The ‘Pantie’ Tumour
Identifieur interne : 002134 ( Pmc/Corpus ); précédent : 002133; suivant : 002135The ‘Pantie’ Tumour
Auteurs : Silada Kanokrungsee ; Vasanop Vachiramon ; Punyaphat SirithanabadeekulSource :
- Case Reports in Dermatology [ 1662-6567 ] ; 2014.
Abstract
We present a case of radiation-associated angiosarcoma. A 67-year-old Thai woman was diagnosed with endometrium carcinoma stage IC and was treated with surgery and radiations. Ten years later, she presented with a gradually enlarging mass on the pubic area, in the shape of a pair of panties. Skin biopsy of lesions confirmed angiosarcoma. The diagnosis was radiation-associated angiosarcoma. She was treated with chemotherapy due to unresectable tumour. The chemotherapy was started with paclitaxel 70 mg/m2 every 2 weeks. After completing the fifth cycle of paclitaxel, the lesion was markedly decreased in size and the symptoms previously described were also completely resolved.
Url:
DOI: 10.1159/000369992
PubMed: 25566052
PubMed Central: 4280461
Links to Exploration step
PMC:4280461Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The ‘Pantie’ Tumour</title><author><name sortKey="Kanokrungsee, Silada" sort="Kanokrungsee, Silada" uniqKey="Kanokrungsee S" first="Silada" last="Kanokrungsee">Silada Kanokrungsee</name><affiliation><nlm:aff id="aff1">Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Vachiramon, Vasanop" sort="Vachiramon, Vasanop" uniqKey="Vachiramon V" first="Vasanop" last="Vachiramon">Vasanop Vachiramon</name><affiliation><nlm:aff id="aff1">Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Sirithanabadeekul, Punyaphat" sort="Sirithanabadeekul, Punyaphat" uniqKey="Sirithanabadeekul P" first="Punyaphat" last="Sirithanabadeekul">Punyaphat Sirithanabadeekul</name><affiliation><nlm:aff id="aff1">Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Khlong Luang, Thailand</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25566052</idno><idno type="pmc">4280461</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280461</idno><idno type="RBID">PMC:4280461</idno><idno type="doi">10.1159/000369992</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002134</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002134</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The ‘Pantie’ Tumour</title><author><name sortKey="Kanokrungsee, Silada" sort="Kanokrungsee, Silada" uniqKey="Kanokrungsee S" first="Silada" last="Kanokrungsee">Silada Kanokrungsee</name><affiliation><nlm:aff id="aff1">Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Vachiramon, Vasanop" sort="Vachiramon, Vasanop" uniqKey="Vachiramon V" first="Vasanop" last="Vachiramon">Vasanop Vachiramon</name><affiliation><nlm:aff id="aff1">Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Sirithanabadeekul, Punyaphat" sort="Sirithanabadeekul, Punyaphat" uniqKey="Sirithanabadeekul P" first="Punyaphat" last="Sirithanabadeekul">Punyaphat Sirithanabadeekul</name><affiliation><nlm:aff id="aff1">Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Khlong Luang, Thailand</nlm:aff></affiliation></author></analytic><series><title level="j">Case Reports in Dermatology</title><idno type="eISSN">1662-6567</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We present a case of radiation-associated angiosarcoma. A 67-year-old Thai woman was diagnosed with endometrium carcinoma stage IC and was treated with surgery and radiations. Ten years later, she presented with a gradually enlarging mass on the pubic area, in the shape of a pair of panties. Skin biopsy of lesions confirmed angiosarcoma. The diagnosis was radiation-associated angiosarcoma. She was treated with chemotherapy due to unresectable tumour. The chemotherapy was started with paclitaxel 70 mg/m<sup>2</sup> every 2 weeks. After completing the fifth cycle of paclitaxel, the lesion was markedly decreased in size and the symptoms previously described were also completely resolved.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Coindre, Jm" uniqKey="Coindre J">JM Coindre</name></author><author><name sortKey="Terrier, P" uniqKey="Terrier P">P Terrier</name></author><author><name sortKey="Guillou, L" uniqKey="Guillou L">L Guillou</name></author><author><name sortKey="Le Doussal, V" uniqKey="Le Doussal V">V Le Doussal</name></author><author><name sortKey="Collin, F" uniqKey="Collin F">F Collin</name></author><author><name sortKey="Ranchere, D" uniqKey="Ranchere D">D Ranchere</name></author><author><name sortKey="Sastre, X" uniqKey="Sastre X">X Sastre</name></author><author><name sortKey="Vilain, Mo" uniqKey="Vilain M">MO Vilain</name></author><author><name sortKey="Bonichon, F" uniqKey="Bonichon F">F Bonichon</name></author><author><name sortKey="N Guyen Bui, B" uniqKey="N Guyen Bui B">B N'Guyen Bui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fayette, J" uniqKey="Fayette J">J Fayette</name></author><author><name sortKey="Martin, E" uniqKey="Martin E">E Martin</name></author><author><name sortKey="Piperno Neumann, S" uniqKey="Piperno Neumann S">S Piperno-Neumann</name></author><author><name sortKey="Le Cesne, A" uniqKey="Le Cesne A">A Le Cesne</name></author><author><name sortKey="Robert, C" uniqKey="Robert C">C Robert</name></author><author><name sortKey="Bonvalot, S" uniqKey="Bonvalot S">S Bonvalot</name></author><author><name sortKey="Ranchere, D" uniqKey="Ranchere D">D Ranchère</name></author><author><name sortKey="Pouillart, P" uniqKey="Pouillart P">P Pouillart</name></author><author><name sortKey="Coindre, Jm" uniqKey="Coindre J">JM Coindre</name></author><author><name sortKey="Blay, Jy" uniqKey="Blay J">JY Blay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arlen, M" uniqKey="Arlen M">M Arlen</name></author><author><name sortKey="Higinbotham, Nl" uniqKey="Higinbotham N">NL Higinbotham</name></author><author><name sortKey="Huvos, Ag" uniqKey="Huvos A">AG Huvos</name></author><author><name sortKey="Marcove, Rc" uniqKey="Marcove R">RC Marcove</name></author><author><name sortKey="Miller, T" uniqKey="Miller T">T Miller</name></author><author><name sortKey="Shah, Ic" uniqKey="Shah I">IC Shah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenn, T" uniqKey="Brenn T">T Brenn</name></author><author><name sortKey="Fletcher, Cd" uniqKey="Fletcher C">CD Fletcher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lucas, Dr" uniqKey="Lucas D">DR Lucas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meis Kindblom, Jm" uniqKey="Meis Kindblom J">JM Meis-Kindblom</name></author><author><name sortKey="Kindblom, Lg" uniqKey="Kindblom L">LG Kindblom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hung, J" uniqKey="Hung J">J Hung</name></author><author><name sortKey="Hiniker, Sm" uniqKey="Hiniker S">SM Hiniker</name></author><author><name sortKey="Lucas, Dr" uniqKey="Lucas D">DR Lucas</name></author><author><name sortKey="Griffith, Ka" uniqKey="Griffith K">KA Griffith</name></author><author><name sortKey="Mchugh, Jb" uniqKey="Mchugh J">JB McHugh</name></author><author><name sortKey="Meirovitz, A" uniqKey="Meirovitz A">A Meirovitz</name></author><author><name sortKey="Thomas, Dg" uniqKey="Thomas D">DG Thomas</name></author><author><name sortKey="Chugh, R" uniqKey="Chugh R">R Chugh</name></author><author><name sortKey="Herman, Jm" uniqKey="Herman J">JM Herman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scott, Mt" uniqKey="Scott M">MT Scott</name></author><author><name sortKey="Portnow, Lh" uniqKey="Portnow L">LH Portnow</name></author><author><name sortKey="Morris, Cg" uniqKey="Morris C">CG Morris</name></author><author><name sortKey="Marcus, Rb" uniqKey="Marcus R">RB Marcus</name></author><author><name sortKey="Mendenhall, Np" uniqKey="Mendenhall N">NP Mendenhall</name></author><author><name sortKey="Mendenhall, Wm" uniqKey="Mendenhall W">WM Mendenhall</name></author><author><name sortKey="Indelicato, Dj" uniqKey="Indelicato D">DJ Indelicato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Ruiz, E" uniqKey="Perez Ruiz E">E Perez-Ruiz</name></author><author><name sortKey="Ribelles, N" uniqKey="Ribelles N">N Ribelles</name></author><author><name sortKey="Sanchez Munoz, A" uniqKey="Sanchez Munoz A">A Sanchez-Munoz</name></author><author><name sortKey="Roman, A" uniqKey="Roman A">A Roman</name></author><author><name sortKey="Marquez, A" uniqKey="Marquez A">A Marquez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Depla, Al" uniqKey="Depla A">AL Depla</name></author><author><name sortKey="Scharloo Karels, Ch" uniqKey="Scharloo Karels C">CH Scharloo-Karels</name></author><author><name sortKey="De Jong, Ma" uniqKey="De Jong M">MA de Jong</name></author><author><name sortKey="Oldenborg, S" uniqKey="Oldenborg S">S Oldenborg</name></author><author><name sortKey="Kolff, Mw" uniqKey="Kolff M">MW Kolff</name></author><author><name sortKey="Oei, Sb" uniqKey="Oei S">SB Oei</name></author><author><name sortKey="Van Coevorden, F" uniqKey="Van Coevorden F">F van Coevorden</name></author><author><name sortKey="Van Rhoon, Gc" uniqKey="Van Rhoon G">GC van Rhoon</name></author><author><name sortKey="Baartman, Ea" uniqKey="Baartman E">EA Baartman</name></author><author><name sortKey="Scholten, Rj" uniqKey="Scholten R">RJ Scholten</name></author><author><name sortKey="Crezee, J" uniqKey="Crezee J">J Crezee</name></author><author><name sortKey="Van Tienhoven, G" uniqKey="Van Tienhoven G">G van Tienhoven</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buehler, D" uniqKey="Buehler D">D Buehler</name></author><author><name sortKey="Rice, Sr" uniqKey="Rice S">SR Rice</name></author><author><name sortKey="Moody, Js" uniqKey="Moody J">JS Moody</name></author><author><name sortKey="Rush, P" uniqKey="Rush P">P Rush</name></author><author><name sortKey="Hafez, Gr" uniqKey="Hafez G">GR Hafez</name></author><author><name sortKey="Attia, S" uniqKey="Attia S">S Attia</name></author><author><name sortKey="Longley, Bj" uniqKey="Longley B">BJ Longley</name></author><author><name sortKey="Kozak, Kr" uniqKey="Kozak K">KR Kozak</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Case Rep Dermatol</journal-id><journal-id journal-id-type="iso-abbrev">Case Rep Dermatol</journal-id><journal-id journal-id-type="publisher-id">CDE</journal-id><journal-title-group><journal-title>Case Reports in Dermatology</journal-title></journal-title-group><issn pub-type="epub">1662-6567</issn><publisher><publisher-name>S. Karger AG</publisher-name><publisher-loc>Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25566052</article-id><article-id pub-id-type="pmc">4280461</article-id><article-id pub-id-type="doi">10.1159/000369992</article-id><article-id pub-id-type="publisher-id">cde-0006-0274</article-id><article-categories><subj-group subj-group-type="heading"><subject>Published online: November, 2014</subject></subj-group></article-categories><title-group><article-title>The ‘Pantie’ Tumour</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kanokrungsee</surname><given-names>Silada</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vachiramon</surname><given-names>Vasanop</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sirithanabadeekul</surname><given-names>Punyaphat</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1"><sup>a</sup>Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand</aff><aff id="aff2"><sup>b</sup>Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Khlong Luang, Thailand</aff><author-notes><corresp id="cor1">*Punyaphat Sirithanabadeekul, MD, Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Khlong Luang, Pathumthani 12120 (Thailand), E-Mail <email>punyaphats@gmail.com</email></corresp></author-notes><pub-date pub-type="collection"><season>Sep-Dec</season><year>2014</year></pub-date><pub-date pub-type="epub"><day>26</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>26</day><month>11</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>6</volume><issue>3</issue><fpage>274</fpage><lpage>278</lpage><permissions><copyright-statement>Copyright © 2014 by S. Karger AG, Basel</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.</license-p></license></permissions><abstract><p>We present a case of radiation-associated angiosarcoma. A 67-year-old Thai woman was diagnosed with endometrium carcinoma stage IC and was treated with surgery and radiations. Ten years later, she presented with a gradually enlarging mass on the pubic area, in the shape of a pair of panties. Skin biopsy of lesions confirmed angiosarcoma. The diagnosis was radiation-associated angiosarcoma. She was treated with chemotherapy due to unresectable tumour. The chemotherapy was started with paclitaxel 70 mg/m<sup>2</sup> every 2 weeks. After completing the fifth cycle of paclitaxel, the lesion was markedly decreased in size and the symptoms previously described were also completely resolved.</p></abstract><kwd-group><title>Key words</title><kwd>Angiosarcoma</kwd><kwd>Radiation</kwd><kwd>Sarcoma</kwd><kwd>Vascular tumour</kwd></kwd-group><counts><fig-count count="2"></fig-count><ref-count count="11"></ref-count><page-count count="5"></page-count></counts></article-meta></front><body><sec id="sec1_1"><title>Case Report</title><p>A 67-year-old Thai woman was diagnosed with endometrium carcinoma stage IC. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy followed by pelvic radiation in 2004. The total radiation dose was 50 Gy.</p><p>In 2014, she presented with a gradually enlarging mass on the pubic area extending to the mons pubis for the past 2 months. It also was painful on palpation and bled easily. The affected site was within the field of prior radiation. She had a history of loss of appetite and weight loss of 3 kg within 2 months. She denied any history of trauma and was not taking any medication.</p><p>Clinical examination revealed a large well-defined firm violaceous plaque, 12 × 25 cm in size, and several bluish nodules on the mons pubis and labia majora, in the shape of a pair of panties (fig. <xref ref-type="fig" rid="F1">1</xref>). Pelvic examination was not performed due to the obstructing mass. There was no palpable lymphadenopathy.</p><p>Histopathology showed poorly circumscribed dermal tumours extending to the subcutaneous tissue (fig. <xref ref-type="fig" rid="F2">2a</xref>), composed of multiple cords and strands of atypical cells with little mitosis, some forming irregular dissecting anastomosing lumen and papillary projection into the lumen (fig. <xref ref-type="fig" rid="F2">2b</xref>). These atypical cells were positive for CD31, but negative for AE1/AE3 and HHV-8.</p><p>The diagnosis was radiation-associated angiosarcoma (RAAS). In our patient, the large tumour could not be resected; chemotherapy was started with paclitaxel 70 mg/m<sup>2</sup> every 2 weeks. After completing the fifth cycle of paclitaxel, the lesion was markedly decreased in size and the symptoms previously described were also completely resolved.</p></sec><sec sec-type="discussion" id="sec1_2"><title>Discussion</title><p>Angiosarcoma is a rare aggressive malignant mesenchymal tumour with endothelial differentiation that accounts for 2% of all soft tissue sarcomas [<xref rid="B1" ref-type="bibr">1</xref>]. The majority of patients develop angiosarcoma at advanced age on sun-exposed skin, with predilection for the scalp. The known risk factors for developing secondary angiosarcoma include chronic lymphedema and prior radiation. The frequency of RAAS is 17–25% of all angiosarcoma cases [<xref rid="B2" ref-type="bibr">2</xref>]. The diagnostic criteria for radiation-induced sarcomas include previous history of radiotherapy with a latency period of more than 3–4 years, development of sarcoma within a previously irradiated field or in the tissues adjacent to the field, and histologic confirmation [<xref rid="B3" ref-type="bibr">3</xref>]. The most frequent clinical setting is the treatment of breast carcinoma, predominantly after radiotherapy in breast conservative therapy, followed by gynaecological malignancies such as ovarian, endometrial or cervical carcinoma. Rare reasons for radiation treatment include acne, ringworm, graft radiation of a renal transplant, congenital hemangioma, Hodgkin's disease, multiple myeloma and melanoma [<xref rid="B4" ref-type="bibr">4</xref>].</p><p>Almost all of the patients are female. The median age at presentation is 68 years; the median radiation dose is 40–60 Gy. The latency between radiation and diagnosis of RAAS is approximately 5–6 years, ranging from 1 to 40 years. The latency period is shorter in patients treated for breast carcinoma than in patients receiving radiation for other reasons (median latency 5.5 and 30 years, respectively) [<xref rid="B4" ref-type="bibr">4</xref>]. The clinical presentation is quite variable, including violaceous or erythematous patches, plaques, nodules or bruise-like discolouration, overlying a painless area of induration. They occasionally bleed or ulcerate. Most are multifocal lesions and the size varies from a few millimetres to more than 20 cm (median 7.5 cm) [<xref rid="B4" ref-type="bibr">4</xref>]. The histologic features range from well to poorly differentiated and can vary within a single case. These lesions are poorly circumscribed, involve the dermis and sometimes subcutaneous tissues. Well-differentiated angiosarcoma consists of irregular interanastomosing channels that infiltrate surrounding tissue, diffusely dissecting the dermal collagen. The atypical endothelial cells are usually multilayered, with enlarged and hyperchromatic nuclei and sometimes nucleoli. Sieve-like architecture is a common feature. Moderately and poorly differentiated angiosarcoma has very heterogeneous cytoarchitectural features. The cytologic appearance can be epithelioid, spindled or pleomorphic. Blood-filled spaces are a frequent feature in these less well-differentiated lesions. Areas of necrosis are frequently present and the mitotic index is high. In poorly differentiated ones, the diagnosis is difficult [<xref rid="B5" ref-type="bibr">5</xref>]. Immunohistochemistry is often necessary to confirm the diagnosis. It shows positive staining with antibodies against endothelial markers including CD31, CD34, FVIII-related antigen and von Willebrand factor [<xref rid="B4" ref-type="bibr">4</xref>]. CD31 is the best marker with a high sensitivity and specificity. D2-40 (podoplanin), known as a lymphatic marker, is positive focally less frequently in angiosarcoma. Cytokeratin positivity may be observed occasionally in epithelioid areas [<xref rid="B6" ref-type="bibr">6</xref>]. Proliferative activity detected by ≥50% Ki-67 nuclear staining is also found [<xref rid="B7" ref-type="bibr">7</xref>].</p><p>Angiosarcoma is a very aggressive tumour. Unfortunately, the treatment options are relatively limited, including surgery, radiation, chemotherapy and combinations thereof. Currently, surgery with complete tumour resection is considered to be a standard treatment. However, when surgery is not possible, re-irradiation and chemotherapy have also proved to be beneficial. Anthracyclines alone or in conjunction with ifosfamide have led to disease control after several months, always in combination with previous surgery [<xref rid="B8" ref-type="bibr">8</xref>]. Over the past few years, paclitaxel has been used in advanced-stage and/or metastatic angiosarcoma [<xref rid="B9" ref-type="bibr">9</xref>].</p><p>RAAS has a poor prognosis. The 5-year survival rates vary from 28 to 54%, and the overall 5-year local recurrence-free interval is 32%. Depla et al. [<xref rid="B10" ref-type="bibr">10</xref>] found that tumour size and age are the prognostic factors for local recurrence and that adding re-irradiation to surgery improves local control. However, some studies suggest a more indolent behaviour of RAAS compared with the conventional or lymphedema-associated variants [<xref rid="B4" ref-type="bibr">4</xref>, <xref rid="B11" ref-type="bibr">11</xref>]. RAAS shows a high rate of recurrence rather than distant metastasis. RAAS of the breast has a significantly better prognosis more than that in other locations (overall survival >60 months and 7 months, respectively) [<xref rid="B11" ref-type="bibr">11</xref>].</p></sec><sec id="sec1_3"><title>Summary</title><p>RAAS is an angiosarcoma developing within a previously irradiated field, and the latency period is approximately 5–6 years. Most of the patients incurred RAAS after the treatment of breast carcinoma, followed by gynaecological malignancies. The clinical presentations are multiple, rarely solitary large violaceous or erythematous patches, plaques, nodules or bruise-like discolouration. However, the clinical and histopathological findings are undistinguishable from primary angiosarcoma. Treatment options include surgery, radiation, chemotherapy and combinations thereof. However, the response to treatment is usually poor.</p></sec><sec id="sec1_4"><title>Disclosure Statement</title><p>The authors report no conflict of interest. There was no funding.</p></sec></body><back><ack><title>Acknowledgment</title><p>The authors acknowledge the assistance of Dr. Marinya Pongpudpunth in histopathological consultation.</p></ack><ref-list><title>References</title><ref id="B1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Coindre</surname><given-names>JM</given-names></name><name><surname>Terrier</surname><given-names>P</given-names></name><name><surname>Guillou</surname><given-names>L</given-names></name><name><surname>Le Doussal</surname><given-names>V</given-names></name><name><surname>Collin</surname><given-names>F</given-names></name><name><surname>Ranchere</surname><given-names>D</given-names></name><name><surname>Sastre</surname><given-names>X</given-names></name><name><surname>Vilain</surname><given-names>MO</given-names></name><name><surname>Bonichon</surname><given-names>F</given-names></name><name><surname>N'Guyen Bui</surname><given-names>B</given-names></name></person-group><article-title>Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group</article-title><source>Cancer</source><year>2001</year><volume>91</volume><fpage>1914</fpage><lpage>1926</lpage><pub-id pub-id-type="pmid">11346874</pub-id></element-citation></ref><ref id="B2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fayette</surname><given-names>J</given-names></name><name><surname>Martin</surname><given-names>E</given-names></name><name><surname>Piperno-Neumann</surname><given-names>S</given-names></name><name><surname>Le Cesne</surname><given-names>A</given-names></name><name><surname>Robert</surname><given-names>C</given-names></name><name><surname>Bonvalot</surname><given-names>S</given-names></name><name><surname>Ranchère</surname><given-names>D</given-names></name><name><surname>Pouillart</surname><given-names>P</given-names></name><name><surname>Coindre</surname><given-names>JM</given-names></name><name><surname>Blay</surname><given-names>JY</given-names></name></person-group><article-title>Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases</article-title><source>Ann Oncol</source><year>2007</year><volume>18</volume><fpage>2030</fpage><lpage>2036</lpage><pub-id pub-id-type="pmid">17974557</pub-id></element-citation></ref><ref id="B3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arlen</surname><given-names>M</given-names></name><name><surname>Higinbotham</surname><given-names>NL</given-names></name><name><surname>Huvos</surname><given-names>AG</given-names></name><name><surname>Marcove</surname><given-names>RC</given-names></name><name><surname>Miller</surname><given-names>T</given-names></name><name><surname>Shah</surname><given-names>IC</given-names></name></person-group><article-title>Radiation-induced sarcoma of bone</article-title><source>Cancer</source><year>1971</year><volume>28</volume><fpage>1087</fpage><lpage>1099</lpage><pub-id pub-id-type="pmid">5288429</pub-id></element-citation></ref><ref id="B4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brenn</surname><given-names>T</given-names></name><name><surname>Fletcher</surname><given-names>CD</given-names></name></person-group><article-title>Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases</article-title><source>Am J Surg Pathol</source><year>2005</year><volume>29</volume><fpage>983</fpage><lpage>996</lpage><pub-id pub-id-type="pmid">16006792</pub-id></element-citation></ref><ref id="B5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lucas</surname><given-names>DR</given-names></name></person-group><article-title>Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion</article-title><source>Arch Pathol Lab Med</source><year>2009</year><volume>133</volume><fpage>1804</fpage><lpage>1809</lpage><pub-id pub-id-type="pmid">19886715</pub-id></element-citation></ref><ref id="B6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Meis-Kindblom</surname><given-names>JM</given-names></name><name><surname>Kindblom</surname><given-names>LG</given-names></name></person-group><article-title>Angiosarcoma of soft tissue: a study of 80 cases</article-title><source>Am J Surg Pathol</source><year>1998</year><volume>22</volume><fpage>683</fpage><lpage>697</lpage><pub-id pub-id-type="pmid">9630175</pub-id></element-citation></ref><ref id="B7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hung</surname><given-names>J</given-names></name><name><surname>Hiniker</surname><given-names>SM</given-names></name><name><surname>Lucas</surname><given-names>DR</given-names></name><name><surname>Griffith</surname><given-names>KA</given-names></name><name><surname>McHugh</surname><given-names>JB</given-names></name><name><surname>Meirovitz</surname><given-names>A</given-names></name><name><surname>Thomas</surname><given-names>DG</given-names></name><name><surname>Chugh</surname><given-names>R</given-names></name><name><surname>Herman</surname><given-names>JM</given-names></name></person-group><article-title>Sporadic versus radiation-associated angiosarcoma: a comparative clinicopathologic and molecular analysis of 48 cases</article-title><source>Sarcoma</source><year>2013</year><volume>2013</volume><fpage>798403</fpage><pub-id pub-id-type="pmid">24082817</pub-id></element-citation></ref><ref id="B8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Scott</surname><given-names>MT</given-names></name><name><surname>Portnow</surname><given-names>LH</given-names></name><name><surname>Morris</surname><given-names>CG</given-names></name><name><surname>Marcus</surname><given-names>RB</given-names><suffix>Jr</suffix></name><name><surname>Mendenhall</surname><given-names>NP</given-names></name><name><surname>Mendenhall</surname><given-names>WM</given-names></name><name><surname>Indelicato</surname><given-names>DJ</given-names></name></person-group><article-title>Radiation therapy for angiosarcoma: the 35-year University of Florida experience</article-title><source>Am J Clin Oncol</source><year>2013</year><volume>36</volume><fpage>174</fpage><lpage>180</lpage><pub-id pub-id-type="pmid">22314000</pub-id></element-citation></ref><ref id="B9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Perez-Ruiz</surname><given-names>E</given-names></name><name><surname>Ribelles</surname><given-names>N</given-names></name><name><surname>Sanchez-Munoz</surname><given-names>A</given-names></name><name><surname>Roman</surname><given-names>A</given-names></name><name><surname>Marquez</surname><given-names>A</given-names></name></person-group><article-title>Response to paclitaxel in a radiotherapy-induced breast angiosarcoma</article-title><source>Acta Oncol</source><year>2009</year><volume>48</volume><fpage>1078</fpage><lpage>1079</lpage><pub-id pub-id-type="pmid">19235566</pub-id></element-citation></ref><ref id="B10"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Depla</surname><given-names>AL</given-names></name><name><surname>Scharloo-Karels</surname><given-names>CH</given-names></name><name><surname>de Jong</surname><given-names>MA</given-names></name><name><surname>Oldenborg</surname><given-names>S</given-names></name><name><surname>Kolff</surname><given-names>MW</given-names></name><name><surname>Oei</surname><given-names>SB</given-names></name><name><surname>van Coevorden</surname><given-names>F</given-names></name><name><surname>van Rhoon</surname><given-names>GC</given-names></name><name><surname>Baartman</surname><given-names>EA</given-names></name><name><surname>Scholten</surname><given-names>RJ</given-names></name><name><surname>Crezee</surname><given-names>J</given-names></name><name><surname>van Tienhoven</surname><given-names>G</given-names></name></person-group><article-title>Treatment and prognostic factors of radiation-associated angiosarcoma (RAAS) after primary breast cancer: a systematic review</article-title><source>Eur J Cancer</source><year>2014</year><volume>50</volume><fpage>1779</fpage><lpage>1788</lpage><pub-id pub-id-type="pmid">24731859</pub-id></element-citation></ref><ref id="B11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Buehler</surname><given-names>D</given-names></name><name><surname>Rice</surname><given-names>SR</given-names></name><name><surname>Moody</surname><given-names>JS</given-names></name><name><surname>Rush</surname><given-names>P</given-names></name><name><surname>Hafez</surname><given-names>GR</given-names></name><name><surname>Attia</surname><given-names>S</given-names></name><name><surname>Longley</surname><given-names>BJ</given-names></name><name><surname>Kozak</surname><given-names>KR</given-names></name></person-group><article-title>Angiosarcoma outcomes and prognostic factors: a 25-year single institution experience</article-title><source>Am J Clin Oncol</source><year>2014</year><volume>37</volume><fpage>473</fpage><lpage>479</lpage><pub-id pub-id-type="pmid">23428947</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. 1</label><caption><p>A large indurated violaceous plaque on the suprapubic area.</p></caption><graphic xlink:href="cde-0006-0274-g01"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Fig. 2</label><caption><p><bold>a</bold> Poorly circumscribed dermal tumours extending to the subcutaneous tissue. Haematoxylin and eosin, original magnification ×40. <bold>b</bold> Atypical cells with little mitosis, some forming irregular dissecting anastomosing lumen. Haematoxylin and eosin, original magnification ×600.</p></caption><graphic xlink:href="cde-0006-0274-g02"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002134 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 002134 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:4280461
|texte= The ‘Pantie’ Tumour
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:25566052" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |