LymphedemaV1, Pmc, Corpus, bibRecord, 001E62

Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity

Identifieur interne : 001E62 ( Pmc/Corpus ); précédent : 001E61; suivant : 001E63

Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity

Auteurs : Camilla Norrmén ; Wouter Vandevelde ; Annelii Ny ; Pipsa Saharinen ; Massimiliano Gentile ; Guttorm Haraldsen ; Pauli Puolakkainen ; Eugene Lukanidin ; Mieke Dewerchin ; Kari Alitalo ; Tatiana V. Petrova

Source :

Blood [ 0006-4971 ] ; 2010.

RBID : PMC:2815506

Abstract

The lymphatic vasculature is important for the regulation of tissue fluid homeostasis, immune response, and lipid absorption, and the development of in vitro models should allow for a better understanding of the mechanisms regulating lymphatic vascular growth, repair, and function. Here we report isolation and characterization of lymphatic endothelial cells from human intestine and show that intestinal lymphatic endothelial cells have a related but distinct gene expression profile from human dermal lymphatic endothelial cells. Furthermore, we identify liprin β1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, as highly expressed in intestinal lymphatic endothelial cells in vitro and lymphatic vasculature in vivo, and show that it plays an important role in the maintenance of lymphatic vessel integrity in Xenopus tadpoles.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815506

DOI: 10.1182/blood-2009-03-212274
PubMed: 19965622
PubMed Central: 2815506

Links to Exploration step

PMC:2815506

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity</title>
<author><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmén">Camilla Norrmén</name>
<affiliation><nlm:aff id="aff1">Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vandevelde, Wouter" sort="Vandevelde, Wouter" uniqKey="Vandevelde W" first="Wouter" last="Vandevelde">Wouter Vandevelde</name>
<affiliation><nlm:aff id="aff2">Vesalius Research Center, VIB-K.U.Leuven, Campus Gasthuisberg, Leuven, Belgium;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ny, Annelii" sort="Ny, Annelii" uniqKey="Ny A" first="Annelii" last="Ny">Annelii Ny</name>
<affiliation><nlm:aff id="aff2">Vesalius Research Center, VIB-K.U.Leuven, Campus Gasthuisberg, Leuven, Belgium;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saharinen, Pipsa" sort="Saharinen, Pipsa" uniqKey="Saharinen P" first="Pipsa" last="Saharinen">Pipsa Saharinen</name>
<affiliation><nlm:aff id="aff1">Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gentile, Massimiliano" sort="Gentile, Massimiliano" uniqKey="Gentile M" first="Massimiliano" last="Gentile">Massimiliano Gentile</name>
<affiliation><nlm:aff id="aff3">Genome Informatics Unit, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haraldsen, Guttorm" sort="Haraldsen, Guttorm" uniqKey="Haraldsen G" first="Guttorm" last="Haraldsen">Guttorm Haraldsen</name>
<affiliation><nlm:aff id="aff4">Laboratory for Immunology and Immunopathology, Division of Pathology, Rikshospitalet University Hospital, Oslo, Norway;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Puolakkainen, Pauli" sort="Puolakkainen, Pauli" uniqKey="Puolakkainen P" first="Pauli" last="Puolakkainen">Pauli Puolakkainen</name>
<affiliation><nlm:aff id="aff5">Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lukanidin, Eugene" sort="Lukanidin, Eugene" uniqKey="Lukanidin E" first="Eugene" last="Lukanidin">Eugene Lukanidin</name>
<affiliation><nlm:aff wicri:cut="; and" id="aff6">Department of Molecular Cancer Biology, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dewerchin, Mieke" sort="Dewerchin, Mieke" uniqKey="Dewerchin M" first="Mieke" last="Dewerchin">Mieke Dewerchin</name>
<affiliation><nlm:aff id="aff2">Vesalius Research Center, VIB-K.U.Leuven, Campus Gasthuisberg, Leuven, Belgium;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation><nlm:aff id="aff1">Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V." last="Petrova">Tatiana V. Petrova</name>
<affiliation><nlm:aff id="aff1">Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19965622</idno>
<idno type="pmc">2815506</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815506</idno>
<idno type="RBID">PMC:2815506</idno>
<idno type="doi">10.1182/blood-2009-03-212274</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">001E62</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E62</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity</title>
<author><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmén">Camilla Norrmén</name>
<affiliation><nlm:aff id="aff1">Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vandevelde, Wouter" sort="Vandevelde, Wouter" uniqKey="Vandevelde W" first="Wouter" last="Vandevelde">Wouter Vandevelde</name>
<affiliation><nlm:aff id="aff2">Vesalius Research Center, VIB-K.U.Leuven, Campus Gasthuisberg, Leuven, Belgium;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ny, Annelii" sort="Ny, Annelii" uniqKey="Ny A" first="Annelii" last="Ny">Annelii Ny</name>
<affiliation><nlm:aff id="aff2">Vesalius Research Center, VIB-K.U.Leuven, Campus Gasthuisberg, Leuven, Belgium;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saharinen, Pipsa" sort="Saharinen, Pipsa" uniqKey="Saharinen P" first="Pipsa" last="Saharinen">Pipsa Saharinen</name>
<affiliation><nlm:aff id="aff1">Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gentile, Massimiliano" sort="Gentile, Massimiliano" uniqKey="Gentile M" first="Massimiliano" last="Gentile">Massimiliano Gentile</name>
<affiliation><nlm:aff id="aff3">Genome Informatics Unit, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haraldsen, Guttorm" sort="Haraldsen, Guttorm" uniqKey="Haraldsen G" first="Guttorm" last="Haraldsen">Guttorm Haraldsen</name>
<affiliation><nlm:aff id="aff4">Laboratory for Immunology and Immunopathology, Division of Pathology, Rikshospitalet University Hospital, Oslo, Norway;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Puolakkainen, Pauli" sort="Puolakkainen, Pauli" uniqKey="Puolakkainen P" first="Pauli" last="Puolakkainen">Pauli Puolakkainen</name>
<affiliation><nlm:aff id="aff5">Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lukanidin, Eugene" sort="Lukanidin, Eugene" uniqKey="Lukanidin E" first="Eugene" last="Lukanidin">Eugene Lukanidin</name>
<affiliation><nlm:aff wicri:cut="; and" id="aff6">Department of Molecular Cancer Biology, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dewerchin, Mieke" sort="Dewerchin, Mieke" uniqKey="Dewerchin M" first="Mieke" last="Dewerchin">Mieke Dewerchin</name>
<affiliation><nlm:aff id="aff2">Vesalius Research Center, VIB-K.U.Leuven, Campus Gasthuisberg, Leuven, Belgium;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation><nlm:aff id="aff1">Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V." last="Petrova">Tatiana V. Petrova</name>
<affiliation><nlm:aff id="aff1">Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland;</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The lymphatic vasculature is important for the regulation of tissue fluid homeostasis, immune response, and lipid absorption, and the development of in vitro models should allow for a better understanding of the mechanisms regulating lymphatic vascular growth, repair, and function. Here we report isolation and characterization of lymphatic endothelial cells from human intestine and show that intestinal lymphatic endothelial cells have a related but distinct gene expression profile from human dermal lymphatic endothelial cells. Furthermore, we identify liprin β1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, as highly expressed in intestinal lymphatic endothelial cells in vitro and lymphatic vasculature in vivo, and show that it plays an important role in the maintenance of lymphatic vessel integrity in <named-content content-type="genus-species">Xenopus</named-content>
 tadpoles.</p>
</div>
</front>
</TEI>
<pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id>
<journal-id journal-id-type="hwp">bloodjournal</journal-id>
<journal-id journal-id-type="pmc">blood</journal-id>
<journal-id journal-id-type="publisher-id">Blood</journal-id>
<journal-title-group><journal-title>Blood</journal-title>
</journal-title-group>
<issn pub-type="ppub">0006-4971</issn>
<issn pub-type="epub">1528-0020</issn>
<publisher><publisher-name>American Society of Hematology</publisher-name>
<publisher-loc>Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19965622</article-id>
<article-id pub-id-type="pmc">2815506</article-id>
<article-id pub-id-type="publisher-id">2009/212274</article-id>
<article-id pub-id-type="doi">10.1182/blood-2009-03-212274</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Vascular Biology</subject>
<subj-group><subject>Brief report</subject>
</subj-group>
</subj-group>
<series-title>Vascular Biology</series-title>
</article-categories>
<title-group><article-title>Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Norrmén</surname>
<given-names>Camilla</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vandevelde</surname>
<given-names>Wouter</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ny</surname>
<given-names>Annelii</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saharinen</surname>
<given-names>Pipsa</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gentile</surname>
<given-names>Massimiliano</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haraldsen</surname>
<given-names>Guttorm</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Puolakkainen</surname>
<given-names>Pauli</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lukanidin</surname>
<given-names>Eugene</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dewerchin</surname>
<given-names>Mieke</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Alitalo</surname>
<given-names>Kari</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Petrova</surname>
<given-names>Tatiana V.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<aff id="aff1"><label>1</label>
Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland;</aff>
<aff id="aff2"><label>2</label>
Vesalius Research Center, VIB-K.U.Leuven, Campus Gasthuisberg, Leuven, Belgium;</aff>
<aff id="aff3"><label>3</label>
Genome Informatics Unit, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland;</aff>
<aff id="aff4"><label>4</label>
Laboratory for Immunology and Immunopathology, Division of Pathology, Rikshospitalet University Hospital, Oslo, Norway;</aff>
<aff id="aff5"><label>5</label>
Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland;</aff>
<aff id="aff6"><label>6</label>
Department of Molecular Cancer Biology, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark; and</aff>
<aff id="aff7"><label>7</label>
Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</aff>
</contrib-group>
<pub-date pub-type="ppub"><day>28</day>
<month>1</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epreprint"><day>30</day>
<month>11</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>28</day>
<month>1</month>
<year>2011</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the 
 					. </pmc-comment>
      <volume>115</volume>
<issue>4</issue>
<fpage>906</fpage>
<lpage>909</lpage>
<history><date date-type="received"><day>25</day>
<month>3</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>27</day>
<month>10</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>© 2010 by The American Society of Hematology</copyright-statement>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zh800410000906.pdf"></self-uri>
<abstract><p>The lymphatic vasculature is important for the regulation of tissue fluid homeostasis, immune response, and lipid absorption, and the development of in vitro models should allow for a better understanding of the mechanisms regulating lymphatic vascular growth, repair, and function. Here we report isolation and characterization of lymphatic endothelial cells from human intestine and show that intestinal lymphatic endothelial cells have a related but distinct gene expression profile from human dermal lymphatic endothelial cells. Furthermore, we identify liprin β1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, as highly expressed in intestinal lymphatic endothelial cells in vitro and lymphatic vasculature in vivo, and show that it plays an important role in the maintenance of lymphatic vessel integrity in <named-content content-type="genus-species">Xenopus</named-content>
 tadpoles.</p>
</abstract>
<funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source>
<award-id rid="CS100">R01 HL 75183-01</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E62 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001E62 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Pmc
   |étape=   Corpus
   |type=    RBID
   |clé=     PMC:2815506
   |texte=   Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i   -Sk "pubmed:19965622" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity

Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki