Combination of physical activity, nutrition, or other metabolic factors and vaccine response
Identifieur interne : 002943 ( Pmc/Corpus ); précédent : 002942; suivant : 002944Combination of physical activity, nutrition, or other metabolic factors and vaccine response
Auteurs : Kenneth W. Hance ; Connie J. Rogers ; Stephen D. Hursting ; John W. GreinerSource :
- Frontiers in bioscience : a journal and virtual library [ 1093-9946 ] ; 2007.
Abstract
A number of lifestyle factors that reduce cancer risk in the primary prevention setting may be potential new targets for use in combination with cancer vaccines. This review discusses the modulation of energy balance (physical activity, calorie restriction, and obesity prevention), and the supplementation with natural and synthetic analogs of vitamins A and E, as potential interventions for use in combination with cancer vaccines. Additionally, the pharmacologic manipulation of nutrient metabolism in the tumor microenvironment (e.g., arachidonic acid, arginine, tryptophan, and glucose metabolism) is discussed. This review includes a brief overview of the role of each agent in primary cancer prevention; outlines the effects of these agents on immune function, specifically adaptive and/or anti-tumor immune mechanisms, when known; and discusses the potential use of these interventions in combination with therapeutic cancer vaccines. Modulation of energy balance through exercise and strategies targeting nutrient metabolism in the tumor microenvironment represent the most promising interventions to partner with therapeutic cancer vaccines. Additionally, the use of vitamin E succinate and the retinoid X receptor-directed rexinoids in combination with cancer vaccines offer promise. In summary, a number of energy balance- and nutrition-related interventions are viable candidates for further study in combination with cancer vaccines.
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PubMed: 17569626
PubMed Central: 2844938
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Hursting</name><affiliation><nlm:aff id="A2"> Division of Nutritional Sciences, University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Department of Carcinogenesis, University of Texas and M.D. Anderson Cancer Center, Smithville, TX 78957</nlm:aff></affiliation></author><author><name sortKey="Greiner, John W" sort="Greiner, John W" uniqKey="Greiner J" first="John W." last="Greiner">John W. Greiner</name><affiliation><nlm:aff id="A1"> Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17569626</idno><idno type="pmc">2844938</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844938</idno><idno type="RBID">PMC:2844938</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">002943</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002943</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Combination of physical activity, nutrition, or other metabolic factors and vaccine response</title><author><name sortKey="Hance, Kenneth W" sort="Hance, Kenneth W" uniqKey="Hance K" first="Kenneth W." last="Hance">Kenneth W. Hance</name><affiliation><nlm:aff id="A1"> Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Rogers, Connie J" sort="Rogers, Connie J" uniqKey="Rogers C" first="Connie J." last="Rogers">Connie J. Rogers</name><affiliation><nlm:aff id="A1"> Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Hursting, Stephen D" sort="Hursting, Stephen D" uniqKey="Hursting S" first="Stephen D." last="Hursting">Stephen D. Hursting</name><affiliation><nlm:aff id="A2"> Division of Nutritional Sciences, University of Texas at Austin, Austin, TX 78712</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Department of Carcinogenesis, University of Texas and M.D. Anderson Cancer Center, Smithville, TX 78957</nlm:aff></affiliation></author><author><name sortKey="Greiner, John W" sort="Greiner, John W" uniqKey="Greiner J" first="John W." last="Greiner">John W. Greiner</name><affiliation><nlm:aff id="A1"> Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892</nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers in bioscience : a journal and virtual library</title><idno type="ISSN">1093-9946</idno><idno type="eISSN">1093-4715</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">A number of lifestyle factors that reduce cancer risk in the primary prevention setting may be potential new targets for use in combination with cancer vaccines. This review discusses the modulation of energy balance (physical activity, calorie restriction, and obesity prevention), and the supplementation with natural and synthetic analogs of vitamins A and E, as potential interventions for use in combination with cancer vaccines. Additionally, the pharmacologic manipulation of nutrient metabolism in the tumor microenvironment (e.g., arachidonic acid, arginine, tryptophan, and glucose metabolism) is discussed. This review includes a brief overview of the role of each agent in primary cancer prevention; outlines the effects of these agents on immune function, specifically adaptive and/or anti-tumor immune mechanisms, when known; and discusses the potential use of these interventions in combination with therapeutic cancer vaccines. Modulation of energy balance through exercise and strategies targeting nutrient metabolism in the tumor microenvironment represent the most promising interventions to partner with therapeutic cancer vaccines. Additionally, the use of vitamin E succinate and the retinoid X receptor-directed rexinoids in combination with cancer vaccines offer promise. In summary, a number of energy balance- and nutrition-related interventions are viable candidates for further study in combination with cancer vaccines.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9709506</journal-id><journal-id journal-id-type="pubmed-jr-id">29838</journal-id><journal-id journal-id-type="nlm-ta">Front Biosci</journal-id><journal-title>Frontiers in bioscience : a journal and virtual library</journal-title><issn pub-type="ppub">1093-9946</issn><issn pub-type="epub">1093-4715</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17569626</article-id><article-id pub-id-type="pmc">2844938</article-id><article-id pub-id-type="manuscript">NIHMS186511</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Combination of physical activity, nutrition, or other metabolic factors and vaccine response</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hance</surname><given-names>Kenneth W.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rogers</surname><given-names>Connie J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hursting</surname><given-names>Stephen D.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Greiner</surname><given-names>John W.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label> Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892</aff><aff id="A2"><label>2</label> Division of Nutritional Sciences, University of Texas at Austin, Austin, TX 78712</aff><aff id="A3"><label>3</label> Department of Carcinogenesis, University of Texas and M.D. Anderson Cancer Center, Smithville, TX 78957</aff><author-notes><corresp id="CR1"><bold>Send correspondence to:</bold> Kenneth W. Hance, Ph.D., M.P.H., Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Cancer Institutes of Health, 10 Center Drive, Building 10, Room 8B04, MDC 1750, Bethesda, MD 20892-1750, Tel: 301-451-1415, Fax: 301-496-2756, <email>hancek@mail.nih.gov</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>3</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>1</day><month>9</month><year>2007</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>3</month><year>2010</year></pub-date><volume>12</volume><fpage>4997</fpage><lpage>5029</lpage><abstract><p id="P1">A number of lifestyle factors that reduce cancer risk in the primary prevention setting may be potential new targets for use in combination with cancer vaccines. This review discusses the modulation of energy balance (physical activity, calorie restriction, and obesity prevention), and the supplementation with natural and synthetic analogs of vitamins A and E, as potential interventions for use in combination with cancer vaccines. Additionally, the pharmacologic manipulation of nutrient metabolism in the tumor microenvironment (e.g., arachidonic acid, arginine, tryptophan, and glucose metabolism) is discussed. This review includes a brief overview of the role of each agent in primary cancer prevention; outlines the effects of these agents on immune function, specifically adaptive and/or anti-tumor immune mechanisms, when known; and discusses the potential use of these interventions in combination with therapeutic cancer vaccines. Modulation of energy balance through exercise and strategies targeting nutrient metabolism in the tumor microenvironment represent the most promising interventions to partner with therapeutic cancer vaccines. Additionally, the use of vitamin E succinate and the retinoid X receptor-directed rexinoids in combination with cancer vaccines offer promise. In summary, a number of energy balance- and nutrition-related interventions are viable candidates for further study in combination with cancer vaccines.</p></abstract><kwd-group><kwd>exercise</kwd><kwd>calorie restriction</kwd><kwd>obesity prevention</kwd><kwd>Vitamin A</kwd><kwd>Vitamin, E</kwd><kwd>arachidonic acid</kwd><kwd>arginine</kwd><kwd>tryptophan</kwd><kwd>glucose</kwd><kwd>immunotherapy</kwd><kwd>cancer vaccine</kwd><kwd>review</kwd></kwd-group><contract-num rid="PHS2">NIH0011268250
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