Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Risk factors for classical Kaposi sarcoma in a population-based case-control study in Sicily</title><author><name sortKey="Anderson, La" sort="Anderson, La" uniqKey="Anderson L" first="La" last="Anderson">La Anderson</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Centre for Clinical and Population Sciences, Queen's University Belfast, Northern Ireland</nlm:aff></affiliation></author><author><name sortKey="Lauria, C" sort="Lauria, C" uniqKey="Lauria C" first="C" last="Lauria">C. Lauria</name><affiliation><nlm:aff id="A3">Lega Italiana per la Lotta Contro i Tumori-Sez Ragusa, Ragusa, Italy</nlm:aff></affiliation></author><author><name sortKey="Romano, N" sort="Romano, N" uniqKey="Romano N" first="N" last="Romano">N. Romano</name><affiliation><nlm:aff id="A4">Dipartimento di Scienze per la promozione della Salute “G.D'Alessandro” - sezione di Igiene - Università degli studi di Palermo, Palermo, Italy</nlm:aff></affiliation></author><author><name sortKey="Brown, Ee" sort="Brown, Ee" uniqKey="Brown E" first="Ee" last="Brown">Ee Brown</name><affiliation><nlm:aff id="A5">Departments of Epidemiology, Medicine and Microbiology, University of Alabama at Birmingham, Birmingham AL, USA</nlm:aff></affiliation></author><author><name sortKey="Whitby, D" sort="Whitby, D" uniqKey="Whitby D" first="D" last="Whitby">D. Whitby</name><affiliation><nlm:aff id="A6">Viral Oncology Section, AIDS and Cancer Virus Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, Maryland</nlm:aff></affiliation></author><author><name sortKey="Graubard, Bi" sort="Graubard, Bi" uniqKey="Graubard B" first="Bi" last="Graubard">Bi Graubard</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Y" sort="Li, Y" uniqKey="Li Y" first="Y" last="Li">Y. Li</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Messina, A" sort="Messina, A" uniqKey="Messina A" first="A" last="Messina">A. Messina</name><affiliation><nlm:aff id="A7">Dipartimento di Scienze Biomediche, Universitá degli studi di Catania, Catania, Italy</nlm:aff></affiliation></author><author><name sortKey="Gafa, L" sort="Gafa, L" uniqKey="Gafa L" first="L" last="Gafà">L. Gafà</name><affiliation><nlm:aff id="A3">Lega Italiana per la Lotta Contro i Tumori-Sez Ragusa, Ragusa, Italy</nlm:aff></affiliation></author><author><name sortKey="Vitale, F" sort="Vitale, F" uniqKey="Vitale F" first="F" last="Vitale">F. Vitale</name><affiliation><nlm:aff id="A4">Dipartimento di Scienze per la promozione della Salute “G.D'Alessandro” - sezione di Igiene - Università degli studi di Palermo, Palermo, Italy</nlm:aff></affiliation></author><author><name sortKey="Goedert, Jj" sort="Goedert, Jj" uniqKey="Goedert J" first="Jj" last="Goedert">Jj Goedert</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19064559</idno><idno type="pmc">2701388</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701388</idno><idno type="RBID">PMC:2701388</idno><idno type="doi">10.1158/1055-9965.EPI-08-0671</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">002909</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002909</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Risk factors for classical Kaposi sarcoma in a population-based case-control study in Sicily</title><author><name sortKey="Anderson, La" sort="Anderson, La" uniqKey="Anderson L" first="La" last="Anderson">La Anderson</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Centre for Clinical and Population Sciences, Queen's University Belfast, Northern Ireland</nlm:aff></affiliation></author><author><name sortKey="Lauria, C" sort="Lauria, C" uniqKey="Lauria C" first="C" last="Lauria">C. Lauria</name><affiliation><nlm:aff id="A3">Lega Italiana per la Lotta Contro i Tumori-Sez Ragusa, Ragusa, Italy</nlm:aff></affiliation></author><author><name sortKey="Romano, N" sort="Romano, N" uniqKey="Romano N" first="N" last="Romano">N. Romano</name><affiliation><nlm:aff id="A4">Dipartimento di Scienze per la promozione della Salute “G.D'Alessandro” - sezione di Igiene - Università degli studi di Palermo, Palermo, Italy</nlm:aff></affiliation></author><author><name sortKey="Brown, Ee" sort="Brown, Ee" uniqKey="Brown E" first="Ee" last="Brown">Ee Brown</name><affiliation><nlm:aff id="A5">Departments of Epidemiology, Medicine and Microbiology, University of Alabama at Birmingham, Birmingham AL, USA</nlm:aff></affiliation></author><author><name sortKey="Whitby, D" sort="Whitby, D" uniqKey="Whitby D" first="D" last="Whitby">D. Whitby</name><affiliation><nlm:aff id="A6">Viral Oncology Section, AIDS and Cancer Virus Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, Maryland</nlm:aff></affiliation></author><author><name sortKey="Graubard, Bi" sort="Graubard, Bi" uniqKey="Graubard B" first="Bi" last="Graubard">Bi Graubard</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Y" sort="Li, Y" uniqKey="Li Y" first="Y" last="Li">Y. Li</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Messina, A" sort="Messina, A" uniqKey="Messina A" first="A" last="Messina">A. Messina</name><affiliation><nlm:aff id="A7">Dipartimento di Scienze Biomediche, Universitá degli studi di Catania, Catania, Italy</nlm:aff></affiliation></author><author><name sortKey="Gafa, L" sort="Gafa, L" uniqKey="Gafa L" first="L" last="Gafà">L. Gafà</name><affiliation><nlm:aff id="A3">Lega Italiana per la Lotta Contro i Tumori-Sez Ragusa, Ragusa, Italy</nlm:aff></affiliation></author><author><name sortKey="Vitale, F" sort="Vitale, F" uniqKey="Vitale F" first="F" last="Vitale">F. Vitale</name><affiliation><nlm:aff id="A4">Dipartimento di Scienze per la promozione della Salute “G.D'Alessandro” - sezione di Igiene - Università degli studi di Palermo, Palermo, Italy</nlm:aff></affiliation></author><author><name sortKey="Goedert, Jj" sort="Goedert, Jj" uniqKey="Goedert J" first="Jj" last="Goedert">Jj Goedert</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Classical Kaposi sarcoma (cKS) is a rare complication of Kaposi sarcoma-associated herpes virus (KSHV) infection. We conducted a population-based, frequency-matched case-control study in Sicily to further investigate the reported inverse relationship between smoking and cKS and to identify other factors associated with altered risk.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">All incident, histologically confirmed, cKS cases in Sicily were eligible. A two-stage cluster sample design was applied to select population controls. KSHV seropositivity was determined using 4 antibody assays (K8.1 and orf73 enzyme immunoassays and 2 immunofluroescence assays). Using SAS-callable SUDAAN we compared the characteristics of cKS cases and KSHV seropositive controls. Odds ratios (ORs) and 95% confidence intervals (CIs) are presented.</p></sec><sec id="S3"><title>Results</title><p id="P3">In total, 142 cKS cases and 123 KSHV seropositive controls were recruited. Current cigarette smoking was associated with reduced risk of cKS (OR 0.20, 95% CI 0.06-0.67). Edema was associated with cKS, but only when it presented on the lower extremities (OR 3.65, 95% CI 1.62-8.23). Irrespective of presentation site, diabetes and oral corticosteroid medications were associated with increased risk (ORs, 95% CIs: 4.73, 2.02-11.1 and 2.34, 1.23-4.45, respectively). Never smoking, diabetes and oral corticosteroid medication use were all independently associated with cKS risk.</p></sec><sec id="S4"><title>Discussion</title><p id="P4">We confirmed previous reports that cigarette smoking was associated with a reduced risk of cKS, and we found that risk was lowest among current smokers. We also found that cKS risk was strongly and independently associated with oral corticosteroid use and diabetes. Corroboration of these observations and investigation of possible underlying mechanisms are warranted.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19064559</article-id><article-id pub-id-type="pmc">2701388</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-08-0671</article-id><article-id pub-id-type="manuscript">NIHMS93096</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Risk factors for classical Kaposi sarcoma in a population-based case-control study in Sicily</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>LA</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lauria</surname><given-names>C</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Romano</surname><given-names>N</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>EE</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Whitby</surname><given-names>D</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Graubard</surname><given-names>BI</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Y</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Messina</surname><given-names>A</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Gafà</surname><given-names>L</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Vitale</surname><given-names>F</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Goedert</surname><given-names>JJ</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</aff><aff id="A2"><label>2</label>Centre for Clinical and Population Sciences, Queen's University Belfast, Northern Ireland</aff><aff id="A3"><label>3</label>Lega Italiana per la Lotta Contro i Tumori-Sez Ragusa, Ragusa, Italy</aff><aff id="A4"><label>4</label>Dipartimento di Scienze per la promozione della Salute “G.D'Alessandro” - sezione di Igiene - Università degli studi di Palermo, Palermo, Italy</aff><aff id="A5"><label>5</label>Departments of Epidemiology, Medicine and Microbiology, University of Alabama at Birmingham, Birmingham AL, USA</aff><aff id="A6"><label>6</label>Viral Oncology Section, AIDS and Cancer Virus Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, Maryland</aff><aff id="A7"><label>7</label>Dipartimento di Scienze Biomediche, Universitá degli studi di Catania, Catania, Italy</aff><author-notes><corresp id="CR1">Address correspondence and reprint requests to: James J Goedert Phone: 301-435-4724 Infections and Immunoepidemiology Branch Fax: 301-402-0817 Division of Cancer Epidemiology and Genetics National Cancer Institute 6120 Executive Blvd, EPS 7068 Rockville, MD 20892, USA Phone: 301-435-4724 Fax: 301-402-0817 Email: <email>goedertj@mail.nih.gov</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>2</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2009</year></pub-date><volume>17</volume><issue>12</issue><fpage>3435</fpage><lpage>3443</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">Classical Kaposi sarcoma (cKS) is a rare complication of Kaposi sarcoma-associated herpes virus (KSHV) infection. We conducted a population-based, frequency-matched case-control study in Sicily to further investigate the reported inverse relationship between smoking and cKS and to identify other factors associated with altered risk.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">All incident, histologically confirmed, cKS cases in Sicily were eligible. A two-stage cluster sample design was applied to select population controls. KSHV seropositivity was determined using 4 antibody assays (K8.1 and orf73 enzyme immunoassays and 2 immunofluroescence assays). Using SAS-callable SUDAAN we compared the characteristics of cKS cases and KSHV seropositive controls. Odds ratios (ORs) and 95% confidence intervals (CIs) are presented.</p></sec><sec id="S3"><title>Results</title><p id="P3">In total, 142 cKS cases and 123 KSHV seropositive controls were recruited. Current cigarette smoking was associated with reduced risk of cKS (OR 0.20, 95% CI 0.06-0.67). Edema was associated with cKS, but only when it presented on the lower extremities (OR 3.65, 95% CI 1.62-8.23). Irrespective of presentation site, diabetes and oral corticosteroid medications were associated with increased risk (ORs, 95% CIs: 4.73, 2.02-11.1 and 2.34, 1.23-4.45, respectively). Never smoking, diabetes and oral corticosteroid medication use were all independently associated with cKS risk.</p></sec><sec id="S4"><title>Discussion</title><p id="P4">We confirmed previous reports that cigarette smoking was associated with a reduced risk of cKS, and we found that risk was lowest among current smokers. We also found that cKS risk was strongly and independently associated with oral corticosteroid use and diabetes. Corroboration of these observations and investigation of possible underlying mechanisms are warranted.</p></sec></abstract><contract-num rid="CP1">Z01 CP010150-08</contract-num><contract-sponsor id="CP1">Division of Cancer Epidemiology and Genetics : NCI</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0029091 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0029091 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.31. |  |