The value of dual-time-point 18F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients
Identifieur interne : 002C96 ( Pmc/Corpus ); précédent : 002C95; suivant : 002C97The value of dual-time-point 18F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients
Auteurs : W H Choi ; I R Yoo ; J H O ; S H Kim ; S K ChungSource :
- The British Journal of Radiology [ 0007-1285 ] ; 2011.
Abstract
The sensitivity of 18-fluorodeoxyglucose
The study included 171 breast cancer patients who underwent pre-operative 18F-FDG PET/CT scans at 2 time-points, the first at 1 h after radiotracer injection and the second 3 h after injection. Where 18F-FDG uptake was in the ALN perceptibly increased, the maximum standardised uptake values for both time-points (SUVmax1 and SUVmax2) and the retention index (RI) were calculated. Correlation between the PET/CT results and post-operative histological results was assessed.
The performance of 1 h and 3 h PET/CT scans was equal, with sensitivity 60.3% and specificity 84.7%, in detecting ALN metastasis. Out of 171 patients, 60 had ALNs with increased 18F-FDG uptake on 1 h or 3 h images. There was no significant difference in RI between the metastatic ALN-positive group and the node-negative group. The area under the receiver operating characteristic (ROC) curve for SUVmax1 was 0.90 (
Dual time-point imaging did not improve the overall performance of 18F-FDG PET/CT in detecting ALN metastasis in breast cancer patients.
Url:
DOI: 10.1259/bjr/56324742
PubMed: 21081574
PubMed Central: 3473484
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PMC:3473484Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The value of dual-time-point <sup>18</sup>
F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients</title>
<author><name sortKey="Choi, W H" sort="Choi, W H" uniqKey="Choi W" first="W H" last="Choi">W H Choi</name>
</author>
<author><name sortKey="Yoo, I R" sort="Yoo, I R" uniqKey="Yoo I" first="I R" last="Yoo">I R Yoo</name>
</author>
<author><name sortKey="O, J H" sort="O, J H" uniqKey="O J" first="J H" last="O">J H O</name>
</author>
<author><name sortKey="Kim, S H" sort="Kim, S H" uniqKey="Kim S" first="S H" last="Kim">S H Kim</name>
</author>
<author><name sortKey="Chung, S K" sort="Chung, S K" uniqKey="Chung S" first="S K" last="Chung">S K Chung</name>
</author>
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<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21081574</idno>
<idno type="pmc">3473484</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473484</idno>
<idno type="RBID">PMC:3473484</idno>
<idno type="doi">10.1259/bjr/56324742</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">002C96</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The value of dual-time-point <sup>18</sup>
F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients</title>
<author><name sortKey="Choi, W H" sort="Choi, W H" uniqKey="Choi W" first="W H" last="Choi">W H Choi</name>
</author>
<author><name sortKey="Yoo, I R" sort="Yoo, I R" uniqKey="Yoo I" first="I R" last="Yoo">I R Yoo</name>
</author>
<author><name sortKey="O, J H" sort="O, J H" uniqKey="O J" first="J H" last="O">J H O</name>
</author>
<author><name sortKey="Kim, S H" sort="Kim, S H" uniqKey="Kim S" first="S H" last="Kim">S H Kim</name>
</author>
<author><name sortKey="Chung, S K" sort="Chung, S K" uniqKey="Chung S" first="S K" last="Chung">S K Chung</name>
</author>
</analytic>
<series><title level="j">The British Journal of Radiology</title>
<idno type="ISSN">0007-1285</idno>
<idno type="eISSN">1748-880X</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
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</fileDesc>
<profileDesc><textClass></textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objective</title>
<p>The sensitivity of 18-fluorodeoxyglucose <bold>(</bold>
<sup>18</sup>
F-FDG) positron emission tomography (PET) for detecting axillary lymph node (ALN) metastases in breast cancer is reported to be low. Several studies have shown, however, that dual-time-point <sup>18</sup>
F-FDG PET imaging provides improved accuracy in the diagnosis of certain primary tumours when compared with single-scan imaging. The purpose of this study was to assess whether the use of dual-time-point <sup>18</sup>
F-FDG PET/CT scans could improve the diagnostic accuracy of ALN metastasis in breast cancer.</p>
</sec>
<sec><title>Method</title>
<p>The study included 171 breast cancer patients who underwent pre-operative <sup>18</sup>
F-FDG PET/CT scans at 2 time-points, the first at 1 h after radiotracer injection and the second 3 h after injection. Where <sup>18</sup>
F-FDG uptake was in the ALN perceptibly increased, the maximum standardised uptake values for both time-points (SUVmax1 and SUVmax2) and the retention index (RI) were calculated. Correlation between the PET/CT results and post-operative histological results was assessed.</p>
</sec>
<sec><title>Results</title>
<p>The performance of 1 h and 3 h PET/CT scans was equal, with sensitivity 60.3% and specificity 84.7%, in detecting ALN metastasis. Out of 171 patients, 60 had ALNs with increased <sup>18</sup>
F-FDG uptake on 1 h or 3 h images. There was no significant difference in RI between the metastatic ALN-positive group and the node-negative group. The area under the receiver operating characteristic (ROC) curve for SUVmax1 was 0.90 (<italic>p</italic>
<0.001) and 0.87 for SUVmax2 (<italic>p</italic>
<0.001).</p>
</sec>
<sec><title>Conclusion</title>
<p>Dual time-point imaging did not improve the overall performance of <sup>18</sup>
F-FDG PET/CT in detecting ALN metastasis in breast cancer patients.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Radiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Br J Radiol</journal-id>
<journal-id journal-id-type="hwp">bjradio</journal-id>
<journal-id journal-id-type="publisher-id">bjr</journal-id>
<journal-title-group><journal-title>The British Journal of Radiology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0007-1285</issn>
<issn pub-type="epub">1748-880X</issn>
<publisher><publisher-name>The British Institute of Radiology.</publisher-name>
<publisher-loc>36 Portland Place, London, W1B 1AT</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21081574</article-id>
<article-id pub-id-type="pmc">3473484</article-id>
<article-id pub-id-type="publisher-id">D9680</article-id>
<article-id pub-id-type="doi">10.1259/bjr/56324742</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Full Paper</subject>
</subj-group>
</article-categories>
<title-group><article-title>The value of dual-time-point <sup>18</sup>
F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients</article-title>
<alt-title alt-title-type="running-head">Dual-time 18F-FDG PET/CT in axillary staging</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Choi</surname>
<given-names>W H</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Yoo</surname>
<given-names>I R</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>O</surname>
<given-names>J H</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>S H</given-names>
</name>
<degrees>MD, PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Chung</surname>
<given-names>S K</given-names>
</name>
<degrees>MD, PhD</degrees>
</contrib>
</contrib-group>
<aff id="aff1"><addr-line>Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea</addr-line>
</aff>
<author-notes><corresp id="cor1">Dr Ie Ryung Yoo, Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seocho-gu, Banpo-dong 505 Seoul, 137-701, Korea. E-mail: <email>iryoo@catholic.ac.kr</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>7</month>
<year>2011</year>
</pub-date>
<volume>84</volume>
<issue>1003</issue>
<fpage>593</fpage>
<lpage>599</lpage>
<history><date date-type="received"><day>17</day>
<month>8</month>
<year>2009</year>
</date>
<date date-type="rev-recd"><day>12</day>
<month>10</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>25</day>
<month>1</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>© 2011 The British Institute of Radiology</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><sec><title>Objective</title>
<p>The sensitivity of 18-fluorodeoxyglucose <bold>(</bold>
<sup>18</sup>
F-FDG) positron emission tomography (PET) for detecting axillary lymph node (ALN) metastases in breast cancer is reported to be low. Several studies have shown, however, that dual-time-point <sup>18</sup>
F-FDG PET imaging provides improved accuracy in the diagnosis of certain primary tumours when compared with single-scan imaging. The purpose of this study was to assess whether the use of dual-time-point <sup>18</sup>
F-FDG PET/CT scans could improve the diagnostic accuracy of ALN metastasis in breast cancer.</p>
</sec>
<sec><title>Method</title>
<p>The study included 171 breast cancer patients who underwent pre-operative <sup>18</sup>
F-FDG PET/CT scans at 2 time-points, the first at 1 h after radiotracer injection and the second 3 h after injection. Where <sup>18</sup>
F-FDG uptake was in the ALN perceptibly increased, the maximum standardised uptake values for both time-points (SUVmax1 and SUVmax2) and the retention index (RI) were calculated. Correlation between the PET/CT results and post-operative histological results was assessed.</p>
</sec>
<sec><title>Results</title>
<p>The performance of 1 h and 3 h PET/CT scans was equal, with sensitivity 60.3% and specificity 84.7%, in detecting ALN metastasis. Out of 171 patients, 60 had ALNs with increased <sup>18</sup>
F-FDG uptake on 1 h or 3 h images. There was no significant difference in RI between the metastatic ALN-positive group and the node-negative group. The area under the receiver operating characteristic (ROC) curve for SUVmax1 was 0.90 (<italic>p</italic>
<0.001) and 0.87 for SUVmax2 (<italic>p</italic>
<0.001).</p>
</sec>
<sec><title>Conclusion</title>
<p>Dual time-point imaging did not improve the overall performance of <sup>18</sup>
F-FDG PET/CT in detecting ALN metastasis in breast cancer patients.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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