Examination of Clinical Efficacy of Keishibukuryogan on Non-Specific Complaints Associated with Varicose Veins of the Lower Extremity
Identifieur interne : 002C36 ( Pmc/Corpus ); précédent : 002C35; suivant : 002C37Examination of Clinical Efficacy of Keishibukuryogan on Non-Specific Complaints Associated with Varicose Veins of the Lower Extremity
Auteurs : Shinobu Hayashi ; Shintaro Shibutani ; Hirotoki Okubo ; Tatsuya Shimogawara ; Tsuyoshi Ichinose ; Yasuhiro Ito ; Kouki Mihara ; Tomohisa Egawa ; Atsushi Nagashima ; Hideaki Obara ; Yuko KitagawaSource :
- Annals of Vascular Diseases [ 1881-641X ] ; 2014.
Abstract
The subjective symptoms of varicose veins of the lower extremity often include malaise, numbness, coldness, pain, and pruritus of the lower extremity, and relieving these complaints is important in managing the quality of life of patients. We have examined the clinical efficacy of keishibukuryogan, a Kampo prescription for improving oketsu (impaired microcirculation, congestion), on non-specific complaints associated with varicose veins of the lower extremity. Keishibukuryogan was administered to 30 patients with non-specific complaints associated with varicose veins of the lower extremity for 12 weeks, resulting in improvements in the scores of subjective symptoms, severity of varicose veins, and oketsu as well as an increase in skin perfusion pressure. And especially the effect was remarkable in female. In addition, oketsu was shown to be involved in the subjective symptoms associated with varicose veins of the lower extremity, demonstrating efficacy of keishibukuryogan. No adverse drug reaction or abnormal laboratory result was observed in patients receiving keishibukuryogan, and the rate of general improvement and usefulness was 73.3%. It was suggested that keishibukuryogan was useful to improve the symptoms of patients with non-specific complaints associated with varicose veins of the lower extremity especially in female patients. (
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DOI: 10.3400/avd.oa.14-00055
PubMed: 25298828
PubMed Central: 4180688
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Examination of Clinical Efficacy of Keishibukuryogan on Non-Specific Complaints Associated with Varicose Veins of the Lower Extremity</title><author><name sortKey="Hayashi, Shinobu" sort="Hayashi, Shinobu" uniqKey="Hayashi S" first="Shinobu" last="Hayashi">Shinobu Hayashi</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Shibutani, Shintaro" sort="Shibutani, Shintaro" uniqKey="Shibutani S" first="Shintaro" last="Shibutani">Shintaro Shibutani</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Okubo, Hirotoki" sort="Okubo, Hirotoki" uniqKey="Okubo H" first="Hirotoki" last="Okubo">Hirotoki Okubo</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Shimogawara, Tatsuya" sort="Shimogawara, Tatsuya" uniqKey="Shimogawara T" first="Tatsuya" last="Shimogawara">Tatsuya Shimogawara</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Ichinose, Tsuyoshi" sort="Ichinose, Tsuyoshi" uniqKey="Ichinose T" first="Tsuyoshi" last="Ichinose">Tsuyoshi Ichinose</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Ito, Yasuhiro" sort="Ito, Yasuhiro" uniqKey="Ito Y" first="Yasuhiro" last="Ito">Yasuhiro Ito</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Mihara, Kouki" sort="Mihara, Kouki" uniqKey="Mihara K" first="Kouki" last="Mihara">Kouki Mihara</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Egawa, Tomohisa" sort="Egawa, Tomohisa" uniqKey="Egawa T" first="Tomohisa" last="Egawa">Tomohisa Egawa</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Nagashima, Atsushi" sort="Nagashima, Atsushi" uniqKey="Nagashima A" first="Atsushi" last="Nagashima">Atsushi Nagashima</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Obara, Hideaki" sort="Obara, Hideaki" uniqKey="Obara H" first="Hideaki" last="Obara">Hideaki Obara</name><affiliation><nlm:aff id="aff2">Department of Surgery, Keio University, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name><affiliation><nlm:aff id="aff2">Department of Surgery, Keio University, Tokyo, Japan</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25298828</idno><idno type="pmc">4180688</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180688</idno><idno type="RBID">PMC:4180688</idno><idno type="doi">10.3400/avd.oa.14-00055</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002C36</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Examination of Clinical Efficacy of Keishibukuryogan on Non-Specific Complaints Associated with Varicose Veins of the Lower Extremity</title><author><name sortKey="Hayashi, Shinobu" sort="Hayashi, Shinobu" uniqKey="Hayashi S" first="Shinobu" last="Hayashi">Shinobu Hayashi</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Shibutani, Shintaro" sort="Shibutani, Shintaro" uniqKey="Shibutani S" first="Shintaro" last="Shibutani">Shintaro Shibutani</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Okubo, Hirotoki" sort="Okubo, Hirotoki" uniqKey="Okubo H" first="Hirotoki" last="Okubo">Hirotoki Okubo</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Shimogawara, Tatsuya" sort="Shimogawara, Tatsuya" uniqKey="Shimogawara T" first="Tatsuya" last="Shimogawara">Tatsuya Shimogawara</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Ichinose, Tsuyoshi" sort="Ichinose, Tsuyoshi" uniqKey="Ichinose T" first="Tsuyoshi" last="Ichinose">Tsuyoshi Ichinose</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Ito, Yasuhiro" sort="Ito, Yasuhiro" uniqKey="Ito Y" first="Yasuhiro" last="Ito">Yasuhiro Ito</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Mihara, Kouki" sort="Mihara, Kouki" uniqKey="Mihara K" first="Kouki" last="Mihara">Kouki Mihara</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Egawa, Tomohisa" sort="Egawa, Tomohisa" uniqKey="Egawa T" first="Tomohisa" last="Egawa">Tomohisa Egawa</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Nagashima, Atsushi" sort="Nagashima, Atsushi" uniqKey="Nagashima A" first="Atsushi" last="Nagashima">Atsushi Nagashima</name><affiliation><nlm:aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Obara, Hideaki" sort="Obara, Hideaki" uniqKey="Obara H" first="Hideaki" last="Obara">Hideaki Obara</name><affiliation><nlm:aff id="aff2">Department of Surgery, Keio University, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name><affiliation><nlm:aff id="aff2">Department of Surgery, Keio University, Tokyo, Japan</nlm:aff></affiliation></author></analytic><series><title level="j">Annals of Vascular Diseases</title><idno type="ISSN">1881-641X</idno><idno type="eISSN">1881-6428</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The subjective symptoms of varicose veins of the lower extremity often include malaise, numbness, coldness, pain, and pruritus of the lower extremity, and relieving these complaints is important in managing the quality of life of patients. We have examined the clinical efficacy of keishibukuryogan, a Kampo prescription for improving oketsu (impaired microcirculation, congestion), on non-specific complaints associated with varicose veins of the lower extremity. Keishibukuryogan was administered to 30 patients with non-specific complaints associated with varicose veins of the lower extremity for 12 weeks, resulting in improvements in the scores of subjective symptoms, severity of varicose veins, and oketsu as well as an increase in skin perfusion pressure. And especially the effect was remarkable in female. In addition, oketsu was shown to be involved in the subjective symptoms associated with varicose veins of the lower extremity, demonstrating efficacy of keishibukuryogan. No adverse drug reaction or abnormal laboratory result was observed in patients receiving keishibukuryogan, and the rate of general improvement and usefulness was 73.3%. It was suggested that keishibukuryogan was useful to improve the symptoms of patients with non-specific complaints associated with varicose veins of the lower extremity especially in female patients. (<xref ref-type="fn" rid="fn1">*</xref>English translation of Jpn J Phlebol 2013; 24: 303-310)</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Vasc Dis</journal-id><journal-id journal-id-type="iso-abbrev">Ann Vasc Dis</journal-id><journal-id journal-id-type="pmc">avd</journal-id><journal-title-group><journal-title>Annals of Vascular Diseases</journal-title></journal-title-group><issn pub-type="ppub">1881-641X</issn><issn pub-type="epub">1881-6428</issn><publisher><publisher-name>The Editorial Committee of Annals of Vascular Diseases</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25298828</article-id><article-id pub-id-type="pmc">4180688</article-id><article-id pub-id-type="publisher-id">avd.oa.14-00055</article-id><article-id pub-id-type="doi">10.3400/avd.oa.14-00055</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Examination of Clinical Efficacy of Keishibukuryogan on Non-Specific Complaints Associated with Varicose Veins of the Lower Extremity</article-title><alt-title alt-title-type="left-running-head">Hayashi S, et al.
The</alt-title><alt-title alt-title-type="right-running-head">Efficacy of Keishibukuryogan on Varicose Veins</alt-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Hayashi</surname><given-names>Shinobu</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shibutani</surname><given-names>Shintaro</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Okubo</surname><given-names>Hirotoki</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shimogawara</surname><given-names>Tatsuya</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ichinose</surname><given-names>Tsuyoshi</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ito</surname><given-names>Yasuhiro</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mihara</surname><given-names>Kouki</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Egawa</surname><given-names>Tomohisa</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Nagashima</surname><given-names>Atsushi</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Obara</surname><given-names>Hideaki</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kitagawa</surname><given-names>Yuko</given-names></name><degrees>MD, PhD, FACS</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><aff id="aff1">Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan</aff><aff id="aff2">Department of Surgery, Keio University, Tokyo, Japan</aff></contrib-group><author-notes><corresp>Corresponding author: Shinobu Hayashi, MD. Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, Yokohama, Kanagawa 230-0012, Japan Tel: +81-45-576-3000, Fax: +81-45-576-3586</corresp><fn><p>E-mail: <email xlink:href="mailto:hayashi@gold.zero.jp">hayashi@gold.zero.jp</email></p></fn></author-notes><pub-date pub-type="epub"><day>30</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="ppub"><year>2014</year></pub-date><volume>7</volume><issue>3</issue><fpage>266</fpage><lpage>273</lpage><history><date date-type="received"><day>24</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>3</day><month>6</month><year>2014</year></date></history><permissions><copyright-statement>© Annals of Vascular Diseases 2014</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p>The subjective symptoms of varicose veins of the lower extremity often include malaise, numbness, coldness, pain, and pruritus of the lower extremity, and relieving these complaints is important in managing the quality of life of patients. We have examined the clinical efficacy of keishibukuryogan, a Kampo prescription for improving oketsu (impaired microcirculation, congestion), on non-specific complaints associated with varicose veins of the lower extremity. Keishibukuryogan was administered to 30 patients with non-specific complaints associated with varicose veins of the lower extremity for 12 weeks, resulting in improvements in the scores of subjective symptoms, severity of varicose veins, and oketsu as well as an increase in skin perfusion pressure. And especially the effect was remarkable in female. In addition, oketsu was shown to be involved in the subjective symptoms associated with varicose veins of the lower extremity, demonstrating efficacy of keishibukuryogan. No adverse drug reaction or abnormal laboratory result was observed in patients receiving keishibukuryogan, and the rate of general improvement and usefulness was 73.3%. It was suggested that keishibukuryogan was useful to improve the symptoms of patients with non-specific complaints associated with varicose veins of the lower extremity especially in female patients. (<xref ref-type="fn" rid="fn1">*</xref>English translation of Jpn J Phlebol 2013; 24: 303-310)</p></abstract><kwd-group><title>Keywords</title><kwd>varicose veins of the lower extremity</kwd><kwd>keishibukuryogan</kwd><kwd>Kampo prescription</kwd><kwd>non-specific complaints</kwd><kwd>oketsu</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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