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Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size

Identifieur interne : 002D41 ( Pmc/Corpus ); précédent : 002D40; suivant : 002D42

Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size

Auteurs : Jong Hoon Lee ; Sung Hwan Kim ; Young Jin Suh ; Byoung Yong Shim ; Hoon Kyo Kim

Source :

Cancer Research and Treatment : Official Journal of Korean Cancer Association [ 1598-2998 ] ; 2010.

RBID : PMC:2848750

Abstract

Purpose

We estimated the likelihood of breast cancer patients having axillary lymph node metastases (ALNM) based on a variety of clinical and pathologic factors.

Materials and Methods

Three hundred sixty-one breast cancer patients without distant metastases and who underwent breast conserving surgery and axillary lymph node dissection (ALND) (level I and II) or modified radical mastectomy (MRM) were identified, and we retrospectively reviewed their pathology records and treatment charts.

Results

Positive axillary lymph nodes were detected in 104 patients for an overall incidence of 28.8%: 2 patients (5%) with T1a tumor, 5 (9.2%) with T1b tumor, 24 (21.8%) with T1c tumor and 73 (44.2%) with T2 tumor. On the multivariate analysis, an increased tumor size (adjusted OR=11.87, p=0.02), the presence of lymphovascular invasion (adjusted OR=7.41, p<0.01), a triple negative profile (ER/PR-, Her2-) (adjusted OR=2.09, p=0.04) and a palpable mass at the time of diagnosis (adjusted OR=2.31, p=0.03) were all significant independent factors for positive ALNM.

Conclusion

In our study, the tumor size, the presence of lymphovascular invasion, a triple negative profile and a palpable mass were the independent predictive factors for ALNM. The tumor size was the strongest predictor of ALNM. Thus, the exact estimation of the extent of tumor is necessary for clinicians to optimize the patients' care. Patients with a triple negative profile have a high incidence of ALNM irrespective of the tumor size.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848750

DOI: 10.4143/crt.2010.42.1.30
PubMed: 20369049
PubMed Central: 2848750

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PMC:2848750

Le document en format XML

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<author><name sortKey="Lee, Jong Hoon" sort="Lee, Jong Hoon" uniqKey="Lee J" first="Jong Hoon" last="Lee">Jong Hoon Lee</name>
<affiliation><nlm:aff id="A1">Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff>
</affiliation>
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<author><name sortKey="Kim, Sung Hwan" sort="Kim, Sung Hwan" uniqKey="Kim S" first="Sung Hwan" last="Kim">Sung Hwan Kim</name>
<affiliation><nlm:aff id="A1">Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Suh, Young Jin" sort="Suh, Young Jin" uniqKey="Suh Y" first="Young Jin" last="Suh">Young Jin Suh</name>
<affiliation><nlm:aff id="A2">Department of Surgical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shim, Byoung Yong" sort="Shim, Byoung Yong" uniqKey="Shim B" first="Byoung Yong" last="Shim">Byoung Yong Shim</name>
<affiliation><nlm:aff id="A3">Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Hoon Kyo" sort="Kim, Hoon Kyo" uniqKey="Kim H" first="Hoon Kyo" last="Kim">Hoon Kyo Kim</name>
<affiliation><nlm:aff id="A3">Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff>
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<idno type="doi">10.4143/crt.2010.42.1.30</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size</title>
<author><name sortKey="Lee, Jong Hoon" sort="Lee, Jong Hoon" uniqKey="Lee J" first="Jong Hoon" last="Lee">Jong Hoon Lee</name>
<affiliation><nlm:aff id="A1">Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Sung Hwan" sort="Kim, Sung Hwan" uniqKey="Kim S" first="Sung Hwan" last="Kim">Sung Hwan Kim</name>
<affiliation><nlm:aff id="A1">Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Suh, Young Jin" sort="Suh, Young Jin" uniqKey="Suh Y" first="Young Jin" last="Suh">Young Jin Suh</name>
<affiliation><nlm:aff id="A2">Department of Surgical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shim, Byoung Yong" sort="Shim, Byoung Yong" uniqKey="Shim B" first="Byoung Yong" last="Shim">Byoung Yong Shim</name>
<affiliation><nlm:aff id="A3">Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Hoon Kyo" sort="Kim, Hoon Kyo" uniqKey="Kim H" first="Hoon Kyo" last="Kim">Hoon Kyo Kim</name>
<affiliation><nlm:aff id="A3">Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff>
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<series><title level="j">Cancer Research and Treatment : Official Journal of Korean Cancer Association</title>
<idno type="ISSN">1598-2998</idno>
<idno type="eISSN">2005-9256</idno>
<imprint><date when="2010">2010</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>We estimated the likelihood of breast cancer patients having axillary lymph node metastases (ALNM) based on a variety of clinical and pathologic factors.</p>
</sec>
<sec><title>Materials and Methods</title>
<p>Three hundred sixty-one breast cancer patients without distant metastases and who underwent breast conserving surgery and axillary lymph node dissection (ALND) (level I and II) or modified radical mastectomy (MRM) were identified, and we retrospectively reviewed their pathology records and treatment charts.</p>
</sec>
<sec><title>Results</title>
<p>Positive axillary lymph nodes were detected in 104 patients for an overall incidence of 28.8%: 2 patients (5%) with T1a tumor, 5 (9.2%) with T1b tumor, 24 (21.8%) with T1c tumor and 73 (44.2%) with T2 tumor. On the multivariate analysis, an increased tumor size (adjusted OR=11.87, p=0.02), the presence of lymphovascular invasion (adjusted OR=7.41, p<0.01), a triple negative profile (ER/PR-, Her2-) (adjusted OR=2.09, p=0.04) and a palpable mass at the time of diagnosis (adjusted OR=2.31, p=0.03) were all significant independent factors for positive ALNM.</p>
</sec>
<sec><title>Conclusion</title>
<p>In our study, the tumor size, the presence of lymphovascular invasion, a triple negative profile and a palpable mass were the independent predictive factors for ALNM. The tumor size was the strongest predictor of ALNM. Thus, the exact estimation of the extent of tumor is necessary for clinicians to optimize the patients' care. Patients with a triple negative profile have a high incidence of ALNM irrespective of the tumor size.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Cancer Res Treat</journal-id>
<journal-id journal-id-type="publisher-id">CRT</journal-id>
<journal-title-group><journal-title>Cancer Research and Treatment : Official Journal of Korean Cancer Association</journal-title>
</journal-title-group>
<issn pub-type="ppub">1598-2998</issn>
<issn pub-type="epub">2005-9256</issn>
<publisher><publisher-name>Korean Cancer Association</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20369049</article-id>
<article-id pub-id-type="pmc">2848750</article-id>
<article-id pub-id-type="doi">10.4143/crt.2010.42.1.30</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Jong Hoon</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Kim</surname>
<given-names>Sung Hwan</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Suh</surname>
<given-names>Young Jin</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shim</surname>
<given-names>Byoung Yong</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Hoon Kyo</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</aff>
<aff id="A2"><label>2</label>
Department of Surgical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</aff>
<aff id="A3"><label>3</label>
Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</aff>
<author-notes><corresp>Correspondence: Sung Hwan Kim, M.D. Department of Radiation Oncology, St. Vincent's Hospital, 93-6, Ji-dong, Paldal-gu, Suwon 442-723, Korea. Tel: 82-31-249-7560, Fax: 82-31-257-3734, <email>kimandre@catholic.ac.kr</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>31</day>
<month>3</month>
<year>2010</year>
</pub-date>
<volume>42</volume>
<issue>1</issue>
<fpage>30</fpage>
<lpage>36</lpage>
<history><date date-type="received"><day>29</day>
<month>10</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>18</day>
<month>12</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2010 Korean Cancer Association</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<abstract><sec><title>Purpose</title>
<p>We estimated the likelihood of breast cancer patients having axillary lymph node metastases (ALNM) based on a variety of clinical and pathologic factors.</p>
</sec>
<sec><title>Materials and Methods</title>
<p>Three hundred sixty-one breast cancer patients without distant metastases and who underwent breast conserving surgery and axillary lymph node dissection (ALND) (level I and II) or modified radical mastectomy (MRM) were identified, and we retrospectively reviewed their pathology records and treatment charts.</p>
</sec>
<sec><title>Results</title>
<p>Positive axillary lymph nodes were detected in 104 patients for an overall incidence of 28.8%: 2 patients (5%) with T1a tumor, 5 (9.2%) with T1b tumor, 24 (21.8%) with T1c tumor and 73 (44.2%) with T2 tumor. On the multivariate analysis, an increased tumor size (adjusted OR=11.87, p=0.02), the presence of lymphovascular invasion (adjusted OR=7.41, p<0.01), a triple negative profile (ER/PR-, Her2-) (adjusted OR=2.09, p=0.04) and a palpable mass at the time of diagnosis (adjusted OR=2.31, p=0.03) were all significant independent factors for positive ALNM.</p>
</sec>
<sec><title>Conclusion</title>
<p>In our study, the tumor size, the presence of lymphovascular invasion, a triple negative profile and a palpable mass were the independent predictive factors for ALNM. The tumor size was the strongest predictor of ALNM. Thus, the exact estimation of the extent of tumor is necessary for clinicians to optimize the patients' care. Patients with a triple negative profile have a high incidence of ALNM irrespective of the tumor size.</p>
</sec>
</abstract>
<kwd-group><kwd>Axillary lymph node</kwd>
<kwd>Breast neoplasms</kwd>
<kwd>Predictor</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size

Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size

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Abstract

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