Very Late Antigen-1 Mediates Corneal Lymphangiogenesis
Identifieur interne : 002E67 ( Pmc/Corpus ); précédent : 002E66; suivant : 002E68Very Late Antigen-1 Mediates Corneal Lymphangiogenesis
Auteurs : Sammy Grimaldo ; Don Yuen ; Tatiana Ecoiffier ; Lu ChenSource :
- Investigative Ophthalmology & Visual Science [ 0146-0404 ] ; 2011.
Abstract
This article reports the novel finding that VLA-1 directly mediates lymphangiogenesis. Anti–VLA-1 treatment is effective in suppressing corneal inflammatory lymphangiogenesis in vivo and several lymphatic endothelial cell functions in vitro.
Url:
DOI: 10.1167/iovs.10-6580
PubMed: 21372020
PubMed Central: 3175962
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PMC:3175962Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Very Late Antigen-1 Mediates Corneal Lymphangiogenesis</title>
<author><name sortKey="Grimaldo, Sammy" sort="Grimaldo, Sammy" uniqKey="Grimaldo S" first="Sammy" last="Grimaldo">Sammy Grimaldo</name>
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<author><name sortKey="Yuen, Don" sort="Yuen, Don" uniqKey="Yuen D" first="Don" last="Yuen">Don Yuen</name>
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<author><name sortKey="Ecoiffier, Tatiana" sort="Ecoiffier, Tatiana" uniqKey="Ecoiffier T" first="Tatiana" last="Ecoiffier">Tatiana Ecoiffier</name>
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<author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Very Late Antigen-1 Mediates Corneal Lymphangiogenesis</title>
<author><name sortKey="Grimaldo, Sammy" sort="Grimaldo, Sammy" uniqKey="Grimaldo S" first="Sammy" last="Grimaldo">Sammy Grimaldo</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
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<author><name sortKey="Yuen, Don" sort="Yuen, Don" uniqKey="Yuen D" first="Don" last="Yuen">Don Yuen</name>
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<author><name sortKey="Ecoiffier, Tatiana" sort="Ecoiffier, Tatiana" uniqKey="Ecoiffier T" first="Tatiana" last="Ecoiffier">Tatiana Ecoiffier</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
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<author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name>
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</analytic>
<series><title level="j">Investigative Ophthalmology & Visual Science</title>
<idno type="ISSN">0146-0404</idno>
<idno type="eISSN">1552-5783</idno>
<imprint><date when="2011">2011</date>
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<front><div type="abstract" xml:lang="en"><p>This article reports the novel finding that VLA-1 directly mediates lymphangiogenesis. Anti–VLA-1 treatment is effective in suppressing corneal inflammatory lymphangiogenesis in vivo and several lymphatic endothelial cell functions in vitro.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Invest Ophthalmol Vis Sci</journal-id>
<journal-id journal-id-type="hwp">iovs</journal-id>
<journal-id journal-id-type="pmc">iovs</journal-id>
<journal-id journal-id-type="publisher-id">IOVS</journal-id>
<journal-title-group><journal-title>Investigative Ophthalmology & Visual Science</journal-title>
</journal-title-group>
<issn pub-type="ppub">0146-0404</issn>
<issn pub-type="epub">1552-5783</issn>
<publisher><publisher-name>Association for Research in Vision and Ophthalmology, Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21372020</article-id>
<article-id pub-id-type="pmc">3175962</article-id>
<article-id pub-id-type="publisher-id">10-6580</article-id>
<article-id pub-id-type="doi">10.1167/iovs.10-6580</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
<subj-group><subject>Cornea</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Very Late Antigen-1 Mediates Corneal Lymphangiogenesis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Grimaldo</surname>
<given-names>Sammy</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="FN1"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yuen</surname>
<given-names>Don</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="FN1"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ecoiffier</surname>
<given-names>Tatiana</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Chen</surname>
<given-names>Lu</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<aff id="aff1">From the<label>1</label>
Center for Eye Disease and Development, Program in Vision Science, University of California, Berkeley, California.</aff>
</contrib-group>
<author-notes><corresp>Corresponding author: Lu Chen, <addr-line>Center for Eye Disease and Development, Program in Vision Science, 689 Minor Hall, University of California, Berkeley, CA 94720</addr-line>
; <email>chenlu@berkeley.edu</email>
.</corresp>
<fn id="FN1" fn-type="equal"><label>2</label>
<p>These authors contributed equally to the work presented here and should therefore be regarded as equivalent authors.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>6</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>30</day>
<month>6</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>12</month>
<year>2011</year>
</pub-date>
<pmc-comment> PMC Release delay is 6 months and 0 days and was based on the
. </pmc-comment>
<volume>52</volume>
<issue>7</issue>
<fpage>4808</fpage>
<lpage>4812</lpage>
<history><date date-type="received"><day>15</day>
<month>9</month>
<year>2010</year>
</date>
<date date-type="rev-recd"><day>31</day>
<month>1</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>16</day>
<month>2</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>Copyright © Association for Research in Vision and Ophthalmology</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="z7g00711004808.pdf"></self-uri>
<abstract abstract-type="precis"><p>This article reports the novel finding that VLA-1 directly mediates lymphangiogenesis. Anti–VLA-1 treatment is effective in suppressing corneal inflammatory lymphangiogenesis in vivo and several lymphatic endothelial cell functions in vitro.</p>
</abstract>
<abstract><sec><title>Purpose.</title>
<p>To investigate the specific role of very late antigen-1 (VLA-1; also known as integrin α1β1) in corneal inflammatory lymphangiogenesis in vivo and lymphatic endothelial cell functions in vitro.</p>
</sec>
<sec><title>Methods.</title>
<p>A standard suture-induced corneal inflammatory lymphangiogenesis model was used in normal adult BALB/c mice to test the effect of systemic administration of VLA-1–neutralizing antibody on lymphatic formation and macrophage infiltration in vivo. Additionally, a human lymphatic endothelial cell culture system was used to examine the effect of VLA-1 gene depletion on lymphatic endothelial cell functions in vitro using small interfering RNAs.</p>
</sec>
<sec><title>Results.</title>
<p>These data demonstrated, for the first time, that VLA-1 blockade significantly suppressed corneal lymphangiogenesis and macrophage infiltration during inflammation. Moreover, VLA-1 gene depletion led to a marked inhibition of lymphatic endothelial cell processes of adhesion, proliferation, and capillary tube formation.</p>
</sec>
<sec><title>Conclusions.</title>
<p>These novel findings together indicate that VLA-1 is critically involved in the processes of lymphangiogenesis. Further investigation on this factor may provide novel therapies for corneal inflammation, transplant rejection, and other lymphatic-related disorders in the body.</p>
</sec>
</abstract>
</article-meta>
</front>
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</record>
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