Diagnostic dilemma; report of a bizarre case of advanced scalp and face angiosarcoma and literature review
Identifieur interne : 002282 ( Pmc/Corpus ); précédent : 002281; suivant : 002283Diagnostic dilemma; report of a bizarre case of advanced scalp and face angiosarcoma and literature review
Auteurs : Jude-Kennedy C. Emejulu ; Igwebuike V. Onyiaorah ; Cornelius O. Ukah ; Titus Og Chukwuanukwu ; Nneka Jf Osuigwe ; Effiong E. Akang ; Adefolarin O. MalomoSource :
- International Medical Case Reports Journal [ 1179-142X ] ; 2011.
Abstract
A 36-year-old male painter presented to our service in 2007 with an ulcerated solitary scalp swelling of 8 months’ duration. The mass was a dormant, painless, pea-sized growth, which he had had since childhood and which he bruised in a passenger motorcycle road traffic accident 8 months prior to presentation. The accident caused it to flare up and progressively increase in size, with associated pain, contact bleeding, and ulceration. A work-up for excision biopsy was proposed, but the patient defaulted and presented 2 years later with an increased number of lesions all around the scalp and face and in an obviously deteriorating clinical status with regional lymph node involvement at this stage. An incisional biopsy was then carried out and the histological reports came out with three different diagnoses of glioblastoma multiforme, poorly differentiated angiosarcoma, and squamous cell carcinoma, constituting a major diagnostic dilemma for our service.
Url:
DOI: 10.2147/IMCRJ.S24975
PubMed: 23754910
PubMed Central: 3658242
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnostic dilemma; report of a bizarre case of advanced scalp and face angiosarcoma and literature review</title><author><name sortKey="Emejulu, Jude Kennedy C" sort="Emejulu, Jude Kennedy C" uniqKey="Emejulu J" first="Jude-Kennedy C" last="Emejulu">Jude-Kennedy C. Emejulu</name><affiliation><nlm:aff id="af1-imcrj-4-073">Neurosurgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Onyiaorah, Igwebuike V" sort="Onyiaorah, Igwebuike V" uniqKey="Onyiaorah I" first="Igwebuike V" last="Onyiaorah">Igwebuike V. Onyiaorah</name><affiliation><nlm:aff id="af2-imcrj-4-073">Department of Pathology, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Ukah, Cornelius O" sort="Ukah, Cornelius O" uniqKey="Ukah C" first="Cornelius O" last="Ukah">Cornelius O. Ukah</name><affiliation><nlm:aff id="af2-imcrj-4-073">Department of Pathology, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Chukwuanukwu, Titus Og" sort="Chukwuanukwu, Titus Og" uniqKey="Chukwuanukwu T" first="Titus Og" last="Chukwuanukwu">Titus Og Chukwuanukwu</name><affiliation><nlm:aff id="af3-imcrj-4-073">Plastic Surgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Osuigwe, Nneka Jf" sort="Osuigwe, Nneka Jf" uniqKey="Osuigwe N" first="Nneka Jf" last="Osuigwe">Nneka Jf Osuigwe</name><affiliation><nlm:aff id="af1-imcrj-4-073">Neurosurgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Akang, Effiong E" sort="Akang, Effiong E" uniqKey="Akang E" first="Effiong E" last="Akang">Effiong E. Akang</name><affiliation><nlm:aff id="af4-imcrj-4-073">Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Malomo, Adefolarin O" sort="Malomo, Adefolarin O" uniqKey="Malomo A" first="Adefolarin O" last="Malomo">Adefolarin O. Malomo</name><affiliation><nlm:aff id="af5-imcrj-4-073">Department of Neurological Surgery, Institute of Neurological Sciences, University College Hospital, Ibadan, Oyo State, Nigeria</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23754910</idno><idno type="pmc">3658242</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658242</idno><idno type="RBID">PMC:3658242</idno><idno type="doi">10.2147/IMCRJ.S24975</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002282</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002282</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diagnostic dilemma; report of a bizarre case of advanced scalp and face angiosarcoma and literature review</title><author><name sortKey="Emejulu, Jude Kennedy C" sort="Emejulu, Jude Kennedy C" uniqKey="Emejulu J" first="Jude-Kennedy C" last="Emejulu">Jude-Kennedy C. Emejulu</name><affiliation><nlm:aff id="af1-imcrj-4-073">Neurosurgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Onyiaorah, Igwebuike V" sort="Onyiaorah, Igwebuike V" uniqKey="Onyiaorah I" first="Igwebuike V" last="Onyiaorah">Igwebuike V. Onyiaorah</name><affiliation><nlm:aff id="af2-imcrj-4-073">Department of Pathology, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Ukah, Cornelius O" sort="Ukah, Cornelius O" uniqKey="Ukah C" first="Cornelius O" last="Ukah">Cornelius O. Ukah</name><affiliation><nlm:aff id="af2-imcrj-4-073">Department of Pathology, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Chukwuanukwu, Titus Og" sort="Chukwuanukwu, Titus Og" uniqKey="Chukwuanukwu T" first="Titus Og" last="Chukwuanukwu">Titus Og Chukwuanukwu</name><affiliation><nlm:aff id="af3-imcrj-4-073">Plastic Surgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Osuigwe, Nneka Jf" sort="Osuigwe, Nneka Jf" uniqKey="Osuigwe N" first="Nneka Jf" last="Osuigwe">Nneka Jf Osuigwe</name><affiliation><nlm:aff id="af1-imcrj-4-073">Neurosurgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Akang, Effiong E" sort="Akang, Effiong E" uniqKey="Akang E" first="Effiong E" last="Akang">Effiong E. Akang</name><affiliation><nlm:aff id="af4-imcrj-4-073">Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Malomo, Adefolarin O" sort="Malomo, Adefolarin O" uniqKey="Malomo A" first="Adefolarin O" last="Malomo">Adefolarin O. Malomo</name><affiliation><nlm:aff id="af5-imcrj-4-073">Department of Neurological Surgery, Institute of Neurological Sciences, University College Hospital, Ibadan, Oyo State, Nigeria</nlm:aff></affiliation></author></analytic><series><title level="j">International Medical Case Reports Journal</title><idno type="eISSN">1179-142X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A 36-year-old male painter presented to our service in 2007 with an ulcerated solitary scalp swelling of 8 months’ duration. The mass was a dormant, painless, pea-sized growth, which he had had since childhood and which he bruised in a passenger motorcycle road traffic accident 8 months prior to presentation. The accident caused it to flare up and progressively increase in size, with associated pain, contact bleeding, and ulceration. A work-up for excision biopsy was proposed, but the patient defaulted and presented 2 years later with an increased number of lesions all around the scalp and face and in an obviously deteriorating clinical status with regional lymph node involvement at this stage. An incisional biopsy was then carried out and the histological reports came out with three different diagnoses of glioblastoma multiforme, poorly differentiated angiosarcoma, and squamous cell carcinoma, constituting a major diagnostic dilemma for our service.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sondak, Vk" uniqKey="Sondak V">VK Sondak</name></author><author><name sortKey="Pawlik, Tm" uniqKey="Pawlik T">TM Pawlik</name></author><author><name sortKey="Rees, Sr" uniqKey="Rees S">SR Rees</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Aust, Mr" uniqKey="Aust M">MR Aust</name></author><author><name sortKey="Olsen, Kd" uniqKey="Olsen K">KD Olsen</name></author><author><name sortKey="Lewis, Je" uniqKey="Lewis J">JE Lewis</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tamiya, Yt" uniqKey="Tamiya Y">YT 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int Med Case Rep J</journal-id><journal-id journal-id-type="iso-abbrev">Int Med Case Rep J</journal-id><journal-title-group><journal-title>International Medical Case Reports Journal</journal-title></journal-title-group><issn pub-type="epub">1179-142X</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23754910</article-id><article-id pub-id-type="pmc">3658242</article-id><article-id pub-id-type="doi">10.2147/IMCRJ.S24975</article-id><article-id pub-id-type="publisher-id">imcrj-4-073</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Diagnostic dilemma; report of a bizarre case of advanced scalp and face angiosarcoma and literature review</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Emejulu</surname><given-names>Jude-Kennedy C</given-names></name><xref ref-type="aff" rid="af1-imcrj-4-073">1</xref><xref ref-type="corresp" rid="c1-imcrj-4-073"></xref></contrib><contrib contrib-type="author"><name><surname>Onyiaorah</surname><given-names>Igwebuike V</given-names></name><xref ref-type="aff" rid="af2-imcrj-4-073">2</xref></contrib><contrib contrib-type="author"><name><surname>Ukah</surname><given-names>Cornelius O</given-names></name><xref ref-type="aff" rid="af2-imcrj-4-073">2</xref></contrib><contrib contrib-type="author"><name><surname>Chukwuanukwu</surname><given-names>Titus OG</given-names></name><xref ref-type="aff" rid="af3-imcrj-4-073">3</xref></contrib><contrib contrib-type="author"><name><surname>Osuigwe</surname><given-names>Nneka JF</given-names></name><xref ref-type="aff" rid="af1-imcrj-4-073">1</xref></contrib><contrib contrib-type="author"><name><surname>Akang</surname><given-names>Effiong E</given-names></name><xref ref-type="aff" rid="af4-imcrj-4-073">4</xref></contrib><contrib contrib-type="author"><name><surname>Malomo</surname><given-names>Adefolarin O</given-names></name><xref ref-type="aff" rid="af5-imcrj-4-073">5</xref></contrib></contrib-group><aff id="af1-imcrj-4-073"><label>1</label>Neurosurgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</aff><aff id="af2-imcrj-4-073"><label>2</label>Department of Pathology, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</aff><aff id="af3-imcrj-4-073"><label>3</label>Plastic Surgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria</aff><aff id="af4-imcrj-4-073"><label>4</label>Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria</aff><aff id="af5-imcrj-4-073"><label>5</label>Department of Neurological Surgery, Institute of Neurological Sciences, University College Hospital, Ibadan, Oyo State, Nigeria</aff><author-notes><corresp id="c1-imcrj-4-073">Correspondence: Jude-Kennedy C Emejulu, Neurosurgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025, Nnewi, Anambra State, Nigeria, Tel +234 803 328 3976, Email <email>judekenny2003@yahoo.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>07</day><month>11</month><year>2011</year></pub-date><volume>4</volume><fpage>73</fpage><lpage>77</lpage><permissions><copyright-statement>© 2011 Emejulu et al, publisher and licensee Dove Medical Press Ltd.</copyright-statement><copyright-year>2011</copyright-year><license><license-p>This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.</license-p></license></permissions><abstract><p>A 36-year-old male painter presented to our service in 2007 with an ulcerated solitary scalp swelling of 8 months’ duration. The mass was a dormant, painless, pea-sized growth, which he had had since childhood and which he bruised in a passenger motorcycle road traffic accident 8 months prior to presentation. The accident caused it to flare up and progressively increase in size, with associated pain, contact bleeding, and ulceration. A work-up for excision biopsy was proposed, but the patient defaulted and presented 2 years later with an increased number of lesions all around the scalp and face and in an obviously deteriorating clinical status with regional lymph node involvement at this stage. An incisional biopsy was then carried out and the histological reports came out with three different diagnoses of glioblastoma multiforme, poorly differentiated angiosarcoma, and squamous cell carcinoma, constituting a major diagnostic dilemma for our service.</p></abstract><kwd-group><kwd>angiosarcoma</kwd><kwd>glioblastoma multiforme</kwd><kwd>head</kwd><kwd>neck</kwd><kwd>squamous cell carcinoma</kwd></kwd-group></article-meta></front><body><sec><title>Introduction</title><p>Angiosarcomas of the face and scalp are very rare, insidious in onset, and primarily affect older persons. Their clinical manifestations vary widely and in early stages they frequently appear to be clinically innocent.<xref ref-type="bibr" rid="b1-imcrj-4-073">1</xref> The lesions may be single or multifocal; bluish or violaceous; nodules, plaques, or flat infiltrating areas; and occasionally bleed or ulcerate. Most early lesions begin as ill-defined bruise-like areas with an indurated border, but more advanced lesions can be elevated, nodular, or occasionally ulcerated.<xref ref-type="bibr" rid="b1-imcrj-4-073">1</xref> Histological diagnosis may be confusing, as they may resemble melanomas or carcinomas.</p><p>We present a case of advanced angiosarcoma of the face and scalp in a relatively young man, the first and only such case in our 6-year-old Neurosurgery Unit. The lesion presented initially as a discrete, benign-looking nodule that was neglected for 2 years until it spread widely, resulting in multiple scalp and facial lesions and posing a major histological diagnostic dilemma in our hospital. There is no publication that we could find on this rare lesion in Nigeria, so we report probably the first case of advanced angiosarcoma of the scalp and face.</p></sec><sec><title>Case report</title><p>A 36-year-old male painter presented to our service in 2007 with an ulcerated solitary scalp swelling of 8 months’ duration. The mass was a dormant, painless, pea-sized growth, which he had had since childhood but which he bruised in a passenger motorcycle road traffic accident 8 months prior to presentation. The accident caused it to flare up and progressively increase in size, with associated pain, contact bleeding, and ulceration. There were no neurological symptoms, previous surgeries, blood transfusion, or positive family history of a similar lesion.</p><p>On clinical examination, the patient was otherwise healthy looking, fully conscious, and alert, with no neurological deficits or regional lymph node enlargement. There was a discrete, firm right frontal scalp mass, which was slightly pulsatile and moderately tender, with purulent discharge and heaped up edges but not attached to underlying bone. Other systems were clinically normal. The clinical diagnosis we made was that of a possible soft-tissue sarcoma or hamartoma.</p><p>We proposed a work-up for excision biopsy, but the patient defaulted on follow-up and the biopsy was not carried out. He presented 2 years later with an increased number of lesions all around the scalp and face and in an obviously deteriorating clinical status marked by pallor; significant weight loss; and foul-smelling, purulent, and slough-filled lesions with tender indurated bases. The regional lymph nodes had become infiltrated by this time, and a clinical diagnosis of advanced soft-tissue sarcoma was made at this stage. The lesions followed a longitudinal, vascular, or neural disposition round the face, appearing to encircle it (see <xref ref-type="fig" rid="f1-imcrj-4-073">Figure 1</xref>).</p><p>Hematological profile, electrolytes/urea/creatinine, and plasma glucose were normal, HIV screening was nonreactive, and enhanced cranial computed tomography showed isodense extracranial soft-tissue masses with homogenous contrast enhancement but no intracranial lesion or bony involvement. An incisional biopsy was then done at this time, harvesting four wedge specimens from representative parts of the lesions, including the edges of the ulcers and nearby normal-looking skin. The masses were briskly and intensely hemorrhagic on incision.</p><p>The first histology report diagnosed glioblastoma multiforme (GBM), but we had our doubts and needed a reconfirmation. The second report diagnosed poorly differentiated angiosarcoma. In seeking to resolve the dilemma, we sent a third specimen to another facility with a neuropathologist. The last report stated the tumour consisted of polygonal cells with abundant eosinophilic cytoplasm, focal dyskeratosis, acantholysis, and surface keratinization. Cells were positive for epithelial markers (AE1/AE3) and negative for vascular markers (CD31 and CD34). Morphologically, the tumor was not a glioblastoma and the report diagnosed squamous cell carcinoma (see <xref ref-type="fig" rid="f2-imcrj-4-073">Figure 2</xref>).</p><p>While awaiting the neuropathologist’s report, the patient was serially transfused with blood due to persistent anemia. However, he progressively deteriorated and finally died in April 2010, about 3 years after his first presentation to our service.</p></sec><sec sec-type="discussion"><title>Discussion</title><p>After several brainstorming sessions and a clinical conference, we finally agreed that the overwhelming evidence in this very confusing case weighed in favor of angiosarcoma and not GBM or squamous cell carcinoma.</p><p>Angiosarcomas are rare vascular tumors, but in the few cases where they present, the majority are in the skin and especially in the head and neck, a region where sarcomas constitute barely 1% of malignancies.<xref ref-type="bibr" rid="b2-imcrj-4-073">2</xref> The cells manifest many of the morphologic and functional properties of normal epithelium and vary from highly differentiated tumors to those with significant anaplasia, often making these tumors difficult to differentiate from melanomas or carcinomas.<xref ref-type="bibr" rid="b3-imcrj-4-073">3</xref></p><p>Aust et al<xref ref-type="bibr" rid="b3-imcrj-4-073">3</xref> reported less than 5% of soft tumor sarcomas occurring in the head and neck, with only approximately 10% being angiosarcomas. Being the only such case in our service in a period of 6 years, our experience appears to support the rarity of this malignancy. By contrast, squamous cell carcinomas are the second most common carcinoma of the skin, after basal cell carcinoma, constituting about 90% of all head and neck malignancies.<xref ref-type="bibr" rid="b4-imcrj-4-073">4</xref></p><p>Even though GBM is the most frequent primary brain tumor, accounting for approximately 12%–15% of all intracranial neoplasms and 50%–60% of all astrocytic tumors, the extracranial metastasis of GBM is rare and is usually observed after the tumor has infiltrated the dural veins, the cranium, or the extracranial soft tissue or, more frequently, after tumor debulking surgery for a recurrent tumor.<xref ref-type="bibr" rid="b5-imcrj-4-073">5</xref></p><p>There are only a few case reports of extracranial metastasis of primary GBM to various organs such as the spleen, skin, heart, bone, cervical lymph nodes, and lung.<xref ref-type="bibr" rid="b6-imcrj-4-073">6</xref>–<xref ref-type="bibr" rid="b14-imcrj-4-073">14</xref> In all these cases the metastases occurred after resection of the primary intracranial tumor with an average time interval of 10 months. Only one case of a spontaneous metastasis of primary GBM to lungs is reported.<xref ref-type="bibr" rid="b13-imcrj-4-073">13</xref></p><p>The diagnosis in most of these cases was based on biopsy and immunophenotyping with glial fibrillary acidic protein (GFAP). This is suggestive of the fact that most, if not all, cases of extracranial glioblastoma are sequel to an intracranial type. Our patient had no intracranial tumor. His lesion might be least likely to have an extracranial GBM.</p><p>Unlike most soft-tissue sarcomas that are located deeply, angiosarcomas have a predilection for skin and superficial soft tissue, just like squamous cell carcinoma. Even though they are usually found on the scalps of elderly people, Aust et al<xref ref-type="bibr" rid="b3-imcrj-4-073">3</xref> reported an age range of 18–91 years in a series of 24 patients treated in the Mayo Clinic, Rochester, MN over an 18-year period, 1974–1992.</p><p>On the other hand, the incidence of squamous cell carcinoma varies with age, gender, race, geography, and genetics, unlike the case with an angiosarcoma, though it is thought to definitely rise with age, and the peak incidence is usually around 66 years of age.<xref ref-type="bibr" rid="b15-imcrj-4-073">15</xref>,<xref ref-type="bibr" rid="b16-imcrj-4-073">16</xref></p><p>Etiologically, chronic lymphedema is the most widely recognized predisposing factor for angiosarcomas of the skin and soft tissue, but, according to Weiss and Goldblum,<xref ref-type="bibr" rid="b17-imcrj-4-073">17</xref> only approximately 10% of tumors are associated with lymphedema. Also, Sondak et al<xref ref-type="bibr" rid="b1-imcrj-4-073">1</xref> contend that lymph stasis is probably not involved significantly in angiosarcoma of the scalp.</p><p>Several associations have been reported for scalp angiosarcoma, the most frequent being prior radiation for either a malignant or benign condition, whereas others include trauma and ultraviolet light exposure to the hairless parts of the head and neck.<xref ref-type="bibr" rid="b18-imcrj-4-073">18</xref> Holden et al<xref ref-type="bibr" rid="b19-imcrj-4-073">19</xref> have, however, questioned the assertion of sun exposure as a tumorigenic agent, because many patients who develop angiosarcomas are women with a full head of hair.</p><p>In our case, the absence of lymphedema correlated with the observations of Weiss and Goldblum and others, and, interestingly, trauma seemed be the reason the lesion became noticed by our patient and probably played a definite role. The pea-size nodule had been dormant for nearly 25 years until the motorcycle accident bruised the nodule. Could it be possible that trauma caused the rapid progression of a malignant disease or that it induced the malignant transformation of a benign lesion?</p><p>With squamous cell carcinoma, chronic sun exposure is known to be the strongest environmental risk factor, though lesions of the head and neck are most commonly associated with the use of alcohol and tobacco, as well.<xref ref-type="bibr" rid="b20-imcrj-4-073">20</xref> The results of one study actually confirmed that tobacco and alcohol use are the main risk factors for the development of head and neck squamous cell carcinoma and affect overall patient survival.<xref ref-type="bibr" rid="b21-imcrj-4-073">21</xref> None of these is strongly implicated in angiosarcoma.</p><p>Correlating strongly with our case, angiosarcoma of the face and scalp is insidious in onset and in the early stages appears to be clinically innocent. It may be single or multifocal; be bluish or violaceous; have nodules, plaques, or flat infiltrating areas; and occasionally may bleed or ulcerate, according to Sondak et al.<xref ref-type="bibr" rid="b1-imcrj-4-073">1</xref> Most early lesions begin as ill-defined bruise-like areas with an indurated border, but the more advanced lesions can be elevated, nodular, or occasionally ulcerated with ill-defined hemorrhagic areas. This morphologic evolution was classic in our case.</p><p>In squamous cell carcinoma, the clinical appearance is highly variable. Usually, the tumor presents as an ulcerated lesion with hard, raised edges, and it may be in the form of a hard plaque or a papule, often with an opalescent quality, with tiny blood vessels. The tumor could lie below the level of the surrounding skin and eventually ulcerate and invade the underlying tissue.<xref ref-type="bibr" rid="b20-imcrj-4-073">20</xref></p><p>Microscopically, angiosarcomas often show extensive involvement of the dermis, with poorly differentiated tumors also invading deep structures such as fascia and subcutis. Their histopathologic features are diverse, with three histologic patterns viz. vascular channels, sheets of cells, and cells of undifferentiated morphologic features, although in some lesions more than one pattern may be present.<xref ref-type="bibr" rid="b1-imcrj-4-073">1</xref></p><p>It should be noted, nonetheless, that low-grade tumors are well-differentiated lesions that retain some of the functional and morphologic properties of normal vascular endothelium, but the poorly differentiated (high-grade) tumors show sheets of pleomorphic cells that may resemble a carcinoma. In other words, the absence of normal vascular epithelium does not exclude the possibility of angiosarcoma, especially in poorly differentiated cases. This may have explained the deft exclusion of angiosarcoma by the third pathology report in our case, while opting instead for squamous cell carcinoma. <xref ref-type="bibr" rid="b1-imcrj-4-073">1</xref> However, it was very likely that what we had was more in keeping with the second histologic diagnosis of a poorly differentiated angiosarcoma.</p><p>Cytologically, the smears of GBM show large, spindle to oval, hyperchromatic and pleomorphic nuclei. A fibrillary or necrotic background is also noticed in some of these tumor cells of GBM and may be recognizable as astrocytic.<xref ref-type="bibr" rid="b22-imcrj-4-073">22</xref> But due to the marked pleomorphism of cohesive groups of tumor cells with frequent mitoses, the recognition of GBM from other poorly differentiated tumors may be quite challenging, supporting the first pathological diagnosis in our case.</p><p>The tumor cells of GBM are immunoreactive for GFAP and vimentin.<xref ref-type="bibr" rid="b23-imcrj-4-073">23</xref> Vimentin immunoreactivity is nondiagnostic due to the significant overlap with other lesions in the differential diagnosis of poorly differentiated tumors.</p><p>Gliosarcoma is another rare subtype of GBM and shows a characteristic biphasic appearance, consisting of a GBM component admixed with sarcomatous elements. This probably did not complicate this case under discussion.<xref ref-type="bibr" rid="b24-imcrj-4-073">24</xref>,<xref ref-type="bibr" rid="b25-imcrj-4-073">25</xref></p><p>In summary, therefore, our case presented initially as a clinically benign lesion that exacerbated after trauma and rapidly extended locally over the face and scalp, showing largely undifferentiated histologic features, before ultimately leading to death within 3 years of onset.</p></sec><sec><title>Conclusion</title><p>With the correlations in the evolution of the lesion, its macroscopic and microscopic characteristics, progression, and outcome, we concluded that ours was a case of advanced poorly differentiated angiosarcoma of the scalp that extended to the face, which was supported by the second histology report. It was less likely to be a GBM or squamous cell carcinoma because, to a great extent, the features of the lesion did not correlate with these two.</p><p>The disease followed the natural history of angiosarcoma, so we are reporting this case in order to add this confusing experience to the body of knowledge that is already available on this rare disease of poor prognosis, especially with the bizarre images it presented. Ours is possibly the first such case to be reported from Nigeria.</p></sec></body><back><fn-group><fn id="fn1-imcrj-4-073"><p><bold>Disclosure</bold></p><p>The authors have no conflict of interests in this publication.</p></fn></fn-group><ref-list><title>References</title><ref id="b1-imcrj-4-073"><label>1</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Sondak</surname><given-names>VK</given-names></name><name><surname>Pawlik</surname><given-names>TM</given-names></name><name><surname>Rees</surname><given-names>SR</given-names></name><etal></etal></person-group><source>Skin: angiosarcoma of the scalp</source><publisher-name>eMedicine</publisher-name><year>2008</year><comment>Available at: <ext-link ext-link-type="uri" xlink:href="http://emedicine.medscape.com/article/1296442-overview">http://emedicine.medscape.com/article/1296442-overview</ext-link></comment><date-in-citation>Accessed September 21, 2011.</date-in-citation></element-citation></ref><ref id="b2-imcrj-4-073"><label>2</label><element-citation publication-type="webpage"><collab>Medscape’s Skin Cancer Resource Center</collab><comment><ext-link ext-link-type="uri" xlink:href="http://www.medscape.com/resource/skincancer">http://www.medscape.com/resource/skincancer</ext-link></comment></element-citation></ref><ref id="b3-imcrj-4-073"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aust</surname><given-names>MR</given-names></name><name><surname>Olsen</surname><given-names>KD</given-names></name><name><surname>Lewis</surname><given-names>JE</given-names></name><etal></etal></person-group><article-title>Angiosarcomas of the head and neck: clinical and pathologic characteristics</article-title><source>Ann Otol Rhinol Laryngol</source><year>1997</year><volume>106</volume><fpage>943</fpage><lpage>951</lpage><pub-id pub-id-type="pmid">9373085</pub-id></element-citation></ref><ref id="b4-imcrj-4-073"><label>4</label><note><p><ext-link ext-link-type="uri" xlink:href="http://www.macmillan.org.uk/Cancerinformation/Cancertypes/Headneck/Aboutheadneckcancers/Typesofheadneckcancer.aspx">http://www.macmillan.org.uk/Cancerinformation/Cancertypes/Headneck/Aboutheadneckcancers/Typesofheadneckcancer.aspx</ext-link></p></note></ref><ref id="b5-imcrj-4-073"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tamiya</surname><given-names>YT</given-names></name><name><surname>Meguro</surname><given-names>T</given-names></name><name><surname>Ichikawa</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Glioblastoma with metastasis to spleen: case report</article-title><source>Neurologica Medico-Chirurgica</source><year>2003</year><volume>43</volume><fpage>452</fpage><lpage>456</lpage></element-citation></ref><ref id="b6-imcrj-4-073"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hata</surname><given-names>N</given-names></name><name><surname>Katsuta</surname><given-names>T</given-names></name><name><surname>Inoue</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Extra-cranial metastasis of glioblastoma to lung and heart with a histological resemblence to small cell carcinoma of the lung: an autopsy case</article-title><source>No Shinkei Geka</source><year>2001</year><volume>29</volume><fpage>438</fpage><lpage>448</lpage></element-citation></ref><ref id="b7-imcrj-4-073"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Figuera</surname><given-names>P</given-names></name><name><surname>Lupton</surname><given-names>JR</given-names></name><name><surname>Remington</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Cutaneous metastasis from an intracranial glioblastoma multiforme</article-title><source>J Am Acad Dermatol</source><year>2002</year><volume>46</volume><fpage>297</fpage><lpage>300</lpage><pub-id pub-id-type="pmid">11807444</pub-id></element-citation></ref><ref id="b8-imcrj-4-073"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Campora</surname><given-names>RG</given-names></name><name><surname>Salverri</surname><given-names>CO</given-names></name><name><surname>Ramirez</surname><given-names>FV</given-names></name><etal></etal></person-group><article-title>Metastatic glioblastoma multiforme in cervical lymph nodes. 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lesions</article-title><source>Acta Cytologica</source><year>1982</year><volume>26</volume><fpage>779</fpage><lpage>786</lpage><pub-id pub-id-type="pmid">6961715</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="f1-imcrj-4-073" position="float"><label>Figure 1</label><caption><p>Views of the lesion: left, front, and right sides.</p></caption><graphic xlink:href="imcrj-4-073f1"></graphic></fig><fig id="f2-imcrj-4-073" position="float"><label>Figure 2</label><caption><p>Histology photomicrographs of the patient, showing abundant eosinophilic cytoplasm and some poorly differentiated vascular channels lined by a few endothelial cells.</p></caption><graphic xlink:href="imcrj-4-073f2"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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