Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis.
Identifieur interne : 001788 ( Pmc/Corpus ); précédent : 001787; suivant : 001789Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis.
Auteurs : R B Lal ; R R Dhawan ; J J Tarrand ; E M Ayoub ; E A OttesenSource :
- Immunology [ 0019-2805 ] ; 1991.
Abstract
It has been suggested that humans are genetically restricted from making IgG4 antibody responses to carbohydrate antigens. To test this hypothesis we examined sera from 35 patients with bancroftian filariasis (an infection known to induce very high levels of IgG4 antibodies to the parasite and known to be associated with repeated streptococcal infections) as well as from 15 normal individuals for their IgG and IgG subclass responses to streptococcal protein [streptolysin-O (SO), deoxyribonuclease B (DB)] and carbohydrate [group A carbohydrate (GAC)] antigens. Levels of IgG antibodies to all three antigens were found to be significantly higher in the filariasis patients compared to normals (P less than 0.01), and the subclass composition of these antibodies proved heterogenous. Although responses to all three antigens included IgG1, IgG2 and IgG3 antibodies and although IgG4 responses to the proteins SO and DB were significantly higher in the filariasis patients than in normals (P less than 0.001), more importantly there were no detectable anti-GAC IgG4 antibodies in either study group. These observations, coupled with our earlier finding of the absence of IgG4 responses to phosphocholine (PC) in patients with lymphatic filariasis, suggest that even the chronic antigenic stimulation of filarial helminth infection, which leads to very prominent IgG4 responses to protein antigens, cannot overcome the genetic restriction in humans for making IgG4 antibodies to carbohydrate antigens, whether of parasite or non-parasite origin.
Url:
PubMed: 1748481
PubMed Central: 1384614
Links to Exploration step
PMC:1384614Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis.</title>
<author><name sortKey="Lal, R B" sort="Lal, R B" uniqKey="Lal R" first="R B" last="Lal">R B Lal</name>
</author>
<author><name sortKey="Dhawan, R R" sort="Dhawan, R R" uniqKey="Dhawan R" first="R R" last="Dhawan">R R Dhawan</name>
</author>
<author><name sortKey="Tarrand, J J" sort="Tarrand, J J" uniqKey="Tarrand J" first="J J" last="Tarrand">J J Tarrand</name>
</author>
<author><name sortKey="Ayoub, E M" sort="Ayoub, E M" uniqKey="Ayoub E" first="E M" last="Ayoub">E M Ayoub</name>
</author>
<author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">1748481</idno>
<idno type="pmc">1384614</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1384614</idno>
<idno type="RBID">PMC:1384614</idno>
<date when="1991">1991</date>
<idno type="wicri:Area/Pmc/Corpus">001788</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001788</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis.</title>
<author><name sortKey="Lal, R B" sort="Lal, R B" uniqKey="Lal R" first="R B" last="Lal">R B Lal</name>
</author>
<author><name sortKey="Dhawan, R R" sort="Dhawan, R R" uniqKey="Dhawan R" first="R R" last="Dhawan">R R Dhawan</name>
</author>
<author><name sortKey="Tarrand, J J" sort="Tarrand, J J" uniqKey="Tarrand J" first="J J" last="Tarrand">J J Tarrand</name>
</author>
<author><name sortKey="Ayoub, E M" sort="Ayoub, E M" uniqKey="Ayoub E" first="E M" last="Ayoub">E M Ayoub</name>
</author>
<author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name>
</author>
</analytic>
<series><title level="j">Immunology</title>
<idno type="ISSN">0019-2805</idno>
<idno type="eISSN">1365-2567</idno>
<imprint><date when="1991">1991</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>It has been suggested that humans are genetically restricted from making IgG4 antibody responses to carbohydrate antigens. To test this hypothesis we examined sera from 35 patients with bancroftian filariasis (an infection known to induce very high levels of IgG4 antibodies to the parasite and known to be associated with repeated streptococcal infections) as well as from 15 normal individuals for their IgG and IgG subclass responses to streptococcal protein [streptolysin-O (SO), deoxyribonuclease B (DB)] and carbohydrate [group A carbohydrate (GAC)] antigens. Levels of IgG antibodies to all three antigens were found to be significantly higher in the filariasis patients compared to normals (P less than 0.01), and the subclass composition of these antibodies proved heterogenous. Although responses to all three antigens included IgG1, IgG2 and IgG3 antibodies and although IgG4 responses to the proteins SO and DB were significantly higher in the filariasis patients than in normals (P less than 0.001), more importantly there were no detectable anti-GAC IgG4 antibodies in either study group. These observations, coupled with our earlier finding of the absence of IgG4 responses to phosphocholine (PC) in patients with lymphatic filariasis, suggest that even the chronic antigenic stimulation of filarial helminth infection, which leads to very prominent IgG4 responses to protein antigens, cannot overcome the genetic restriction in humans for making IgG4 antibodies to carbohydrate antigens, whether of parasite or non-parasite origin.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Immunology</journal-id>
<journal-title>Immunology</journal-title>
<issn pub-type="ppub">0019-2805</issn>
<issn pub-type="epub">1365-2567</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">1748481</article-id>
<article-id pub-id-type="pmc">1384614</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lal</surname>
<given-names>R B</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Dhawan</surname>
<given-names>R R</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tarrand</surname>
<given-names>J J</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ayoub</surname>
<given-names>E M</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ottesen</surname>
<given-names>E A</given-names>
</name>
</contrib>
</contrib-group>
<aff>Division of Tropical Public Health, Uniformed Services University of Health Services, Bethesda, Maryland.</aff>
<pub-date pub-type="ppub"><month>10</month>
<year>1991</year>
</pub-date>
<volume>74</volume>
<issue>2</issue>
<fpage>333</fpage>
<lpage>337</lpage>
<abstract><p>It has been suggested that humans are genetically restricted from making IgG4 antibody responses to carbohydrate antigens. To test this hypothesis we examined sera from 35 patients with bancroftian filariasis (an infection known to induce very high levels of IgG4 antibodies to the parasite and known to be associated with repeated streptococcal infections) as well as from 15 normal individuals for their IgG and IgG subclass responses to streptococcal protein [streptolysin-O (SO), deoxyribonuclease B (DB)] and carbohydrate [group A carbohydrate (GAC)] antigens. Levels of IgG antibodies to all three antigens were found to be significantly higher in the filariasis patients compared to normals (P less than 0.01), and the subclass composition of these antibodies proved heterogenous. Although responses to all three antigens included IgG1, IgG2 and IgG3 antibodies and although IgG4 responses to the proteins SO and DB were significantly higher in the filariasis patients than in normals (P less than 0.001), more importantly there were no detectable anti-GAC IgG4 antibodies in either study group. These observations, coupled with our earlier finding of the absence of IgG4 responses to phosphocholine (PC) in patients with lymphatic filariasis, suggest that even the chronic antigenic stimulation of filarial helminth infection, which leads to very prominent IgG4 responses to protein antigens, cannot overcome the genetic restriction in humans for making IgG4 antibodies to carbohydrate antigens, whether of parasite or non-parasite origin.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001788 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001788 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Pmc |étape= Corpus |type= RBID |clé= PMC:1384614 |texte= Lack of IgG4 antibody response to carbohydrate antigens in patients with lymphatic filariasis. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:1748481" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |