Innovative combination of therapeutic mammoplasty and expandable-implant breast augmentation for immediate partial breast reconstruction
Identifieur interne : 002273 ( Pmc/Corpus ); précédent : 002272; suivant : 002274Innovative combination of therapeutic mammoplasty and expandable-implant breast augmentation for immediate partial breast reconstruction
Auteurs : A. M. H. Choo ; P. Forouhi ; C. M. MalataSource :
- International Journal of Surgery Case Reports [ 2210-2612 ] ; 2016.
Abstract
An “augmentation-therapeutic mastopexy” for invasive tubular carcinoma is described. It is a rare technique to optimise symmetry of prosthetic reconstruction. It enlarges and reshapes the breast while adequately treating ipsilateral cancer.
Url:
DOI: 10.1016/j.ijscr.2016.04.031
PubMed: 27132043
PubMed Central: 4855789
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Innovative combination of therapeutic mammoplasty and expandable-implant breast augmentation for immediate partial breast reconstruction</title><author><name sortKey="Choo, A M H" sort="Choo, A M H" uniqKey="Choo A" first="A. M. H." last="Choo">A. M. H. Choo</name><affiliation><nlm:aff id="aff0005">University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Forouhi, P" sort="Forouhi, P" uniqKey="Forouhi P" first="P." last="Forouhi">P. Forouhi</name><affiliation><nlm:aff id="aff0010">Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Malata, C M" sort="Malata, C M" uniqKey="Malata C" first="C. M." last="Malata">C. M. Malata</name><affiliation><nlm:aff id="aff0010">Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="aff0020">Postgraduate Medical Institute, Faculty of Health Sciences at Anglia Ruskin University, Cambridge, Chelmsford, United Kingdom</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27132043</idno><idno type="pmc">4855789</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855789</idno><idno type="RBID">PMC:4855789</idno><idno type="doi">10.1016/j.ijscr.2016.04.031</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002273</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002273</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Innovative combination of therapeutic mammoplasty and expandable-implant breast augmentation for immediate partial breast reconstruction</title><author><name sortKey="Choo, A M H" sort="Choo, A M H" uniqKey="Choo A" first="A. M. H." last="Choo">A. M. H. Choo</name><affiliation><nlm:aff id="aff0005">University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Forouhi, P" sort="Forouhi, P" uniqKey="Forouhi P" first="P." last="Forouhi">P. Forouhi</name><affiliation><nlm:aff id="aff0010">Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Malata, C M" sort="Malata, C M" uniqKey="Malata C" first="C. M." last="Malata">C. M. Malata</name><affiliation><nlm:aff id="aff0010">Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="aff0020">Postgraduate Medical Institute, Faculty of Health Sciences at Anglia Ruskin University, Cambridge, Chelmsford, United Kingdom</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Surgery Case Reports</title><idno type="eISSN">2210-2612</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple"><list-item id="lsti0005"><label>•</label><p>An “augmentation-therapeutic mastopexy” for invasive tubular carcinoma is described.</p></list-item><list-item id="lsti0010"><label>•</label><p>It is a rare technique to optimise symmetry of prosthetic reconstruction.</p></list-item><list-item id="lsti0015"><label>•</label><p>It enlarges and reshapes the breast while adequately treating ipsilateral cancer.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Losken, A" uniqKey="Losken A">A. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Surg Case Rep</journal-id><journal-id journal-id-type="iso-abbrev">Int J Surg Case Rep</journal-id><journal-title-group><journal-title>International Journal of Surgery Case Reports</journal-title></journal-title-group><issn pub-type="epub">2210-2612</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27132043</article-id><article-id pub-id-type="pmc">4855789</article-id><article-id pub-id-type="publisher-id">S2210-2612(16)30091-8</article-id><article-id pub-id-type="doi">10.1016/j.ijscr.2016.04.031</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Innovative combination of therapeutic mammoplasty and expandable-implant breast augmentation for immediate partial breast reconstruction</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Choo</surname><given-names>A.M.H.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Forouhi</surname><given-names>P.</given-names></name><xref rid="aff0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Malata</surname><given-names>C.M.</given-names></name><email>cmalata@hotmail.com</email><xref rid="aff0010" ref-type="aff">b</xref><xref rid="aff0015" ref-type="aff">c</xref><xref rid="aff0020" ref-type="aff">d</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>University of Cambridge, Cambridge, United Kingdom</aff><aff id="aff0010"><label>b</label>Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom</aff><aff id="aff0015"><label>c</label>Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom</aff><aff id="aff0020"><label>d</label>Postgraduate Medical Institute, Faculty of Health Sciences at Anglia Ruskin University, Cambridge, Chelmsford, United Kingdom</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author at: Department of Plastic and Reconstructive Surgery, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, CB2 2QQ, United Kingdom.Department of Plastic and Reconstructive SurgeryAddenbrooke's HospitalCambridge University Hospitals NHS Foundation TrustCambridgeUnited Kingdom <email>cmalata@hotmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>20</day><month>4</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>4</month><year>2016</year></pub-date><volume>23</volume><fpage>146</fpage><lpage>150</lpage><history><date date-type="received"><day>28</day><month>1</month><year>2016</year></date><date date-type="accepted"><day>16</day><month>4</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 The Authors</copyright-statement><copyright-year>2016</copyright-year><license license-type="CC BY-NC-ND" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/"><license-p>This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).</license-p></license></permissions><abstract abstract-type="author-highlights"><title>Highlights</title><p><list list-type="simple"><list-item id="lsti0005"><label>•</label><p>An “augmentation-therapeutic mastopexy” for invasive tubular carcinoma is described.</p></list-item><list-item id="lsti0010"><label>•</label><p>It is a rare technique to optimise symmetry of prosthetic reconstruction.</p></list-item><list-item id="lsti0015"><label>•</label><p>It enlarges and reshapes the breast while adequately treating ipsilateral cancer.</p></list-item></list></p></abstract><abstract><sec><title>Introduction</title><p>Therapeutic mammoplasty is used in the treatment of suitably-sized and appropriately-located breast cancers to achieve adequate cancer excision, resulting in well-shaped but smaller breasts. In patients wishing to maintain or increase their breast size, simultaneous augmentation will be required.</p></sec><sec><title>Presentation of case</title><p>A 48-year-old female underwent an “augmentation-therapeutic mastopexy”. She required mastectomy for a multifocal cancer of the right breast and breast conservation for a unifocal localised cancer in the upper part of the left breast. She requested right immediate breast reconstruction and hoped for larger breasts than she had. Due to complications during neoadjuvant chemotherapy, the right reconstruction plan was changed from a deep inferior epigastric perforator (DIEP) flap to an implant-based technique. On the left, an extended superomedial pedicle therapeutic mammoplasty was combined with a subpectoral augmentation using an expandable-implant.</p></sec><sec><title>Discussion</title><p>The use of expandable-implants for reconstruction of partial mastectomy defects in combination with therapeutic mammoplasty has not been reported. This case report shows that such “augmentation-therapeutic mastopexy” is feasible.</p></sec><sec><title>Conclusion</title><p>A “novel” oncoplastic technique herein termed “augmentation-therapeutic mastopexy” is described for partial breast reconstruction during the treatment of a patient with bilateral breast cancer. It enabled adequate treatment of her cancer while reshaping the breast and achieving the desired larger breast size. It should be considered in selected breast-conservation patients who wish to maintain or increase their breast size.</p></sec></abstract></article-meta></front><body><sec id="sec0005"><label>1</label><title>Introduction</title><p>Therapeutic mammoplasty is a well-established treatment modality for suitably-sized and appropriately-located breast cancers. The Wise pattern is the most widely used mammoplasty technique for this purpose <xref rid="bib0005" ref-type="bibr">[1]</xref>, <xref rid="bib0010" ref-type="bibr">[2]</xref>. It is particularly suitable for patients with large and/or ptotic breasts. Therapeutic mammoplasty results in smaller breasts because of the wide tumour resection as well as the skin and gland resection necessary for surgical closure. This is desirable in many patients as it improves cosmetic outcome, allows more uniform delivery of postoperative radiotherapy (RT) and addresses macromastia symptoms <xref rid="bib0015" ref-type="bibr">[3]</xref>. The technique can be used in women with smaller breasts to produce a better shaped post-treatment breast, but some patients may find the resulting smaller breasts undesirable. Patients who wish to maintain their breast volume may therefore request simultaneous augmentation of their breast.</p><p>Breast enlargement in this setting can be accomplished with the use of fixed-volume implants or expandable-implants (so called “permanent expanders”). Although expandable-implants are widely used in post-mastectomy immediate breast reconstruction <xref rid="bib0020" ref-type="bibr">[4]</xref>, <xref rid="bib0025" ref-type="bibr">[5]</xref>, their use has not been hitherto described for partial breast reconstruction in combination with therapeutic mammoplasty.</p><p>We present a patient who underwent such an “augmentation-therapeutic mastopexy”, simultaneously treating her tumour located superiorly above the nipple-areolar complex (NAC), and achieving her desire to enlarge her pre-existing breast size.</p></sec><sec id="sec0010"><label>2</label><title>Presentation of case</title><p>A 48-year-old female (<xref rid="fig0005" ref-type="fig">Fig. 1</xref>) presented with a multifocal lobular cancer of the right breast (requiring mastectomy) and a smaller localised tubular carcinoma of the left breast. She requested right immediate breast reconstruction (IBR) and hoped for larger breasts than she had. She was scheduled for bilateral mastectomies and reconstruction with deep inferior epigastric perforator (DIEP) flaps. During neoadjuvant chemotherapy she lost significant weight and ruptured a thoracic disc, making a DIEP flap contraindicated. She was offered expandable-implant and Strattice™ (porcine-derived acellular dermal matrix (ADM)) reconstruction on the right, and a therapeutic mammoplasty with expanded-implant augmentation on the left.</p><p>Bilateral Wise pattern skin reduction markings were made prior to surgery (<xref rid="fig0010" ref-type="fig">Fig. 2</xref>). A right mastectomy and level 2 axillary clearance were performed (specimen weight = 398 g, skin ellipse = 35 mm × 25 mm) and a reconstruction undertaken with an expandable-implant (nominal volume = 495–520 cm<sup>3</sup>) with 50 ml of intraoperative saline fill. The Strattice™ strip (10 cm × 16 cm) was sutured to the inferolateral border of the pectoralis major muscle and the inframammary fold to cover the inferolateral portion of the expander.</p><p>A simultaneous left Wise pattern therapeutic mammoplasty with an extended superomedial pedicle (<xref rid="fig0015" ref-type="fig">Fig. 3</xref>) was carried out with the extension transposed into the tumour excision defect. The tumour located in the breast meridian superior to the nipple-areolar complex (NAC) was widely excised with at least 1 cm margins radially using the previously-deployed guide wires/coils (specimen weight = 16 g). The completeness of resection was confirmed by intraoperative specimen radiographs (<xref rid="fig0020" ref-type="fig">Fig. 4</xref>). A sentinel lymph node biopsy was then performed through the breast incision. Next, an expandable-implant (nominal volume = 295–315 cm<sup>3</sup>) was inserted into the subpectoral pocket with 50 ml of intraoperative saline fill. The wide local excision defect above the neo-NAC position was reconstructed by the transposition of superomedial pedicle extension and secured with interrupted 2/0 PDS. Glandular tissue rearrangement was achieved using 2/0 PDS. Both breasts were closed in a standard manner over suction drains.</p><p>Histological examination confirmed complete disease excision bilaterally and negative left sentinel lymph nodes. The patient was reviewed regularly in clinic postoperatively and four weekly expander inflations yielded saline fill volumes of 485 ml (right) and 310 ml (left). She received postoperative right chest wall and left breast RT (40 Gy in 15 fractions with left tumour bed boost at 12 Gy in 4 fractions). Her preoperative and 11 month postoperative (post-RT) appearances are shown in <xref rid="fig0005" ref-type="fig">Fig. 1</xref>. Although she developed Grade IV capsular contracture secondary to RT despite the Strattice™ ADM support on the right (<xref rid="fig0005" ref-type="fig">Fig. 1</xref>), there was no evidence of capsular contracture on the left therapeutic mammoplasty side (<xref rid="fig0025" ref-type="fig">Fig. 5</xref>). The right breast was subsequently treated with a right free flap salvage after a failed capsulectomy and implant exchange.</p></sec><sec id="sec0015"><label>3</label><title>Discussion</title><p>Most oncoplastic surgical techniques utilise breast parenchymal rearrangements after full-thickness resections of skin and glandular tissue or employ established breast reduction or mastopexy patterns to enable wide tumour resections while preserving or enhancing the shape of the remaining breast <xref rid="bib0030" ref-type="bibr">[6]</xref>. This often necessitates concomitant contralateral balancing surgery for optimal symmetry <xref rid="bib0035" ref-type="bibr">[7]</xref>. 95% of patients undergoing immediate partial breast reconstruction using therapeutic mammoplasty require a contralateral breast reduction <xref rid="bib0040" ref-type="bibr">[8]</xref>. Other techniques employed include mastopexy, breast augmentation, augmentation-mastopexy, and mastectomy and bilateral immediate breast reconstruction (IBR) <xref rid="bib0045" ref-type="bibr">[9]</xref>. Breast augmentation for contralateral balancing breast surgery is indicated in patients with small breasts. It is, however, unreported to augment a breast simultaneous with tumour treatment by therapeutic mammoplasty and removal of the contralateral breast by mastectomy with immediate prosthetic reconstruction.</p><sec id="sec0020"><label>3.1</label><title>The contralateral breast</title><p>Reduction mammoplasty and simple mastopexy are the most common symmetrising procedures following unilateral postmastectomy breast reconstruction <xref rid="bib0050" ref-type="bibr">[10]</xref>. Symmetrisation can be undertaken as a primary or delayed procedure based on the patient and surgeon preference, and also patient selection <xref rid="bib0055" ref-type="bibr">[11]</xref>, <xref rid="bib0060" ref-type="bibr">[12]</xref>. It is carefully considered or withheld till margin status and the need for further oncological survey is known <xref rid="bib0015" ref-type="bibr">[3]</xref>. This may change the size and shape of the index breast, and one may find that the previously reduced breast now does not match the cancerous breast. Additionally, the index breast will undergo postoperative radiotherapy (RT), potentially increasing breast asymmetry if contralateral symmetrisation is done as a primary procedure <xref rid="bib0005" ref-type="bibr">[1]</xref>, <xref rid="bib0065" ref-type="bibr">[13]</xref>. The irradiated (therapeutic mammoplasty) breast may become bigger (due to chronic oedema from impaired lymphatic drainage) or smaller (consequent to RT-induced fat necrosis, fibrosis and atrophy) <xref rid="bib0055" ref-type="bibr">[11]</xref>. In the Cambridge Breast Unit (CBU) it is preferred to undertake simultaneous contralateral breast reduction, as most patients desire this and CBU’s radiation regimens have not found radiation-induced breast shrinkage or fibrosis to be a major problem. The latter may be because CBU routinely leaves the opposite non-cancerous breast at least 10% bigger than the index breast, similar to the Emory University group’s recommendations <xref rid="bib0005" ref-type="bibr">[1]</xref>.</p><p>Some patients may have small and ptotic breasts and require an augmentation-mastopexy. This procedure is complex <xref rid="bib0070" ref-type="bibr">[14]</xref> and less frequently utilised. Principal among the challenges is the difficulty in balancing the conflicting objectives of ideal augmentation and degree of breast lift. Without careful preoperative surgical execution, there is a high risk of recurrence of breast ptosis <xref rid="bib0075" ref-type="bibr">[15]</xref>. It is therefore not surprising that augmentation-therapeutic mastopexy has not been reported as simultaneous balancing surgery for contralateral immediate prosthetic breast reconstruction. However, the present case report shows that the technique can be successfully performed with good results.</p><p>Our patient posed a number of challenges. These included her request to have larger breasts than she had preoperatively, the chemotherapy-induced complications precluding the use of an abdominal flap, and the requirement for postoperative RT.</p></sec><sec id="sec0025"><label>3.2</label><title>Postoperative radiotherapy effects on total and partial breast reconstruction</title><p>The need for postoperative bilateral RT in this patient was determined preoperatively using the Cambridge Radiotherapy Index <xref rid="bib0080" ref-type="bibr">[16]</xref>. RT can lead to fibrosis, compromised skin and soft tissue quality, increased possibility of complications from reconstruction, and a suboptimal aesthetic result <xref rid="bib0085" ref-type="bibr">[17]</xref>. Our patient demonstrated this on the mastectomy side with the severe capsular contracture necessitating total capsulectomy and implant exchange. The RT-induced tissue damage was so severe that a few weeks after surgery, she developed wound dehiscence and implant exposure culminating in explantation. This has subsequently been successfully salvaged by conversion to a totally autologous deep inferior epigastric perforator (DIEP) flap <xref rid="bib0090" ref-type="bibr">[18]</xref>.</p><p>Irradiating the reduced or uplifted breast presents a different set of problems, notably fat necrosis, contraction or fibrosis of breast tissue and chronic lymphoedema of breast tissue and skin (after therapeutic mammoplasty). It may make the reduced breast firmer <xref rid="bib0085" ref-type="bibr">[17]</xref>, indurated and difficult to shape later. Hence, the MD Anderson group prefers to perform the contralateral balancing reduction sequentially, after RT <xref rid="bib0015" ref-type="bibr">[3]</xref>. Interestingly, our patient did not develop any of these problems on the side of the “augmentation-therapeutic mastopexy” despite the severe RT reaction on the side of the mastectomy, and the expandable-implant could be inflated satisfactorily. It was not feasible to undertake the therapeutic mammoplasty at a later date as the patient had cancer in this breast—the therapeutic mammoplasty was being used not only for the symmetrisation purposes but also for the cancer treatment.</p></sec><sec id="sec0030"><label>3.3</label><title>“Augmentation-therapeutic mastopexy”</title><p>Similar to therapeutic mammoplasties, the “augmentation-therapeutic mastopexy” herein described is easy to incorporate into the practice of surgeons who routinely perform cosmetic reduction mammoplasties and mastopexies. It is a useful addition to the reconstructive armamentarium available for partial mastectomy defects in women with suboptimal breast shapes who also desire an increase in their breast size.</p></sec></sec><sec id="sec0035"><label>4</label><title>Conclusion</title><p>Augmentation-mastopexy for cosmetic breast surgery is well-established. It is, however, not been described for or in context of partial breast reconstruction. It enables the enlargement of the patient’s breasts while reshaping the breasts and adequately treating a suitably located breast cancer. “Augmentation-therapeutic mastopexy” is a novel technique which should be considered in selected patients.</p></sec><sec id="sec0040"><title>Conflict of interest</title><p>None.</p></sec><sec id="sec0045"><title>Funding</title><p>None.</p></sec><sec id="sec0050"><title>Ethical approval</title><p>Not applicable - case report.</p><p>Patient consent obtained for publication.</p></sec><sec id="sec0055"><title>Consent</title><p>Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal on request.</p></sec><sec id="sec0060"><title>Author contribution</title><p>Choo A: Design, literature search and write-up.</p><p>Forouhi P: Write-up and editing.</p><p>Malata CM: Design, write-up and editing.</p></sec><sec id="sec0065"><title>Guarantor</title><p>Professor Charles. M. 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Please note the prosthetic nipple on the mastectomy (right) side.</p></caption><alt-text id="at0075">Fig. 1</alt-text><graphic xlink:href="gr1"></graphic></fig><fig id="fig0010"><label>Fig. 2</label><caption><p>Planned surgical incisions (Wise pattern) for the right mastectomy and left therapeutic mammoplasty. Please note the nipple preservation on the left therapeutic mammoplasty side.</p></caption><alt-text id="at0080">Fig. 2</alt-text><graphic xlink:href="gr2"></graphic></fig><fig id="fig0015"><label>Fig. 3</label><caption><p>Schematic diagram showing a left nipple-areola preserving Wise pattern therapeutic mammoplasty with extended superomedial pedicle prior to transposition into the lumpectomy defect at 12 o’ clock.</p></caption><alt-text id="at0085">Fig. 3</alt-text><graphic xlink:href="gr3"></graphic></fig><fig id="fig0020"><label>Fig. 4</label><caption><p>Intraoperative radiograph with wire and coil deployed confirming the completeness of excision.</p></caption><alt-text id="at0090">Fig. 4</alt-text><graphic xlink:href="gr4"></graphic></fig><fig id="fig0025"><label>Fig. 5</label><caption><p>Severe soft tissue reaction to radiotherapy (12 days after its completion). Note the prosthetic nipple in situ on the right.</p></caption><alt-text id="at0095">Fig. 5</alt-text><graphic xlink:href="gr5"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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