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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increased Lymphatic Vessel Length Is Associated With the Fibroblast Reticulum and Disease Severity in Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia</title><author><name sortKey="Lara, Abigail R" sort="Lara, Abigail R" uniqKey="Lara A" first="Abigail R." last="Lara">Abigail R. Lara</name></author><author><name sortKey="Cosgrove, Gregory P" sort="Cosgrove, Gregory P" uniqKey="Cosgrove G" first="Gregory P." last="Cosgrove">Gregory P. Cosgrove</name></author><author><name sortKey="Janssen, William J" sort="Janssen, William J" uniqKey="Janssen W" first="William J." last="Janssen">William J. Janssen</name></author><author><name sortKey="Huie, Tristan J" sort="Huie, Tristan J" uniqKey="Huie T" first="Tristan J." last="Huie">Tristan J. Huie</name></author><author><name sortKey="Burnham, Ellen L" sort="Burnham, Ellen L" uniqKey="Burnham E" first="Ellen L." last="Burnham">Ellen L. Burnham</name></author><author><name sortKey="Heinz, David E" sort="Heinz, David E" uniqKey="Heinz D" first="David E." last="Heinz">David E. Heinz</name></author><author><name sortKey="Curran Everett, Douglas" sort="Curran Everett, Douglas" uniqKey="Curran Everett D" first="Douglas" last="Curran-Everett">Douglas Curran-Everett</name></author><author><name sortKey="Sahin, Hakan" sort="Sahin, Hakan" uniqKey="Sahin H" first="Hakan" last="Sahin">Hakan Sahin</name></author><author><name sortKey="Schwarz, Marvin I" sort="Schwarz, Marvin I" uniqKey="Schwarz M" first="Marvin I." last="Schwarz">Marvin I. Schwarz</name></author><author><name sortKey="Cool, Carlyne D" sort="Cool, Carlyne D" uniqKey="Cool C" first="Carlyne D." last="Cool">Carlyne D. Cool</name></author><author><name sortKey="Groshong, Steve D" sort="Groshong, Steve D" uniqKey="Groshong S" first="Steve D." last="Groshong">Steve D. Groshong</name></author><author><name sortKey="Geraci, Mark W" sort="Geraci, Mark W" uniqKey="Geraci M" first="Mark W." last="Geraci">Mark W. Geraci</name></author><author><name sortKey="Tuder, Rubin M" sort="Tuder, Rubin M" uniqKey="Tuder R" first="Rubin M." last="Tuder">Rubin M. Tuder</name></author><author><name sortKey="Hyde, Dallas M" sort="Hyde, Dallas M" uniqKey="Hyde D" first="Dallas M." last="Hyde">Dallas M. Hyde</name></author><author><name sortKey="Henson, Peter M" sort="Henson, Peter M" uniqKey="Henson P" first="Peter M." last="Henson">Peter M. Henson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22797508</idno><idno type="pmc">3515029</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515029</idno><idno type="RBID">PMC:3515029</idno><idno type="doi">10.1378/chest.12-0029</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002D48</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002D48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Increased Lymphatic Vessel Length Is Associated With the Fibroblast Reticulum and Disease Severity in Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia</title><author><name sortKey="Lara, Abigail R" sort="Lara, Abigail R" uniqKey="Lara A" first="Abigail R." last="Lara">Abigail R. Lara</name></author><author><name sortKey="Cosgrove, Gregory P" sort="Cosgrove, Gregory P" uniqKey="Cosgrove G" first="Gregory P." last="Cosgrove">Gregory P. Cosgrove</name></author><author><name sortKey="Janssen, William J" sort="Janssen, William J" uniqKey="Janssen W" first="William J." last="Janssen">William J. Janssen</name></author><author><name sortKey="Huie, Tristan J" sort="Huie, Tristan J" uniqKey="Huie T" first="Tristan J." last="Huie">Tristan J. Huie</name></author><author><name sortKey="Burnham, Ellen L" sort="Burnham, Ellen L" uniqKey="Burnham E" first="Ellen L." last="Burnham">Ellen L. Burnham</name></author><author><name sortKey="Heinz, David E" sort="Heinz, David E" uniqKey="Heinz D" first="David E." last="Heinz">David E. Heinz</name></author><author><name sortKey="Curran Everett, Douglas" sort="Curran Everett, Douglas" uniqKey="Curran Everett D" first="Douglas" last="Curran-Everett">Douglas Curran-Everett</name></author><author><name sortKey="Sahin, Hakan" sort="Sahin, Hakan" uniqKey="Sahin H" first="Hakan" last="Sahin">Hakan Sahin</name></author><author><name sortKey="Schwarz, Marvin I" sort="Schwarz, Marvin I" uniqKey="Schwarz M" first="Marvin I." last="Schwarz">Marvin I. Schwarz</name></author><author><name sortKey="Cool, Carlyne D" sort="Cool, Carlyne D" uniqKey="Cool C" first="Carlyne D." last="Cool">Carlyne D. Cool</name></author><author><name sortKey="Groshong, Steve D" sort="Groshong, Steve D" uniqKey="Groshong S" first="Steve D." last="Groshong">Steve D. Groshong</name></author><author><name sortKey="Geraci, Mark W" sort="Geraci, Mark W" uniqKey="Geraci M" first="Mark W." last="Geraci">Mark W. Geraci</name></author><author><name sortKey="Tuder, Rubin M" sort="Tuder, Rubin M" uniqKey="Tuder R" first="Rubin M." last="Tuder">Rubin M. Tuder</name></author><author><name sortKey="Hyde, Dallas M" sort="Hyde, Dallas M" uniqKey="Hyde D" first="Dallas M." last="Hyde">Dallas M. Hyde</name></author><author><name sortKey="Henson, Peter M" sort="Henson, Peter M" uniqKey="Henson P" first="Peter M." last="Henson">Peter M. Henson</name></author></analytic><series><title level="j">Chest</title><idno type="ISSN">0012-3692</idno><idno type="eISSN">1931-3543</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Lymphangiogenesis responds to tissue injury as a key component of normal wound healing. The development of fibrosis in the idiopathic interstitial pneumonias may result from abnormal wound healing in response to injury. We hypothesize that increased lymphatic vessel (LV) length, a marker of lymphangiogenesis, is associated with parenchymal components of the fibroblast reticulum (organizing collagen, fibrotic collagen, and fibroblast foci), and its extent correlates with disease severity.</p></sec><sec><title>Methods:</title><p>We assessed stereologically the parenchymal structure of fibrotic lungs and its associated lymphatic network, which was highlighted immunohistochemically in age-matched samples of usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP) with FVC < 80%, COPD with a Global Initiative for Obstructive Lung Disease stage 0, and normal control lungs.</p></sec><sec><title>Results:</title><p>LV length density, as opposed to vessel volume density, was found to be associated with organizing and fibrotic collagen density (<italic>P</italic> < .0001). Length density of LVs and the volume density of organizing and fibrotic collagen were significantly associated with severity of both % FVC (<italic>P</italic> < .001) and diffusing capacity of the lung for carbon monoxide (<italic>P</italic> < .001).</p></sec><sec><title>Conclusions:</title><p>Severity of disease in UIP and NSIP is associated with increased LV length and is strongly associated with components of the fibroblast reticulum, namely organizing and fibrotic collagen, which supports a pathogenic role of LVs in these two diseases. Furthermore, the absence of definable differences between UIP and NSIP suggests that LVs are a unifying mechanism for the development of fibrosis in these fibrotic lung diseases.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Chest</journal-id><journal-id journal-id-type="iso-abbrev">Chest</journal-id><journal-id journal-id-type="pmc">chest</journal-id><journal-id journal-id-type="publisher-id">Chest</journal-id><journal-title-group><journal-title>Chest</journal-title></journal-title-group><issn pub-type="ppub">0012-3692</issn><issn pub-type="epub">1931-3543</issn><publisher><publisher-name>American College of Chest Physicians</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22797508</article-id><article-id pub-id-type="pmc">3515029</article-id><article-id pub-id-type="publisher-id">chest.12-0029</article-id><article-id pub-id-type="doi">10.1378/chest.12-0029</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject><subj-group><subject>Diffuse Lung Disease</subject></subj-group></subj-group></article-categories><title-group><article-title>Increased Lymphatic Vessel Length Is Associated With the Fibroblast Reticulum and Disease Severity in Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia</article-title><alt-title alt-title-type="short">Lymphangiogenesis in Pulmonary Fibrosis</alt-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Lara</surname><given-names>Abigail R.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Cosgrove</surname><given-names>Gregory P.</given-names></name><degrees>MD, FCCP</degrees></contrib><contrib contrib-type="author"><name><surname>Janssen</surname><given-names>William J.</given-names></name><degrees>MD, FCCP</degrees></contrib><contrib contrib-type="author"><name><surname>Huie</surname><given-names>Tristan J.</given-names></name><degrees>MD, FCCP</degrees></contrib><contrib contrib-type="author"><name><surname>Burnham</surname><given-names>Ellen L.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Heinz</surname><given-names>David E.</given-names></name><degrees>BS</degrees></contrib><contrib contrib-type="author"><name><surname>Curran-Everett</surname><given-names>Douglas</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Sahin</surname><given-names>Hakan</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Schwarz</surname><given-names>Marvin I.</given-names></name><degrees>MD, FCCP</degrees></contrib><contrib contrib-type="author"><name><surname>Cool</surname><given-names>Carlyne D.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Groshong</surname><given-names>Steve D.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Geraci</surname><given-names>Mark W.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Tuder</surname><given-names>Rubin M.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Hyde</surname><given-names>Dallas M.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Henson</surname><given-names>Peter M.</given-names></name><degrees>PhD, DVM</degrees></contrib><aff id="aff1">From the Division of Pulmonary Science and Critical Care Medicine (Drs Lara, Cosgrove, Burnham, Schwarz, Geraci, and Tuder and Mr Heinz), Department of Biostatistics and Informatics, Colorado School of Public Health (Dr Curran-Everett), Department of Radiology (Dr Sahin), and the Department of Pathology (Dr Cool),University of Colorado Denver, Aurora, CO; Division of Pulmonary and Critical Care Medicine (Drs Cosgrove, Janssen, and Huie), Department of Biostatistics and Bioinformatics (Dr Curran-Everett), Department of Pathology (Dr Groshong), Division of Immunology (Dr Henson), National Jewish Health, Denver, CO; and the Department of Anatomy, Physiology and Cell Biology (Dr Hyde), School of Veterinary Medicine, University of California-Davis, Davis, CA.</aff></contrib-group><author-notes><corresp id="cor1"><bold>Correspondence to:</bold> Abigail R. Lara, MD, University of Colorado Denver, Division of Pulmonary Sciences and Critical Care Medicine, Research Bldg 2, Box C272, 12700 E 19th Ave, Aurora, CO 80045; e-mail: <email>Abigail.Lara@UCDenver.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>19</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>142</volume><issue>6</issue><fpage>1569</fpage><lpage>1576</lpage><history><date date-type="received"><day>4</day><month>1</month><year>2012</year></date><date date-type="accepted"><day>25</day><month>5</month><year>2012</year></date></history><permissions><copyright-statement>© 2012 American College of Chest Physicians</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="chest_142_6_1569.pdf"></self-uri><abstract><sec><title>Background:</title><p>Lymphangiogenesis responds to tissue injury as a key component of normal wound healing. The development of fibrosis in the idiopathic interstitial pneumonias may result from abnormal wound healing in response to injury. We hypothesize that increased lymphatic vessel (LV) length, a marker of lymphangiogenesis, is associated with parenchymal components of the fibroblast reticulum (organizing collagen, fibrotic collagen, and fibroblast foci), and its extent correlates with disease severity.</p></sec><sec><title>Methods:</title><p>We assessed stereologically the parenchymal structure of fibrotic lungs and its associated lymphatic network, which was highlighted immunohistochemically in age-matched samples of usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP) with FVC < 80%, COPD with a Global Initiative for Obstructive Lung Disease stage 0, and normal control lungs.</p></sec><sec><title>Results:</title><p>LV length density, as opposed to vessel volume density, was found to be associated with organizing and fibrotic collagen density (<italic>P</italic> < .0001). Length density of LVs and the volume density of organizing and fibrotic collagen were significantly associated with severity of both % FVC (<italic>P</italic> < .001) and diffusing capacity of the lung for carbon monoxide (<italic>P</italic> < .001).</p></sec><sec><title>Conclusions:</title><p>Severity of disease in UIP and NSIP is associated with increased LV length and is strongly associated with components of the fibroblast reticulum, namely organizing and fibrotic collagen, which supports a pathogenic role of LVs in these two diseases. Furthermore, the absence of definable differences between UIP and NSIP suggests that LVs are a unifying mechanism for the development of fibrosis in these fibrotic lung diseases.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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