NONMELANOMA SKIN CANCER IN INDIA: CURRENT SCENARIO
Identifieur interne : 002658 ( Pmc/Corpus ); précédent : 002657; suivant : 002659NONMELANOMA SKIN CANCER IN INDIA: CURRENT SCENARIO
Auteurs : Saumya PandaSource :
- Indian Journal of Dermatology [ 0019-5154 ] ; 2010.
Abstract
Incidence of skin cancers has been increasing since the last few decades worldwide. Nonmelanoma skin cancer (NMSC) is the commonest variety of cutaneous malignancy. Conventional wisdom has it that the incidence of all varieties of skin cancers is lower among Indians due to the protective effects of melanin. Though national surveys and cross-country data in India are unavailable, there are indirect indications from several smaller reports that NMSCs may be on the rise in India. Reports of quite a few atypical cases lead us to hypothesize that factors other than ultraviolet radiation may be important in the occurrences of these cancers, particularly in the skin types prevalent in India. The descriptive epidemiology and clinical characteristics of squamous and basal cell carcinoma in India, including their variants, are discussed here along with hypotheses on their etiopathogenesis. Novel management techniques currently available in India are also highlighted.
Url:
DOI: 10.4103/0019-5154.74551
PubMed: 21430894
PubMed Central: 3051301
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PMC:3051301Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">NONMELANOMA SKIN CANCER IN INDIA: CURRENT SCENARIO</title><author><name sortKey="Panda, Saumya" sort="Panda, Saumya" uniqKey="Panda S" first="Saumya" last="Panda">Saumya Panda</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21430894</idno><idno type="pmc">3051301</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051301</idno><idno type="RBID">PMC:3051301</idno><idno type="doi">10.4103/0019-5154.74551</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002658</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002658</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">NONMELANOMA SKIN CANCER IN INDIA: CURRENT SCENARIO</title><author><name sortKey="Panda, Saumya" sort="Panda, Saumya" uniqKey="Panda S" first="Saumya" last="Panda">Saumya Panda</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Indian Journal of Dermatology</title><idno type="ISSN">0019-5154</idno><idno type="eISSN">1998-3611</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Incidence of skin cancers has been increasing since the last few decades worldwide. Nonmelanoma skin cancer (NMSC) is the commonest variety of cutaneous malignancy. Conventional wisdom has it that the incidence of all varieties of skin cancers is lower among Indians due to the protective effects of melanin. Though national surveys and cross-country data in India are unavailable, there are indirect indications from several smaller reports that NMSCs may be on the rise in India. Reports of quite a few atypical cases lead us to hypothesize that factors other than ultraviolet radiation may be important in the occurrences of these cancers, particularly in the skin types prevalent in India. The descriptive epidemiology and clinical characteristics of squamous and basal cell carcinoma in India, including their variants, are discussed here along with hypotheses on their etiopathogenesis. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian J Dermatol</journal-id><journal-id journal-id-type="publisher-id">IJD</journal-id><journal-title-group><journal-title>Indian Journal of Dermatology</journal-title></journal-title-group><issn pub-type="ppub">0019-5154</issn><issn pub-type="epub">1998-3611</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21430894</article-id><article-id pub-id-type="pmc">3051301</article-id><article-id pub-id-type="publisher-id">IJD-55-373</article-id><article-id pub-id-type="doi">10.4103/0019-5154.74551</article-id><article-categories><subj-group subj-group-type="heading"><subject>Current Perspective</subject></subj-group></article-categories><title-group><article-title>NONMELANOMA SKIN CANCER IN INDIA: CURRENT SCENARIO</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Panda</surname><given-names>Saumya</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1"><italic>From the Department of Dermatology, KPC Medical College, Kolkata, India</italic></aff><author-notes><corresp id="cor1"><italic><bold>Address for correspondence:</bold> Dr. Saumya Panda, 122/4, Dr Jiban Ratan Dhar Road, Kolkata 700 028, India <email xlink:href="saumyapan@gmail.com">saumyapan@gmail.com</email></italic></corresp></author-notes><pub-date pub-type="ppub"><season>Oct-Dec</season><year>2010</year></pub-date><volume>55</volume><issue>4</issue><fpage>373</fpage><lpage>378</lpage><history><date date-type="received"><month>10</month><year>2010</year></date><date date-type="accepted"><month>10</month><year>2010</year></date></history><permissions><copyright-statement>Copyright: © Indian Journal of Dermatology</copyright-statement><copyright-year>2010</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Incidence of skin cancers has been increasing since the last few decades worldwide. Nonmelanoma skin cancer (NMSC) is the commonest variety of cutaneous malignancy. Conventional wisdom has it that the incidence of all varieties of skin cancers is lower among Indians due to the protective effects of melanin. Though national surveys and cross-country data in India are unavailable, there are indirect indications from several smaller reports that NMSCs may be on the rise in India. Reports of quite a few atypical cases lead us to hypothesize that factors other than ultraviolet radiation may be important in the occurrences of these cancers, particularly in the skin types prevalent in India. The descriptive epidemiology and clinical characteristics of squamous and basal cell carcinoma in India, including their variants, are discussed here along with hypotheses on their etiopathogenesis. Novel management techniques currently available in India are also highlighted.</p></abstract><kwd-group><kwd><italic>Squamous cell carcinoma</italic></kwd><kwd><italic>basal cell carcinoma</italic></kwd><kwd><italic>nonmelanoma skin cancer</italic></kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-1"><title>Introduction</title><p>Nonmelanoma skin cancers (NMSCs) consist of, for the most part, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), if tumors of mucous membrane are excluded. These two cancers of skin are the most frequent malignant conditions worldwide.[<xref ref-type="bibr" rid="ref1">1</xref>] The largest incidence is seen in the White population. The incidence shows an inverse relation with the degree of pigmentation, presumably due to the protective effect of eumelanin on ultraviolet light (UVL)-induced damage.[<xref ref-type="bibr" rid="ref2">2</xref>] We shall review here the epidemiology, clinical presentations, etiopathogenesis, and management options of SCC, BCC and their variants, specifically in the context of India.</p><sec id="sec2-1"><title>Descriptive Epidemiology</title><p>More than one-third of all cancers in the United States are NMSCs.[<xref ref-type="bibr" rid="ref3">3</xref>] Smaller surveys suggest that the incidence may have increased by as much as 65% since 1980.[<xref ref-type="bibr" rid="ref4">4</xref>] BCCs are the commonest cutaneous tumors accounting for approximately 70% of all malignant diseases of the skin.[<xref ref-type="bibr" rid="ref5">5</xref>] The exact incidence in India is not known. But NMSC is known to be uncommon in Asians.[<xref ref-type="bibr" rid="ref6">6</xref>] Among dark-skinned individuals, SCC is commoner than BCC. Various studies from India consistently report SCC to be the most prevalent skin malignancy.[<xref ref-type="bibr" rid="ref7">7</xref>] In dark-skinned people, SCC often occurs in sites that have not been exposed to the sun and is often aggressive.[<xref ref-type="bibr" rid="ref8">8</xref>] Otherwise, exposure to sunlight is the principal cause of both BCC and SCC. The incidence of SCC increases more rapidly with age and with cumulative sun exposure than does the incidence of BCC.[<xref ref-type="bibr" rid="ref9">9</xref>] SCC in heavily pigmented skin often arises in association with scarring processes.[<xref ref-type="bibr" rid="ref10">10</xref>] The incidence of BCC appears to be increasing worldwide.[<xref ref-type="bibr" rid="ref11">11</xref>] A recent retrospective analysis presented at the American Society for Dermatologic Surgery (ASDS) 2009 Annual Meeting by A Metelitsa <italic>et al</italic> looked at nearly 100,000 patients diagnosed with NMSC and entered into the Alberta Cancer Registry between 1988 and 2007. An evaluation of the data showed an initial overall rapid increase of NMSC rates between 1988 and the mid-1990s, followed by stabilization across the genders that started in 2000. Most of the nonmelanoma cancers were in the head and neck. The study contradicted some previous findings on rising skin cancers among younger people and concluded that NMSC incidence rates were leveling off.</p></sec><sec id="sec2-2"><title>Etiopathogenesis</title><p>Both SCC and BCC arise from keratinocytes. Epidemiologic data and experimental evidence indicate that ultraviolet B (UVB) radiation (wavelength 290–320 nm) includes the most important wavelengths for the induction of skin cancer.[<xref ref-type="bibr" rid="ref12">12</xref>] Depletion of ozone in the atmosphere increases the levels of UVB radiation at the surface of the earth and the risk of skin cancer. Mathematical models suggest an increase of 2-4% in the incidence of tumors for each 1% reduction in the ozone layer, with the increase being larger for SCC than for BCC.[<xref ref-type="bibr" rid="ref13">13</xref>] Other important etiological agents include radiation therapy, arsenic, coal tar and various hydrocarbons.[<xref ref-type="bibr" rid="ref14">14</xref>] BCC is the most frequent carcinoma occurring at the region of the body to which radiotherapy is delivered.[<xref ref-type="bibr" rid="ref15">15</xref>] Human papilloma virus (HPV) may play a role in immunosuppressed patients,[<xref ref-type="bibr" rid="ref16">16</xref>] particularly in SCC. The role of HPV in BCC is controversial, with an Iranian study failing to find a significant relationship based on immunohistochemical techniques.[<xref ref-type="bibr" rid="ref17">17</xref>] Patients whose immune status is deficient, particularly organ transplant recipients, are also predisposed to develop these tumors.[<xref ref-type="bibr" rid="ref18">18</xref>] It has been estimated that renal transplant recipients have a risk of developing cutaneous SCC, which is 18 times that of the general population.[<xref ref-type="bibr" rid="ref19">19</xref>] These patients develop skin cancer earlier than the normal population.[<xref ref-type="bibr" rid="ref20">20</xref>] Patients of NMSC are at risk of having a second NMSC, either concurrently or later. In a retrospective study of 456 consecutive patients with NMSC who presented for Mohs surgery, more than 39% either had synchronous multiple NMSCs or had experienced a subsequent (metachronous) NMSC within 2 years of presentation.[<xref ref-type="bibr" rid="ref21">21</xref>]</p></sec></sec><sec id="sec1-2"><title>Clinical Aspects</title><sec id="sec2-3"><title>Squamous cell carcinoma</title><p>According to the unitarian viewpoint of Ackerman, the following conditions are morphological expressions of SCC: actinic keratosis and its analogues, arsenical and radiation keratoses, Bowen's disease and bowenoid papulosis, giant condyloma and verrucous carcinoma, keratoacanthoma, and proliferating tricholemmal cysts.[<xref ref-type="bibr" rid="ref22">22</xref>]</p><p>Most SCCs arise in areas of direct exposure to the sun.[<xref ref-type="bibr" rid="ref23">23</xref>] Non-exposed areas are occasionally affected, remarkably more often in the heavily pigmented skin.[<xref ref-type="bibr" rid="ref24">24</xref>] When the genitalia are affected, typically patients in this part of the world are very late in seeking medical attention [<xref ref-type="fig" rid="F1">Figure 1</xref>]. A case of Bowen's disease of the periareolar skin causing destruction of the nipple has been reported from North India.[<xref ref-type="bibr" rid="ref25">25</xref>] Sunlight and arsenic exposure are the usual culprits in the causation of Bowen's disease[<xref ref-type="bibr" rid="ref26">26</xref>] Keratoacanthoma has been reported to occur in the suprapubic area and presenting as verruca vulgaris-like lesions.[<xref ref-type="bibr" rid="ref27">27</xref>] Among other unusual sites, SCC of the leg has been reported in a 26-year-old female patient with Kindler syndrome.[<xref ref-type="bibr" rid="ref28">28</xref>] SCC of the nail bed, reported in the Indian literature, is not only difficult to recognize, but difficult to treat as well.[<xref ref-type="bibr" rid="ref29">29</xref>] Carcinoma cuniculatum, a low-grade SCC (verrucous carcinoma) of plantar skin, has been reported to occur on the flanks, leg, face, and palm too in a series of 12 patients.[<xref ref-type="bibr" rid="ref30">30</xref>] Kangri cancer is, of course, a well-known pattern of SCC that develops on or over erythema ab igne. It is typically seen to occur on the lower extremities and the abdominal wall following the use or exposure of kangri, an indigenous fire pot tucked in between the thighs to generate warmth during the winter months. This cancer is seen exclusively among the impoverished people of the Kashmir valley, and was reported as early as in 1879.[<xref ref-type="bibr" rid="ref31">31</xref>] These tumors have an aggressive biological behavior with a substantial risk of loco-regional metastasis in 20-50% cases.[<xref ref-type="bibr" rid="ref32">32</xref>]</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>SCC of penis with massive local tissue destruction (courtesy: Dr Aditi Chakraborty)</p></caption><graphic xlink:href="IJD-55-373-g001"></graphic></fig><p>There are uncommon reports of SCC arising from burns scar and presenting as cutaneous horn,[<xref ref-type="bibr" rid="ref33">33</xref>] SCC <italic>in situ</italic> arising in smallpox vaccination scar,[<xref ref-type="bibr" rid="ref34">34</xref>] etc. Tumors arising from scars are usually aggressive, and local recurrences are common.[<xref ref-type="bibr" rid="ref35">35</xref>] The term “Marjolin's ulcer” has been used for SCCs arising in sites of chronic injury or irritation such as scars, ulcers and sinuses, although Marjolin did not describe the condition with which he is eponymously credited.[<xref ref-type="bibr" rid="ref36">36</xref>]</p><p>In the Indian scenario, development of SCC has been associated with certain dermatological conditions where the pathogenesis is akin to the development of SCC in scars. One of these is discoid lupus erythematosus (DLE). There are numerous Indian reports of SCC developing on chronic DLE lesions despite the easy availability of topical steroids, protective sunscreens, antimalarials and growing awareness levels of patients.[<xref ref-type="bibr" rid="ref37">37</xref>–<xref ref-type="bibr" rid="ref39">39</xref>] Another such condition is lupus vulgaris (LV). Ten per cent of all long-standing cases of LV undergo malignant change, of which SCC is the commonest.[<xref ref-type="bibr" rid="ref40">40</xref>] Russian dermatologists have christened this malignant change as “lupus carcinoma”.[<xref ref-type="bibr" rid="ref41">41</xref>] There are numerous reports from various parts of India on malignant transformation of LV into SCC.[<xref ref-type="bibr" rid="ref42">42</xref><xref ref-type="bibr" rid="ref43">43</xref>]</p><p>Other uncommon occurrences of SCC on pre-existing dermatological conditions, which have been reported from India include the following: lichen planus (LP)[<xref ref-type="bibr" rid="ref44">44</xref>] including LP hypertrophicus,[<xref ref-type="bibr" rid="ref45">45</xref>] necrobiosis lipoidica diabeticorum (NLD),[<xref ref-type="bibr" rid="ref46">46</xref>] lichen simplex chronicus (LSC),[<xref ref-type="bibr" rid="ref47">47</xref>] psoriasis,[<xref ref-type="bibr" rid="ref48">48</xref>] chronic lymphedema,[<xref ref-type="bibr" rid="ref49">49</xref>] and disseminated porokeratosis.[<xref ref-type="bibr" rid="ref50">50</xref>] Various pathogenetic factors have been ascribed to the malignant transformation in these conditions, <italic>inter alia</italic>, hypoxic status of poorly vascularized cicatricial structures in NLD, chronically irritated skin of LSC, deficiency in afferent lymphatic drainage preventing early recognition of tumor-specific antigen in chronic lymphedema,[<xref ref-type="bibr" rid="ref51">51</xref>] and overexpression of p53 in the keratinocytes near the cornoid lamella in the porokeratotic lesion.[<xref ref-type="bibr" rid="ref52">52</xref>]</p><p>Other than these, eruptive keratoacanthomas have been described in Hodgkin's disease,[<xref ref-type="bibr" rid="ref53">53</xref>] verrucous carcinoma in erythema elevatum diutinum,[<xref ref-type="bibr" rid="ref54">54</xref>] and epidermodysplasia verruciformis with vulval Bowen's disease.[<xref ref-type="bibr" rid="ref55">55</xref>] SCC and its variants, viz., keratoacanthoma, are seen in increased frequency in patients with xeroderma pigmentosum.[<xref ref-type="bibr" rid="ref56">56</xref>–<xref ref-type="bibr" rid="ref58">58</xref>] Likewise, malignant progression of actinic keratoses to SCC has been reported to occur in increased frequency among albinos from India.[<xref ref-type="bibr" rid="ref59">59</xref>]</p><p>SCCs are found predominantly among older people; they are rare in adolescence and childhood.[<xref ref-type="bibr" rid="ref60">60</xref>] Clinically, they typically present as shallow ulcers, often with a keratinized crust and elevated, indurated margins.</p><p>A few atypical variants find mention in the Indian literature. Centrifugal necrotic keratoacanthoma represents the intermediate state of the spectrum where keratoacanthoma and overt SCC represent the most benign and the most malignant ends, respectively.[<xref ref-type="bibr" rid="ref61">61</xref>] A very rare variant, sarcomatoid or spindle cell SCC, was described in an atypical presentation of a painful centrofacial erythematous plaque with multiple discharging sinuses and blackish granule-like nasal discharge in a 28-year-old male from eastern India.[<xref ref-type="bibr" rid="ref62">62</xref>] Probably, this is the first case ever, and the only instance of an NMSC until now, when a primary cutaneous malignancy presented as multiple discharging sinuses [<xref ref-type="fig" rid="F2">Figure 2</xref>]. Another case of primary skin cancer, a malignant melanoma, has been reported to present as multiple discharging sinuses, that too from India.[<xref ref-type="bibr" rid="ref63">63</xref>] Other rare variants of SCC are the adenoid, pseudovascular, clear cell, “signet ring”, pigmented, inflammatory, basaloid, infiltrative, desmoplastic and rhabdoid types.</p><fig id="F2" position="float"><label>Figure 2</label><caption><p>Erythematous plaque with indistinct margination on the left cheek encroaching upon the left nose with multiple sinuses and the blackish granule-like discharge from the left nostril containing purulent necrotic debris in a case of spindle-cell SCC</p></caption><graphic xlink:href="IJD-55-373-g002"></graphic></fig></sec><sec id="sec2-4"><title>Basal cell carcinoma</title><p>BCCs are found predominantly on areas of skin exposed to the sun.[<xref ref-type="bibr" rid="ref64">64</xref>] They are rarer in dark-skinned individuals.[<xref ref-type="bibr" rid="ref65">65</xref>] Up to 80% of all lesions are found on the head and neck, whereas approximately 15% develop on the shoulders, back or chest.[<xref ref-type="bibr" rid="ref66">66</xref>] There are isolated reports documenting involvement of the lower extremities,[<xref ref-type="bibr" rid="ref67">67</xref>] the clitoris and the vulva,[<xref ref-type="bibr" rid="ref68">68</xref>] perianal region,[<xref ref-type="bibr" rid="ref69">69</xref>] etc. Rare instances of BCC developing in verrucous epidermal nevus,[<xref ref-type="bibr" rid="ref70">70</xref>] and coexisting with multiple trichoepithelioma[<xref ref-type="bibr" rid="ref71">71</xref>] have been reported from India. Multiple BCCs may develop in the nevoid basal cell epithelioma (Gorlin's) syndrome.[<xref ref-type="bibr" rid="ref72">72</xref>] Gorlin's syndrome presents with characteristic facies, pitting of palms and soles, and radiological evidence of osseous abnormalities, including fusion of ribs and vertebrae, lytic lesions of the mandible, and calcification of the falx cerebri.[<xref ref-type="bibr" rid="ref73">73</xref>] A unique case has been described from eastern India in a 74-year-old man where BCC occurred in a two-decade old lesion of LP.[<xref ref-type="bibr" rid="ref74">74</xref>] This case possibly represents the first ever of LP transforming into BCC.</p><p>BCCs are more common in males, presumably due to greater occupational and recreational exposure to UV light. An Indian series reported an unusual female preponderance.[<xref ref-type="bibr" rid="ref75">75</xref>] They tend to occur in older people, although they have also been documented in children and young adults.[<xref ref-type="bibr" rid="ref76">76</xref>]</p><p>The clinical presentation of BCC can be quite variable. It may be a papulonodular lesion with a pearly translucent edge, an ulcerated destructive lesion (rodent ulcer), a pale plaque with variable induration, an erythematous plaque with visible telangiectasia, or a partly cystic nodule.[<xref ref-type="bibr" rid="ref77">77</xref>] Cutaneous horn overlying a nodulo-ulcerative lesion of BCC has been described.[<xref ref-type="bibr" rid="ref78">78</xref>] Variants with mutilation of the face have also been documented.[<xref ref-type="bibr" rid="ref79">79</xref>]</p><p>Although most BCCs are slow-growing, relatively non-aggressive tumors, a minority have an aggressive behavior with local tissue destruction and rarely, metastasis.[<xref ref-type="bibr" rid="ref80">80</xref>] Thus, there are rare instances of BCC eroding into the eye.[<xref ref-type="bibr" rid="ref81">81</xref>] Metastatic BCC has a reported incidence of only 0.0028-0.5%.[<xref ref-type="bibr" rid="ref82">82</xref>]</p><p>There is considerable variability in the morphology of the BCCs, and as a consequence, a number of histopathological subtypes have been defined. BCCs are composed of islands or nests of basaloid cells, with palisading of the cells at the periphery and a haphazard arrangement of those in the centers of the islands. The vast majority of cases show some connection to the undersurface of the epidermis [<xref ref-type="fig" rid="F3">Figure 3</xref>]. Islands of tumor cells are surrounded by a stroma, which is newly formed and different from the adjacent dermis. A variable inflammatory infiltrate is usually present. The morphological subtypes include solid (nodular), micronodular, cystic, superficial, multifocal, pigmented, adenoid, infiltrating, sclerosing, keratotic, infundibulocystic, metatypical, basosquamous,[<xref ref-type="bibr" rid="ref83">83</xref>] and fibroepitheliomatous.[<xref ref-type="bibr" rid="ref84">84</xref>] Mixed patterns are quite common,[<xref ref-type="bibr" rid="ref85">85</xref>] and have been reported from India.[<xref ref-type="bibr" rid="ref86">86</xref>]</p><fig id="F3" position="float"><label>Figure 3</label><caption><p>Lobules of basaloid cells, stromal separation, connection of tumor lobule with the undersurface of the basal layer of the epidermis (shown with an arrow), foci of melanin incontinence (hematoxylin and eosin stain, magnification ×400)</p></caption><graphic xlink:href="IJD-55-373-g003"></graphic></fig></sec></sec><sec id="sec1-3"><title>Management Issues</title><p>The lynchpin of management of NMSCs is surgical extirpation of various kinds. This includes non-excisional ablative techniques, conventional surgical excision, and Mohs micrographic surgery. Regardless of the surgical modality, recurrence is a frequent cause of concern. In a classic study, Rowe <italic>et al</italic>. reviewed all major series of SCC dating back to determine risk factors associated with recurrence and metastasis.[<xref ref-type="bibr" rid="ref87">87</xref>] The characteristics of “high risk” lesions are diameter greater than 2 cm; depth greater than 4 mm and Clark level IV or V; tumor involvement of bone, muscle and nerve; location on ear and lip; tumor arising in scar; poor differentiation (Broders grade 3 or 4); immunosuppression of patient; and absence of inflammatory infiltrate. Curettage and desiccation is one of the most frequently used surgical modalities for BCC.[<xref ref-type="bibr" rid="ref88">88</xref>] Cryotherapy is another destructive modality used in BCC, which has been successful in difficult sites like the eyelid.[<xref ref-type="bibr" rid="ref89">89</xref>]</p><p>Among topical therapies, imiquimod 5%, a novel immune modifier, capable of inducing local production of cytokines, has been used successfully in a number of NMSCs, including Bowen's disease[<xref ref-type="bibr" rid="ref90">90</xref><xref ref-type="bibr" rid="ref91">91</xref>] and BCC.[<xref ref-type="bibr" rid="ref92">92</xref>] 5-fluorouracil has been used in the treatment of actinic keratoses as well as BCCs. Topical tazarotene gel (0.05%) has been reported to successfully treat Bowenoid papulosis of the genitalia.[<xref ref-type="bibr" rid="ref93">93</xref>]</p><p>Among physical therapies, photodynamic therapy (PDT) and radiation have been found to be effective. PDT with exogenous δ-aminolevulonic acid increases intracellular production of the endogenous photosensitizer protoporphyrin type IX which preferentially accumulates in tumor cells of BCCs, producing activated oxygen species that destroy the constituent cancer cells.[<xref ref-type="bibr" rid="ref94">94</xref>] Radiation is a useful adjuvant to excisional surgery in NMSCs. X-ray therapy may be useful in cases of primary BCC. Recently, a cohort of NMSC patients were reported to be successfully managed with plesiotherapy using stepping stone <sup>192</sup>Ir HDR source.[<xref ref-type="bibr" rid="ref95">95</xref>]</p></sec><sec sec-type="conclusion" id="sec1-4"><title>Conclusions</title><p>NMSC occupies a smaller space in the perception of clinical dermatologists in India than perhaps is its due, mainly because of the supposedly protective effects of eumelanin in the brown skin of the Indian population. As we have seen in this review, not an inconsiderable body of work exists in the Indian literature, which is a testimony to a large variety of cases of NMSC occurring in this country. Many atypical forms of NMSC are seen in our clinical setting, ranging from the archetypal Kangri cancer in Kashmir to unique entities like a sarcomatoid SCC presenting as multiple discharging sinuses (till now possibly the only case of primary NMSC to be reported to present in such a fashion), and a case of LP transforming into BCC, the first such instance of probable malignant transformation of LP into BCC to be reported in the world literature. SCC is predominant in the Indian population rather than the BCC; this is an epidemiological characteristic that sets us apart from the global trend. The Indian clinicians, within the limited parameters set by infrastructural and logistic constraints, have also carried out significant research in management of NMSCs, particularly in the areas of topical therapy and radiation.</p></sec></body><back><fn-group><fn fn-type="supported-by"><p><bold>Source of Support:</bold> Nil</p></fn><fn fn-type="conflict"><p><bold>Conflict of Interest:</bold> Nil.</p></fn></fn-group><ref-list><title>References</title><ref id="ref1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Preston</surname><given-names>DS</given-names></name><name><surname>Stern</surname><given-names>RS</given-names></name></person-group><article-title>Nonmelanoma cancers of the skin</article-title><source>N Engl J Med</source><year>1992</year><volume>327</volume><fpage>1649</fpage><lpage>62</lpage><pub-id pub-id-type="pmid">1435901</pub-id></element-citation></ref><ref 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