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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vascular Endothelial Growth Factor Receptor -2 in Breast Cancer</title><author><name sortKey="Guo, Shanchun" sort="Guo, Shanchun" uniqKey="Guo S" first="Shanchun" last="Guo">Shanchun Guo</name><affiliation><nlm:aff id="A1"> Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA 30310</nlm:aff></affiliation></author><author><name sortKey="Colbert, Laronna S" sort="Colbert, Laronna S" uniqKey="Colbert L" first="Laronna S." last="Colbert">Laronna S. Colbert</name><affiliation><nlm:aff id="A2"> Clinical Medicine, Hematology/Oncology Section, Morehouse School of Medicine, Atlanta, GA 30310</nlm:aff></affiliation></author><author><name sortKey="Fuller, Miles" sort="Fuller, Miles" uniqKey="Fuller M" first="Miles" last="Fuller">Miles Fuller</name><affiliation><nlm:aff id="A1"> Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA 30310</nlm:aff></affiliation></author><author><name sortKey="Zhang, Yuanyuan" sort="Zhang, Yuanyuan" uniqKey="Zhang Y" first="Yuanyuan" last="Zhang">Yuanyuan Zhang</name><affiliation><nlm:aff id="A1"> Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA 30310</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Perez, Ruben R" sort="Gonzalez Perez, Ruben R" uniqKey="Gonzalez Perez R" first="Ruben R." last="Gonzalez-Perez">Ruben R. Gonzalez-Perez</name><affiliation><nlm:aff id="A1"> Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA 30310</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20462514</idno><idno type="pmc">2885515</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885515</idno><idno type="RBID">PMC:2885515</idno><idno type="doi">10.1016/j.bbcan.2010.04.004</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002747</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002747</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Vascular Endothelial Growth Factor Receptor -2 in Breast Cancer</title><author><name sortKey="Guo, Shanchun" sort="Guo, Shanchun" uniqKey="Guo S" first="Shanchun" last="Guo">Shanchun Guo</name><affiliation><nlm:aff id="A1"> Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA 30310</nlm:aff></affiliation></author><author><name sortKey="Colbert, Laronna S" sort="Colbert, Laronna S" uniqKey="Colbert L" first="Laronna S." last="Colbert">Laronna S. Colbert</name><affiliation><nlm:aff id="A2"> Clinical Medicine, Hematology/Oncology Section, Morehouse School of Medicine, Atlanta, GA 30310</nlm:aff></affiliation></author><author><name sortKey="Fuller, Miles" sort="Fuller, Miles" uniqKey="Fuller M" first="Miles" last="Fuller">Miles Fuller</name><affiliation><nlm:aff id="A1"> Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA 30310</nlm:aff></affiliation></author><author><name sortKey="Zhang, Yuanyuan" sort="Zhang, Yuanyuan" uniqKey="Zhang Y" first="Yuanyuan" last="Zhang">Yuanyuan Zhang</name><affiliation><nlm:aff id="A1"> Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA 30310</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Perez, Ruben R" sort="Gonzalez Perez, Ruben R" uniqKey="Gonzalez Perez R" first="Ruben R." last="Gonzalez-Perez">Ruben R. Gonzalez-Perez</name><affiliation><nlm:aff id="A1"> Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA 30310</nlm:aff></affiliation></author></analytic><series><title level="j">Biochimica et biophysica acta</title><idno type="ISSN">0006-3002</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Investigations over the last decade have established the essential role of growth factors and their receptors during angiogenesis and carcinogenesis. The vascular endothelial growth factor receptor (VEGFR) family in mammals contains three members, VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4), which are transmembrane tyrosine kinase receptors that regulate the formation of blood and lymphatic vessels. In the early 1990s, the above VEGFR were structurally characterized by cDNA cloning. Among these three receptors, VEGFR-2 is generally recognized to have a principal role in mediating VEGF-induced responses. VEGFR-2 is considered as the earliest marker for endothelial cell development. Importantly, VEGFR-2 directly regulates tumor angiogenesis. Therefore, several inhibitors of VEGFR-2 have been developed and many of them are now in clinical trials. In addition to targeting endothelial cells, the VEGF/VEGFR-2 system works as an essential autocrine/paracrine process for cancer cell proliferation and survival. Recent studies mark the continuous and increased interest in this related, but distinct, function of VEGF/VEGFR-2 in cancer cells: the autocrine/paracrine loop. Several mechanisms regulate VEGFR-2 levels and modulate its role in tumor angiogenesis and physiologic functions, i.e.: cellular localization/trafficking, regulation of cis-elements of promoter, epigenetic regulation and signaling from Notch, cytokines/growth factors and estrogen, etc. In this review, we will focus on updated information regarding VEGFR-2 research with respect to the molecular mechanisms of VEGFR-2 regulation in human breast cancer. Investigations in the activation, function, and regulation of VEGFR-2 in breast cancer will allow the development of new pharmacological strategies aimed at directly targeting cancer cell proliferation and survival.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0217513</journal-id><journal-id journal-id-type="pubmed-jr-id">1037</journal-id><journal-id journal-id-type="nlm-ta">Biochim Biophys Acta</journal-id><journal-title>Biochimica et biophysica acta</journal-title><issn pub-type="ppub">0006-3002</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20462514</article-id><article-id pub-id-type="pmc">2885515</article-id><article-id pub-id-type="doi">10.1016/j.bbcan.2010.04.004</article-id><article-id pub-id-type="manuscript">NIHMS203219</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Vascular Endothelial Growth Factor Receptor -2 in Breast Cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Shanchun</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Colbert</surname><given-names>Laronna S.</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Fuller</surname><given-names>Miles</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Yuanyuan</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Gonzalez-Perez</surname><given-names>Ruben R.</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label> Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA 30310</aff><aff id="A2"><label>2</label> Clinical Medicine, Hematology/Oncology Section, Morehouse School of Medicine, Atlanta, GA 30310</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author: Ruben R. Gonzalez-Perez (<email>rgonzalez@msm.edu</email>), Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA 30310, Telephone: 404-752-1581</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>5</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>11</day><month>5</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>8</month><year>2011</year></pub-date><volume>1806</volume><issue>1</issue><fpage>108</fpage><lpage>121</lpage><abstract><p id="P2">Investigations over the last decade have established the essential role of growth factors and their receptors during angiogenesis and carcinogenesis. The vascular endothelial growth factor receptor (VEGFR) family in mammals contains three members, VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4), which are transmembrane tyrosine kinase receptors that regulate the formation of blood and lymphatic vessels. In the early 1990s, the above VEGFR were structurally characterized by cDNA cloning. Among these three receptors, VEGFR-2 is generally recognized to have a principal role in mediating VEGF-induced responses. VEGFR-2 is considered as the earliest marker for endothelial cell development. Importantly, VEGFR-2 directly regulates tumor angiogenesis. Therefore, several inhibitors of VEGFR-2 have been developed and many of them are now in clinical trials. In addition to targeting endothelial cells, the VEGF/VEGFR-2 system works as an essential autocrine/paracrine process for cancer cell proliferation and survival. Recent studies mark the continuous and increased interest in this related, but distinct, function of VEGF/VEGFR-2 in cancer cells: the autocrine/paracrine loop. Several mechanisms regulate VEGFR-2 levels and modulate its role in tumor angiogenesis and physiologic functions, i.e.: cellular localization/trafficking, regulation of cis-elements of promoter, epigenetic regulation and signaling from Notch, cytokines/growth factors and estrogen, etc. In this review, we will focus on updated information regarding VEGFR-2 research with respect to the molecular mechanisms of VEGFR-2 regulation in human breast cancer. Investigations in the activation, function, and regulation of VEGFR-2 in breast cancer will allow the development of new pharmacological strategies aimed at directly targeting cancer cell proliferation and survival.</p></abstract><kwd-group><kwd>VEGF</kwd><kwd>VEGFR-2</kwd><kwd>Tumor angiogenesis</kwd><kwd>Breast cancer</kwd><kwd>autocrine/paracrine loop</kwd><kwd>leptin</kwd></kwd-group><contract-num rid="CA1">SC1 CA138658-02S1
||CA</contract-num><contract-num rid="CA1">SC1 CA138658-02
||CA</contract-num><contract-num rid="CA1">SC1 CA138658-01
||CA</contract-num><contract-num rid="RR1">G12 RR003034-24S1
||RR</contract-num><contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor><contract-sponsor id="RR1">National Center for Research Resources : NCRR</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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