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<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">MINIMAL LIMB VOLUME CHANGE HAS A SIGNIFICANT IMPACT ON BREAST CANCER SURVIVORS</title>
<author>
<name sortKey="Cormier, J N" sort="Cormier, J N" uniqKey="Cormier J" first="J. N." last="Cormier">J. N. Cormier</name>
</author>
<author>
<name sortKey="Xing, Y" sort="Xing, Y" uniqKey="Xing Y" first="Y." last="Xing">Y. Xing</name>
</author>
<author>
<name sortKey="Zaniletti, I" sort="Zaniletti, I" uniqKey="Zaniletti I" first="I." last="Zaniletti">I. Zaniletti</name>
</author>
<author>
<name sortKey="Askew, R L" sort="Askew, R L" uniqKey="Askew R" first="R. L." last="Askew">R. L. Askew</name>
</author>
<author>
<name sortKey="Stewart, B R" sort="Stewart, B R" uniqKey="Stewart B" first="B. R." last="Stewart">B. R. Stewart</name>
</author>
<author>
<name sortKey="Armer, J M" sort="Armer, J M" uniqKey="Armer J" first="J. M." last="Armer">J. M. Armer</name>
</author>
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<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">20218084</idno>
<idno type="pmc">2882028</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882028</idno>
<idno type="RBID">PMC:2882028</idno>
<date when="2009">2009</date>
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<title xml:lang="en" level="a" type="main">MINIMAL LIMB VOLUME CHANGE HAS A SIGNIFICANT IMPACT ON BREAST CANCER SURVIVORS</title>
<author>
<name sortKey="Cormier, J N" sort="Cormier, J N" uniqKey="Cormier J" first="J. N." last="Cormier">J. N. Cormier</name>
</author>
<author>
<name sortKey="Xing, Y" sort="Xing, Y" uniqKey="Xing Y" first="Y." last="Xing">Y. Xing</name>
</author>
<author>
<name sortKey="Zaniletti, I" sort="Zaniletti, I" uniqKey="Zaniletti I" first="I." last="Zaniletti">I. Zaniletti</name>
</author>
<author>
<name sortKey="Askew, R L" sort="Askew, R L" uniqKey="Askew R" first="R. L." last="Askew">R. L. Askew</name>
</author>
<author>
<name sortKey="Stewart, B R" sort="Stewart, B R" uniqKey="Stewart B" first="B. R." last="Stewart">B. R. Stewart</name>
</author>
<author>
<name sortKey="Armer, J M" sort="Armer, J M" uniqKey="Armer J" first="J. M." last="Armer">J. M. Armer</name>
</author>
</analytic>
<series>
<title level="j">Lymphology</title>
<idno type="ISSN">0024-7766</idno>
<imprint>
<date when="2009">2009</date>
</imprint>
</series>
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<div type="abstract" xml:lang="en">
<p id="P1">We sought to define the incidence, risk factors, symptoms, and quality of life (QOL) outcomes associated with various degrees of postoperative limb volume change (LVC). A prospective cohort study was performed obtaining serial limb volume measurements using a perometer on 269 women undergoing surgery for breast cancer. Four groups were created based on maximum LVC: none <5.0%, mild 5.0–9.9%, moderate 10.0–14.9%, and severe 15.0%. Symptoms and QOL were assessed. 81 (30.1%), 70 (26.0%), and 14 (5.2%) women developed mild, moderate, and severe LVC, respectively. Increases in body mass index (p<0.001) and post-operative complications (p=0.002) were associated with increasing LVC. Lower QOL scores were associated with a moderate LVC (OR=3.72, 95% CI, 1.29–10.73, p=0.015) and postoperative infections (OR=5.04, 95% CI, 1.73–14.70, p=0.003). LVC at 5.0% occurs in up to 61.3% of breast cancer survivors and is associated with a significant increase in symptoms and a change in reported quality of life.</p>
</div>
</front>
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<pmc article-type="research-article" xml:lang="EN">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">0155112</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5518</journal-id>
<journal-id journal-id-type="nlm-ta">Lymphology</journal-id>
<journal-title>Lymphology</journal-title>
<issn pub-type="ppub">0024-7766</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">20218084</article-id>
<article-id pub-id-type="pmc">2882028</article-id>
<article-id pub-id-type="manuscript">NIHMS201683</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
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<title-group>
<article-title>MINIMAL LIMB VOLUME CHANGE HAS A SIGNIFICANT IMPACT ON BREAST CANCER SURVIVORS</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Cormier</surname>
<given-names>J.N.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Xing</surname>
<given-names>Y.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zaniletti</surname>
<given-names>I.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Askew</surname>
<given-names>R.L.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Stewart</surname>
<given-names>B.R.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Armer</surname>
<given-names>J.M.</given-names>
</name>
</contrib>
<aff id="A1">Department of Surgical Oncology (JNC,YX, RLA), The University of Texas M.D. Anderson Cancer Center, Houston, Texas and Ellis Fischel Cancer Center, Sinclair School of Nursing (IZ, BRS, JMA), University of Missouri, Columbia, MO, USA</aff>
</contrib-group>
<author-notes>
<corresp id="FN1">Janice N. Cormier, MD, MPH, Department of Surgical Oncology, Unit 444, The University of Texas M.D. Anderson, Cancer Center, 1400 Holcombe Boulevard, P.O. Box 301402, Houston, Texas 77230-1402, Phone: 713-792-6949, Fax: 713-745-1921,
<email>jcormier@mdanderson.org</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>4</day>
<month>5</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub">
<month>12</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>8</day>
<month>6</month>
<year>2010</year>
</pub-date>
<volume>42</volume>
<issue>4</issue>
<fpage>161</fpage>
<lpage>175</lpage>
<abstract>
<p id="P1">We sought to define the incidence, risk factors, symptoms, and quality of life (QOL) outcomes associated with various degrees of postoperative limb volume change (LVC). A prospective cohort study was performed obtaining serial limb volume measurements using a perometer on 269 women undergoing surgery for breast cancer. Four groups were created based on maximum LVC: none <5.0%, mild 5.0–9.9%, moderate 10.0–14.9%, and severe 15.0%. Symptoms and QOL were assessed. 81 (30.1%), 70 (26.0%), and 14 (5.2%) women developed mild, moderate, and severe LVC, respectively. Increases in body mass index (p<0.001) and post-operative complications (p=0.002) were associated with increasing LVC. Lower QOL scores were associated with a moderate LVC (OR=3.72, 95% CI, 1.29–10.73, p=0.015) and postoperative infections (OR=5.04, 95% CI, 1.73–14.70, p=0.003). LVC at 5.0% occurs in up to 61.3% of breast cancer survivors and is associated with a significant increase in symptoms and a change in reported quality of life.</p>
</abstract>
<kwd-group>
<kwd>lymphedema</kwd>
<kwd>quality of life</kwd>
<kwd>breast cancer</kwd>
<kwd>symptom assessment</kwd>
</kwd-group>
<contract-num rid="NR1">R01 NR005342-01A1 ||NR</contract-num>
<contract-sponsor id="NR1">National Institute of Nursing Research : NINR</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>

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