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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow</title><author><name sortKey="Datar, Sanjeev A" sort="Datar, Sanjeev A" uniqKey="Datar S" first="Sanjeev A." last="Datar">Sanjeev A. Datar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Johnson, Eric G" sort="Johnson, Eric G" uniqKey="Johnson E" first="Eric G." last="Johnson">Eric G. Johnson</name><affiliation><nlm:aff id="aff5">Surgical and Radiological Sciences, University of California, Davis, California</nlm:aff></affiliation></author><author><name sortKey="Oishi, Peter E" sort="Oishi, Peter E" uniqKey="Oishi P" first="Peter E." last="Oishi">Peter E. Oishi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Cardiovascular Research Institute, University of California, San Francisco;</nlm:aff></affiliation></author><author><name sortKey="Johengen, Michael" sort="Johengen, Michael" uniqKey="Johengen M" first="Michael" last="Johengen">Michael Johengen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tang, Eric" sort="Tang, Eric" uniqKey="Tang E" first="Eric" last="Tang">Eric Tang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Aramburo, Angela" sort="Aramburo, Angela" uniqKey="Aramburo A" first="Angela" last="Aramburo">Angela Aramburo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Barton, Jubilee" sort="Barton, Jubilee" uniqKey="Barton J" first="Jubilee" last="Barton">Jubilee Barton</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kuo, Hsuan Chang" sort="Kuo, Hsuan Chang" uniqKey="Kuo H" first="Hsuan-Chang" last="Kuo">Hsuan-Chang Kuo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bennett, Stephen" sort="Bennett, Stephen" uniqKey="Bennett S" first="Stephen" last="Bennett">Stephen Bennett</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Xoinis, Konstantine" sort="Xoinis, Konstantine" uniqKey="Xoinis K" first="Konstantine" last="Xoinis">Konstantine Xoinis</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Reel, Bhupinder" sort="Reel, Bhupinder" uniqKey="Reel B" first="Bhupinder" last="Reel">Bhupinder Reel</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kalkan, Gokhan" sort="Kalkan, Gokhan" uniqKey="Kalkan G" first="Gokhan" last="Kalkan">Gokhan Kalkan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Sajti, Eniko" sort="Sajti, Eniko" uniqKey="Sajti E" first="Eniko" last="Sajti">Eniko Sajti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Osorio, Oscar" sort="Osorio, Oscar" uniqKey="Osorio O" first="Oscar" last="Osorio">Oscar Osorio</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Raff, Gary W" sort="Raff, Gary W" uniqKey="Raff G" first="Gary W." last="Raff">Gary W. Raff</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Matthay, Michael A" sort="Matthay, Michael A" uniqKey="Matthay M" first="Michael A." last="Matthay">Michael A. Matthay</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Medicine and Anesthesia</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Cardiovascular Research Institute, University of California, San Francisco;</nlm:aff></affiliation></author><author><name sortKey="Fineman, Jeffrey R" sort="Fineman, Jeffrey R" uniqKey="Fineman J" first="Jeffrey R." last="Fineman">Jeffrey R. Fineman</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Cardiovascular Research Institute, University of California, San Francisco;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22207591</idno><idno type="pmc">3311527</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311527</idno><idno type="RBID">PMC:3311527</idno><idno type="doi">10.1152/ajplung.00324.2011</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002B94</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow</title><author><name sortKey="Datar, Sanjeev A" sort="Datar, Sanjeev A" uniqKey="Datar S" first="Sanjeev A." last="Datar">Sanjeev A. Datar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Johnson, Eric G" sort="Johnson, Eric G" uniqKey="Johnson E" first="Eric G." last="Johnson">Eric G. Johnson</name><affiliation><nlm:aff id="aff5">Surgical and Radiological Sciences, University of California, Davis, California</nlm:aff></affiliation></author><author><name sortKey="Oishi, Peter E" sort="Oishi, Peter E" uniqKey="Oishi P" first="Peter E." last="Oishi">Peter E. Oishi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Cardiovascular Research Institute, University of California, San Francisco;</nlm:aff></affiliation></author><author><name sortKey="Johengen, Michael" sort="Johengen, Michael" uniqKey="Johengen M" first="Michael" last="Johengen">Michael Johengen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tang, Eric" sort="Tang, Eric" uniqKey="Tang E" first="Eric" last="Tang">Eric Tang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Aramburo, Angela" sort="Aramburo, Angela" uniqKey="Aramburo A" first="Angela" last="Aramburo">Angela Aramburo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Barton, Jubilee" sort="Barton, Jubilee" uniqKey="Barton J" first="Jubilee" last="Barton">Jubilee Barton</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kuo, Hsuan Chang" sort="Kuo, Hsuan Chang" uniqKey="Kuo H" first="Hsuan-Chang" last="Kuo">Hsuan-Chang Kuo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bennett, Stephen" sort="Bennett, Stephen" uniqKey="Bennett S" first="Stephen" last="Bennett">Stephen Bennett</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Xoinis, Konstantine" sort="Xoinis, Konstantine" uniqKey="Xoinis K" first="Konstantine" last="Xoinis">Konstantine Xoinis</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Reel, Bhupinder" sort="Reel, Bhupinder" uniqKey="Reel B" first="Bhupinder" last="Reel">Bhupinder Reel</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kalkan, Gokhan" sort="Kalkan, Gokhan" uniqKey="Kalkan G" first="Gokhan" last="Kalkan">Gokhan Kalkan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Sajti, Eniko" sort="Sajti, Eniko" uniqKey="Sajti E" first="Eniko" last="Sajti">Eniko Sajti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Osorio, Oscar" sort="Osorio, Oscar" uniqKey="Osorio O" first="Oscar" last="Osorio">Oscar Osorio</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Raff, Gary W" sort="Raff, Gary W" uniqKey="Raff G" first="Gary W." last="Raff">Gary W. Raff</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Matthay, Michael A" sort="Matthay, Michael A" uniqKey="Matthay M" first="Michael A." last="Matthay">Michael A. Matthay</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Medicine and Anesthesia</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Cardiovascular Research Institute, University of California, San Francisco;</nlm:aff></affiliation></author><author><name sortKey="Fineman, Jeffrey R" sort="Fineman, Jeffrey R" uniqKey="Fineman J" first="Jeffrey R." last="Fineman">Jeffrey R. Fineman</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Cardiovascular Research Institute, University of California, San Francisco;</nlm:aff></affiliation></author></analytic><series><title level="j">American Journal of Physiology - Lung Cellular and Molecular Physiology</title><idno type="ISSN">1040-0605</idno><idno type="eISSN">1522-1504</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Abnormalities of the lymphatic circulation are well recognized in patients with congenital heart defects. However, it is not known how the associated abnormal blood flow patterns, such as increased pulmonary blood flow (PBF), might affect pulmonary lymphatic function and structure. Using well-established ovine models of acute and chronic increases in PBF, we cannulated the efferent lymphatic duct of the caudal mediastinal node and collected and analyzed lymph effluent from the lungs of lambs with acutely increased PBF (<italic>n</italic> = 6), chronically increased PBF (<italic>n</italic> = 6), and age-matched normal lambs (<italic>n</italic> = 8). When normalized to PBF, we found that lymph flow was unchanged following acute increases in PBF but decreased following chronic increases in PBF. The lymph:plasma protein ratio decreased with both acute and chronic increases in PBF. Lymph bioavailable nitric oxide increased following acute increases in PBF but decreased following chronic increases in PBF. In addition, we found perturbations in the transit kinetics of contrast material through the pleural lymphatics of lambs with chronic increases in PBF. Finally, there were structural changes in the pulmonary lymphatic system in lambs with chronic increases in PBF: lymphatics from these lambs were larger and more dilated, and there were alterations in the expression of vascular endothelial growth factor-C, lymphatic vessel endothelial hyaluronan receptor-1, and Angiopoietin-2, proteins known to be important for lymphatic growth, development, and remodeling. Taken together these data suggest that chronic increases in PBF lead to both functional and structural aberrations of lung lymphatics. These findings have important therapeutic implications that warrant further study.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Physiol Lung Cell Mol Physiol</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Physiol. Lung Cell Mol. Physiol</journal-id><journal-id journal-id-type="hwp">ajplung</journal-id><journal-id journal-id-type="pmc">ajplung</journal-id><journal-id journal-id-type="publisher-id">AJPLUNG</journal-id><journal-title-group><journal-title>American Journal of Physiology - Lung Cellular and Molecular Physiology</journal-title></journal-title-group><issn pub-type="ppub">1040-0605</issn><issn pub-type="epub">1522-1504</issn><publisher><publisher-name>American Physiological Society</publisher-name><publisher-loc>Bethesda, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22207591</article-id><article-id pub-id-type="pmc">3311527</article-id><article-id pub-id-type="publisher-id">L-00324-2011</article-id><article-id pub-id-type="doi">10.1152/ajplung.00324.2011</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Datar</surname><given-names>Sanjeev A.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Eric G.</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Oishi</surname><given-names>Peter E.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Johengen</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Aramburo</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Barton</surname><given-names>Jubilee</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kuo</surname><given-names>Hsuan-Chang</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bennett</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Xoinis</surname><given-names>Konstantine</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Reel</surname><given-names>Bhupinder</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kalkan</surname><given-names>Gokhan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sajti</surname><given-names>Eniko</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Osorio</surname><given-names>Oscar</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Raff</surname><given-names>Gary W.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Matthay</surname><given-names>Michael A.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Fineman</surname><given-names>Jeffrey R.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><aff id="aff1">Departments of<sup>1</sup>Pediatrics and</aff><aff id="aff2"><sup>2</sup>Medicine and Anesthesia, and</aff><aff id="aff3"><sup>3</sup>Cardiovascular Research Institute, University of California, San Francisco;</aff><aff id="aff4">Departments of<sup>4</sup>Surgery and Pediatrics and</aff><aff id="aff5"><sup>5</sup>Surgical and Radiological Sciences, University of California, Davis, California</aff></contrib-group><author-notes><corresp>Address for reprint requests and other correspondence: J. Fineman, <addr-line>Dept. of Pediatrics, Univ. of California San Francisco, 505 Parnassus Ave., Box 0106, Room M-680, San Francisco, CA 94143-0106</addr-line> (e-mail: <email>jeff.fineman@ucsf.edu</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>29</day><month>12</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>3</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>302</volume><issue>6</issue><fpage>L530</fpage><lpage>L540</lpage><history><date date-type="received"><day>6</day><month>10</month><year>2011</year></date><date date-type="accepted"><day>23</day><month>12</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2012 the American Physiological Society</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zh500612000530.pdf"></self-uri><abstract><p>Abnormalities of the lymphatic circulation are well recognized in patients with congenital heart defects. However, it is not known how the associated abnormal blood flow patterns, such as increased pulmonary blood flow (PBF), might affect pulmonary lymphatic function and structure. Using well-established ovine models of acute and chronic increases in PBF, we cannulated the efferent lymphatic duct of the caudal mediastinal node and collected and analyzed lymph effluent from the lungs of lambs with acutely increased PBF (<italic>n</italic> = 6), chronically increased PBF (<italic>n</italic> = 6), and age-matched normal lambs (<italic>n</italic> = 8). When normalized to PBF, we found that lymph flow was unchanged following acute increases in PBF but decreased following chronic increases in PBF. The lymph:plasma protein ratio decreased with both acute and chronic increases in PBF. Lymph bioavailable nitric oxide increased following acute increases in PBF but decreased following chronic increases in PBF. In addition, we found perturbations in the transit kinetics of contrast material through the pleural lymphatics of lambs with chronic increases in PBF. Finally, there were structural changes in the pulmonary lymphatic system in lambs with chronic increases in PBF: lymphatics from these lambs were larger and more dilated, and there were alterations in the expression of vascular endothelial growth factor-C, lymphatic vessel endothelial hyaluronan receptor-1, and Angiopoietin-2, proteins known to be important for lymphatic growth, development, and remodeling. Taken together these data suggest that chronic increases in PBF lead to both functional and structural aberrations of lung lymphatics. These findings have important therapeutic implications that warrant further study.</p></abstract><kwd-group><kwd>lymph flow</kwd><kwd>lymphatic imaging</kwd><kwd>lymphatic endothelial dysfunction</kwd></kwd-group><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source><award-id rid="CS100">K12HD047349</award-id><award-id rid="CS100">T32HD049303</award-id><award-id rid="CS100">HLO86513</award-id><award-id rid="CS100">HL51854</award-id><award-id rid="CS100">HL61284</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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