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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Calciphylaxis in Patients With Preserved Kidney Function</title>
<author><name sortKey="Maroz, Natallia" sort="Maroz, Natallia" uniqKey="Maroz N" first="Natallia" last="Maroz">Natallia Maroz</name>
<affiliation><nlm:aff id="aff1">Renal Physicians Inc., Dayton, OH, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Department of Medicine, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mohandes, Samer" sort="Mohandes, Samer" uniqKey="Mohandes S" first="Samer" last="Mohandes">Samer Mohandes</name>
<affiliation><nlm:aff id="aff2">Department of Medicine, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Miamy Valley Hospital, Dayton, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Field, Halle" sort="Field, Halle" uniqKey="Field H" first="Halle" last="Field">Halle Field</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Kettering Medical Center, Dayton, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kabakov, Zlata" sort="Kabakov, Zlata" uniqKey="Kabakov Z" first="Zlata" last="Kabakov">Zlata Kabakov</name>
<affiliation><nlm:aff id="aff1">Renal Physicians Inc., Dayton, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simman, Richard" sort="Simman, Richard" uniqKey="Simman R" first="Richard" last="Simman">Richard Simman</name>
<affiliation><nlm:aff id="aff5">Division of Plastic and Reconstructive Surgery, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Department of Pharmacology and Toxicology, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Department of Dermatology, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26442208</idno>
<idno type="pmc">4566866</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566866</idno>
<idno type="RBID">PMC:4566866</idno>
<idno type="doi">10.1016/j.jccw.2015.08.002</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">001E81</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Calciphylaxis in Patients With Preserved Kidney Function</title>
<author><name sortKey="Maroz, Natallia" sort="Maroz, Natallia" uniqKey="Maroz N" first="Natallia" last="Maroz">Natallia Maroz</name>
<affiliation><nlm:aff id="aff1">Renal Physicians Inc., Dayton, OH, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Department of Medicine, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mohandes, Samer" sort="Mohandes, Samer" uniqKey="Mohandes S" first="Samer" last="Mohandes">Samer Mohandes</name>
<affiliation><nlm:aff id="aff2">Department of Medicine, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Miamy Valley Hospital, Dayton, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Field, Halle" sort="Field, Halle" uniqKey="Field H" first="Halle" last="Field">Halle Field</name>
<affiliation><nlm:aff id="aff4">Department of Medicine, Kettering Medical Center, Dayton, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kabakov, Zlata" sort="Kabakov, Zlata" uniqKey="Kabakov Z" first="Zlata" last="Kabakov">Zlata Kabakov</name>
<affiliation><nlm:aff id="aff1">Renal Physicians Inc., Dayton, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simman, Richard" sort="Simman, Richard" uniqKey="Simman R" first="Richard" last="Simman">Richard Simman</name>
<affiliation><nlm:aff id="aff5">Division of Plastic and Reconstructive Surgery, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Department of Pharmacology and Toxicology, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Department of Dermatology, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of the American College of Clinical Wound Specialists</title>
<idno type="eISSN">2213-5103</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a devastating disease typically seen in patients with end stage renal disease. It manifests as extremely painful symmetrical wounds resistant to surgical and medical interventions. The prevalence of CUA among hemodialysis dependent patients was found to be as high as 4.1%. The management of patients with CUA requires a multidisciplinary approach by the medical team, yet often results in a low rate of successful outcomes. Recently, non-uremic calciphylaxis (NUC) has been described in the absence of kidney disease. Limited knowledge exists on the management of NUC and the outcomes of this condition. Herein we describe three clinical scenarios of patients diagnosed with NUC in the absence of permanent or prolonged acute renal pathology. The reporting of successful and fruitless therapeutic interventions for wound management in NUC is important for compiling the evidence of effective therapeutic strategies.</p>
</div>
</front>
</TEI>
<pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Am Coll Clin Wound Spec</journal-id>
<journal-id journal-id-type="iso-abbrev">J Am Coll Clin Wound Spec</journal-id>
<journal-title-group><journal-title>The Journal of the American College of Clinical Wound Specialists</journal-title>
</journal-title-group>
<issn pub-type="epub">2213-5103</issn>
<publisher><publisher-name>Elsevier</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26442208</article-id>
<article-id pub-id-type="pmc">4566866</article-id>
<article-id pub-id-type="publisher-id">S2213-5103(15)00049-4</article-id>
<article-id pub-id-type="doi">10.1016/j.jccw.2015.08.002</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Study</subject>
</subj-group>
</article-categories>
<title-group><article-title>Calciphylaxis in Patients With Preserved Kidney Function</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Maroz</surname>
<given-names>Natallia</given-names>
</name>
<degrees>MD, FASN, FACP</degrees>
<email>natallia.maroz@wright.edu</email>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="cor1" ref-type="corresp">∗</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mohandes</surname>
<given-names>Samer</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="aff3" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Field</surname>
<given-names>Halle</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff4" ref-type="aff">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kabakov</surname>
<given-names>Zlata</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Simman</surname>
<given-names>Richard</given-names>
</name>
<degrees>MD, FACS, FACCWS</degrees>
<xref rid="aff5" ref-type="aff">e</xref>
<xref rid="aff6" ref-type="aff">f</xref>
<xref rid="aff7" ref-type="aff">g</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>a</label>
Renal Physicians Inc., Dayton, OH, USA</aff>
<aff id="aff2"><label>b</label>
Department of Medicine, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</aff>
<aff id="aff3"><label>c</label>
Miamy Valley Hospital, Dayton, OH, USA</aff>
<aff id="aff4"><label>d</label>
Department of Medicine, Kettering Medical Center, Dayton, OH, USA</aff>
<aff id="aff5"><label>e</label>
Division of Plastic and Reconstructive Surgery, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</aff>
<aff id="aff6"><label>f</label>
Department of Pharmacology and Toxicology, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</aff>
<aff id="aff7"><label>g</label>
Department of Dermatology, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA</aff>
<author-notes><corresp id="cor1"><label>∗</label>
Corresponding author. One Elizabeth Place, Suite 190, Dayton, OH 45417, USA. <email>natallia.maroz@wright.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>07</day>
<month>8</month>
<year>2015</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="collection"><month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>07</day>
<month>8</month>
<year>2015</year>
</pub-date>
<volume>6</volume>
<issue>1-2</issue>
<fpage>24</fpage>
<lpage>28</lpage>
<permissions><copyright-statement>© 2015 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>Elsevier Inc.</copyright-holder>
</permissions>
<abstract><p>Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a devastating disease typically seen in patients with end stage renal disease. It manifests as extremely painful symmetrical wounds resistant to surgical and medical interventions. The prevalence of CUA among hemodialysis dependent patients was found to be as high as 4.1%. The management of patients with CUA requires a multidisciplinary approach by the medical team, yet often results in a low rate of successful outcomes. Recently, non-uremic calciphylaxis (NUC) has been described in the absence of kidney disease. Limited knowledge exists on the management of NUC and the outcomes of this condition. Herein we describe three clinical scenarios of patients diagnosed with NUC in the absence of permanent or prolonged acute renal pathology. The reporting of successful and fruitless therapeutic interventions for wound management in NUC is important for compiling the evidence of effective therapeutic strategies.</p>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>Wound healing</kwd>
<kwd>Non-uremic calciphylaxis</kwd>
<kwd>Sodium thiosulfate</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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