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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Very Late Antigen-1 Mediates Corneal Lymphangiogenesis</title><author><name sortKey="Grimaldo, Sammy" sort="Grimaldo, Sammy" uniqKey="Grimaldo S" first="Sammy" last="Grimaldo">Sammy Grimaldo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yuen, Don" sort="Yuen, Don" uniqKey="Yuen D" first="Don" last="Yuen">Don Yuen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ecoiffier, Tatiana" sort="Ecoiffier, Tatiana" uniqKey="Ecoiffier T" first="Tatiana" last="Ecoiffier">Tatiana Ecoiffier</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21372020</idno><idno type="pmc">3175962</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175962</idno><idno type="RBID">PMC:3175962</idno><idno type="doi">10.1167/iovs.10-6580</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002E67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Very Late Antigen-1 Mediates Corneal Lymphangiogenesis</title><author><name sortKey="Grimaldo, Sammy" sort="Grimaldo, Sammy" uniqKey="Grimaldo S" first="Sammy" last="Grimaldo">Sammy Grimaldo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yuen, Don" sort="Yuen, Don" uniqKey="Yuen D" first="Don" last="Yuen">Don Yuen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ecoiffier, Tatiana" sort="Ecoiffier, Tatiana" uniqKey="Ecoiffier T" first="Tatiana" last="Ecoiffier">Tatiana Ecoiffier</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Investigative Ophthalmology & Visual Science</title><idno type="ISSN">0146-0404</idno><idno type="eISSN">1552-5783</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This article reports the novel finding that VLA-1 directly mediates lymphangiogenesis. Anti–VLA-1 treatment is effective in suppressing corneal inflammatory lymphangiogenesis in vivo and several lymphatic endothelial cell functions in vitro.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Invest Ophthalmol Vis Sci</journal-id><journal-id journal-id-type="hwp">iovs</journal-id><journal-id journal-id-type="pmc">iovs</journal-id><journal-id journal-id-type="publisher-id">IOVS</journal-id><journal-title-group><journal-title>Investigative Ophthalmology & Visual Science</journal-title></journal-title-group><issn pub-type="ppub">0146-0404</issn><issn pub-type="epub">1552-5783</issn><publisher><publisher-name>Association for Research in Vision and Ophthalmology, Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21372020</article-id><article-id pub-id-type="pmc">3175962</article-id><article-id pub-id-type="publisher-id">10-6580</article-id><article-id pub-id-type="doi">10.1167/iovs.10-6580</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject><subj-group><subject>Cornea</subject></subj-group></subj-group></article-categories><title-group><article-title>Very Late Antigen-1 Mediates Corneal Lymphangiogenesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Grimaldo</surname><given-names>Sammy</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="FN1"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yuen</surname><given-names>Don</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="FN1"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ecoiffier</surname><given-names>Tatiana</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Chen</surname><given-names>Lu</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><aff id="aff1">From the<label>1</label>Center for Eye Disease and Development, Program in Vision Science, University of California, Berkeley, California.</aff></contrib-group><author-notes><corresp>Corresponding author: Lu Chen, <addr-line>Center for Eye Disease and Development, Program in Vision Science, 689 Minor Hall, University of California, Berkeley, CA 94720</addr-line>; <email>chenlu@berkeley.edu</email>.</corresp><fn id="FN1" fn-type="equal"><label>2</label><p>These authors contributed equally to the work presented here and should therefore be regarded as equivalent authors.</p></fn></author-notes><pub-date pub-type="ppub"><month>6</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>30</day><month>6</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2011</year></pub-date><pmc-comment> PMC Release delay is 6 months and 0 days and was based on the
<volume>52</volume><issue>7</issue><fpage>4808</fpage><lpage>4812</lpage><history><date date-type="received"><day>15</day><month>9</month><year>2010</year></date><date date-type="rev-recd"><day>31</day><month>1</month><year>2011</year></date><date date-type="accepted"><day>16</day><month>2</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © Association for Research in Vision and Ophthalmology</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="z7g00711004808.pdf"></self-uri><abstract abstract-type="precis"><p>This article reports the novel finding that VLA-1 directly mediates lymphangiogenesis. Anti–VLA-1 treatment is effective in suppressing corneal inflammatory lymphangiogenesis in vivo and several lymphatic endothelial cell functions in vitro.</p></abstract><abstract><sec><title>Purpose.</title><p>To investigate the specific role of very late antigen-1 (VLA-1; also known as integrin α1β1) in corneal inflammatory lymphangiogenesis in vivo and lymphatic endothelial cell functions in vitro.</p></sec><sec><title>Methods.</title><p>A standard suture-induced corneal inflammatory lymphangiogenesis model was used in normal adult BALB/c mice to test the effect of systemic administration of VLA-1–neutralizing antibody on lymphatic formation and macrophage infiltration in vivo. Additionally, a human lymphatic endothelial cell culture system was used to examine the effect of VLA-1 gene depletion on lymphatic endothelial cell functions in vitro using small interfering RNAs.</p></sec><sec><title>Results.</title><p>These data demonstrated, for the first time, that VLA-1 blockade significantly suppressed corneal lymphangiogenesis and macrophage infiltration during inflammation. Moreover, VLA-1 gene depletion led to a marked inhibition of lymphatic endothelial cell processes of adhesion, proliferation, and capillary tube formation.</p></sec><sec><title>Conclusions.</title><p>These novel findings together indicate that VLA-1 is critically involved in the processes of lymphangiogenesis. Further investigation on this factor may provide novel therapies for corneal inflammation, transplant rejection, and other lymphatic-related disorders in the body.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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