Lymphatic system acts as a vital link between metabolic syndrome and inflammation
Identifieur interne : 002847 ( Pmc/Corpus ); précédent : 002846; suivant : 002848Lymphatic system acts as a vital link between metabolic syndrome and inflammation
Auteurs : Sanjukta Chakraborty ; Scott Zawieja ; Wei Wang ; David C. Zawieja ; Mariappan MuthuchamySource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2010.
Abstract
Metabolic syndrome is defined by a cluster of different metabolic risk factors that include overall and central obesity, elevated fasting glucose levels, dyslipidemia, hypertension, and intimal atherogenesis. Metabolic syndrome leads to increased risk for the development of type 2 diabetes and cardiovascular disease (e.g., heart disease and stroke). The exacerbated progression of metabolic syndrome to cardiovascular disease has lead to intense study of the physiological ramifications of metabolic syndrome on the blood vasculature. These studies have particularly focused on the signaling and architectural alterations that manifest in hypertension and atherosclerosis. However, despite the overlap of metabolic syndrome pathology with lymphatic function, tangent effects on the lymphatic system have not been extensively documented. In this review, we discuss the current status of metabolic syndrome and provide evidence and remaining challenges in the connection between the lymphatic system, lipid transport, obesity, insulin resistance, and general inflammation.
Url:
DOI: 10.1111/j.1749-6632.2010.05752.x
PubMed: 20961312
PubMed Central: 2965625
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PMC:2965625Le document en format XML
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<author><name sortKey="Chakraborty, Sanjukta" sort="Chakraborty, Sanjukta" uniqKey="Chakraborty S" first="Sanjukta" last="Chakraborty">Sanjukta Chakraborty</name>
<affiliation><nlm:aff id="A1"> Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Division of Lymphatic Biology, Texas A&M Health Science Center College of Medicine, College Station, TX</nlm:aff>
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<author><name sortKey="Zawieja, Scott" sort="Zawieja, Scott" uniqKey="Zawieja S" first="Scott" last="Zawieja">Scott Zawieja</name>
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<front><div type="abstract" xml:lang="en"><p id="P1">Metabolic syndrome is defined by a cluster of different metabolic risk
factors that include overall and central obesity, elevated fasting glucose
levels, dyslipidemia, hypertension, and intimal atherogenesis. Metabolic
syndrome leads to increased risk for the development of type 2 diabetes and
cardiovascular disease (e.g., heart disease and stroke). The exacerbated
progression of metabolic syndrome to cardiovascular disease has lead to intense
study of the physiological ramifications of metabolic syndrome on the blood
vasculature. These studies have particularly focused on the signaling and
architectural alterations that manifest in hypertension and atherosclerosis.
However, despite the overlap of metabolic syndrome pathology with lymphatic
function, tangent effects on the lymphatic system have not been extensively
documented. In this review, we discuss the current status of metabolic syndrome
and provide evidence and remaining challenges in the connection between the
lymphatic system, lipid transport, obesity, insulin resistance, and general
inflammation.</p>
</div>
</front>
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<title-group><article-title>Lymphatic system acts as a vital link between metabolic syndrome and
inflammation</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Chakraborty</surname>
<given-names>Sanjukta</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
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<xref rid="A1" ref-type="aff">1</xref>
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<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Wei</given-names>
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<contrib contrib-type="author"><name><surname>Zawieja</surname>
<given-names>David C.</given-names>
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<contrib contrib-type="author"><name><surname>Muthuchamy</surname>
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<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
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<aff id="A1"><label>1</label>
Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Division of Lymphatic Biology, Texas A&M Health Science Center College of Medicine, College Station, TX</aff>
<author-notes><corresp id="FN1">Correspondence: Mariappan Muthuchamy, Department of Systems
Biology and Translational Medicine, Texas A&M Health Science Center College
of Medicine, 336 Reynolds Medical Building, College Station, TX 77843,
<email>marim@tamu.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>19</day>
<month>8</month>
<year>2010</year>
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<pub-date pub-type="ppub"><month>10</month>
<year>2010</year>
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<pub-date pub-type="pmc-release"><day>1</day>
<month>10</month>
<year>2011</year>
</pub-date>
<volume>1207</volume>
<issue>Suppl 1</issue>
<fpage>E94</fpage>
<lpage>102</lpage>
<abstract><p id="P1">Metabolic syndrome is defined by a cluster of different metabolic risk
factors that include overall and central obesity, elevated fasting glucose
levels, dyslipidemia, hypertension, and intimal atherogenesis. Metabolic
syndrome leads to increased risk for the development of type 2 diabetes and
cardiovascular disease (e.g., heart disease and stroke). The exacerbated
progression of metabolic syndrome to cardiovascular disease has lead to intense
study of the physiological ramifications of metabolic syndrome on the blood
vasculature. These studies have particularly focused on the signaling and
architectural alterations that manifest in hypertension and atherosclerosis.
However, despite the overlap of metabolic syndrome pathology with lymphatic
function, tangent effects on the lymphatic system have not been extensively
documented. In this review, we discuss the current status of metabolic syndrome
and provide evidence and remaining challenges in the connection between the
lymphatic system, lipid transport, obesity, insulin resistance, and general
inflammation.</p>
</abstract>
<kwd-group><kwd>metabolic syndrome</kwd>
<kwd>lymphatic pump</kwd>
<kwd>lymphatics and lipid transport</kwd>
<kwd>inflammation</kwd>
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<contract-num rid="HL1">R01 HL080526-05
||HL</contract-num>
<contract-num rid="HL1">K02 HL086650-04
||HL</contract-num>
<contract-sponsor id="HL1">National Heart, Lung, and Blood Institute : NHLBI</contract-sponsor>
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