Determinants of Success in National Programs to Eliminate Lymphatic Filariasis: A Perspective Identifying Essential Elements and Research Needs
Identifieur interne : 002760 ( Pmc/Corpus ); précédent : 002759; suivant : 002761Determinants of Success in National Programs to Eliminate Lymphatic Filariasis: A Perspective Identifying Essential Elements and Research Needs
Auteurs : Dominique Kyelem ; Gautam Biswas ; Moses J. Bockarie ; Mark H. Bradley ; Maged El-Setouhy ; Peter U. Fischer ; Ralph H. Henderson ; James W. Kazura ; Patrick J. Lammie ; Sammy M. Njenga ; Eric A. Ottesen ; Kapa D. Ramaiah ; Frank O. Richards ; Gary J. Weil ; Steven A. WilliamsSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2008.
Abstract
The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000. To understand why some national programs have been more successful than others, a panel of individuals with expertise in LF elimination efforts met to assess available data from programs in 8 countries. The goal was to identify: 1) the factors determining success for national LF elimination programs (defined as the rapid, sustained reduction in microfilaremia/antigenemia after repeated mass drug administration [MDA]); 2) the priorities for operational research to enhance LF elimination efforts.
Of more than 40 factors identified, the most prominent were 1) initial level of LF endemicity; 2) effectiveness of vector mosquitoes; 3) MDA drug regimen; 4) population compliance.
Research important for facilitating program success was identified as either
While addressing these challenges is important, many key determinants of program success are already clearly understood; operationalizing these as soon as possible will greatly increase the potential for national program success.
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PubMed: 18840733
PubMed Central: 2694403
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<idno type="ISSN">0002-9637</idno>
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<front><div type="abstract" xml:lang="en"><p id="P1">The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000. To understand why some national programs have been more successful than others, a panel of individuals with expertise in LF elimination efforts met to assess available data from programs in 8 countries. The goal was to identify: 1) the factors determining success for national LF elimination programs (defined as the rapid, sustained reduction in microfilaremia/antigenemia after repeated mass drug administration [MDA]); 2) the priorities for operational research to enhance LF elimination efforts.</p>
<p id="P2">Of more than 40 factors identified, the most prominent were 1) initial level of LF endemicity; 2) effectiveness of vector mosquitoes; 3) MDA drug regimen; 4) population compliance.</p>
<p id="P3">Research important for facilitating program success was identified as either <italic>biologic</italic>
(i.e., [1] quantifying differences in vectorial capacity; [2] identifying seasonal variations affecting LF transmission) or <italic>programmatic</italic>
(i.e., [1] identifying quantitative thresholds, especially the population compliance levels necessary for success, and the antigenemia or microfilaremia prevalence at which MDA programs can stop with minimal risk of resumption of transmission; [2] defining optimal drug distribution strategies and timing; [3] identifying those individuals who are “persistently non-compliant” during MDAs, the reasons for this non-compliance and approaches to overcoming it).</p>
<p id="P4">While addressing these challenges is important, many key determinants of program success are already clearly understood; operationalizing these as soon as possible will greatly increase the potential for national program success.</p>
</div>
</front>
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<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370507</journal-id>
<journal-id journal-id-type="pubmed-jr-id">473</journal-id>
<journal-id journal-id-type="nlm-ta">Am J Trop Med Hyg</journal-id>
<journal-title>The American journal of tropical medicine and hygiene</journal-title>
<issn pub-type="ppub">0002-9637</issn>
<issn pub-type="epub">1476-1645</issn>
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<article-meta><article-id pub-id-type="pmid">18840733</article-id>
<article-id pub-id-type="pmc">2694403</article-id>
<article-id pub-id-type="manuscript">NIHMS104991</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Determinants of Success in National Programs to Eliminate Lymphatic Filariasis: A Perspective Identifying Essential Elements and Research Needs</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kyelem</surname>
<given-names>Dominique</given-names>
</name>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Biswas</surname>
<given-names>Gautam</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Bockarie</surname>
<given-names>Moses J.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Bradley</surname>
<given-names>Mark H.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>El-Setouhy</surname>
<given-names>Maged</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Fischer</surname>
<given-names>Peter U.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Henderson</surname>
<given-names>Ralph H.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kazura</surname>
<given-names>James W.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lammie</surname>
<given-names>Patrick J.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Njenga</surname>
<given-names>Sammy M.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ottesen</surname>
<given-names>Eric A.</given-names>
</name>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ramaiah</surname>
<given-names>Kapa D.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Richards</surname>
<given-names>Frank O.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Weil</surname>
<given-names>Gary J.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Williams</surname>
<given-names>Steven A.</given-names>
</name>
</contrib>
<aff id="A1">Lymphatic Filariasis Support Center, Task Force for Child Survival and Development, Decatur, Georgia; Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland; Lymphatic Filariasis Support Centre, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Global Community Partnerships, GlaxoSmithKline, Brentford, United Kingdom; Department of Public Health, Ain Shams University, Cairo, Egypt; School of Medicine, Washington University, St. Louis, Missouri; Center for Global Health & Diseases, Case Western Reserve University, Cleveland, Ohio; Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Kenya Medical Research Institute, Nairobi, Kenya; Vector Control Research Centre, Indian Council of Medical Research, Pondicherry, India; Carter Center, Atlanta, Georgia; Clark Science Center, Smith College, Northampton, Massachusetts</aff>
</contrib-group>
<author-notes><corresp id="FN1"><label>*</label>
Address correspondence to Dominique Kyelem or Eric A. Ottesen, Lymphatic Filariasis Support Center, Task Force for Child Survival and Development, Decatur, Georgia. E-mails: <email>dkyelem@taskforce.org</email>
and <email>eottesen@taskforce.org</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>13</day>
<month>4</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>10</day>
<month>6</month>
<year>2009</year>
</pub-date>
<volume>79</volume>
<issue>4</issue>
<fpage>480</fpage>
<lpage>484</lpage>
<abstract><p id="P1">The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000. To understand why some national programs have been more successful than others, a panel of individuals with expertise in LF elimination efforts met to assess available data from programs in 8 countries. The goal was to identify: 1) the factors determining success for national LF elimination programs (defined as the rapid, sustained reduction in microfilaremia/antigenemia after repeated mass drug administration [MDA]); 2) the priorities for operational research to enhance LF elimination efforts.</p>
<p id="P2">Of more than 40 factors identified, the most prominent were 1) initial level of LF endemicity; 2) effectiveness of vector mosquitoes; 3) MDA drug regimen; 4) population compliance.</p>
<p id="P3">Research important for facilitating program success was identified as either <italic>biologic</italic>
(i.e., [1] quantifying differences in vectorial capacity; [2] identifying seasonal variations affecting LF transmission) or <italic>programmatic</italic>
(i.e., [1] identifying quantitative thresholds, especially the population compliance levels necessary for success, and the antigenemia or microfilaremia prevalence at which MDA programs can stop with minimal risk of resumption of transmission; [2] defining optimal drug distribution strategies and timing; [3] identifying those individuals who are “persistently non-compliant” during MDAs, the reasons for this non-compliance and approaches to overcoming it).</p>
<p id="P4">While addressing these challenges is important, many key determinants of program success are already clearly understood; operationalizing these as soon as possible will greatly increase the potential for national program success.</p>
</abstract>
<contract-num rid="AI1">U19 AI065717-04</contract-num>
<contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>
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