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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Concordant podoplanin expression in cancer-associated fibroblasts and tumor cells is an adverse prognostic factor in esophageal squamous cell carcinoma</title><author><name sortKey="Chuang, Wen Yu" sort="Chuang, Wen Yu" uniqKey="Chuang W" first="Wen-Yu" last="Chuang">Wen-Yu Chuang</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yeh, Chi Ju" sort="Yeh, Chi Ju" uniqKey="Yeh C" first="Chi-Ju" last="Yeh">Chi-Ju Yeh</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chao, Yin Kai" sort="Chao, Yin Kai" uniqKey="Chao Y" first="Yin-Kai" last="Chao">Yin-Kai Chao</name><affiliation><nlm:aff id="au2"><institution>Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Liu, Yun Hen" sort="Liu, Yun Hen" uniqKey="Liu Y" first="Yun-Hen" last="Liu">Yun-Hen Liu</name><affiliation><nlm:aff id="au2"><institution>Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chang, Yu Sun" sort="Chang, Yu Sun" uniqKey="Chang Y" first="Yu-Sun" last="Chang">Yu-Sun Chang</name><affiliation><nlm:aff id="au3"><institution>Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tseng, Chen Kan" sort="Tseng, Chen Kan" uniqKey="Tseng C" first="Chen-Kan" last="Tseng">Chen-Kan Tseng</name><affiliation><nlm:aff id="au4"><institution>Department of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chang, Hsien Kun" sort="Chang, Hsien Kun" uniqKey="Chang H" first="Hsien-Kun" last="Chang">Hsien-Kun Chang</name><affiliation><nlm:aff id="au5"><institution>Division of Hematology and Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wan, Yung Liang" sort="Wan, Yung Liang" uniqKey="Wan Y" first="Yung-Liang" last="Wan">Yung-Liang Wan</name><affiliation><nlm:aff id="au6"><institution>Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hsueh, Chuen" sort="Hsueh, Chuen" uniqKey="Hsueh C" first="Chuen" last="Hsueh">Chuen Hsueh</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25197355</idno><idno type="pmc">4152045</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152045</idno><idno type="RBID">PMC:4152045</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002E56</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Concordant podoplanin expression in cancer-associated fibroblasts and tumor cells is an adverse prognostic factor in esophageal squamous cell carcinoma</title><author><name sortKey="Chuang, Wen Yu" sort="Chuang, Wen Yu" uniqKey="Chuang W" first="Wen-Yu" last="Chuang">Wen-Yu Chuang</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yeh, Chi Ju" sort="Yeh, Chi Ju" uniqKey="Yeh C" first="Chi-Ju" last="Yeh">Chi-Ju Yeh</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chao, Yin Kai" sort="Chao, Yin Kai" uniqKey="Chao Y" first="Yin-Kai" last="Chao">Yin-Kai Chao</name><affiliation><nlm:aff id="au2"><institution>Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Liu, Yun Hen" sort="Liu, Yun Hen" uniqKey="Liu Y" first="Yun-Hen" last="Liu">Yun-Hen Liu</name><affiliation><nlm:aff id="au2"><institution>Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chang, Yu Sun" sort="Chang, Yu Sun" uniqKey="Chang Y" first="Yu-Sun" last="Chang">Yu-Sun Chang</name><affiliation><nlm:aff id="au3"><institution>Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tseng, Chen Kan" sort="Tseng, Chen Kan" uniqKey="Tseng C" first="Chen-Kan" last="Tseng">Chen-Kan Tseng</name><affiliation><nlm:aff id="au4"><institution>Department of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chang, Hsien Kun" sort="Chang, Hsien Kun" uniqKey="Chang H" first="Hsien-Kun" last="Chang">Hsien-Kun Chang</name><affiliation><nlm:aff id="au5"><institution>Division of Hematology and Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wan, Yung Liang" sort="Wan, Yung Liang" uniqKey="Wan Y" first="Yung-Liang" last="Wan">Yung-Liang Wan</name><affiliation><nlm:aff id="au6"><institution>Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hsueh, Chuen" sort="Hsueh, Chuen" uniqKey="Hsueh C" first="Chuen" last="Hsueh">Chuen Hsueh</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Clinical and Experimental Pathology</title><idno type="eISSN">1936-2625</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>There is growing evidence that cancer-associated fibroblasts (CAFs) interact with tumor cells and play important roles in tumor progression and invasion. Podoplanin is a type-1 transmembrane glycoprotein expressed in a variety of normal human tissues, including lymphatic endothelium. Tumor cell expression of podoplanin correlates with nodal metastasis and poor prognosis in squamous cell carcinoma (SCC) of oral cavity and esophagus. Recently, podoplanin-positive CAFs have been shown to exert adverse or beneficial prognostic effect on different cancer types. However, the significance of podoplanin-positive CAFs in esophageal SCC has not been investigated. This is the first study to investigate podoplanin expression in CAFs and tumor cells by immunohistochemistry in 59 cases of surgically resected esophageal SCC. We found significant association of podoplanin expression between CAFs and tumor cells (<italic>P</italic> = 0.031). Although the abundance of podoplanin-positive CAFs per se had no prognostic effect, concordant podoplanin expression in CAFs and tumor cells (both high or both low) was strongly associated with short survival (<italic>P</italic> = 0.00088). Multivariate analysis showed that concordant podoplanin expression was the strongest independent adverse prognostic factor (hazard ratio: 3.62; 95% confidence interval: 1.69-7.77; <italic>P</italic> = 0.00094). Our data suggest that interaction between podoplanin-positive CAFs and tumor cells is important in tumor biology of esophageal SCC.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Clin Exp Pathol</journal-id><journal-id journal-id-type="iso-abbrev">Int J Clin Exp Pathol</journal-id><journal-id journal-id-type="publisher-id">ijcep</journal-id><journal-title-group><journal-title>International Journal of Clinical and Experimental Pathology</journal-title></journal-title-group><issn pub-type="epub">1936-2625</issn><publisher><publisher-name>e-Century Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25197355</article-id><article-id pub-id-type="pmc">4152045</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Concordant podoplanin expression in cancer-associated fibroblasts and tumor cells is an adverse prognostic factor in esophageal squamous cell carcinoma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chuang</surname><given-names>Wen-Yu</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yeh</surname><given-names>Chi-Ju</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chao</surname><given-names>Yin-Kai</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Yun-Hen</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>Yu-Sun</given-names></name><xref ref-type="aff" rid="au3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tseng</surname><given-names>Chen-Kan</given-names></name><xref ref-type="aff" rid="au4">4</xref></contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>Hsien-Kun</given-names></name><xref ref-type="aff" rid="au5">5</xref></contrib><contrib contrib-type="author"><name><surname>Wan</surname><given-names>Yung-Liang</given-names></name><xref ref-type="aff" rid="au6">6</xref></contrib><contrib contrib-type="author"><name><surname>Hsueh</surname><given-names>Chuen</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au3">3</xref></contrib><aff id="au1"><label>1</label><institution>Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></aff><aff id="au2"><label>2</label><institution>Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></aff><aff id="au3"><label>3</label><institution>Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></aff><aff id="au4"><label>4</label><institution>Department of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></aff><aff id="au5"><label>5</label><institution>Division of Hematology and Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></aff><aff id="au6"><label>6</label><institution>Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital and Chang Gung University College of Medicine</institution><addr-line>Taoyuan, Taiwan</addr-line></aff></contrib-group><author-notes><corresp><bold>Address correspondence to:</bold> Dr. Chuen Hsueh, Department of Pathology, Chang Gung Memorial Hospital, 5 Fu-Hsing Street, Kwei-Shan, Taoyuan 333, Taiwan. Tel: +886-3-3281200 Ext. 2741; Fax: +886-3-3280147; E-mail: <email>ch9211@adm.cgmh.org.tw</email></corresp></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>7</month><year>2014</year></pub-date><volume>7</volume><issue>8</issue><fpage>4847</fpage><lpage>4856</lpage><history><date date-type="received"><day>16</day><month>6</month><year>2014</year></date><date date-type="accepted"><day>28</day><month>7</month><year>2014</year></date></history><permissions><copyright-statement>IJCEP Copyright © 2014</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p>There is growing evidence that cancer-associated fibroblasts (CAFs) interact with tumor cells and play important roles in tumor progression and invasion. Podoplanin is a type-1 transmembrane glycoprotein expressed in a variety of normal human tissues, including lymphatic endothelium. Tumor cell expression of podoplanin correlates with nodal metastasis and poor prognosis in squamous cell carcinoma (SCC) of oral cavity and esophagus. Recently, podoplanin-positive CAFs have been shown to exert adverse or beneficial prognostic effect on different cancer types. However, the significance of podoplanin-positive CAFs in esophageal SCC has not been investigated. This is the first study to investigate podoplanin expression in CAFs and tumor cells by immunohistochemistry in 59 cases of surgically resected esophageal SCC. We found significant association of podoplanin expression between CAFs and tumor cells (<italic>P</italic> = 0.031). Although the abundance of podoplanin-positive CAFs per se had no prognostic effect, concordant podoplanin expression in CAFs and tumor cells (both high or both low) was strongly associated with short survival (<italic>P</italic> = 0.00088). Multivariate analysis showed that concordant podoplanin expression was the strongest independent adverse prognostic factor (hazard ratio: 3.62; 95% confidence interval: 1.69-7.77; <italic>P</italic> = 0.00094). Our data suggest that interaction between podoplanin-positive CAFs and tumor cells is important in tumor biology of esophageal SCC.</p></abstract><kwd-group><kwd>Podoplanin</kwd><kwd>cancer-associated fibroblast</kwd><kwd>esophagus</kwd><kwd>squamous cell carcinoma</kwd><kwd>prognosis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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