
PubMed: 23987739
PubMed Central: 4047843
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Womens Health (Larchmt)</journal-id><journal-id journal-id-type="iso-abbrev">J Womens Health (Larchmt)</journal-id><journal-id journal-id-type="publisher-id">jwh</journal-id><journal-title-group><journal-title>Journal of Women's Health</journal-title></journal-title-group><issn pub-type="ppub">1540-9996</issn><issn pub-type="epub">1931-843X</issn><publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name><publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23987739</article-id><article-id pub-id-type="pmc">4047843</article-id><article-id pub-id-type="publisher-id">10.1089/jwh.2013.4407</article-id><article-id pub-id-type="doi">10.1089/jwh.2013.4407</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Challenging and Complex Decisions in the Management of the BRCA Mutation Carrier</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Stan</surname><given-names>Daniela L.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shuster</surname><given-names>Lynne T.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wick</surname><given-names>Myra J.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Swanson</surname><given-names>Casey L.</given-names></name><degrees>PA-C</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pruthi</surname><given-names>Sandhya</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bakkum-Gamez</surname><given-names>Jamie N.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><aff id="aff1"><label><sup>1</sup></label>Division of General Internal Medicine,<institution>Mayo Clinic</institution>, Rochester, Minnesota.</aff><aff id="aff2"><label><sup>2</sup></label>Department of Obstetrics and Gynecology,<institution>Mayo Clinic</institution>, Rochester, Minnesota.</aff></contrib-group><author-notes><corresp>Address correspondence to: <italic>Daniela L. Stan, MD, Division of General Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905. E-mail:</italic><email xlink:href="mailto:stan.daniela@mayo.edu">stan.daniela@mayo.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>10</month><year>2013</year><pmc-comment>string-date: October 2013</pmc-comment>
</pub-date><volume>22</volume><issue>10</issue><fpage>825</fpage><lpage>834</lpage><permissions><copyright-statement>Copyright 2013, Mary Ann Liebert, Inc.</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri xlink:type="simple" xlink:href="jwh.2013.4407.pdf"></self-uri><abstract><title>Abstract</title><p>Women afflicted by the hereditary breast and ovarian cancer syndrome face complex decisions regarding medical interventions aimed at reducing their risk of ovarian and breast cancer, interventions which in turn may interfere with their fertility and cause early menopause. This review addresses selected topics of importance and controversy in the management of the BRCA mutation carrier, such as psychological well-being and quality of life, breast and ovarian cancer screening, risk-reducing interventions for breast cancer and ovarian cancer, the issue of hysterectomy at the time of the risk-reducing salpingo-oophorectomy, health consequences of early surgical menopause, and safety of hormonal therapy after oophorectomy. The information presented is based on an extensive review of the literature on the selected topics and on the expertise of our multidisciplinary team.</p></abstract><counts><table-count count="1"></table-count><ref-count count="111"></ref-count><page-count count="10"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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