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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Age-related lymphatic dysfunction in melanoma patients</title><author><name sortKey="Conway, W Charles" sort="Conway, W Charles" uniqKey="Conway W" first="W. Charles" last="Conway">W. Charles Conway</name><affiliation><nlm:aff id="A1"> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</nlm:aff></affiliation></author><author><name sortKey="Faries, Mark B" sort="Faries, Mark B" uniqKey="Faries M" first="Mark B." last="Faries">Mark B. Faries</name><affiliation><nlm:aff id="A1"> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</nlm:aff></affiliation></author><author><name sortKey="Nicholl, Michael B" sort="Nicholl, Michael B" uniqKey="Nicholl M" first="Michael B." last="Nicholl">Michael B. Nicholl</name><affiliation><nlm:aff id="A1"> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</nlm:aff></affiliation></author><author><name sortKey="Terando, Alicia M" sort="Terando, Alicia M" uniqKey="Terando A" first="Alicia M." last="Terando">Alicia M. Terando</name><affiliation><nlm:aff id="A1"> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</nlm:aff></affiliation></author><author><name sortKey="Glass, Edwin C" sort="Glass, Edwin C" uniqKey="Glass E" first="Edwin C." last="Glass">Edwin C. Glass</name><affiliation><nlm:aff id="A3"> Department of Nuclear Medicine, West Los Angeles VA Medical Center</nlm:aff></affiliation></author><author><name sortKey="Sim, Myungshin" sort="Sim, Myungshin" uniqKey="Sim M" first="Myungshin" last="Sim">Myungshin Sim</name><affiliation><nlm:aff id="A2"> Department of Biostatistics, John Wayne Cancer Institute at Saint John’s Health Center, Santa Monica, CA</nlm:aff></affiliation></author><author><name sortKey="Morton, Donald L" sort="Morton, Donald L" uniqKey="Morton D" first="Donald L." last="Morton">Donald L. Morton</name><affiliation><nlm:aff id="A1"> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19277787</idno><idno type="pmc">2752947</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752947</idno><idno type="RBID">PMC:2752947</idno><idno type="doi">10.1245/s10434-009-0420-x</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">002921</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002921</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Age-related lymphatic dysfunction in melanoma patients</title><author><name sortKey="Conway, W Charles" sort="Conway, W Charles" uniqKey="Conway W" first="W. Charles" last="Conway">W. Charles Conway</name><affiliation><nlm:aff id="A1"> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</nlm:aff></affiliation></author><author><name sortKey="Faries, Mark B" sort="Faries, Mark B" uniqKey="Faries M" first="Mark B." last="Faries">Mark B. Faries</name><affiliation><nlm:aff id="A1"> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</nlm:aff></affiliation></author><author><name sortKey="Nicholl, Michael B" sort="Nicholl, Michael B" uniqKey="Nicholl M" first="Michael B." last="Nicholl">Michael B. Nicholl</name><affiliation><nlm:aff id="A1"> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</nlm:aff></affiliation></author><author><name sortKey="Terando, Alicia M" sort="Terando, Alicia M" uniqKey="Terando A" first="Alicia M." last="Terando">Alicia M. Terando</name><affiliation><nlm:aff id="A1"> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</nlm:aff></affiliation></author><author><name sortKey="Glass, Edwin C" sort="Glass, Edwin C" uniqKey="Glass E" first="Edwin C." last="Glass">Edwin C. Glass</name><affiliation><nlm:aff id="A3"> Department of Nuclear Medicine, West Los Angeles VA Medical Center</nlm:aff></affiliation></author><author><name sortKey="Sim, Myungshin" sort="Sim, Myungshin" uniqKey="Sim M" first="Myungshin" last="Sim">Myungshin Sim</name><affiliation><nlm:aff id="A2"> Department of Biostatistics, John Wayne Cancer Institute at Saint John’s Health Center, Santa Monica, CA</nlm:aff></affiliation></author><author><name sortKey="Morton, Donald L" sort="Morton, Donald L" uniqKey="Morton D" first="Donald L." last="Morton">Donald L. Morton</name><affiliation><nlm:aff id="A1"> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</nlm:aff></affiliation></author></analytic><series><title level="j">Annals of surgical oncology</title><idno type="ISSN">1068-9265</idno><idno type="eISSN">1534-4681</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Age-related outcomes have become increasingly common in evaluating patients with melanoma. For instance, as age increases, sentinel node (SN) non-identification increases and SN positivity decreases. Furthermore, advanced age is a risk factor for in transit disease. We hypothesized that increasing age is accompanied by alterations in lymphatic function, possibly explaining these findings</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Our center’s melanoma database was queried to identify patients who underwent successful sentinel node biopsy (SNB) after lymphoscintigraphy. Records of those treated between 2000 and 2005 were reviewed for age, sex, drainage basin, intraoperative radioactivity, and SN pathology.</p></sec><sec id="S3"><title>Results</title><p id="P3">The 858 patients had a mean age of 55 years; 59% were male. Mean radioactivity in the hottest SN was 5232 counts/second; 179 patients (21%) had SN metastases. SN count-rates were significantly and inversely related to age (p<0.001 by Pearson correlation, ANOVA and chi-square). Mean counts/second were 6105, 5883 and 2720 for axillary, inguinal and cervical basins, respectively (p<0.01), and count-rates in these basins were consistently lower with increasing age (neck and axilla, p<0.001; groin, p=0.060; Pearson correlation). Multivariate analysis confirmed an independent inverse association between age and count-rates (p<0.001), overall and within each primary site.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Lymphatic function, as assessed by radiocolloid transit to and uptake within the SN, declines with age. Altered lymphatic function in older patients may modify metastatic patterns and help clarify findings of reduced nodal positivity and increased in-transit disease in this population.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9420840</journal-id><journal-id journal-id-type="pubmed-jr-id">8578</journal-id><journal-id journal-id-type="nlm-ta">Ann Surg Oncol</journal-id><journal-title>Annals of surgical oncology</journal-title><issn pub-type="ppub">1068-9265</issn><issn pub-type="epub">1534-4681</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19277787</article-id><article-id pub-id-type="pmc">2752947</article-id><article-id pub-id-type="doi">10.1245/s10434-009-0420-x</article-id><article-id pub-id-type="manuscript">NIHMS103878</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Age-related lymphatic dysfunction in melanoma patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Conway</surname><given-names>W. Charles</given-names></name><degrees>M.D.</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Faries</surname><given-names>Mark B.</given-names></name><degrees>M.D.</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Nicholl</surname><given-names>Michael B.</given-names></name><degrees>M.D.</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Terando</surname><given-names>Alicia M.</given-names></name><degrees>M.D.</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Glass</surname><given-names>Edwin C.</given-names></name><degrees>M.D.</degrees><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Sim</surname><given-names>MyungShin</given-names></name><degrees>DrPH.</degrees><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Morton</surname><given-names>Donald L.</given-names></name><degrees>M.D.</degrees><xref rid="A1" ref-type="aff">1</xref></contrib></contrib-group><aff id="A1"><label>1</label> Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA</aff><aff id="A2"><label>2</label> Department of Biostatistics, John Wayne Cancer Institute at Saint John’s Health Center, Santa Monica, CA</aff><aff id="A3"><label>3</label> Department of Nuclear Medicine, West Los Angeles VA Medical Center</aff><author-notes><corresp id="FN1">Correspondence: Mark B. Faries, MD, John Wayne Cancer Institute, 2200 Santa Monica Blvd., Santa Monica, CA 90404. Telephone: 310-449-5205. Fax: 310-582-7185. E-mail: <email>fariesm@jwci.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>3</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>11</day><month>3</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>6</month><year>2010</year></pub-date><volume>16</volume><issue>6</issue><fpage>1548</fpage><lpage>1552</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">Age-related outcomes have become increasingly common in evaluating patients with melanoma. For instance, as age increases, sentinel node (SN) non-identification increases and SN positivity decreases. Furthermore, advanced age is a risk factor for in transit disease. We hypothesized that increasing age is accompanied by alterations in lymphatic function, possibly explaining these findings</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Our center’s melanoma database was queried to identify patients who underwent successful sentinel node biopsy (SNB) after lymphoscintigraphy. Records of those treated between 2000 and 2005 were reviewed for age, sex, drainage basin, intraoperative radioactivity, and SN pathology.</p></sec><sec id="S3"><title>Results</title><p id="P3">The 858 patients had a mean age of 55 years; 59% were male. Mean radioactivity in the hottest SN was 5232 counts/second; 179 patients (21%) had SN metastases. SN count-rates were significantly and inversely related to age (p<0.001 by Pearson correlation, ANOVA and chi-square). Mean counts/second were 6105, 5883 and 2720 for axillary, inguinal and cervical basins, respectively (p<0.01), and count-rates in these basins were consistently lower with increasing age (neck and axilla, p<0.001; groin, p=0.060; Pearson correlation). Multivariate analysis confirmed an independent inverse association between age and count-rates (p<0.001), overall and within each primary site.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Lymphatic function, as assessed by radiocolloid transit to and uptake within the SN, declines with age. Altered lymphatic function in older patients may modify metastatic patterns and help clarify findings of reduced nodal positivity and increased in-transit disease in this population.</p></sec></abstract><kwd-group><kwd>Melanoma</kwd><kwd>sentinel node</kwd><kwd>lymphatics</kwd><kwd>elderly</kwd></kwd-group><contract-num rid="CA1">P01 CA029605-278051</contract-num><contract-num rid="CA1">P01 CA029605-27</contract-num><contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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