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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>MYC</italic> High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema</title><author><name sortKey="Manner, Johanna" sort="Manner, Johanna" uniqKey="Manner J" first="Johanna" last="Manner">Johanna Manner</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Radlwimmer, Bernhard" sort="Radlwimmer, Bernhard" uniqKey="Radlwimmer B" first="Bernhard" last="Radlwimmer">Bernhard Radlwimmer</name><affiliation><nlm:aff id="aff3">German Cancer Research Center (DKFZ), Division of Molecular Genetics, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name><affiliation><nlm:aff id="aff2">Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Mossinger, Katharina" sort="Mossinger, Katharina" uniqKey="Mossinger K" first="Katharina" last="Mössinger">Katharina Mössinger</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kuffer, Stefan" sort="Kuffer, Stefan" uniqKey="Kuffer S" first="Stefan" last="Küffer">Stefan Küffer</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sauer, Christian" sort="Sauer, Christian" uniqKey="Sauer C" first="Christian" last="Sauer">Christian Sauer</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Belharazem, Djeda" sort="Belharazem, Djeda" uniqKey="Belharazem D" first="Djeda" last="Belharazem">Djeda Belharazem</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Zettl, Andreas" sort="Zettl, Andreas" uniqKey="Zettl A" first="Andreas" last="Zettl">Andreas Zettl</name><affiliation><nlm:aff id="aff4">Pathology Viollier, Basle, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Coindre, Jean Michel" sort="Coindre, Jean Michel" uniqKey="Coindre J" first="Jean-Michel" last="Coindre">Jean-Michel Coindre</name><affiliation><nlm:aff id="aff5">Department of Pathology and INSERM U916, Institut Bergonié and Laboratory of Pathology, University Victor Ségalen, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name><affiliation><nlm:aff id="aff6">Department of Dermatology, Fachklinik Hornheide, Münster, Germany</nlm:aff></affiliation></author><author><name sortKey="Hartmann, Jorg Thomas" sort="Hartmann, Jorg Thomas" uniqKey="Hartmann J" first="Jörg Thomas" last="Hartmann">Jörg Thomas Hartmann</name><affiliation><nlm:aff id="aff7">Department of Medical Oncology, Medical Center II, Eberhard-Karls-University, Tuebingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Katenkamp, Detlef" sort="Katenkamp, Detlef" uniqKey="Katenkamp D" first="Detlef" last="Katenkamp">Detlef Katenkamp</name><affiliation><nlm:aff id="aff8">Institute of Pathology, University of Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Katenkamp, Kathrin" sort="Katenkamp, Kathrin" uniqKey="Katenkamp K" first="Kathrin" last="Katenkamp">Kathrin Katenkamp</name><affiliation><nlm:aff id="aff8">Institute of Pathology, University of Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Schoffski, Patrick" sort="Schoffski, Patrick" uniqKey="Schoffski P" first="Patrick" last="Schöffski">Patrick Schöffski</name><affiliation><nlm:aff id="aff9">Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Sciot, Raf" sort="Sciot, Raf" uniqKey="Sciot R" first="Raf" last="Sciot">Raf Sciot</name><affiliation><nlm:aff id="aff10">Laboratory of Morphology and Molecular Pathology, Department of Pathology, University Hospital, Catholic University of Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wozniak, Agnieszka" sort="Wozniak, Agnieszka" uniqKey="Wozniak A" first="Agnieszka" last="Wozniak">Agnieszka Wozniak</name><affiliation><nlm:aff id="aff9">Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name><affiliation><nlm:aff id="aff3">German Cancer Research Center (DKFZ), Division of Molecular Genetics, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20008140</idno><idno type="pmc">2797867</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797867</idno><idno type="RBID">PMC:2797867</idno><idno type="doi">10.2353/ajpath.2010.090637</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001E61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E61</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>MYC</italic> High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema</title><author><name sortKey="Manner, Johanna" sort="Manner, Johanna" uniqKey="Manner J" first="Johanna" last="Manner">Johanna Manner</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Radlwimmer, Bernhard" sort="Radlwimmer, Bernhard" uniqKey="Radlwimmer B" first="Bernhard" last="Radlwimmer">Bernhard Radlwimmer</name><affiliation><nlm:aff id="aff3">German Cancer Research Center (DKFZ), Division of Molecular Genetics, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name><affiliation><nlm:aff id="aff2">Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Mossinger, Katharina" sort="Mossinger, Katharina" uniqKey="Mossinger K" first="Katharina" last="Mössinger">Katharina Mössinger</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kuffer, Stefan" sort="Kuffer, Stefan" uniqKey="Kuffer S" first="Stefan" last="Küffer">Stefan Küffer</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sauer, Christian" sort="Sauer, Christian" uniqKey="Sauer C" first="Christian" last="Sauer">Christian Sauer</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Belharazem, Djeda" sort="Belharazem, Djeda" uniqKey="Belharazem D" first="Djeda" last="Belharazem">Djeda Belharazem</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Zettl, Andreas" sort="Zettl, Andreas" uniqKey="Zettl A" first="Andreas" last="Zettl">Andreas Zettl</name><affiliation><nlm:aff id="aff4">Pathology Viollier, Basle, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Coindre, Jean Michel" sort="Coindre, Jean Michel" uniqKey="Coindre J" first="Jean-Michel" last="Coindre">Jean-Michel Coindre</name><affiliation><nlm:aff id="aff5">Department of Pathology and INSERM U916, Institut Bergonié and Laboratory of Pathology, University Victor Ségalen, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name><affiliation><nlm:aff id="aff6">Department of Dermatology, Fachklinik Hornheide, Münster, Germany</nlm:aff></affiliation></author><author><name sortKey="Hartmann, Jorg Thomas" sort="Hartmann, Jorg Thomas" uniqKey="Hartmann J" first="Jörg Thomas" last="Hartmann">Jörg Thomas Hartmann</name><affiliation><nlm:aff id="aff7">Department of Medical Oncology, Medical Center II, Eberhard-Karls-University, Tuebingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Katenkamp, Detlef" sort="Katenkamp, Detlef" uniqKey="Katenkamp D" first="Detlef" last="Katenkamp">Detlef Katenkamp</name><affiliation><nlm:aff id="aff8">Institute of Pathology, University of Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Katenkamp, Kathrin" sort="Katenkamp, Kathrin" uniqKey="Katenkamp K" first="Kathrin" last="Katenkamp">Kathrin Katenkamp</name><affiliation><nlm:aff id="aff8">Institute of Pathology, University of Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Schoffski, Patrick" sort="Schoffski, Patrick" uniqKey="Schoffski P" first="Patrick" last="Schöffski">Patrick Schöffski</name><affiliation><nlm:aff id="aff9">Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Sciot, Raf" sort="Sciot, Raf" uniqKey="Sciot R" first="Raf" last="Sciot">Raf Sciot</name><affiliation><nlm:aff id="aff10">Laboratory of Morphology and Molecular Pathology, Department of Pathology, University Hospital, Catholic University of Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wozniak, Agnieszka" sort="Wozniak, Agnieszka" uniqKey="Wozniak A" first="Agnieszka" last="Wozniak">Agnieszka Wozniak</name><affiliation><nlm:aff id="aff9">Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name><affiliation><nlm:aff id="aff3">German Cancer Research Center (DKFZ), Division of Molecular Genetics, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><affiliation><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">The American Journal of Pathology</title><idno type="ISSN">0002-9440</idno><idno type="eISSN">1525-2191</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Angiosarcomas (AS) are rare vascular malignancies that arise either <bold><italic>de novo</italic></bold> as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied array-comparative genomic hybridization as a screening method to identify recurrent alterations in 22 cases. Recurrent genetic alterations were identified only in secondary but not in primary AS. The most frequent recurrent alterations were high level amplifications on chromosome 8q24.21 (50%), followed by 10p12.33 (33%) and 5q35.3 (11%). Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors secondary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of <bold><italic>MYC</italic></bold> on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS. Amplification of <bold><italic>MYC</italic></bold> did not predispose to high grade morphology or increased cell turnover. In conclusion, despite their identical morphology, secondary AS are genetically different from primary AS and are characterized by a high frequency of high level amplifications of <bold><italic>MYC</italic></bold>. This finding may have implications both for the diagnosis and treatment of these tumors.</p></div></front></TEI><pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Pathol</journal-id><journal-title-group><journal-title>The American Journal of Pathology</journal-title></journal-title-group><issn pub-type="ppub">0002-9440</issn><issn pub-type="epub">1525-2191</issn><publisher><publisher-name>American Society for Investigative Pathology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20008140</article-id><article-id pub-id-type="pmc">2797867</article-id><article-id pub-id-type="publisher-id">AJPA60322</article-id><article-id pub-id-type="doi">10.2353/ajpath.2010.090637</article-id><article-categories><subj-group subj-group-type="heading"><subject>Short Communications</subject></subj-group></article-categories><title-group><article-title><italic>MYC</italic> High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Manner</surname><given-names>Johanna</given-names></name><xref rid="aff1" ref-type="aff">*</xref></contrib><contrib contrib-type="author"><name><surname>Radlwimmer</surname><given-names>Bernhard</given-names></name><xref rid="aff3" ref-type="aff">†</xref></contrib><contrib contrib-type="author"><name><surname>Hohenberger</surname><given-names>Peter</given-names></name><xref rid="aff2" ref-type="aff">‡</xref></contrib><contrib contrib-type="author"><name><surname>Mössinger</surname><given-names>Katharina</given-names></name><xref rid="aff1" ref-type="aff">*</xref></contrib><contrib contrib-type="author"><name><surname>Küffer</surname><given-names>Stefan</given-names></name><xref rid="aff1" ref-type="aff">*</xref></contrib><contrib contrib-type="author"><name><surname>Sauer</surname><given-names>Christian</given-names></name><xref rid="aff1" ref-type="aff">*</xref></contrib><contrib contrib-type="author"><name><surname>Belharazem</surname><given-names>Djeda</given-names></name><xref rid="aff1" ref-type="aff">*</xref></contrib><contrib contrib-type="author"><name><surname>Zettl</surname><given-names>Andreas</given-names></name><xref rid="aff4" ref-type="aff">§</xref></contrib><contrib contrib-type="author"><name><surname>Coindre</surname><given-names>Jean-Michel</given-names></name><xref rid="aff5" ref-type="aff">¶</xref></contrib><contrib contrib-type="author"><name><surname>Hallermann</surname><given-names>Christian</given-names></name><xref rid="aff6" ref-type="aff">∥</xref></contrib><contrib contrib-type="author"><name><surname>Hartmann</surname><given-names>Jörg Thomas</given-names></name><xref rid="aff7" ref-type="aff">**</xref></contrib><contrib contrib-type="author"><name><surname>Katenkamp</surname><given-names>Detlef</given-names></name><xref rid="aff8" ref-type="aff">††</xref></contrib><contrib contrib-type="author"><name><surname>Katenkamp</surname><given-names>Kathrin</given-names></name><xref rid="aff8" ref-type="aff">††</xref></contrib><contrib contrib-type="author"><name><surname>Schöffski</surname><given-names>Patrick</given-names></name><xref rid="aff9" ref-type="aff">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Sciot</surname><given-names>Raf</given-names></name><xref rid="aff10" ref-type="aff">§§</xref></contrib><contrib contrib-type="author"><name><surname>Wozniak</surname><given-names>Agnieszka</given-names></name><xref rid="aff9" ref-type="aff">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Lichter</surname><given-names>Peter</given-names></name><xref rid="aff3" ref-type="aff">†</xref></contrib><contrib contrib-type="author"><name><surname>Marx</surname><given-names>Alexander</given-names></name><xref rid="aff1" ref-type="aff">*</xref></contrib><contrib contrib-type="author"><name><surname>Ströbel</surname><given-names>Philipp</given-names></name><email>philipp.stroebel@umm.de</email><xref rid="aff1" ref-type="aff">*</xref><xref rid="cor1" ref-type="corresp">*</xref></contrib></contrib-group><aff id="aff1"><label>*</label>Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</aff><aff id="aff2"><label>‡</label>Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</aff><aff id="aff3"><label>†</label>German Cancer Research Center (DKFZ), Division of Molecular Genetics, Heidelberg, Germany</aff><aff id="aff4"><label>§</label>Pathology Viollier, Basle, Switzerland</aff><aff id="aff5"><label>¶</label>Department of Pathology and INSERM U916, Institut Bergonié and Laboratory of Pathology, University Victor Ségalen, Bordeaux, France</aff><aff id="aff6"><label>∥</label>Department of Dermatology, Fachklinik Hornheide, Münster, Germany</aff><aff id="aff7"><label>**</label>Department of Medical Oncology, Medical Center II, Eberhard-Karls-University, Tuebingen, Germany</aff><aff id="aff8"><label>††</label>Institute of Pathology, University of Jena, Germany</aff><aff id="aff9"><label>‡‡</label>Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium</aff><aff id="aff10"><label>§§</label>Laboratory of Morphology and Molecular Pathology, Department of Pathology, University Hospital, Catholic University of Leuven, Belgium</aff><author-notes><corresp id="cor1"><label>*</label>Address reprint requests to Prof. Philipp Ströbel, M.D., Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Germany, Theodor-Kutzer-Ufer 1-3, D-68135 Mannheim <email>philipp.stroebel@umm.de</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2010</year></pub-date><volume>176</volume><issue>1</issue><fpage>34</fpage><lpage>39</lpage><history><date date-type="accepted"><day>3</day><month>9</month><year>2009</year></date></history><permissions><copyright-statement>© 2010 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year><copyright-holder>American Society for Investigative Pathology</copyright-holder></permissions><abstract><p>Angiosarcomas (AS) are rare vascular malignancies that arise either <bold><italic>de novo</italic></bold> as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied array-comparative genomic hybridization as a screening method to identify recurrent alterations in 22 cases. Recurrent genetic alterations were identified only in secondary but not in primary AS. The most frequent recurrent alterations were high level amplifications on chromosome 8q24.21 (50%), followed by 10p12.33 (33%) and 5q35.3 (11%). Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors secondary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of <bold><italic>MYC</italic></bold> on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS. Amplification of <bold><italic>MYC</italic></bold> did not predispose to high grade morphology or increased cell turnover. In conclusion, despite their identical morphology, secondary AS are genetically different from primary AS and are characterized by a high frequency of high level amplifications of <bold><italic>MYC</italic></bold>. This finding may have implications both for the diagnosis and treatment of these tumors.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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