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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Eosinophil-Associated Processes Underlie Differences in Clinical Presentation of Loiasis Between Temporary Residents and Those Indigenous to <italic>Loa</italic>
-Endemic Areas</title>
<author><name sortKey="Herrick, Jesica A" sort="Herrick, Jesica A" uniqKey="Herrick J" first="Jesica A." last="Herrick">Jesica A. Herrick</name>
</author>
<author><name sortKey="Metenou, Simon" sort="Metenou, Simon" uniqKey="Metenou S" first="Simon" last="Metenou">Simon Metenou</name>
</author>
<author><name sortKey="Makiya, Michelle A" sort="Makiya, Michelle A" uniqKey="Makiya M" first="Michelle A." last="Makiya">Michelle A. Makiya</name>
</author>
<author><name sortKey="Taylar Williams, Cheryl A" sort="Taylar Williams, Cheryl A" uniqKey="Taylar Williams C" first="Cheryl A." last="Taylar-Williams">Cheryl A. Taylar-Williams</name>
</author>
<author><name sortKey="Law, Melissa A" sort="Law, Melissa A" uniqKey="Law M" first="Melissa A." last="Law">Melissa A. Law</name>
</author>
<author><name sortKey="Klion, Amy D" sort="Klion, Amy D" uniqKey="Klion A" first="Amy D." last="Klion">Amy D. Klion</name>
</author>
<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25234520</idno>
<idno type="pmc">4296126</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296126</idno>
<idno type="RBID">PMC:4296126</idno>
<idno type="doi">10.1093/cid/ciu723</idno>
<date when="2014">2014</date>
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<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002D56</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Eosinophil-Associated Processes Underlie Differences in Clinical Presentation of Loiasis Between Temporary Residents and Those Indigenous to <italic>Loa</italic>
-Endemic Areas</title>
<author><name sortKey="Herrick, Jesica A" sort="Herrick, Jesica A" uniqKey="Herrick J" first="Jesica A." last="Herrick">Jesica A. Herrick</name>
</author>
<author><name sortKey="Metenou, Simon" sort="Metenou, Simon" uniqKey="Metenou S" first="Simon" last="Metenou">Simon Metenou</name>
</author>
<author><name sortKey="Makiya, Michelle A" sort="Makiya, Michelle A" uniqKey="Makiya M" first="Michelle A." last="Makiya">Michelle A. Makiya</name>
</author>
<author><name sortKey="Taylar Williams, Cheryl A" sort="Taylar Williams, Cheryl A" uniqKey="Taylar Williams C" first="Cheryl A." last="Taylar-Williams">Cheryl A. Taylar-Williams</name>
</author>
<author><name sortKey="Law, Melissa A" sort="Law, Melissa A" uniqKey="Law M" first="Melissa A." last="Law">Melissa A. Law</name>
</author>
<author><name sortKey="Klion, Amy D" sort="Klion, Amy D" uniqKey="Klion A" first="Amy D." last="Klion">Amy D. Klion</name>
</author>
<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
</author>
</analytic>
<series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title>
<idno type="ISSN">1058-4838</idno>
<idno type="eISSN">1537-6591</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>This comprehensive study of individuals infected with <italic>Loa loa</italic>
provides evidence that alterations in eosinophil production, activation, and regulation are responsible for the vastly differing clinical presentations of loiasis seen between long term travelers (or temporary residents) and those individuals indigenous to Loa-endemic regions of the world.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id>
<journal-id journal-id-type="publisher-id">cid</journal-id>
<journal-id journal-id-type="hwp">cid</journal-id>
<journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title>
</journal-title-group>
<issn pub-type="ppub">1058-4838</issn>
<issn pub-type="epub">1537-6591</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25234520</article-id>
<article-id pub-id-type="pmc">4296126</article-id>
<article-id pub-id-type="doi">10.1093/cid/ciu723</article-id>
<article-id pub-id-type="publisher-id">ciu723</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles and Commentaries</subject>
</subj-group>
</article-categories>
<title-group><article-title>Eosinophil-Associated Processes Underlie Differences in Clinical Presentation of Loiasis Between Temporary Residents and Those Indigenous to <italic>Loa</italic>
-Endemic Areas</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Herrick</surname>
<given-names>Jesica A.</given-names>
</name>
<xref ref-type="author-notes" rid="AN1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Metenou</surname>
<given-names>Simon</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Makiya</surname>
<given-names>Michelle A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Taylar-Williams</surname>
<given-names>Cheryl A.</given-names>
</name>
<xref ref-type="author-notes" rid="AN1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Law</surname>
<given-names>Melissa A.</given-names>
</name>
<xref ref-type="author-notes" rid="AN1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klion</surname>
<given-names>Amy D.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Nutman</surname>
<given-names>Thomas B.</given-names>
</name>
</contrib>
<aff><addr-line>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases</addr-line>
,<institution>National Institutes of Health</institution>
,<addr-line>Bethesda, Maryland</addr-line>
</aff>
</contrib-group>
<author-notes><fn id="AN1" fn-type="con"><label>a</label>
<p>Present affiliations: Division of Infectious Diseases, Immunology, and International Medicine, University of Illinois at Chicago (J. A. H.); National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland (C. A. T.-W.); Collaborative Clinical Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (M. A. L.).</p>
</fn>
<corresp>Correspondence: Jesica A. Herrick, MD, MS, Division of Infectious Diseases, Immunology, and International Medicine, University of Illinois at Chicago, 808 S Wood St, MC 735, Chicago, IL 60612 (<email>christe5@uic.edu</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>01</day>
<month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>18</day>
<month>9</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>1</month>
<year>2016</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the . </pmc-comment>
<volume>60</volume>
<issue>1</issue>
<fpage>55</fpage>
<lpage>63</lpage>
<history><date date-type="received"><day>25</day>
<month>4</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>7</day>
<month>9</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="ciu723.pdf"></self-uri>
<abstract abstract-type="precis"><p>This comprehensive study of individuals infected with <italic>Loa loa</italic>
provides evidence that alterations in eosinophil production, activation, and regulation are responsible for the vastly differing clinical presentations of loiasis seen between long term travelers (or temporary residents) and those individuals indigenous to Loa-endemic regions of the world.</p>
</abstract>
<abstract><p><bold><italic>Background.</italic>
</bold>
<italic>Loa loa</italic>
has emerged as an important public health problem due to the occurrence of immune-mediated severe posttreatment reactions following ivermectin distribution. Also thought to be immune-mediated are the dramatic differences seen in clinical presentation between infected temporary residents (TR) and individuals native to endemic regions (END).</p>
<p><bold><italic>Methods.</italic>
</bold>
All patients diagnosed with loiasis at the National Institutes of Health between 1976 and 2012 were included. Patients enrolled in the study underwent a baseline clinical and laboratory evaluation and had serum collected and stored. Stored pretreatment serum was used to measure filaria-specific antibody responses, eosinophil-related cytokines, and eosinophil granule proteins.</p>
<p><bold><italic>Results.</italic>
</bold>
<italic>Loa loa</italic>
infection in TR was characterized by the presence of Calabar swelling (in 82% of subjects), markedly elevated eosinophil counts, and increased filaria-specific immunoglobulin G (IgG) levels; these findings were thought to reflect an unmodulated immune response. In contrast, END showed strong evidence for immune tolerance to the parasite, with high levels of circulating microfilariae, few clinical symptoms, and diminished filaria-specific IgG. The striking elevation in eosinophil counts among the TR group was accompanied by increased eosinophil granule protein levels (associated with eosinophil activation and degranulation) as well as elevated levels of eosinophil-associated cytokines.</p>
<p><bold><italic>Conclusions.</italic>
</bold>
These data support the hypothesis that differing eosinophil-associated responses to the parasite may be responsible for the marked differences in clinical presentations between TR and END populations with loiasis.</p>
</abstract>
<kwd-group><kwd><italic>Loa loa</italic>
</kwd>
<kwd>eosinophil</kwd>
<kwd>loiasis</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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