Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
Identifieur interne : 002E16 ( Pmc/Corpus ); précédent : 002E15; suivant : 002E17Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
Auteurs : R. Sathish Srinivasan ; Guillermo OliverSource :
- Genes & Development [ 0890-9369 ] ; 2011.
Abstract
In characterizing the embryonic lymphovenous valves that control the communication between the blood and lymphatic vasculature, it is found that these valves are formed by intercalation of Prox1+ lymphatic endothelial cells (LECs) with Prox1+ ECs present in adjacent veins. Prox1 heterozygous embryos lack this valve formation due to a reduction in the number of Prox1+ ECs and LEC progenitors caused by reduced Coup-TFII/Prox1 complex formation.
Url:
DOI: 10.1101/gad.16974811
PubMed: 22012621
PubMed Central: 3205588
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves</title><author><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name></author><author><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22012621</idno><idno type="pmc">3205588</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205588</idno><idno type="RBID">PMC:3205588</idno><idno type="doi">10.1101/gad.16974811</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002E16</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves</title><author><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name></author><author><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name></author></analytic><series><title level="j">Genes & Development</title><idno type="ISSN">0890-9369</idno><idno type="eISSN">1549-5477</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In characterizing the embryonic lymphovenous valves that control the communication between the blood and lymphatic vasculature, it is found that these valves are formed by intercalation of Prox1<sup>+</sup> lymphatic endothelial cells (LECs) with Prox1<sup>+</sup> ECs present in adjacent veins. Prox1 heterozygous embryos lack this valve formation due to a reduction in the number of Prox1<sup>+</sup> ECs and LEC progenitors caused by reduced Coup-TFII/Prox1 complex formation.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Genes Dev</journal-id><journal-id journal-id-type="publisher-id">GAD</journal-id><journal-title-group><journal-title>Genes & Development</journal-title></journal-title-group><issn pub-type="ppub">0890-9369</issn><issn pub-type="epub">1549-5477</issn><publisher><publisher-name>Cold Spring Harbor Laboratory Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22012621</article-id><article-id pub-id-type="pmc">3205588</article-id><article-id pub-id-type="medline">8711660</article-id><article-id pub-id-type="doi">10.1101/gad.16974811</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject></subj-group></article-categories><title-group><article-title>Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves</article-title><alt-title alt-title-type="left-running">Srinivasan and Oliver</alt-title><alt-title alt-title-type="right-running">Formation of the lymphovenous valves</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Srinivasan</surname><given-names>R. Sathish</given-names></name></contrib><contrib contrib-type="author"><name><surname>Oliver</surname><given-names>Guillermo</given-names></name><xref ref-type="corresp" rid="cor1">1</xref></contrib></contrib-group><aff>Department of Genetics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA</aff><author-notes><corresp id="cor1"><label>1</label>Corresponding author.E-mail <email>guillermo.oliver@stjude.org</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>10</month><year>2011</year></pub-date><volume>25</volume><issue>20</issue><fpage>2187</fpage><lpage>2197</lpage><history><date date-type="received"><day>6</day><month>5</month><year>2011</year></date><date date-type="accepted"><day>6</day><month>9</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2011 by Cold Spring Harbor Laboratory Press</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="2187.pdf"></self-uri><abstract abstract-type="precis"><p>In characterizing the embryonic lymphovenous valves that control the communication between the blood and lymphatic vasculature, it is found that these valves are formed by intercalation of Prox1<sup>+</sup> lymphatic endothelial cells (LECs) with Prox1<sup>+</sup> ECs present in adjacent veins. Prox1 heterozygous embryos lack this valve formation due to a reduction in the number of Prox1<sup>+</sup> ECs and LEC progenitors caused by reduced Coup-TFII/Prox1 complex formation.</p></abstract><abstract><p>Arteries, veins, and lymphatic vessels are functionally linked, and their physical interaction is tightly regulated. The lymphatic vessels communicate with the blood vessels only at the junction of the jugular and subclavian veins. Here, we characterize the embryonic lymphovenous valves controlling this vital communication and show that they are formed by the intercalation of lymphatic endothelial cells (LECs) with a subpopulation of venous endothelial cells (ECs) at the junction of the jugular and subclavian veins. We found that unlike LEC progenitors, which move out from the veins and differentiate into mature LECs, these Prox1-expressing ECs remain in the veins and do not acquire LEC features. We demonstrate that the development of this Prox1-expressing venous EC population, and therefore of lymphovenous valves, requires two functional copies of <italic>Prox1</italic>, as the valves are absent in <italic>Prox1</italic> heterozygous mice. We show that this is due to a defect in the maintenance of Prox1 expression in venous ECs and LEC progenitors promoted by a reduction in Coup-TFII/Prox1 complex formation. This is the first report describing the molecular mechanism controlling lymphovenous communication.</p></abstract><kwd-group><kwd>LEC progenitors</kwd><kwd>Prox1</kwd><kwd>lymphatics</kwd><kwd>lymphovenous valves</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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