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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An essential role for <italic>Prox1</italic> in the induction of the lymphatic endothelial cell phenotype</title><author><name sortKey="Wigle, Jeffrey T" sort="Wigle, Jeffrey T" uniqKey="Wigle J" first="Jeffrey T." last="Wigle">Jeffrey T. Wigle</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff></affiliation><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Present address: Division of Stroke and Vascular Disease and Department of Biochemistry and Medical Genetics, St Boniface General Hospital Research Centre, Winnipeg, Canada</nlm:aff></affiliation></author><author><name sortKey="Harvey, Natasha" sort="Harvey, Natasha" uniqKey="Harvey N" first="Natasha" last="Harvey">Natasha Harvey</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114,</nlm:aff></affiliation></author><author><name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff></affiliation></author><author><name sortKey="Grosveld, Gerard" sort="Grosveld, Gerard" uniqKey="Grosveld G" first="Gerard" last="Grosveld">Gerard Grosveld</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff></affiliation></author><author><name sortKey="Gunn, Michael D" sort="Gunn, Michael D" uniqKey="Gunn M" first="Michael D." last="Gunn">Michael D. Gunn</name><affiliation><nlm:aff wicri:cut=" and" id="N0x99ab270.0x8bcf128">Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA</nlm:aff></affiliation></author><author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK</nlm:aff></affiliation></author><author><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff></affiliation><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Corresponding author e-mail: guillermo.oliver@stjude.org</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">11927535</idno><idno type="pmc">125938</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125938</idno><idno type="RBID">PMC:125938</idno><idno type="doi">10.1093/emboj/21.7.1505</idno><date when="2002">2002</date><idno type="wicri:Area/Pmc/Corpus">001752</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001752</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An essential role for <italic>Prox1</italic> in the induction of the lymphatic endothelial cell phenotype</title><author><name sortKey="Wigle, Jeffrey T" sort="Wigle, Jeffrey T" uniqKey="Wigle J" first="Jeffrey T." last="Wigle">Jeffrey T. Wigle</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff></affiliation><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Present address: Division of Stroke and Vascular Disease and Department of Biochemistry and Medical Genetics, St Boniface General Hospital Research Centre, Winnipeg, Canada</nlm:aff></affiliation></author><author><name sortKey="Harvey, Natasha" sort="Harvey, Natasha" uniqKey="Harvey N" first="Natasha" last="Harvey">Natasha Harvey</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114,</nlm:aff></affiliation></author><author><name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff></affiliation></author><author><name sortKey="Grosveld, Gerard" sort="Grosveld, Gerard" uniqKey="Grosveld G" first="Gerard" last="Grosveld">Gerard Grosveld</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff></affiliation></author><author><name sortKey="Gunn, Michael D" sort="Gunn, Michael D" uniqKey="Gunn M" first="Michael D." last="Gunn">Michael D. Gunn</name><affiliation><nlm:aff wicri:cut=" and" id="N0x99ab270.0x8bcf128">Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA</nlm:aff></affiliation></author><author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK</nlm:aff></affiliation></author><author><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff></affiliation><affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Corresponding author e-mail: guillermo.oliver@stjude.org</nlm:aff></affiliation></author></analytic><series><title level="j">The EMBO Journal</title><idno type="ISSN">0261-4189</idno><idno type="eISSN">1460-2075</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene <italic>Prox1</italic> is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In <italic>Prox1</italic><sup>–</sup><sup>/–</sup> embryos, this budding becomes arrested at around embryonic day (E)11.5, resulting in embryos without lymphatic vasculature. Unlike the endothelial cells that bud off in E11.5 wild-type embryos, those of <italic>Prox1</italic>-null embryos did not co-express any lymphatic markers such as VEGFR-3, LYVE-1 or SLC. Instead, the mutant cells appeared to have a blood vascular phenotype, as determined by their expression of laminin and CD34. These results suggest that <italic>Prox1</italic> activity is required for both maintenance of the budding of the venous endothelial cells and differentiation toward the lymphatic phenotype. On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">EMBO J</journal-id><journal-title>The EMBO Journal</journal-title><issn pub-type="ppub">0261-4189</issn><issn pub-type="epub">1460-2075</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">11927535</article-id><article-id pub-id-type="pmc">125938</article-id><article-id pub-id-type="publisher-id">cdf152</article-id><article-id pub-id-type="doi">10.1093/emboj/21.7.1505</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>An essential role for <italic>Prox1</italic> in the induction of the lymphatic endothelial cell phenotype</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wigle</surname><given-names>Jeffrey T.</given-names></name><xref ref-type="aff" rid="N0x99ab270.0x8bcf128">1</xref><xref ref-type="aff" rid="N0x99ab270.0x8bcf128">2</xref></contrib><contrib contrib-type="author"><name><surname>Harvey</surname><given-names>Natasha</given-names></name><xref ref-type="aff" rid="N0x99ab270.0x8bcf128">1</xref></contrib><contrib contrib-type="author"><name><surname>Detmar</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="N0x99ab270.0x8bcf128">3</xref></contrib><contrib contrib-type="author"><name><surname>Lagutina</surname><given-names>Irina</given-names></name><xref ref-type="aff" rid="N0x99ab270.0x8bcf128">1</xref></contrib><contrib contrib-type="author"><name><surname>Grosveld</surname><given-names>Gerard</given-names></name><xref ref-type="aff" rid="N0x99ab270.0x8bcf128">1</xref></contrib><contrib contrib-type="author"><name><surname>Gunn</surname><given-names>Michael D.</given-names></name><xref ref-type="aff" rid="N0x99ab270.0x8bcf128">4</xref></contrib><contrib contrib-type="author"><name><surname>Jackson</surname><given-names>David G.</given-names></name><xref ref-type="aff" rid="N0x99ab270.0x8bcf128">5</xref></contrib><contrib contrib-type="author"><name><surname>Oliver</surname><given-names>Guillermo</given-names></name><xref ref-type="aff" rid="N0x99ab270.0x8bcf128">1</xref><xref ref-type="aff" rid="N0x99ab270.0x8bcf128">6</xref></contrib></contrib-group><aff id="N0x99ab270.0x8bcf128"><label>1</label>Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,<label>3</label>Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114,<label>4</label>Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA and<label>5</label>MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK<label>2</label>Present address: Division of Stroke and Vascular Disease and Department of Biochemistry and Medical Genetics, St Boniface General Hospital Research Centre, Winnipeg, Canada<label>6</label>Corresponding author e-mail: guillermo.oliver@stjude.org</aff><pub-date pub-type="ppub"><day>2</day><month>4</month><year>2002</year></pub-date><volume>21</volume><issue>7</issue><fpage>1505</fpage><lpage>1513</lpage><ext-link ext-link-type="uri" xlink:href="http://www.emboj.oupjournals.org/content/vol21/issue7/"></ext-link><history><date date-type="received"><day>17</day><month>12</month><year>2001</year></date><date date-type="rev-recd"><day>22</day><month>1</month><year>2002</year></date><date date-type="accepted"><day>31</day><month>1</month><year>2002</year></date></history><copyright-statement>Copyright © 2002 European Molecular Biology Organization</copyright-statement><copyright-year>2002</copyright-year><abstract><p>The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene <italic>Prox1</italic> is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In <italic>Prox1</italic><sup>–</sup><sup>/–</sup> embryos, this budding becomes arrested at around embryonic day (E)11.5, resulting in embryos without lymphatic vasculature. Unlike the endothelial cells that bud off in E11.5 wild-type embryos, those of <italic>Prox1</italic>-null embryos did not co-express any lymphatic markers such as VEGFR-3, LYVE-1 or SLC. Instead, the mutant cells appeared to have a blood vascular phenotype, as determined by their expression of laminin and CD34. These results suggest that <italic>Prox1</italic> activity is required for both maintenance of the budding of the venous endothelial cells and differentiation toward the lymphatic phenotype. On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.</p></abstract><kwd-group><kwd>lymphangiogenesis/lymphatic endothelial cells/<italic>LYVE-1/Prox1</italic>/<italic>SLC</italic>/<italic>VEGFR-3</italic></kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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