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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Combined Blockade of VEGFR-3 and VLA-1 Markedly Promotes High-Risk Corneal Transplant Survival</title><author><name sortKey="Zhang, Hui" sort="Zhang, Hui" uniqKey="Zhang H" first="Hui" last="Zhang">Hui Zhang</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff></affiliation></author><author><name sortKey="Grimaldo, Sammy" sort="Grimaldo, Sammy" uniqKey="Grimaldo S" first="Sammy" last="Grimaldo">Sammy Grimaldo</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff></affiliation></author><author><name sortKey="Yuen, Don" sort="Yuen, Don" uniqKey="Yuen D" first="Don" last="Yuen">Don Yuen</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff></affiliation></author><author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21715348</idno><idno type="pmc">3176031</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176031</idno><idno type="RBID">PMC:3176031</idno><idno type="doi">10.1167/iovs.11-7454</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002E70</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Combined Blockade of VEGFR-3 and VLA-1 Markedly Promotes High-Risk Corneal Transplant Survival</title><author><name sortKey="Zhang, Hui" sort="Zhang, Hui" uniqKey="Zhang H" first="Hui" last="Zhang">Hui Zhang</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff></affiliation></author><author><name sortKey="Grimaldo, Sammy" sort="Grimaldo, Sammy" uniqKey="Grimaldo S" first="Sammy" last="Grimaldo">Sammy Grimaldo</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff></affiliation></author><author><name sortKey="Yuen, Don" sort="Yuen, Don" uniqKey="Yuen D" first="Don" last="Yuen">Don Yuen</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff></affiliation></author><author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff></affiliation></author></analytic><series><title level="j">Investigative Ophthalmology & Visual Science</title><idno type="ISSN">0146-0404</idno><idno type="eISSN">1552-5783</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The authors provide the first evidence that a combined blockade of VEGFR-3 and VLA-1 promotes 90% survival of high-risk corneal transplants. Moreover, a strong correlation is revealed between high-risk transplant rejection and high degree of lymphangiogenesis reaching the donor-graft border.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Invest Ophthalmol Vis Sci</journal-id><journal-id journal-id-type="hwp">iovs</journal-id><journal-id journal-id-type="pmc">iovs</journal-id><journal-id journal-id-type="publisher-id">IOVS</journal-id><journal-title-group><journal-title>Investigative Ophthalmology & Visual Science</journal-title></journal-title-group><issn pub-type="ppub">0146-0404</issn><issn pub-type="epub">1552-5783</issn><publisher><publisher-name>Association for Research in Vision and Ophthalmology, Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21715348</article-id><article-id pub-id-type="pmc">3176031</article-id><article-id pub-id-type="publisher-id">11-7454</article-id><article-id pub-id-type="doi">10.1167/iovs.11-7454</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject><subj-group><subject>Cornea</subject></subj-group></subj-group></article-categories><title-group><article-title>Combined Blockade of VEGFR-3 and VLA-1 Markedly Promotes High-Risk Corneal Transplant Survival</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Hui</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Grimaldo</surname><given-names>Sammy</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Yuen</surname><given-names>Don</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Chen</surname><given-names>Lu</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</aff></contrib-group><author-notes><corresp>Corresponding author: Lu Chen, <addr-line>Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, 689 Minor Hall, Berkeley, CA 94720</addr-line>; <email>chenlu@berkeley.edu</email>.</corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>17</day><month>8</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>2</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 6 months and 0 days and was based on the
<volume>52</volume><issue>9</issue><fpage>6529</fpage><lpage>6535</lpage><history><date date-type="received"><day>25</day><month>2</month><year>2011</year></date><date date-type="rev-recd"><day>24</day><month>5</month><year>2011</year></date><date date-type="accepted"><day>16</day><month>6</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © Association for Research in Vision and Ophthalmology</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="z7g00911006529.pdf"></self-uri><abstract abstract-type="precis"><p>The authors provide the first evidence that a combined blockade of VEGFR-3 and VLA-1 promotes 90% survival of high-risk corneal transplants. Moreover, a strong correlation is revealed between high-risk transplant rejection and high degree of lymphangiogenesis reaching the donor-graft border.</p></abstract><abstract><sec><title>Purpose.</title><p>High-risk corneal transplantation refers to grafting performed on inflamed and highly vascularized host beds. It represents a clinical dilemma because the rejection rate can be as high as 90%, irrespective of current treatment modalities. This study was conducted to investigate whether combined blockade of VEGFR-3 (vascular endothelial growth factor receptor-3) and VLA-1 (very late antigen-1) promotes high-risk transplant survival and how it correlates with corneal lymphangiogenesis and hemangiogenesis before and after transplantation.</p></sec><sec><title>Methods.</title><p>High-risk corneal transplantation was performed between normal C57BL/6 (donor) and inflamed BALB/c (recipient) mice. The recipients were randomized to receive intraperitoneal injections of VEGFR-3 and VLA-1–neutralizing antibodies or their controls twice a week for up to 8 weeks after transplantation. Corneal grafts were evaluated by ophthalmic slit-lamp biomicroscopy and analyzed by Kaplan-Meier survival curve. Additionally, whole-mount corneas before and after transplantation were examined by immunofluorescent microscopic assays, and the correlation between lymphatic or blood vessel distribution and transplant outcome was analyzed.</p></sec><sec><title>Results.</title><p>The combined blockade markedly promotes 90% survival of high-risk transplants. This strategy specifically modified host beds by selective inhibition of lymphangiogenesis but not hemangiogenesis. A strong correlation was also identified between high-risk transplant rejection and severe lymphatic invasion reaching the donor-graft border.</p></sec><sec><title>Conclusions.</title><p>These novel findings not only provide a new and potentially powerful strategy to promote high-risk transplant survival, they also confirm a critical role of high-degree lymphangiogenesis in mediating high-risk transplant rejection. Results from this study may also shed new light on our understanding and management of other lymphatic- and immune-related diseases in general.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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