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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Heightened Measures of Immune Complex and Complement Function and Immune Complex–Mediated Granulocyte Activation in Human Lymphatic Filariasis</title><author><name sortKey="Senbagavalli, Prakash" sort="Senbagavalli, Prakash" uniqKey="Senbagavalli P" first="Prakash" last="Senbagavalli">Prakash Senbagavalli</name></author><author><name sortKey="Anuradha, Rajamanickam" sort="Anuradha, Rajamanickam" uniqKey="Anuradha R" first="Rajamanickam" last="Anuradha">Rajamanickam Anuradha</name></author><author><name sortKey="Ramanathan, Vadakkuppattu D" sort="Ramanathan, Vadakkuppattu D" uniqKey="Ramanathan V" first="Vadakkuppattu D." last="Ramanathan">Vadakkuppattu D. Ramanathan</name></author><author><name sortKey="Kumaraswami, Vasanthapuram" sort="Kumaraswami, Vasanthapuram" uniqKey="Kumaraswami V" first="Vasanthapuram" last="Kumaraswami">Vasanthapuram Kumaraswami</name></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name></author><author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21734131</idno><idno type="pmc">3122350</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122350</idno><idno type="RBID">PMC:3122350</idno><idno type="doi">10.4269/ajtmh.2011.11-0086</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002C12</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Heightened Measures of Immune Complex and Complement Function and Immune Complex–Mediated Granulocyte Activation in Human Lymphatic Filariasis</title><author><name sortKey="Senbagavalli, Prakash" sort="Senbagavalli, Prakash" uniqKey="Senbagavalli P" first="Prakash" last="Senbagavalli">Prakash Senbagavalli</name></author><author><name sortKey="Anuradha, Rajamanickam" sort="Anuradha, Rajamanickam" uniqKey="Anuradha R" first="Rajamanickam" last="Anuradha">Rajamanickam Anuradha</name></author><author><name sortKey="Ramanathan, Vadakkuppattu D" sort="Ramanathan, Vadakkuppattu D" uniqKey="Ramanathan V" first="Vadakkuppattu D." last="Ramanathan">Vadakkuppattu D. Ramanathan</name></author><author><name sortKey="Kumaraswami, Vasanthapuram" sort="Kumaraswami, Vasanthapuram" uniqKey="Kumaraswami V" first="Vasanthapuram" last="Kumaraswami">Vasanthapuram Kumaraswami</name></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name></author><author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name></author></analytic><series><title level="j">The American Journal of Tropical Medicine and Hygiene</title><idno type="ISSN">0002-9637</idno><idno type="eISSN">1476-1645</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The presence of circulating immune complexes (CICs) is a characteristic feature of human lymphatic filariasis. However, the role of CICs in modulating granulocyte function and complement functional activity in filarial infection is unknown. The levels of CICs in association with complement activation in clinically asymptomatic, filarial-infected patients (INF); filarial-infected patients with overt lymphatic pathologic changes (CPDT); and uninfected controls (EN) were examined. Significantly increased levels of CICs and enhanced functional efficiency of the classical and mannose-binding lectin pathways of the complement system was observed in INF compared with CPDT and EN. Polyethylene glycol–precipitated CICs from INF and CPDT induced significantly increased granulocyte activation compared with those from EN, determined by the increased production of neutrophil granular proteins and a variety of pro-inflammatory cytokines. Thus, CIC-mediated enhanced granulocyte activation and modulation of complement function are important features of filarial infection and disease.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Trop Med Hyg</journal-id><journal-id journal-id-type="publisher-id">tpmd</journal-id><journal-title-group><journal-title>The American Journal of Tropical Medicine and Hygiene</journal-title></journal-title-group><issn pub-type="ppub">0002-9637</issn><issn pub-type="epub">1476-1645</issn><publisher><publisher-name>The American Society of Tropical Medicine and Hygiene</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21734131</article-id><article-id pub-id-type="pmc">3122350</article-id><article-id pub-id-type="doi">10.4269/ajtmh.2011.11-0086</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Heightened Measures of Immune Complex and Complement Function and Immune Complex–Mediated Granulocyte Activation in Human Lymphatic Filariasis</article-title><alt-title alt-title-type="left-running-head">SENBAGAVALLI AND OTHERS</alt-title><alt-title alt-title-type="right-running-head">IMMUNE COMPLEXES IN LYMPHATIC FILARIASIS</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Senbagavalli</surname><given-names>Prakash</given-names></name></contrib><contrib contrib-type="author"><name><surname>Anuradha</surname><given-names>Rajamanickam</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ramanathan</surname><given-names>Vadakkuppattu D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kumaraswami</surname><given-names>Vasanthapuram</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nutman</surname><given-names>Thomas B.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Babu</surname><given-names>Subash</given-names></name><xref ref-type="corresp" rid="COR1">*</xref></contrib></contrib-group><aff id="AFF1">National Institutes of Health–International Center for Excellence in Research, Chennai, India; Tuberculosis Research Center, Chennai, India; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; SAIC-Frederick, Inc., National Cancer Institute–Frederick, Frederick, Maryland</aff><author-notes><corresp id="COR1">*Address correspondence to Subash Babu, Tuberculosis Research Centre-International Center for Excellence in Research, Clinical Monitoring Research Program, SAIC-Frederick Inc., National Institute of Allergy and Infectious Diseases, Chetpet, Chennai, India. E-mail: <email>sbabu@mail.nih.gov</email></corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>7</month><year>2011</year></pub-date><volume>85</volume><issue>1</issue><fpage>89</fpage><lpage>96</lpage><history><date date-type="received"><day>09</day><month>2</month><year>2011</year></date><date date-type="accepted"><day>13</day><month>4</month><year>2011</year></date></history><permissions><copyright-statement>©The American Society of Tropical Medicine and Hygiene</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p>The presence of circulating immune complexes (CICs) is a characteristic feature of human lymphatic filariasis. However, the role of CICs in modulating granulocyte function and complement functional activity in filarial infection is unknown. The levels of CICs in association with complement activation in clinically asymptomatic, filarial-infected patients (INF); filarial-infected patients with overt lymphatic pathologic changes (CPDT); and uninfected controls (EN) were examined. Significantly increased levels of CICs and enhanced functional efficiency of the classical and mannose-binding lectin pathways of the complement system was observed in INF compared with CPDT and EN. Polyethylene glycol–precipitated CICs from INF and CPDT induced significantly increased granulocyte activation compared with those from EN, determined by the increased production of neutrophil granular proteins and a variety of pro-inflammatory cytokines. Thus, CIC-mediated enhanced granulocyte activation and modulation of complement function are important features of filarial infection and disease.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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