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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Normal Lymphatic Development and Function in Mice Deficient for the Lymphatic Hyaluronan Receptor LYVE-1<xref ref-type="fn" rid="fn3">▿</xref> <xref ref-type="fn" rid="fn1">†</xref> </title><author><name sortKey="Gale, Nicholas W" sort="Gale, Nicholas W" uniqKey="Gale N" first="Nicholas W." last="Gale">Nicholas W. Gale</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Prevo, Remko" sort="Prevo, Remko" uniqKey="Prevo R" first="Remko" last="Prevo">Remko Prevo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Espinosa, Jorge" sort="Espinosa, Jorge" uniqKey="Espinosa J" first="Jorge" last="Espinosa">Jorge Espinosa</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ferguson, David J" sort="Ferguson, David J" uniqKey="Ferguson D" first="David J." last="Ferguson">David J. Ferguson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dominguez, Melissa G" sort="Dominguez, Melissa G" uniqKey="Dominguez M" first="Melissa G." last="Dominguez">Melissa G. Dominguez</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yancopoulos, George D" sort="Yancopoulos, George D" uniqKey="Yancopoulos G" first="George D." last="Yancopoulos">George D. Yancopoulos</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Thurston, Gavin" sort="Thurston, Gavin" uniqKey="Thurston G" first="Gavin" last="Thurston">Gavin Thurston</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17101772</idno><idno type="pmc">1800809</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800809</idno><idno type="RBID">PMC:1800809</idno><idno type="doi">10.1128/MCB.01503-06</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">001963</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001963</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Normal Lymphatic Development and Function in Mice Deficient for the Lymphatic Hyaluronan Receptor LYVE-1<xref ref-type="fn" rid="fn3">▿</xref> <xref ref-type="fn" rid="fn1">†</xref> </title><author><name sortKey="Gale, Nicholas W" sort="Gale, Nicholas W" uniqKey="Gale N" first="Nicholas W." last="Gale">Nicholas W. Gale</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Prevo, Remko" sort="Prevo, Remko" uniqKey="Prevo R" first="Remko" last="Prevo">Remko Prevo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Espinosa, Jorge" sort="Espinosa, Jorge" uniqKey="Espinosa J" first="Jorge" last="Espinosa">Jorge Espinosa</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ferguson, David J" sort="Ferguson, David J" uniqKey="Ferguson D" first="David J." last="Ferguson">David J. Ferguson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dominguez, Melissa G" sort="Dominguez, Melissa G" uniqKey="Dominguez M" first="Melissa G." last="Dominguez">Melissa G. Dominguez</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yancopoulos, George D" sort="Yancopoulos, George D" uniqKey="Yancopoulos G" first="George D." last="Yancopoulos">George D. Yancopoulos</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Thurston, Gavin" sort="Thurston, Gavin" uniqKey="Thurston G" first="Gavin" last="Thurston">Gavin Thurston</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Molecular and Cellular Biology</title><idno type="ISSN">0270-7306</idno><idno type="eISSN">1098-5549</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The hyaluronan receptor LYVE-1 is expressed abundantly on the surfaces of lymphatic vessels and lymph node sinus endothelial cells from early development, where it has been suggested to function both in cell adhesion/transmigration and as a scavenger for hyaluronan turnover. To investigate the physiological role(s) of LYVE-1, we generated mice in which the gene for the receptor was inactivated by replacement with a β-galactosidase reporter. LYVE-1<sup>−/−</sup> mice displayed an apparently normal phenotype, with no obvious alteration in lymphatic vessel ultrastructure or function and no apparent change in secondary lymphoid tissue structure or cellularity. In addition, the levels of hyaluronan in tissue and blood were unchanged. LYVE-1<sup>−/−</sup> mice also displayed normal trafficking of cutaneous CD11c<sup>+</sup> dendritic cells to draining lymph nodes via afferent lymphatics and normal resolution of oxazolone-induced skin inflammation. Finally, LYVE-1<sup>−/−</sup> mice supported normal growth of transplanted B16F10 melanomas and Lewis lung carcinomas. These results indicate that LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mol Cell Biol</journal-id><journal-id journal-id-type="publisher-id">mcb</journal-id><journal-title>Molecular and Cellular Biology</journal-title><issn pub-type="ppub">0270-7306</issn><issn pub-type="epub">1098-5549</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17101772</article-id><article-id pub-id-type="pmc">1800809</article-id><article-id pub-id-type="publisher-id">1503-06</article-id><article-id pub-id-type="doi">10.1128/MCB.01503-06</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Normal Lymphatic Development and Function in Mice Deficient for the Lymphatic Hyaluronan Receptor LYVE-1<xref ref-type="fn" rid="fn3">▿</xref> <xref ref-type="fn" rid="fn1">†</xref> </article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gale</surname><given-names>Nicholas W.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="fn2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Prevo</surname><given-names>Remko</given-names></name><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="fn" rid="fn2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Espinosa</surname><given-names>Jorge</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Ferguson</surname><given-names>David J.</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Dominguez</surname><given-names>Melissa G.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yancopoulos</surname><given-names>George D.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Thurston</surname><given-names>Gavin</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jackson</surname><given-names>David G.</given-names></name><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1">Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591,<label>1</label> MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom,<label>2</label> Nuffield Department of Pathology, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom<label>3</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom. Phone: 44 1865 222313. Fax: 44 1865 222502. E-mail: <email>djackson@hammer.imm.ox.ac.uk</email>.</p></fn><fn id="fn2"><label>‡</label><p>The contributions of both of these authors should be considered equal.</p></fn></author-notes><pub-date pub-type="ppub"><month>1</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2006</year></pub-date><volume>27</volume><issue>2</issue><fpage>595</fpage><lpage>604</lpage><history><date date-type="received"><day>12</day><month>8</month><year>2006</year></date><date date-type="rev-recd"><day>19</day><month>9</month><year>2006</year></date><date date-type="accepted"><day>28</day><month>10</month><year>2006</year></date></history><copyright-statement>Copyright © 2007, American Society for Microbiology</copyright-statement><copyright-year>2007</copyright-year><self-uri xlink:title="pdf" xlink:href="zmb00207000595.pdf"></self-uri><abstract><p>The hyaluronan receptor LYVE-1 is expressed abundantly on the surfaces of lymphatic vessels and lymph node sinus endothelial cells from early development, where it has been suggested to function both in cell adhesion/transmigration and as a scavenger for hyaluronan turnover. To investigate the physiological role(s) of LYVE-1, we generated mice in which the gene for the receptor was inactivated by replacement with a β-galactosidase reporter. LYVE-1<sup>−/−</sup> mice displayed an apparently normal phenotype, with no obvious alteration in lymphatic vessel ultrastructure or function and no apparent change in secondary lymphoid tissue structure or cellularity. In addition, the levels of hyaluronan in tissue and blood were unchanged. LYVE-1<sup>−/−</sup> mice also displayed normal trafficking of cutaneous CD11c<sup>+</sup> dendritic cells to draining lymph nodes via afferent lymphatics and normal resolution of oxazolone-induced skin inflammation. Finally, LYVE-1<sup>−/−</sup> mice supported normal growth of transplanted B16F10 melanomas and Lewis lung carcinomas. These results indicate that LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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