Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of nitric oxide in host defense against an extracellular, metazoan parasite, Brugia malayi.</title><author><name sortKey="Rajan, T V" sort="Rajan, T V" uniqKey="Rajan T" first="T V" last="Rajan">T V Rajan</name></author><author><name sortKey="Porte, P" sort="Porte, P" uniqKey="Porte P" first="P" last="Porte">P. Porte</name></author><author><name sortKey="Yates, J A" sort="Yates, J A" uniqKey="Yates J" first="J A" last="Yates">J A Yates</name></author><author><name sortKey="Keefer, L" sort="Keefer, L" uniqKey="Keefer L" first="L" last="Keefer">L. Keefer</name></author><author><name sortKey="Shultz, L D" sort="Shultz, L D" uniqKey="Shultz L" first="L D" last="Shultz">L D Shultz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">8757874</idno><idno type="pmc">174228</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC174228</idno><idno type="RBID">PMC:174228</idno><date when="1996">1996</date><idno type="wicri:Area/Pmc/Corpus">001806</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001806</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of nitric oxide in host defense against an extracellular, metazoan parasite, Brugia malayi.</title><author><name sortKey="Rajan, T V" sort="Rajan, T V" uniqKey="Rajan T" first="T V" last="Rajan">T V Rajan</name></author><author><name sortKey="Porte, P" sort="Porte, P" uniqKey="Porte P" first="P" last="Porte">P. Porte</name></author><author><name sortKey="Yates, J A" sort="Yates, J A" uniqKey="Yates J" first="J A" last="Yates">J A Yates</name></author><author><name sortKey="Keefer, L" sort="Keefer, L" uniqKey="Keefer L" first="L" last="Keefer">L. Keefer</name></author><author><name sortKey="Shultz, L D" sort="Shultz, L D" uniqKey="Shultz L" first="L D" last="Shultz">L D Shultz</name></author></analytic><series><title level="j">Infection and Immunity</title><idno type="ISSN">0019-9567</idno><idno type="eISSN">1098-5522</idno><imprint><date when="1996">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The mechanisms by which mammalian hosts eliminate microparasites such as bacteria and viruses are well established. In viral infections, these mechanisms include the interferons, neutralizing and opsonizing antibodies, and cytotoxic T lymphocytes. In bacterial infections, polymorphonuclear leukocytes and macrophages, often facilitated by opsonizing antibodies, ingest the infectious agent and mediate host defense. In addition, complement, in the presence of specific antibodies directed against surface antigens, can lyse certain bacterial pathogens. In contrast, our understanding of the host defenses against metazoan, extracellular parasites is less well grounded. We obtained data by two different approaches to document the role of nitric oxide (NO) as a mediator of host defense against a human nematode parasite. First, treatment of immunocompetent, nonpermissive mice with an inhibitor of NO synthase abrogated resistance to Brugia malayi, one of the causative agents of human lymphatic filariasis. Second, treatment of permissive, immunodeficient mice with a compound that releases NO conferred resistance to infection. These data reinforce studies by James and her coworkers (I. P. Oswald, T. A. Wynn, A. Sher, and S. L. James, Comp. Biochem. Physiol. Pharmacol. Toxicol. Endocrinol. 108:11-18, 1994) on the role of NO in defense against trematode parasites and of Kanazawa et al. (T. Kanazawa, H. Asahi, H. Hata; K. Machida, N. Kagei, and M. J. Stadecker, Parasite Immunol. 15: 619-623, 1993) on cestode parasites.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Immun</journal-id><journal-title>Infection and Immunity</journal-title><issn pub-type="ppub">0019-9567</issn><issn pub-type="epub">1098-5522</issn></journal-meta><article-meta><article-id pub-id-type="pmid">8757874</article-id><article-id pub-id-type="pmc">174228</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Role of nitric oxide in host defense against an extracellular, metazoan parasite, Brugia malayi.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rajan</surname><given-names>T V</given-names></name></contrib><contrib contrib-type="author"><name><surname>Porte</surname><given-names>P</given-names></name></contrib><contrib contrib-type="author"><name><surname>Yates</surname><given-names>J A</given-names></name></contrib><contrib contrib-type="author"><name><surname>Keefer</surname><given-names>L</given-names></name></contrib><contrib contrib-type="author"><name><surname>Shultz</surname><given-names>L D</given-names></name></contrib></contrib-group><aff>Department of Pathology, University of Connecticut Health Center, Farmington, USA.</aff><pub-date pub-type="ppub"><month>8</month><year>1996</year></pub-date><volume>64</volume><issue>8</issue><fpage>3351</fpage><lpage>3353</lpage><abstract><p>The mechanisms by which mammalian hosts eliminate microparasites such as bacteria and viruses are well established. In viral infections, these mechanisms include the interferons, neutralizing and opsonizing antibodies, and cytotoxic T lymphocytes. In bacterial infections, polymorphonuclear leukocytes and macrophages, often facilitated by opsonizing antibodies, ingest the infectious agent and mediate host defense. In addition, complement, in the presence of specific antibodies directed against surface antigens, can lyse certain bacterial pathogens. In contrast, our understanding of the host defenses against metazoan, extracellular parasites is less well grounded. We obtained data by two different approaches to document the role of nitric oxide (NO) as a mediator of host defense against a human nematode parasite. First, treatment of immunocompetent, nonpermissive mice with an inhibitor of NO synthase abrogated resistance to Brugia malayi, one of the causative agents of human lymphatic filariasis. Second, treatment of permissive, immunodeficient mice with a compound that releases NO conferred resistance to infection. These data reinforce studies by James and her coworkers (I. P. Oswald, T. A. Wynn, A. Sher, and S. L. James, Comp. Biochem. Physiol. Pharmacol. Toxicol. Endocrinol. 108:11-18, 1994) on the role of NO in defense against trematode parasites and of Kanazawa et al. (T. Kanazawa, H. Asahi, H. Hata; K. Machida, N. Kagei, and M. J. Stadecker, Parasite Immunol. 15: 619-623, 1993) on cestode parasites.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0018068 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0018068 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.31. |  |