The value of dual-time-point 18F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients
Identifieur interne : 002C96 ( Pmc/Corpus ); précédent : 002C95; suivant : 002C97The value of dual-time-point 18F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients
Auteurs : W H Choi ; I R Yoo ; J H O ; S H Kim ; S K ChungSource :
- The British Journal of Radiology [ 0007-1285 ] ; 2011.
Abstract
The sensitivity of 18-fluorodeoxyglucose
The study included 171 breast cancer patients who underwent pre-operative 18F-FDG PET/CT scans at 2 time-points, the first at 1 h after radiotracer injection and the second 3 h after injection. Where 18F-FDG uptake was in the ALN perceptibly increased, the maximum standardised uptake values for both time-points (SUVmax1 and SUVmax2) and the retention index (RI) were calculated. Correlation between the PET/CT results and post-operative histological results was assessed.
The performance of 1 h and 3 h PET/CT scans was equal, with sensitivity 60.3% and specificity 84.7%, in detecting ALN metastasis. Out of 171 patients, 60 had ALNs with increased 18F-FDG uptake on 1 h or 3 h images. There was no significant difference in RI between the metastatic ALN-positive group and the node-negative group. The area under the receiver operating characteristic (ROC) curve for SUVmax1 was 0.90 (
Dual time-point imaging did not improve the overall performance of 18F-FDG PET/CT in detecting ALN metastasis in breast cancer patients.
Url:
DOI: 10.1259/bjr/56324742
PubMed: 21081574
PubMed Central: 3473484
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The value of dual-time-point <sup>18</sup>F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients</title><author><name sortKey="Choi, W H" sort="Choi, W H" uniqKey="Choi W" first="W H" last="Choi">W H Choi</name></author><author><name sortKey="Yoo, I R" sort="Yoo, I R" uniqKey="Yoo I" first="I R" last="Yoo">I R Yoo</name></author><author><name sortKey="O, J H" sort="O, J H" uniqKey="O J" first="J H" last="O">J H O</name></author><author><name sortKey="Kim, S H" sort="Kim, S H" uniqKey="Kim S" first="S H" last="Kim">S H Kim</name></author><author><name sortKey="Chung, S K" sort="Chung, S K" uniqKey="Chung S" first="S K" last="Chung">S K Chung</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21081574</idno><idno type="pmc">3473484</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473484</idno><idno type="RBID">PMC:3473484</idno><idno type="doi">10.1259/bjr/56324742</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002C96</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The value of dual-time-point <sup>18</sup>F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients</title><author><name sortKey="Choi, W H" sort="Choi, W H" uniqKey="Choi W" first="W H" last="Choi">W H Choi</name></author><author><name sortKey="Yoo, I R" sort="Yoo, I R" uniqKey="Yoo I" first="I R" last="Yoo">I R Yoo</name></author><author><name sortKey="O, J H" sort="O, J H" uniqKey="O J" first="J H" last="O">J H O</name></author><author><name sortKey="Kim, S H" sort="Kim, S H" uniqKey="Kim S" first="S H" last="Kim">S H Kim</name></author><author><name sortKey="Chung, S K" sort="Chung, S K" uniqKey="Chung S" first="S K" last="Chung">S K Chung</name></author></analytic><series><title level="j">The British Journal of Radiology</title><idno type="ISSN">0007-1285</idno><idno type="eISSN">1748-880X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>The sensitivity of 18-fluorodeoxyglucose <bold>(</bold><sup>18</sup>F-FDG) positron emission tomography (PET) for detecting axillary lymph node (ALN) metastases in breast cancer is reported to be low. Several studies have shown, however, that dual-time-point <sup>18</sup>F-FDG PET imaging provides improved accuracy in the diagnosis of certain primary tumours when compared with single-scan imaging. The purpose of this study was to assess whether the use of dual-time-point <sup>18</sup>F-FDG PET/CT scans could improve the diagnostic accuracy of ALN metastasis in breast cancer.</p></sec><sec><title>Method</title><p>The study included 171 breast cancer patients who underwent pre-operative <sup>18</sup>F-FDG PET/CT scans at 2 time-points, the first at 1 h after radiotracer injection and the second 3 h after injection. Where <sup>18</sup>F-FDG uptake was in the ALN perceptibly increased, the maximum standardised uptake values for both time-points (SUVmax1 and SUVmax2) and the retention index (RI) were calculated. Correlation between the PET/CT results and post-operative histological results was assessed.</p></sec><sec><title>Results</title><p>The performance of 1 h and 3 h PET/CT scans was equal, with sensitivity 60.3% and specificity 84.7%, in detecting ALN metastasis. Out of 171 patients, 60 had ALNs with increased <sup>18</sup>F-FDG uptake on 1 h or 3 h images. There was no significant difference in RI between the metastatic ALN-positive group and the node-negative group. The area under the receiver operating characteristic (ROC) curve for SUVmax1 was 0.90 (<italic>p</italic><0.001) and 0.87 for SUVmax2 (<italic>p</italic><0.001).</p></sec><sec><title>Conclusion</title><p>Dual time-point imaging did not improve the overall performance of <sup>18</sup>F-FDG PET/CT in detecting ALN metastasis in breast cancer patients.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Radiol</journal-id><journal-id journal-id-type="iso-abbrev">Br J Radiol</journal-id><journal-id journal-id-type="hwp">bjradio</journal-id><journal-id journal-id-type="publisher-id">bjr</journal-id><journal-title-group><journal-title>The British Journal of Radiology</journal-title></journal-title-group><issn pub-type="ppub">0007-1285</issn><issn pub-type="epub">1748-880X</issn><publisher><publisher-name>The British Institute of Radiology.</publisher-name><publisher-loc>36 Portland Place, London, W1B 1AT</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21081574</article-id><article-id pub-id-type="pmc">3473484</article-id><article-id pub-id-type="publisher-id">D9680</article-id><article-id pub-id-type="doi">10.1259/bjr/56324742</article-id><article-categories><subj-group subj-group-type="heading"><subject>Full Paper</subject></subj-group></article-categories><title-group><article-title>The value of dual-time-point <sup>18</sup>F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients</article-title><alt-title alt-title-type="running-head">Dual-time 18F-FDG PET/CT in axillary staging</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Choi</surname><given-names>W H</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Yoo</surname><given-names>I R</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>O</surname><given-names>J H</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>S H</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Chung</surname><given-names>S K</given-names></name><degrees>MD, PhD</degrees></contrib></contrib-group><aff id="aff1"><addr-line>Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea</addr-line></aff><author-notes><corresp id="cor1">Dr Ie Ryung Yoo, Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seocho-gu, Banpo-dong 505 Seoul, 137-701, Korea. E-mail: <email>iryoo@catholic.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2011</year></pub-date><volume>84</volume><issue>1003</issue><fpage>593</fpage><lpage>599</lpage><history><date date-type="received"><day>17</day><month>8</month><year>2009</year></date><date date-type="rev-recd"><day>12</day><month>10</month><year>2009</year></date><date date-type="accepted"><day>25</day><month>1</month><year>2010</year></date></history><permissions><copyright-statement>© 2011 The British Institute of Radiology</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><sec><title>Objective</title><p>The sensitivity of 18-fluorodeoxyglucose <bold>(</bold><sup>18</sup>F-FDG) positron emission tomography (PET) for detecting axillary lymph node (ALN) metastases in breast cancer is reported to be low. Several studies have shown, however, that dual-time-point <sup>18</sup>F-FDG PET imaging provides improved accuracy in the diagnosis of certain primary tumours when compared with single-scan imaging. The purpose of this study was to assess whether the use of dual-time-point <sup>18</sup>F-FDG PET/CT scans could improve the diagnostic accuracy of ALN metastasis in breast cancer.</p></sec><sec><title>Method</title><p>The study included 171 breast cancer patients who underwent pre-operative <sup>18</sup>F-FDG PET/CT scans at 2 time-points, the first at 1 h after radiotracer injection and the second 3 h after injection. Where <sup>18</sup>F-FDG uptake was in the ALN perceptibly increased, the maximum standardised uptake values for both time-points (SUVmax1 and SUVmax2) and the retention index (RI) were calculated. Correlation between the PET/CT results and post-operative histological results was assessed.</p></sec><sec><title>Results</title><p>The performance of 1 h and 3 h PET/CT scans was equal, with sensitivity 60.3% and specificity 84.7%, in detecting ALN metastasis. Out of 171 patients, 60 had ALNs with increased <sup>18</sup>F-FDG uptake on 1 h or 3 h images. There was no significant difference in RI between the metastatic ALN-positive group and the node-negative group. The area under the receiver operating characteristic (ROC) curve for SUVmax1 was 0.90 (<italic>p</italic><0.001) and 0.87 for SUVmax2 (<italic>p</italic><0.001).</p></sec><sec><title>Conclusion</title><p>Dual time-point imaging did not improve the overall performance of <sup>18</sup>F-FDG PET/CT in detecting ALN metastasis in breast cancer patients.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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