Probability risk transmission matrix as a decision tool for assessing methods of transmission interruption of Wuchereria bancrofti infection
Identifieur interne : 002718 ( Pmc/Corpus ); précédent : 002717; suivant : 002719Probability risk transmission matrix as a decision tool for assessing methods of transmission interruption of Wuchereria bancrofti infection
Auteurs : P. K. Das ; P. VanamailSource :
- Epidemiology and Infection [ 0950-2688 ] ; 2007.
Abstract
Lymphatic filariasis continues to cause severe morbidity and economic loss. The World Health Assembly (WHA) has passed a resolution to eliminate this disease by 2020. The major thrust of the elimination strategy is interrupting transmission by anti-parasitic treatment of entire communities. However, both vector density and community microfilaria load (CMFL) influence the intensity of transmission. Therefore, using a logistic regression approach a relationship has been established between the Risk of Infection Index (RII), vector density and CMFL. The present analysis indicates that there is no risk of transmission as long as the CMFL is maintained below 5 microfilaria (mf)/60 mm3 and the vector density per man-hour (MHD) is <25. However, transmission may continue when vector density is >25 and CMFL is <5 mf/60 mm3. In situations where CMFL is very high, parasitic control by mass administration may be cost effective in interrupting transmission. But at lower level of CMFL (<4 mf) and higher level of vector density it might be more cost effective to use vector control methods. A RII value <0·2 is considered to be the threshold for confirming interruption of transmission. Thus, the relationship has been depicted in the form of a probability matrix, which could be used for selecting an appropriate control strategy.
Url:
DOI: 10.1017/S0950268807008953
PubMed: 17579929
PubMed Central: 2870840
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Probability risk transmission matrix as a decision tool for assessing methods of transmission interruption of <italic>Wuchereria bancrofti</italic> infection</title><author><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P. K." last="Das">P. K. Das</name><affiliation><nlm:aff id="aff001">Vector Control Research Centre, Pondicherry, India</nlm:aff></affiliation></author><author><name sortKey="Vanamail, P" sort="Vanamail, P" uniqKey="Vanamail P" first="P." last="Vanamail">P. Vanamail</name><affiliation><nlm:aff id="aff001">Vector Control Research Centre, Pondicherry, India</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17579929</idno><idno type="pmc">2870840</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870840</idno><idno type="RBID">PMC:2870840</idno><idno type="doi">10.1017/S0950268807008953</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">002718</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002718</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Probability risk transmission matrix as a decision tool for assessing methods of transmission interruption of <italic>Wuchereria bancrofti</italic> infection</title><author><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P. K." last="Das">P. K. Das</name><affiliation><nlm:aff id="aff001">Vector Control Research Centre, Pondicherry, India</nlm:aff></affiliation></author><author><name sortKey="Vanamail, P" sort="Vanamail, P" uniqKey="Vanamail P" first="P." last="Vanamail">P. Vanamail</name><affiliation><nlm:aff id="aff001">Vector Control Research Centre, Pondicherry, India</nlm:aff></affiliation></author></analytic><series><title level="j">Epidemiology and Infection</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p>Lymphatic filariasis continues to cause severe morbidity and economic loss. The World Health Assembly (WHA) has passed a resolution to eliminate this disease by 2020. The major thrust of the elimination strategy is interrupting transmission by anti-parasitic treatment of entire communities. However, both vector density and community microfilaria load (CMFL) influence the intensity of transmission. Therefore, using a logistic regression approach a relationship has been established between the Risk of Infection Index (RII), vector density and CMFL. The present analysis indicates that there is no risk of transmission as long as the CMFL is maintained below 5 microfilaria (mf)/60 mm<sup>3</sup> and the vector density per man-hour (MHD) is <25. However, transmission may continue when vector density is >25 and CMFL is <5 mf/60 mm<sup>3</sup>. In situations where CMFL is very high, parasitic control by mass administration may be cost effective in interrupting transmission. But at lower level of CMFL (<4 mf) and higher level of vector density it might be more cost effective to use vector control methods. A RII value <0·2 is considered to be the threshold for confirming interruption of transmission. Thus, the relationship has been depicted in the form of a probability matrix, which could be used for selecting an appropriate control strategy.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Epidemiol Infect</journal-id><journal-id journal-id-type="publisher-id">HYG</journal-id><journal-title>Epidemiology and Infection</journal-title><issn pub-type="ppub">0950-2688</issn><issn pub-type="epub">1469-4409</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17579929</article-id><article-id pub-id-type="pmc">2870840</article-id><article-id pub-id-type="doi">10.1017/S0950268807008953</article-id><article-id pub-id-type="pii">S0950268807008953</article-id><article-id pub-id-type="publisher-id">00895</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Papers</subject></subj-group></article-categories><title-group><article-title>Probability risk transmission matrix as a decision tool for assessing methods of transmission interruption of <italic>Wuchereria bancrofti</italic> infection</article-title><alt-title alt-title-type="left-running">P. K. Das and P. Vanamail</alt-title><alt-title alt-title-type="right-running">Decision tool for interruption of lymphatic filariasis transmission</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>DAS</surname><given-names>P. K.</given-names></name><xref ref-type="aff" rid="aff001"></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib><contrib contrib-type="author"><name><surname>VANAMAIL</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="aff001"></xref></contrib></contrib-group><aff id="aff001">Vector Control Research Centre, Pondicherry, India</aff><author-notes><corresp id="cor001"><label>*</label>Author for correspondence: Dr P. K. Das, Vector Control Research Centre, Medical Complex, Indira Nagar, Pondicherry-605 006, India. (Email: <email xlink:href="vcrc@vsnl.com">vcrc@vsnl.com</email>)</corresp></author-notes><pub-date pub-type="ppub"><month>4</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>20</day><month>6</month><year>2007</year></pub-date><volume>136</volume><issue>4</issue><fpage>520</fpage><lpage>524</lpage><history><date date-type="accepted"><day>11</day><month>5</month><year>2007</year></date></history><copyright-statement>Cambridge University Press</copyright-statement><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="S0950268807008953a.pdf"></self-uri><abstract><title>SUMMARY</title><p>Lymphatic filariasis continues to cause severe morbidity and economic loss. The World Health Assembly (WHA) has passed a resolution to eliminate this disease by 2020. The major thrust of the elimination strategy is interrupting transmission by anti-parasitic treatment of entire communities. However, both vector density and community microfilaria load (CMFL) influence the intensity of transmission. Therefore, using a logistic regression approach a relationship has been established between the Risk of Infection Index (RII), vector density and CMFL. The present analysis indicates that there is no risk of transmission as long as the CMFL is maintained below 5 microfilaria (mf)/60 mm<sup>3</sup> and the vector density per man-hour (MHD) is <25. However, transmission may continue when vector density is >25 and CMFL is <5 mf/60 mm<sup>3</sup>. In situations where CMFL is very high, parasitic control by mass administration may be cost effective in interrupting transmission. But at lower level of CMFL (<4 mf) and higher level of vector density it might be more cost effective to use vector control methods. A RII value <0·2 is considered to be the threshold for confirming interruption of transmission. Thus, the relationship has been depicted in the form of a probability matrix, which could be used for selecting an appropriate control strategy.</p></abstract><counts><page-count count="5"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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