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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Integrated Optical Coherence Tomography and Microscopy for <italic>Ex Vivo</italic> Multiscale Evaluation of Human Breast Tissues</title><author><name sortKey="Zhou, Chao" sort="Zhou, Chao" uniqKey="Zhou C" first="Chao" last="Zhou">Chao Zhou</name><affiliation><nlm:aff id="A1">Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Cohen, David W" sort="Cohen, David W" uniqKey="Cohen D" first="David W." last="Cohen">David W. Cohen</name><affiliation><nlm:aff id="A2">Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Yihong" sort="Wang, Yihong" uniqKey="Wang Y" first="Yihong" last="Wang">Yihong Wang</name><affiliation><nlm:aff id="A2">Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Pathology, Montefiore Medical Center and Albert Einstein Medical School, Bronx, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Hsiang Chieh" sort="Lee, Hsiang Chieh" uniqKey="Lee H" first="Hsiang-Chieh" last="Lee">Hsiang-Chieh Lee</name><affiliation><nlm:aff id="A1">Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Mondelblatt, Amy E" sort="Mondelblatt, Amy E" uniqKey="Mondelblatt A" first="Amy E." last="Mondelblatt">Amy E. Mondelblatt</name><affiliation><nlm:aff id="A2">Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Tsai, Tsung Han" sort="Tsai, Tsung Han" uniqKey="Tsai T" first="Tsung-Han" last="Tsai">Tsung-Han Tsai</name><affiliation><nlm:aff id="A1">Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Aguirre, Aaron D" sort="Aguirre, Aaron D" uniqKey="Aguirre A" first="Aaron D." last="Aguirre">Aaron D. Aguirre</name><affiliation><nlm:aff id="A1">Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Harvard-MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Fujimoto, James G" sort="Fujimoto, James G" uniqKey="Fujimoto J" first="James G." last="Fujimoto">James G. Fujimoto</name><affiliation><nlm:aff id="A1">Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Connolly, James L" sort="Connolly, James L" uniqKey="Connolly J" first="James L." last="Connolly">James L. Connolly</name><affiliation><nlm:aff id="A2">Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21056988</idno><idno type="pmc">3028517</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028517</idno><idno type="RBID">PMC:3028517</idno><idno type="doi">10.1158/0008-5472.CAN-10-2968</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002838</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002838</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Integrated Optical Coherence Tomography and Microscopy for <italic>Ex Vivo</italic> Multiscale Evaluation of Human Breast Tissues</title><author><name sortKey="Zhou, Chao" sort="Zhou, Chao" uniqKey="Zhou C" first="Chao" last="Zhou">Chao Zhou</name><affiliation><nlm:aff id="A1">Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Cohen, David W" sort="Cohen, David W" uniqKey="Cohen D" first="David W." last="Cohen">David W. Cohen</name><affiliation><nlm:aff id="A2">Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Yihong" sort="Wang, Yihong" uniqKey="Wang Y" first="Yihong" last="Wang">Yihong Wang</name><affiliation><nlm:aff id="A2">Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Pathology, Montefiore Medical Center and Albert Einstein Medical School, Bronx, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Hsiang Chieh" sort="Lee, Hsiang Chieh" uniqKey="Lee H" first="Hsiang-Chieh" last="Lee">Hsiang-Chieh Lee</name><affiliation><nlm:aff id="A1">Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Mondelblatt, Amy E" sort="Mondelblatt, Amy E" uniqKey="Mondelblatt A" first="Amy E." last="Mondelblatt">Amy E. Mondelblatt</name><affiliation><nlm:aff id="A2">Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Tsai, Tsung Han" sort="Tsai, Tsung Han" uniqKey="Tsai T" first="Tsung-Han" last="Tsai">Tsung-Han Tsai</name><affiliation><nlm:aff id="A1">Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Aguirre, Aaron D" sort="Aguirre, Aaron D" uniqKey="Aguirre A" first="Aaron D." last="Aguirre">Aaron D. Aguirre</name><affiliation><nlm:aff id="A1">Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Harvard-MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Fujimoto, James G" sort="Fujimoto, James G" uniqKey="Fujimoto J" first="James G." last="Fujimoto">James G. Fujimoto</name><affiliation><nlm:aff id="A1">Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Connolly, James L" sort="Connolly, James L" uniqKey="Connolly J" first="James L." last="Connolly">James L. Connolly</name><affiliation><nlm:aff id="A2">Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer research</title><idno type="ISSN">0008-5472</idno><idno type="eISSN">1538-7445</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">3D tissue imaging methods are expected to improve surgical management of cancer. In this study, we examined the feasibility of two 3D imaging technologies, optical coherence tomography (OCT) and optical coherence microscopy (OCM), to view human breast specimens based on intrinsic optical contrast. Specifically, we imaged 44 <italic>ex vivo</italic> breast specimens including 34 benign and 10 malignant lesions with an integrated OCT and OCM system developed in our laboratory. The system enabled 4 μm axial resolution (OCT and OCM) with 14 μm (OCT) and 2 μm (OCM) transverse resolution, respectively. OCT and OCM images were compared with corresponding histologic sections to identify characteristic features from benign and malignant breast lesions at multiple resolution scales. OCT and OCM provide complimentary information about tissue microstructure, demonstrating distinctive patterns for adipose tissue, fibrous stroma, breast lobules and ducts, cysts and microcysts, as well as <italic>in situ</italic> and invasive carcinomas. The 3D imaging capability of OCT and OCM provided complementary information to individual 2D images, allowing tracking features from different levels to identify low contrast structures that were difficult to appreciate from single images alone. Our results lay the foundation for future <italic>in vivo</italic> optical evaluation of breast tissues using OCT and OCM, which has the potential to guide core needle biopsies, assess surgical margins and evaluate nodal involvement in breast cancer.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">2984705R</journal-id><journal-id journal-id-type="pubmed-jr-id">2786</journal-id><journal-id journal-id-type="nlm-ta">Cancer Res</journal-id><journal-title>Cancer research</journal-title><issn pub-type="ppub">0008-5472</issn><issn pub-type="epub">1538-7445</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21056988</article-id><article-id pub-id-type="pmc">3028517</article-id><article-id pub-id-type="doi">10.1158/0008-5472.CAN-10-2968</article-id><article-id pub-id-type="manuscript">NIHMS250436</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Integrated Optical Coherence Tomography and Microscopy for <italic>Ex Vivo</italic> Multiscale Evaluation of Human Breast Tissues</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Chao</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Cohen</surname><given-names>David W.</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yihong</given-names></name><xref rid="A2" ref-type="aff">2</xref><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Hsiang-Chieh</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Mondelblatt</surname><given-names>Amy E.</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Tsai</surname><given-names>Tsung-Han</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Aguirre</surname><given-names>Aaron D.</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Fujimoto</surname><given-names>James G.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Connolly</surname><given-names>James L.</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</aff><aff id="A2"><label>2</label>Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA</aff><aff id="A3"><label>3</label>Department of Pathology, Montefiore Medical Center and Albert Einstein Medical School, Bronx, NY, USA</aff><aff id="A4"><label>4</label>Harvard-MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA, USA</aff><author-notes><corresp id="FN1">Corresponding Author: Prof. James L. Connolly, Address: Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, Tel: 617-667-5754, Fax: 617-975-5620, <email>jconnoll@bidmc.harvard.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>1</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>5</day><month>11</month><year>2010</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>12</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>12</month><year>2011</year></pub-date><volume>70</volume><issue>24</issue><fpage>10071</fpage><lpage>10079</lpage><abstract><p id="P1">3D tissue imaging methods are expected to improve surgical management of cancer. In this study, we examined the feasibility of two 3D imaging technologies, optical coherence tomography (OCT) and optical coherence microscopy (OCM), to view human breast specimens based on intrinsic optical contrast. Specifically, we imaged 44 <italic>ex vivo</italic> breast specimens including 34 benign and 10 malignant lesions with an integrated OCT and OCM system developed in our laboratory. The system enabled 4 μm axial resolution (OCT and OCM) with 14 μm (OCT) and 2 μm (OCM) transverse resolution, respectively. OCT and OCM images were compared with corresponding histologic sections to identify characteristic features from benign and malignant breast lesions at multiple resolution scales. OCT and OCM provide complimentary information about tissue microstructure, demonstrating distinctive patterns for adipose tissue, fibrous stroma, breast lobules and ducts, cysts and microcysts, as well as <italic>in situ</italic> and invasive carcinomas. The 3D imaging capability of OCT and OCM provided complementary information to individual 2D images, allowing tracking features from different levels to identify low contrast structures that were difficult to appreciate from single images alone. Our results lay the foundation for future <italic>in vivo</italic> optical evaluation of breast tissues using OCT and OCM, which has the potential to guide core needle biopsies, assess surgical margins and evaluate nodal involvement in breast cancer.</p></abstract><kwd-group><kwd>Optical coherence tomography (OCT)</kwd><kwd>Optical coherence microscopy (OCM)</kwd><kwd>Breast</kwd><kwd>Pathology</kwd><kwd>Cancer</kwd></kwd-group><contract-num rid="CA1">R01 CA075289-13
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